NO329113B1 - Nye retinoider, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdom - Google Patents
Nye retinoider, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdom Download PDFInfo
- Publication number
- NO329113B1 NO329113B1 NO20031480A NO20031480A NO329113B1 NO 329113 B1 NO329113 B1 NO 329113B1 NO 20031480 A NO20031480 A NO 20031480A NO 20031480 A NO20031480 A NO 20031480A NO 329113 B1 NO329113 B1 NO 329113B1
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- Norway
- Prior art keywords
- tetramethyl
- compound according
- tetrahydro
- mmol
- formula
- Prior art date
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
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- C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23745900P | 2000-10-02 | 2000-10-02 | |
PCT/EP2001/011017 WO2002028810A2 (en) | 2000-10-02 | 2001-09-24 | Retinoids for the treatment of emphysema |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20031480D0 NO20031480D0 (no) | 2003-04-01 |
NO20031480L NO20031480L (no) | 2003-05-20 |
NO329113B1 true NO329113B1 (no) | 2010-08-30 |
Family
ID=22893812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20031480A NO329113B1 (no) | 2000-10-02 | 2003-04-01 | Nye retinoider, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdom |
Country Status (36)
Country | Link |
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US (1) | US6777418B2 (hu) |
EP (1) | EP1324970B1 (hu) |
JP (1) | JP4118675B2 (hu) |
KR (1) | KR100682144B1 (hu) |
CN (1) | CN1321101C (hu) |
AR (1) | AR034156A1 (hu) |
AT (1) | ATE413375T1 (hu) |
AU (2) | AU2001289913B2 (hu) |
BR (1) | BRPI0114344B8 (hu) |
CA (1) | CA2422805C (hu) |
CY (1) | CY1109045T1 (hu) |
CZ (1) | CZ307141B6 (hu) |
DE (1) | DE60136477D1 (hu) |
DK (1) | DK1324970T3 (hu) |
EC (1) | ECSP034518A (hu) |
ES (1) | ES2316471T3 (hu) |
GT (1) | GT200100199A (hu) |
HK (1) | HK1061229A1 (hu) |
HR (1) | HRP20030230B1 (hu) |
HU (1) | HU230063B1 (hu) |
IL (2) | IL154810A0 (hu) |
JO (1) | JO2434B1 (hu) |
MA (1) | MA26950A1 (hu) |
MX (1) | MXPA03002861A (hu) |
MY (1) | MY137435A (hu) |
NO (1) | NO329113B1 (hu) |
NZ (1) | NZ524603A (hu) |
PA (1) | PA8529701A1 (hu) |
PL (1) | PL208665B1 (hu) |
PT (1) | PT1324970E (hu) |
RS (1) | RS50354B (hu) |
RU (1) | RU2282616C2 (hu) |
SI (1) | SI1324970T1 (hu) |
TW (1) | TWI304805B (hu) |
WO (1) | WO2002028810A2 (hu) |
ZA (1) | ZA200301978B (hu) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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US20030236301A1 (en) * | 2001-12-19 | 2003-12-25 | Bob Sanders | Liposomal delivery of vitamin E based compounds |
MXPA06007255A (es) | 2003-12-26 | 2006-08-18 | Allergan Inc | Oximas de chalcona disubstituidas que tienen actividad antagonista de los receptores retinoides rar?. |
US7476673B2 (en) * | 2003-12-30 | 2009-01-13 | Allergan, Inc. | Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors |
GB2411115A (en) * | 2004-02-19 | 2005-08-24 | Medical Res Council | Retinoic acid antagonists for the treatment of oesophageal disorders |
KR20070007818A (ko) | 2004-03-10 | 2007-01-16 | 재단법인 이쯔우 연구소 | 기억 고정 촉진제 |
BRPI0709886A2 (pt) * | 2006-03-31 | 2011-07-26 | Hoffmann La Roche | processo para a preparaÇço de compostos retinàides |
EP2089023A2 (en) * | 2006-11-02 | 2009-08-19 | Aestus Therapeutics, Inc. | Methods of treating neuropathic pain with agonists of ppar-gamma |
TW201014598A (en) * | 2008-08-27 | 2010-04-16 | Otsuka Pharma Co Ltd | Agent for treating pulmonary disease |
BR112013004685B1 (pt) | 2010-09-01 | 2021-09-21 | Thomas Jefferson University | Uso de um agonista de receptor gama de ácido retinóico (rar?) para reparação e regeneração muscular |
CN105188753B (zh) | 2012-11-08 | 2018-12-18 | 国立大学法人山口大学 | 角结膜病症的治疗剂 |
KR102303316B1 (ko) | 2013-05-22 | 2021-09-23 | 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 | 망막 맥락막 장해의 억제제 |
EP3009435B1 (en) * | 2014-10-15 | 2016-08-17 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Apixaban glycol esters as key intermediates and impurities of the synthesis of Apixaban |
US10940127B2 (en) | 2015-11-25 | 2021-03-09 | Io Therapeutics, Inc. | Use of CYP26-resistant RAR alpha selective agonists in the treatment of cancer |
ES2963348T3 (es) | 2016-06-08 | 2024-03-26 | Clementia Pharmaceuticals Inc | Métodos para tratar la osificación heterotópica |
AU2017278220C1 (en) | 2016-06-10 | 2022-10-13 | Io Therapeutics, Inc. | Receptor selective retinoid and rexinoid compounds and immune modulators for cancer immunotherapy |
KR20180036522A (ko) * | 2016-09-30 | 2018-04-09 | (주)나노믹스 | 스틸벤 유도체 및 그 제조 방법 |
EP3541380B1 (en) | 2016-11-16 | 2021-12-15 | Clementia Pharmaceuticals Inc. | Methods for treating multiple osteochondroma (mo) |
