ZA200501082B - Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereof - Google Patents
Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereofInfo
- Publication number
- ZA200501082B ZA200501082B ZA200501082A ZA200501082A ZA200501082B ZA 200501082 B ZA200501082 B ZA 200501082B ZA 200501082 A ZA200501082 A ZA 200501082A ZA 200501082 A ZA200501082 A ZA 200501082A ZA 200501082 B ZA200501082 B ZA 200501082B
- Authority
- ZA
- South Africa
- Prior art keywords
- derivatives
- diphenylprop
- substituted
- preparation
- concerns
- Prior art date
Links
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical class C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 title abstract 2
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0208571A FR2841900B1 (fr) | 2002-07-08 | 2002-07-08 | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200501082B true ZA200501082B (en) | 2007-01-31 |
Family
ID=29725283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200501082A ZA200501082B (en) | 2002-07-08 | 2005-02-07 | Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereof |
Country Status (24)
Country | Link |
---|---|
US (3) | US7943661B2 (no) |
EP (1) | EP1525177B1 (no) |
JP (1) | JP4575771B2 (no) |
KR (1) | KR100974577B1 (no) |
CN (1) | CN100548960C (no) |
AT (1) | ATE365703T1 (no) |
AU (1) | AU2003264698B2 (no) |
BR (1) | BRPI0312398B8 (no) |
CA (1) | CA2490986C (no) |
CY (1) | CY1108085T1 (no) |
DE (1) | DE60314633T2 (no) |
DK (1) | DK1525177T3 (no) |
EA (1) | EA011090B1 (no) |
ES (1) | ES2287528T3 (no) |
FR (1) | FR2841900B1 (no) |
IL (2) | IL165696A0 (no) |
MX (1) | MXPA05000427A (no) |
NO (1) | NO329700B1 (no) |
NZ (1) | NZ538051A (no) |
PL (1) | PL207362B1 (no) |
PT (1) | PT1525177E (no) |
SI (1) | SI1525177T1 (no) |
WO (1) | WO2004005233A1 (no) |
ZA (1) | ZA200501082B (no) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2841784B1 (fr) | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
FR2841900B1 (fr) | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
WO2005073184A1 (fr) * | 2004-01-08 | 2005-08-11 | Genfit | Composes derives de 1,3-diphenylprop-2-en-1-one, preparation et utilisations |
FR2902789A1 (fr) | 2006-06-21 | 2007-12-28 | Genfit Sa | Derives de 1,3-diphenylpropane substitues, preparations et utilisations |
US20100285126A1 (en) * | 2007-08-02 | 2010-11-11 | Rahul Dabre | Pharmaceutical compositions of fenofibrate |
CA2781451C (en) * | 2009-11-26 | 2019-04-16 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
US9221751B2 (en) | 2009-11-26 | 2015-12-29 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
US10722575B2 (en) | 2009-11-26 | 2020-07-28 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
WO2011080276A1 (en) | 2009-12-29 | 2011-07-07 | Genfit | Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative |
ES2656330T3 (es) | 2010-05-17 | 2018-02-26 | Genfit | Preparación mejorada de derivados de chalcona |
TWI415600B (zh) * | 2011-08-10 | 2013-11-21 | Univ Kaohsiung Medical | 用於治療動脈粥狀硬化的組合物及其製備方法 |
CA2858285C (en) | 2011-12-28 | 2021-06-08 | Genfit | 1,3-diphenylpropane derivatives, preparations and uses thereof |
CN102697757B (zh) * | 2012-05-18 | 2014-06-04 | 广州军区广州总医院 | 对羟基苄叉丙酮在制备预防和/或治疗脑病药物中的应用 |
EP2948137B1 (en) | 2013-01-18 | 2018-11-14 | Genfit | Methods of treatment of fibrosis and cancers |
US10442761B2 (en) | 2016-02-16 | 2019-10-15 | Concert Pharmaceuticals, Inc. | Deuterated GFT-505 |
CN109152756B (zh) | 2016-03-31 | 2022-05-17 | 基恩菲特公司 | 胆汁淤积性疾病的治疗方法 |
FR3056908B1 (fr) * | 2016-09-30 | 2019-04-19 | Nashpharm | Sel de metformine et d'elafibranor presentant une activite duale pour le traitement de l'obesite associee a la steato-hepatite non alcoolique (nash) et a l'hypertriglyceridemie |
