NO20045301L - Substituert 1,3-diphenylprop-2-en-1-one derivat, fremstilling og anvendelse derav. - Google Patents

Substituert 1,3-diphenylprop-2-en-1-one derivat, fremstilling og anvendelse derav.

Info

Publication number
NO20045301L
NO20045301L NO20045301A NO20045301A NO20045301L NO 20045301 L NO20045301 L NO 20045301L NO 20045301 A NO20045301 A NO 20045301A NO 20045301 A NO20045301 A NO 20045301A NO 20045301 L NO20045301 L NO 20045301L
Authority
NO
Norway
Prior art keywords
diphenylprop
substituted
preparation
derivative
derivatives
Prior art date
Application number
NO20045301A
Other languages
English (en)
Other versions
NO329700B1 (no
Inventor
Jamila Najib
Karine Caumont-Bertrand
Original Assignee
Genfit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit filed Critical Genfit
Publication of NO20045301L publication Critical patent/NO20045301L/no
Publication of NO329700B1 publication Critical patent/NO329700B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Oppfinnelsen vedrører substituerte l,3-difenylprop-2-en-l-on-derivater, farmasøytiske preparater som inneholder disse, terapeutiske anvendelser av dem, særlig for behandling av cerebral iskemi. Oppfinnelsen vedrører også en fremgangsmåte til fremstilling av derivatene.
NO20045301A 2002-07-08 2004-12-03 Substituerte 1,3-diphenylprop-2-en-1-one derivat og farmasoytiskepreparater derav, samt fremgangsmate til fremstilling derav NO329700B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0208571A FR2841900B1 (fr) 2002-07-08 2002-07-08 Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
PCT/FR2003/002127 WO2004005233A1 (fr) 2002-07-08 2003-07-08 Derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations

Publications (2)

Publication Number Publication Date
NO20045301L true NO20045301L (no) 2005-02-04
NO329700B1 NO329700B1 (no) 2010-12-06

Family

ID=29725283

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045301A NO329700B1 (no) 2002-07-08 2004-12-03 Substituerte 1,3-diphenylprop-2-en-1-one derivat og farmasoytiskepreparater derav, samt fremgangsmate til fremstilling derav

Country Status (24)

Country Link
US (3) US7943661B2 (no)
EP (1) EP1525177B1 (no)
JP (1) JP4575771B2 (no)
KR (1) KR100974577B1 (no)
CN (1) CN100548960C (no)
AT (1) ATE365703T1 (no)
AU (1) AU2003264698B2 (no)
BR (1) BRPI0312398B8 (no)
CA (1) CA2490986C (no)
CY (1) CY1108085T1 (no)
DE (1) DE60314633T2 (no)
DK (1) DK1525177T3 (no)
EA (1) EA011090B1 (no)
ES (1) ES2287528T3 (no)
FR (1) FR2841900B1 (no)
IL (2) IL165696A0 (no)
MX (1) MXPA05000427A (no)
NO (1) NO329700B1 (no)
NZ (1) NZ538051A (no)
PL (1) PL207362B1 (no)
PT (1) PT1525177E (no)
SI (1) SI1525177T1 (no)
WO (1) WO2004005233A1 (no)
ZA (1) ZA200501082B (no)

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FR2841900B1 (fr) 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
BRPI0506718A (pt) * 2004-01-08 2007-05-02 Genfit compostos, processo de preparação dos mesmos, e, composição farmacêutica ou cosmética
FR2902789A1 (fr) 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations
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CA2781451C (en) * 2009-11-26 2019-04-16 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
US10722575B2 (en) 2009-11-26 2020-07-28 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
ES2656330T3 (es) 2010-05-17 2018-02-26 Genfit Preparación mejorada de derivados de chalcona
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MX362862B (es) 2011-12-28 2019-02-20 Genfit Derivados de 1,3-difenilpropano, preparaciones y usos de los mismos.
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WO2019186410A1 (en) * 2018-03-27 2019-10-03 Lupin Limited Solid forms of elafibranor and processes thereof
TW202019870A (zh) * 2018-08-03 2020-06-01 法商Ｇｅｎｆｉｔ公司 艾拉菲諾鹽
WO2020039297A1 (en) * 2018-08-24 2020-02-27 Mankind Pharma Ltd. Novel compounds and their use in preparation of elafibranor and pharmaceutical acceptable salts thereof
WO2020115628A1 (en) * 2018-12-03 2020-06-11 Mankind Pharma Ltd. Solid forms of elafibranor and process of preparation thereof
CN110156648A (zh) * 2019-05-30 2019-08-23 河北科技大学 一种Elafibranor中间体的制备方法
CA3153784A1 (en) 2019-10-28 2021-05-06 Nicolas STANKOVIC-VALENTIN Combination therapy of elafibranor and nitazoxanide having antioxident properties
CN112824380A (zh) * 2019-11-21 2021-05-21 杭州百诚医药科技股份有限公司 α-氟代查耳酮类衍生物及其应用
CN111138264B (zh) * 2019-11-29 2023-08-04 温州医科大学 一种丁香醛衍生物及其在制备抗妇科肿瘤药物中的应用
CN113121394B (zh) * 2019-12-30 2022-11-08 中国药科大学 一种苯氧乙酸类衍生物的制备方法
AU2021219286A1 (en) 2020-02-10 2022-09-22 Genfit Polymorphs of elafibranor
KR20230011958A (ko) 2020-05-18 2023-01-25 장피트 원발성 경화성 담관염의 치료를 위한 엘라피브라노
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Also Published As

Publication number Publication date
US20070032543A1 (en) 2007-02-08
PT1525177E (pt) 2007-09-06
US7566737B2 (en) 2009-07-28
ZA200501082B (en) 2007-01-31
SI1525177T1 (sl) 2007-10-31
EP1525177A1 (fr) 2005-04-27
PL207362B1 (pl) 2010-12-31
US8058308B2 (en) 2011-11-15
CN100548960C (zh) 2009-10-14
CY1108085T1 (el) 2014-02-12
EA200500169A1 (ru) 2005-06-30
JP4575771B2 (ja) 2010-11-04
BR0312398A (pt) 2005-04-12
ES2287528T3 (es) 2007-12-16
FR2841900A1 (fr) 2004-01-09
EP1525177B1 (fr) 2007-06-27
KR20050025327A (ko) 2005-03-14
AU2003264698B2 (en) 2009-09-17
MXPA05000427A (es) 2005-09-30
DE60314633T2 (de) 2008-02-28
AU2003264698A1 (en) 2004-01-23
WO2004005233A1 (fr) 2004-01-15
BRPI0312398B1 (pt) 2016-11-08
NZ538051A (en) 2007-11-30
KR100974577B1 (ko) 2010-08-06
DK1525177T3 (da) 2007-10-22
JP2005532385A (ja) 2005-10-27
US7943661B2 (en) 2011-05-17
CN1668565A (zh) 2005-09-14
BRPI0312398B8 (pt) 2021-05-25
ATE365703T1 (de) 2007-07-15
CA2490986C (fr) 2012-09-18
NO329700B1 (no) 2010-12-06
DE60314633D1 (de) 2007-08-09
US20050176808A1 (en) 2005-08-11
EA011090B1 (ru) 2008-12-30
FR2841900B1 (fr) 2007-03-02
US20110190515A1 (en) 2011-08-04
IL165696A0 (en) 2006-01-15
IL165696A (en) 2012-09-24
CA2490986A1 (fr) 2004-01-15
PL372809A1 (en) 2005-08-08

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