NO329376B1 - Farmasoytiske formuleringer som inneholder organiske forbindelser, og anvendelse derav - Google Patents
Farmasoytiske formuleringer som inneholder organiske forbindelser, og anvendelse derav Download PDFInfo
- Publication number
- NO329376B1 NO329376B1 NO20003930A NO20003930A NO329376B1 NO 329376 B1 NO329376 B1 NO 329376B1 NO 20003930 A NO20003930 A NO 20003930A NO 20003930 A NO20003930 A NO 20003930A NO 329376 B1 NO329376 B1 NO 329376B1
- Authority
- NO
- Norway
- Prior art keywords
- epothilone
- formulation according
- pharmaceutical formulation
- infusion
- pharmaceutically acceptable
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 21
- 150000002894 organic compounds Chemical class 0.000 title 1
- 229930013356 epothilone Natural products 0.000 claims description 39
- 150000003883 epothilone derivatives Chemical class 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 28
- 238000001802 infusion Methods 0.000 claims description 21
- 239000012141 concentrate Substances 0.000 claims description 20
- 239000002904 solvent Substances 0.000 claims description 18
- 239000003978 infusion fluid Substances 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 238000009472 formulation Methods 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 238000011282 treatment Methods 0.000 claims description 15
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- -1 polyoxyethylene Polymers 0.000 claims description 2
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- HESCAJZNRMSMJG-HGYUPSKWSA-N epothilone A Natural products O=C1[C@H](C)[C@H](O)[C@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C HESCAJZNRMSMJG-HGYUPSKWSA-N 0.000 description 39
- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 description 28
- QXRSDHAAWVKZLJ-PVYNADRNSA-N epothilone B Chemical group C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 QXRSDHAAWVKZLJ-PVYNADRNSA-N 0.000 description 24
- QXRSDHAAWVKZLJ-OXZHEXMSSA-N Epothilone B Chemical group O=C1[C@H](C)[C@H](O)[C@@H](C)CCC[C@@]2(C)O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C QXRSDHAAWVKZLJ-OXZHEXMSSA-N 0.000 description 23
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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GBGB9802451.6A GB9802451D0 (en) | 1998-02-05 | 1998-02-05 | Organic compounds |
GBGB9813646.8A GB9813646D0 (en) | 1998-06-24 | 1998-06-24 | Organic compounds |
PCT/EP1999/000702 WO1999039694A2 (en) | 1998-02-05 | 1999-02-03 | Compositions containing organic compounds |
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NO20003930D0 NO20003930D0 (no) | 2000-08-03 |
NO20003930L NO20003930L (no) | 2000-10-04 |
NO329376B1 true NO329376B1 (no) | 2010-10-04 |
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NO20003930A NO329376B1 (no) | 1998-02-05 | 2000-08-03 | Farmasoytiske formuleringer som inneholder organiske forbindelser, og anvendelse derav |
NO20100302A NO20100302L (no) | 1998-02-05 | 2010-03-04 | Sammensetninger som inneholder organiske forbindelser |
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NO20100302A NO20100302L (no) | 1998-02-05 | 2010-03-04 | Sammensetninger som inneholder organiske forbindelser |
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US (5) | US20030203876A1 (pl) |
EP (1) | EP1052974B1 (pl) |
JP (2) | JP4644364B2 (pl) |
KR (3) | KR20080016756A (pl) |
CN (2) | CN100396276C (pl) |
AR (1) | AR017979A1 (pl) |
AT (1) | ATE431733T1 (pl) |
AU (1) | AU753519B2 (pl) |
BE (1) | BE1012140A3 (pl) |
BR (1) | BR9907647B1 (pl) |
CA (1) | CA2320182C (pl) |
CL (1) | CL2003002786A1 (pl) |
CO (1) | CO4920246A1 (pl) |
CY (1) | CY1109311T1 (pl) |
CZ (1) | CZ303168B6 (pl) |
DE (1) | DE69940904D1 (pl) |
DK (1) | DK1052974T3 (pl) |
ES (1) | ES2324378T3 (pl) |
FR (1) | FR2774909B1 (pl) |
HK (1) | HK1033809A1 (pl) |
HU (1) | HUP0101564A3 (pl) |
ID (1) | ID26549A (pl) |
IL (2) | IL137550A0 (pl) |
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MX (1) | MXPA00007681A (pl) |
MY (1) | MY125921A (pl) |
NO (2) | NO329376B1 (pl) |
NZ (1) | NZ506389A (pl) |
PE (1) | PE20000272A1 (pl) |
PL (1) | PL201329B1 (pl) |
PT (1) | PT1052974E (pl) |
RU (1) | RU2214246C2 (pl) |
SI (1) | SI1052974T1 (pl) |
SK (2) | SK287487B6 (pl) |
TR (1) | TR200002299T2 (pl) |
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