FR3056909B1 (fr) * | 2016-09-30 | 2019-04-19 | Nashpharm | Composition comprenant au moins un sel pharmaceutiquement acceptable d'elafibranor soluble en milieux aqueux presentant une absorption intestinale amelioree |
WO2018112037A1 (en) * | 2016-12-16 | 2018-06-21 | Jia Zhou | Inhibitors of bromodomain-containing protein 4 (brd4) |
CA3051146A1 (en) * | 2017-01-22 | 2018-07-26 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystal form of gft-505 and preparation method and use thereof |
ES2959842T3 (es) | 2017-02-21 | 2024-02-28 | Genfit | Combinación de un agonista de PPAR con un agonista de FXR |
EP3585384A1 (en) | 2017-02-24 | 2020-01-01 | Genfit | Pharmaceutical compositions for combination therapy |
SG11201909168VA (en) | 2017-04-18 | 2019-11-28 | Genfit | Combination comprising a ppar agonist such as elafibranor and an acetyl-coa carboxylase (acc) inhibitor |
CN108658908B (zh) * | 2017-07-31 | 2019-05-10 | 广州必贝特医药技术有限公司 | 1,3-二取代烯酮类化合物及其应用 |
CN111183132A (zh) | 2017-08-04 | 2020-05-19 | 阿德万泰克咨询与技术股份有限公司 | Elafibranor的制备方法及新型合成中间体 |
CN111093705A (zh) | 2017-09-13 | 2020-05-01 | 诺华股份有限公司 | 包含fxr激动剂的组合 |
WO2019099761A1 (en) | 2017-11-16 | 2019-05-23 | Teva Pharmaceuticals International Gmbh | Solid state forms of elafibranor |
EP3719010B1 (en) | 2017-11-30 | 2023-07-26 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Aromatic compound, pharmaceutical composition thereof and use thereof |
EP3514541A1 (de) | 2018-01-17 | 2019-07-24 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zur quantitativen bestimmung eines therapeutischen tnf-alpha inhibitors |
WO2019186410A1 (en) * | 2018-03-27 | 2019-10-03 | Lupin Limited | Solid forms of elafibranor and processes thereof |
EP3830070A1 (en) | 2018-08-03 | 2021-06-09 | Genfit | Elafibranor salts |
WO2020039297A1 (en) * | 2018-08-24 | 2020-02-27 | Mankind Pharma Ltd. | Novel compounds and their use in preparation of elafibranor and pharmaceutical acceptable salts thereof |
WO2020115628A1 (en) * | 2018-12-03 | 2020-06-11 | Mankind Pharma Ltd. | Solid forms of elafibranor and process of preparation thereof |
CN110156648A (zh) * | 2019-05-30 | 2019-08-23 | 河北科技大学 | 一种Elafibranor中间体的制备方法 |
AU2020376223A1 (en) | 2019-10-28 | 2022-06-02 | Genfit | Combination therapy having antioxydant properties |
CN112824380A (zh) * | 2019-11-21 | 2021-05-21 | 杭州百诚医药科技股份有限公司 | α-氟代查耳酮类衍生物及其应用 |
CN111138264B (zh) * | 2019-11-29 | 2023-08-04 | 温州医科大学 | 一种丁香醛衍生物及其在制备抗妇科肿瘤药物中的应用 |
CN113121394B (zh) * | 2019-12-30 | 2022-11-08 | 中国药科大学 | 一种苯氧乙酸类衍生物的制备方法 |
EP4103546A1 (en) * | 2020-02-10 | 2022-12-21 | Genfit | Polymorphs of elafibranor |
EP4153156A1 (en) | 2020-05-18 | 2023-03-29 | Genfit | Elafibranor for the treatment of primary sclerosing cholangitis |
JP2023539490A (ja) | 2020-08-26 | 2023-09-14 | ジェンフィット | 原発性胆汁性胆管炎の治療のための組成物及び方法 |
CN113230240B (zh) * | 2021-03-22 | 2022-12-27 | 广州医科大学 | 1,3-二苯基丙-2-烯-1-酮衍生物及其应用 |
CN114853686B (zh) | 2021-08-23 | 2023-06-20 | 中国药科大学 | 三氮唑酮类化合物及其医药用途 |
CN115894379A (zh) | 2022-01-20 | 2023-04-04 | 中国药科大学 | 海因类化合物及其医药用途 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3558612A (en) * | 1968-05-22 | 1971-01-26 | Dow Chemical Co | Substituted phenoxyacetic acids |
CH593224A5 (no) * | 1973-10-30 | 1977-11-30 | Taisho Pharmaceutical Co Ltd | |
US3994955A (en) * | 1975-01-20 | 1976-11-30 | G. D. Searle & Co. | Substituted phenoxydialkylacetic acids and esters |
JPS5278856A (en) | 1975-12-26 | 1977-07-02 | Taisho Pharmaceut Co Ltd | Preparation of chalcone ethers |