AU2018298193A1 (en) | 2017-07-06 | 2020-01-02 | Jiangsu Hengrui Medicine Co., Ltd. | Indole-formamide derivative, preparation method therefor and use thereof in medicine |
CA3069672A1 (en) | 2017-07-13 | 2019-01-17 | Io Therapeutics, Inc. | Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy |
AU2018326617B2 (en) | 2017-08-31 | 2022-12-01 | Io Therapeutics, Inc. | Rar selective agonists in combination with immune modulators for cancer immunotherapy |
KR20240111779A (ko) * | 2021-11-23 | 2024-07-17 | 아이오 테라퓨틱스, 인크. | 암 치료를 위해 RARγ 효능제를 사용하는 방법 |
CN115073394A (zh) * | 2022-06-29 | 2022-09-20 | 上海中医药大学 | 一种高烯丙基类化合物及其制备方法和应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3202100A1 (de) * | 1982-01-23 | 1983-08-04 | Basf Ag, 6700 Ludwigshafen | Substituierte benzoesaeure-4-hydroxyanilide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
US5527945A (en) | 1989-02-10 | 1996-06-18 | Basf Aktiengesellschaft | Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom |
US5324840A (en) | 1992-06-11 | 1994-06-28 | Allergan, Inc. | Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects |
ES2139063T3 (es) * | 1993-01-11 | 2000-02-01 | Ligand Pharm Inc | Compuestos que tienen selectividad por receptores de retinoides x. |
CA2129773C (en) * | 1993-09-02 | 2007-05-01 | Michael Klaus | Aromatic carboxylic acid derivatives |
WO1995033745A2 (en) | 1994-06-07 | 1995-12-14 | Sri International | Novel compounds useful in modulating gene expression of retinoid responsive genes and/or having anti-ap-1 activity |
AU693682B2 (en) | 1995-04-10 | 1998-07-02 | Taiho Pharmaceutical Co., Ltd. | Cancerous metastasis inhibitor |
US5965606A (en) * | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
FR2746098B1 (fr) | 1996-03-14 | 1998-04-30 | Composes propynyl biaromatiques | |
FR2753091B1 (fr) | 1996-09-09 | 2001-03-16 | Oreal | Utilisation d'un agoniste des recepteurs des retinoides de type rxr pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute |
US5998486A (en) * | 1997-07-08 | 1999-12-07 | Georgetown University School Of Medicine | Treatment of emphysema with retinoic acid or other retinoids by inducing formation of gas-exchange units (alveoli) |
TWI281911B (en) * | 2000-04-04 | 2007-06-01 | Allergan Inc | Treatment of tumors with RARalpha selective retinoid compounds in combination with other anti-tumor agents |
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2001
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- 2001-09-24 WO PCT/EP2001/011017 patent/WO2002028810A2/en active IP Right Grant
- 2001-09-24 CN CNB018167098A patent/CN1321101C/zh not_active Expired - Lifetime
- 2001-09-24 RU RU2003112608/04A patent/RU2282616C2/ru active
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- 2001-09-24 AU AU8991301A patent/AU8991301A/xx active Pending
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- 2001-09-24 CZ CZ2003-1216A patent/CZ307141B6/cs not_active IP Right Cessation
- 2001-09-24 RS YUP-244/03A patent/RS50354B/sr unknown
- 2001-09-24 CA CA2422805A patent/CA2422805C/en not_active Expired - Lifetime
- 2001-09-24 KR KR1020037004742A patent/KR100682144B1/ko active IP Right Grant
- 2001-09-24 HU HU0303006A patent/HU230063B1/hu unknown
- 2001-09-24 DE DE60136477T patent/DE60136477D1/de not_active Expired - Lifetime
- 2001-09-24 DK DK01969762T patent/DK1324970T3/da active
- 2001-09-24 AT AT01969762T patent/ATE413375T1/de active
- 2001-09-24 NZ NZ524603A patent/NZ524603A/en not_active IP Right Cessation
- 2001-09-24 BR BRPI0114344 patent/BRPI0114344B8/pt not_active IP Right Cessation
- 2001-09-24 ES ES01969762T patent/ES2316471T3/es not_active Expired - Lifetime
- 2001-09-27 JO JO2001155A patent/JO2434B1/en active
- 2001-09-27 AR ARP010104552A patent/AR034156A1/es unknown
- 2001-09-28 PA PA20018529701A patent/PA8529701A1/es unknown
- 2001-09-28 MY MYPI20014544A patent/MY137435A/en unknown
- 2001-10-01 US US09/968,425 patent/US6777418B2/en not_active Expired - Lifetime
- 2001-10-02 GT GT200100199A patent/GT200100199A/es unknown
- 2001-10-02 TW TW090124279A patent/TWI304805B/zh not_active IP Right Cessation
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2003
- 2003-03-06 IL IL154810A patent/IL154810A/en active IP Right Grant
- 2003-03-11 ZA ZA200301978A patent/ZA200301978B/en unknown
- 2003-03-18 EC EC2003004518A patent/ECSP034518A/es unknown
- 2003-03-24 HR HR20030230A patent/HRP20030230B1/xx not_active IP Right Cessation
- 2003-04-01 NO NO20031480A patent/NO329113B1/no not_active IP Right Cessation
- 2003-04-01 MA MA27085A patent/MA26950A1/fr unknown
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2004
- 2004-06-15 HK HK04104315A patent/HK1061229A1/xx not_active IP Right Cessation
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