BR0114344A - Retinóides para o tratamento de enfisema - Google Patents

Retinóides para o tratamento de enfisema

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Publication number
BR0114344A
BR0114344A BR0114344-1A BRPI0114344A BR0114344A BR 0114344 A BR0114344 A BR 0114344A BR PI0114344 A BRPI0114344 A BR PI0114344A BR 0114344 A BR0114344 A BR 0114344A
Authority
BR
Brazil
Prior art keywords
retinoids
emphysema
treatment
cancer
treating
Prior art date
Application number
BR0114344-1A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0114344A publication Critical patent/BR0114344A/pt
Publication of BRPI0114344B1 publication Critical patent/BRPI0114344B1/pt
Publication of BRPI0114344B8 publication Critical patent/BRPI0114344B8/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
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    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Furan Compounds (AREA)
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Abstract

"RETINóIDES PARA O TRATAMENTO DE ENFISEMA". A presente invenção fornece novos compostos retinóides e métodos para sua síntese, o uso de tais compostos para a preparação de medicamentos para tratar ou prevenir enfisema, câncer e distúrbios dermatológicos, métodos para tais doenças e composições farmacêuticas adequadas para o tratamento ou prevenção de enfisema, câncer e distúrbios dermatológicos.
BRPI0114344 2000-10-02 2001-09-24 composto retinóide, seu uso, sua composição farmacêutica e seu processo de preparação BRPI0114344B8 (pt)

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US23745900P 2000-10-02 2000-10-02
PCT/EP2001/011017 WO2002028810A2 (en) 2000-10-02 2001-09-24 Retinoids for the treatment of emphysema

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BR0114344A true BR0114344A (pt) 2003-07-01
BRPI0114344B1 BRPI0114344B1 (pt) 2018-07-17
BRPI0114344B8 BRPI0114344B8 (pt) 2021-05-25

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US20100222304A1 (en) * 2006-11-02 2010-09-02 Lillian W Chiang Methods of Treating Neuropathic Pain by Modulation of Glycogenolysis or Glycolysis
TW201500053A (zh) * 2008-08-27 2015-01-01 Otsuka Pharma Co Ltd 用於治療肺部疾病之藥劑（二）
CN103200937B (zh) 2010-09-01 2020-07-03 托马斯杰弗逊大学 用于肌肉修复和再生的组合物和方法
CA2890424C (en) * 2012-11-08 2020-11-17 Yamaguchi University Therapeutic agent for keratoconjunctive disorders
ES2694831T3 (es) 2013-05-22 2018-12-27 Yamaguchi University Inhibidor para trastornos retinocoroideos
EP3098221B1 (en) * 2014-10-15 2017-12-06 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for preparing apixaban form n-1
PL3380086T3 (pl) 2015-11-25 2022-02-21 Io Therapeutics, Inc. Oporne na cyp26 agonisty selektywne względem rar-alfa w leczeniu nowotworu
MX2018015108A (es) 2016-06-08 2019-08-29 Clementia Pharmaceuticals Inc Metodos para tratar la osificacion heterotopica.
EP3468600A4 (en) 2016-06-10 2019-11-13 IO Therapeutics, Inc. RETINOID COMPOUNDS AND RELECTIVE REXINOIDS OF THE RECEPTOR AND IMMUNE MODULATORS FOR IMMUNOTHERAPY OF CANCER
KR20180036522A (ko) * 2016-09-30 2018-04-09 (주)나노믹스 스틸벤 유도체 및 그 제조 방법
AU2017359673B2 (en) 2016-11-16 2021-10-21 Clementia Pharmaceuticals Inc. Methods for treating multiple osteochondroma (MO)
BR112019026945A2 (pt) 2017-07-06 2020-06-30 Jiangsu Hengrui Medicine Co., Ltd. derivado de indol-formamida, método de preparação para ele e seu uso em medicina
KR20200029544A (ko) 2017-07-13 2020-03-18 아이오 테라퓨틱스, 인크. 암 면역요법을 위해 면역 조절제와 조합된 면역조절 레티노이드 및 렉시노이드 화합물
SG11202001479RA (en) 2017-08-31 2020-03-30 Io Therapeutics Inc Rar selective agonists in combination with immune modulators for cancer immunotherapy
KR20240111779A (ko) 2021-11-23 2024-07-17 아이오 테라퓨틱스, 인크. 암 치료를 위해 RARγ 효능제를 사용하는 방법
CN115073394A (zh) * 2022-06-29 2022-09-20 上海中医药大学 一种高烯丙基类化合物及其制备方法和应用

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CY1109045T1 (el) 2014-07-02
NZ524603A (en) 2004-10-29
YU24403A (sh) 2006-08-17
GT200100199A (es) 2002-05-23
NO20031480L (no) 2003-05-20
AU2001289913A2 (en) 2002-04-15
KR100682144B1 (ko) 2007-02-28
ATE413375T1 (de) 2008-11-15
MXPA03002861A (es) 2003-07-14
RU2282616C2 (ru) 2006-08-27
AU2001289913B2 (en) 2006-08-17
DK1324970T3 (da) 2009-01-05
RS50354B (sr) 2009-11-10
CZ20031216A3 (cs) 2003-10-15
SI1324970T1 (sl) 2009-02-28
JP2004510728A (ja) 2004-04-08
WO2002028810A2 (en) 2002-04-11
WO2002028810A3 (en) 2002-09-26
CN1468207A (zh) 2004-01-14
AU8991301A (en) 2002-04-15
ZA200301978B (en) 2004-06-25
JP4118675B2 (ja) 2008-07-16
HRP20030230B1 (en) 2011-06-30
KR20030036879A (ko) 2003-05-09
DE60136477D1 (de) 2008-12-18
IL154810A0 (en) 2003-10-31
ECSP034518A (es) 2003-04-25
BRPI0114344B1 (pt) 2018-07-17
MA26950A1 (fr) 2004-12-20
PL208665B1 (pl) 2011-05-31
CN1321101C (zh) 2007-06-13
PA8529701A1 (es) 2002-07-30
CA2422805C (en) 2010-09-14
MY137435A (en) 2009-01-30
PL362671A1 (en) 2004-11-02
JO2434B1 (en) 2008-04-17
EP1324970A2 (en) 2003-07-09
HU230063B1 (hu) 2015-06-29
HUP0303006A3 (en) 2004-03-01
ES2316471T3 (es) 2009-04-16
HUP0303006A2 (hu) 2003-12-29
CA2422805A1 (en) 2002-04-11
NO20031480D0 (no) 2003-04-01
HRP20030230A2 (en) 2005-02-28
BRPI0114344B8 (pt) 2021-05-25
AR034156A1 (es) 2004-02-04
NO329113B1 (no) 2010-08-30
HK1061229A1 (en) 2004-09-10
EP1324970B1 (en) 2008-11-05
CZ307141B6 (cs) 2018-01-31
US6777418B2 (en) 2004-08-17
PT1324970E (pt) 2009-01-02
US20020082265A1 (en) 2002-06-27
IL154810A (en) 2010-11-30

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