US4190671A (en) * | 1977-03-17 | 1980-02-26 | Biorex Laboratories Limited | Chalcone derivatives |
JPS5419947A (en) | 1977-07-16 | 1979-02-15 | Taisho Pharmaceut Co Ltd | Chalcone derivatives |
GB8426424D0 (en) * | 1984-10-19 | 1984-11-28 | Biorex Laboratories Ltd | Chalcone derivatives |
JPS6310720A (ja) | 1986-07-01 | 1988-01-18 | Nippon Kayaku Co Ltd | 5−リポキシゲナ−ゼ阻害剤および抗アレルギ−剤 |
JPH023670A (ja) * | 1988-06-22 | 1990-01-09 | Nippon Oil & Fats Co Ltd | アルキルチオカルコン誘導体 |
DE68915269T2 (de) * | 1988-11-25 | 1994-09-29 | Dainippon Ink & Chemicals | Polyvalentes entzündungshemmendes mittel. |
JPH0442229A (ja) * | 1990-06-08 | 1992-02-12 | Fujitsu Ltd | レジスト材料およびパターンの形成方法 |
JPH05255655A (ja) | 1992-03-12 | 1993-10-05 | Kanebo Ltd | 紫外線吸収剤 |
JPH06122623A (ja) | 1992-10-09 | 1994-05-06 | Minofuaagen Seiyaku Honpo:Goushi | 抗腫瘍剤 |
US5276058A (en) * | 1993-06-09 | 1994-01-04 | Nippon Hypox Laboratories Incorporated | 3,4-dihydroxychalcone derivatives |
DE4327365A1 (de) | 1993-08-14 | 1995-02-16 | Boehringer Mannheim Gmbh | Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung |
US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
WO1998027970A2 (en) | 1996-12-24 | 1998-07-02 | National Research Council Of Canada | Treatment of diseases or prevention of cellular damage caused by oxygen-containing free radicals |
EP0947511A1 (en) | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity |
WO2000023073A1 (en) | 1998-10-20 | 2000-04-27 | Korea Institute Of Science And Technology | Bioflavonoids as plasma high density lipoprotein level increasing agent |
WO2001054682A1 (fr) * | 2000-01-27 | 2001-08-02 | Takara Bio Inc. | Medicaments |
MXPA02012660A (es) | 2000-06-20 | 2004-05-14 | Atherogenics Inc | 1,3-(fenilo-substituido-bis)-2-propen-1-onas y su uso para el tratamiento de padecimientos transmitidos por el vcam-1. |
EP1254759B1 (de) | 2001-05-03 | 2009-03-18 | Leister Process Technologies | Düse zum Schweissen von Kunststoffbahnen oder -folien |
FR2841900B1 (fr) | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
FR2841784B1 (fr) * | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
FR2857361B1 (fr) * | 2003-07-08 | 2005-09-09 | Genfit S A | PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one |
WO2005073184A1 (fr) * | 2004-01-08 | 2005-08-11 | Genfit | Composes derives de 1,3-diphenylprop-2-en-1-one, preparation et utilisations |
-
2002
- 2002-07-08 FR FR0208571A patent/FR2841900B1/fr not_active Expired - Fee Related
-
2003
- 2003-07-08 IL IL16569603A patent/IL165696A0/xx unknown
- 2003-07-08 JP JP2004518890A patent/JP4575771B2/ja not_active Expired - Lifetime
- 2003-07-08 EP EP03762749A patent/EP1525177B1/fr not_active Expired - Lifetime
- 2003-07-08 NZ NZ538051A patent/NZ538051A/en not_active IP Right Cessation
- 2003-07-08 SI SI200330864T patent/SI1525177T1/sl unknown
- 2003-07-08 ES ES03762749T patent/ES2287528T3/es not_active Expired - Lifetime
- 2003-07-08 PT PT03762749T patent/PT1525177E/pt unknown
- 2003-07-08 MX MXPA05000427A patent/MXPA05000427A/es active IP Right Grant
- 2003-07-08 CA CA2490986A patent/CA2490986C/fr not_active Expired - Fee Related
- 2003-07-08 WO PCT/FR2003/002127 patent/WO2004005233A1/fr active IP Right Grant
- 2003-07-08 EA EA200500169A patent/EA011090B1/ru not_active IP Right Cessation
- 2003-07-08 US US10/520,079 patent/US7943661B2/en active Active
- 2003-07-08 CN CNB038163667A patent/CN100548960C/zh not_active Expired - Lifetime
- 2003-07-08 BR BRPI0312398A patent/BRPI0312398B8/pt not_active IP Right Cessation
- 2003-07-08 PL PL372809A patent/PL207362B1/pl unknown
- 2003-07-08 AU AU2003264698A patent/AU2003264698B2/en not_active Ceased
- 2003-07-08 KR KR1020057000349A patent/KR100974577B1/ko active IP Right Grant
- 2003-07-08 DK DK03762749T patent/DK1525177T3/da active
- 2003-07-08 AT AT03762749T patent/ATE365703T1/de active
- 2003-07-08 DE DE60314633T patent/DE60314633T2/de not_active Expired - Lifetime
-
2004
- 2004-12-03 NO NO20045301A patent/NO329700B1/no not_active IP Right Cessation
- 2004-12-09 IL IL165696A patent/IL165696A/en active IP Right Grant
-
2005
- 2005-02-07 ZA ZA200501082A patent/ZA200501082B/xx unknown
-
2006
- 2006-07-26 US US11/493,040 patent/US7566737B2/en not_active Expired - Lifetime
-
2007
- 2007-08-03 CY CY20071101040T patent/CY1108085T1/el unknown
-
2011
- 2011-04-11 US US13/083,659 patent/US8058308B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA200501082B (en) | Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereof | |
IL165977A (en) | Substituted pyrimidinylaminobenzamides , process for the preparation thereof and pharmaceutical compositions comprising the same | |
AU2003233010A8 (en) | Process for the preparation of 3,3,4,4-tetrafluoropyrrolidine and derivatives thereof | |
MY125978A (en) | Admantane derivatives | |
HK1167332A1 (en) | Pharmaceutical composition, use thereof and method for making the same | |
IL160440A0 (en) | Novel dihydropteridinones, method for producing the same and the use thereof as medicaments | |
GR1003350B (el) | Νεες ενωσεις | |
IL150225A0 (en) | Lipopeptides, pharmaceutical compositions containing the same and methods for the production thereof | |
AU2003297199A8 (en) | Human chondroitinase glycoprotein (chasegp), process for preparing the same, and pharmaceutical compositions comprising thereof | |
IL161428A0 (en) | Oligoamine derivatives, methods for the production thereof and pharmaceutical compositions containing the same | |
WO2002067865A3 (en) | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof | |
EP1539718A4 (en) | 1,2,4-TRIAZOL DERIVATIVE, METHOD FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF | |
AU2002368133A1 (en) | 1,3-azole derivative and medicinal composition containing the derivative for treatment for thombosis | |
IL164887A0 (en) | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith | |
AU6814701A (en) | Methods and compositions for producing a neurosalutary effect in a subject | |
WO2002076930A3 (en) | Substituted diarylureas as stimulators for fas-mediated apoptosis | |
MXPA03010259A (es) | Nuevos derivados de 5-tio-ss-d-xilopiranosida, procedimiento de preparacion, composiciones farmaceuticas que los contienen y el uso terapeutico de los mismos. | |
HUP0103686A2 (en) | Use of rolipram, ariflo or diazepino-indole, triazolo-quinazoline derivatives for the preparation of pharmaceutical compositions preventing or treating diseases associated with an excess in il-12 production | |
RS47804A (en) | 1,3-diarylprop-2-en-1-ones, compositions containing same and use thereof | |
AU2003249999A8 (en) | 1,4,7,10-tetraazacyclododecanes as modulators of the guanine-binding protein for treating tumours | |
EP1515960A4 (en) | 2-THIOXOTHIAZOL DERIVATIVE, METHOD FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF | |
AU2003232684A8 (en) | Pyrazole-3-one derivative, method for preparing the same, and pharmaceutical composition containing the same | |
MXPA03008636A (es) | Derivados de isoquinuclidina, metodo para fabricar los mismos y agentes terapeuticos que contienen estos compuestos. | |
WO2004078761A8 (en) | Enantiomerically pure cilazapril,process for preparation | |
EP1338275A4 (en) | Pharmaceutical composition, its use and method of making the same |