GT200100199A - Nuevos retinoides para el tratamiento de efisema. - Google Patents
Nuevos retinoides para el tratamiento de efisema.Info
- Publication number
- GT200100199A GT200100199A GT200100199A GT200100199A GT200100199A GT 200100199 A GT200100199 A GT 200100199A GT 200100199 A GT200100199 A GT 200100199A GT 200100199 A GT200100199 A GT 200100199A GT 200100199 A GT200100199 A GT 200100199A
- Authority
- GT
- Guatemala
- Prior art keywords
- treatment
- efisema
- cancer
- methods
- new retinoids
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
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- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
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- C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
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- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA NUEVOS COMPUESTOS RETINOIDES Y METODOS PARA SU SINTESIS, EL USO DE TALES COMPUESTOS PARA LA PREPARACION DE MEDICAMENTOS PARA EL TRATAMIENTO O PREVENCION DE EFISEMA, CANCER Y TRASTORNOS DERMATOLOGICOS, METODOS PARA TALES ENFERMEDADES Y COMPOSICIONES FARMACEUTICAS ADECUADAS PARAL EL TRATAMIENTO O PREVENCION DE EFISEMA, CANCER Y TRASTORNOS DERMATOLOGICOS
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US23745900P | 2000-10-02 | 2000-10-02 |
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GT200100199A true GT200100199A (es) | 2002-05-23 |
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GT200100199A GT200100199A (es) | 2000-10-02 | 2001-10-02 | Nuevos retinoides para el tratamiento de efisema. |
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EP (1) | EP1324970B1 (es) |
JP (1) | JP4118675B2 (es) |
KR (1) | KR100682144B1 (es) |
CN (1) | CN1321101C (es) |
AR (1) | AR034156A1 (es) |
AT (1) | ATE413375T1 (es) |
AU (2) | AU2001289913B2 (es) |
BR (1) | BRPI0114344B8 (es) |
CA (1) | CA2422805C (es) |
CY (1) | CY1109045T1 (es) |
CZ (1) | CZ307141B6 (es) |
DE (1) | DE60136477D1 (es) |
DK (1) | DK1324970T3 (es) |
EC (1) | ECSP034518A (es) |
ES (1) | ES2316471T3 (es) |
GT (1) | GT200100199A (es) |
HK (1) | HK1061229A1 (es) |
HR (1) | HRP20030230B1 (es) |
HU (1) | HU230063B1 (es) |
IL (2) | IL154810A0 (es) |
JO (1) | JO2434B1 (es) |
MA (1) | MA26950A1 (es) |
MX (1) | MXPA03002861A (es) |
MY (1) | MY137435A (es) |
NO (1) | NO329113B1 (es) |
NZ (1) | NZ524603A (es) |
PA (1) | PA8529701A1 (es) |
PL (1) | PL208665B1 (es) |
PT (1) | PT1324970E (es) |
RS (1) | RS50354B (es) |
RU (1) | RU2282616C2 (es) |
SI (1) | SI1324970T1 (es) |
TW (1) | TWI304805B (es) |
WO (1) | WO2002028810A2 (es) |
ZA (1) | ZA200301978B (es) |
Families Citing this family (22)
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US20030236301A1 (en) * | 2001-12-19 | 2003-12-25 | Bob Sanders | Liposomal delivery of vitamin E based compounds |
DE602004019685D1 (de) * | 2003-12-26 | 2009-04-09 | Allergan Inc | DISUBSTITUIERTE CHALCOGENOXIME MIT ANTAGONISTISCHER WIRKUNG AM RAR(Gamma)-RETINOIDREZEPTOR |
US7476673B2 (en) * | 2003-12-30 | 2009-01-13 | Allergan, Inc. | Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors |
GB2411115A (en) * | 2004-02-19 | 2005-08-24 | Medical Res Council | Retinoic acid antagonists for the treatment of oesophageal disorders |
CN100548288C (zh) | 2004-03-10 | 2009-10-14 | 财团法人乙卯研究所 | 记忆固定促进剂 |
WO2007113122A1 (en) * | 2006-03-31 | 2007-10-11 | F. Hoffmann-La Roche Ag | Process for preparing retinoid compounds |
WO2008063842A2 (en) * | 2006-11-02 | 2008-05-29 | Aestus Therapeutics, Inc. | Methods of treating neuropathic pain with agonists of ppar-gamma |
TW201500053A (zh) * | 2008-08-27 | 2015-01-01 | Otsuka Pharma Co Ltd | 用於治療肺部疾病之藥劑(二) |
JP5986570B2 (ja) | 2010-09-01 | 2016-09-06 | トーマス・ジェファーソン・ユニバーシティThomas Jefferson University | 筋修復および再生のための組成物および方法 |
CN109589324B (zh) * | 2012-11-08 | 2022-06-14 | 国立大学法人山口大学 | 角结膜病症的治疗剂 |
KR102303316B1 (ko) | 2013-05-22 | 2021-09-23 | 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 | 망막 맥락막 장해의 억제제 |
EP3098221B1 (en) * | 2014-10-15 | 2017-12-06 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for preparing apixaban form n-1 |
EP4098257A1 (en) | 2015-11-25 | 2022-12-07 | IO Therapeutics, Inc. | Use of cyp26-resistant rar alpha selective agonists in the treatment of cancer |
EA201892497A1 (ru) | 2016-06-08 | 2019-05-31 | Клементиа Фармасьютикалз Инк. | Способы лечения гетеротопической оссификации |
CN109310763B (zh) | 2016-06-10 | 2022-10-21 | Io治疗公司 | 用于癌症免疫疗法的受体选择性类视黄醇和rexinoid化合物和免疫调节剂 |
KR20180036522A (ko) * | 2016-09-30 | 2018-04-09 | (주)나노믹스 | 스틸벤 유도체 및 그 제조 방법 |
CN110381939B (zh) | 2016-11-16 | 2022-12-02 | 同理制药公司 | 用于治疗多发性骨软骨瘤(mo)的方法 |
AU2018298193A1 (en) | 2017-07-06 | 2020-01-02 | Jiangsu Hengrui Medicine Co., Ltd. | Indole-formamide derivative, preparation method therefor and use thereof in medicine |
MX2020000467A (es) | 2017-07-13 | 2020-08-03 | Io Therapeutics Inc | Compuestos retinoides y rexinoides inmunomoduladores en combinacion con inmunomoduladores para inmunoterapia contra cancer. |
KR20200044889A (ko) | 2017-08-31 | 2020-04-29 | 아이오 테라퓨틱스, 인크. | 암 면역요법을 위해 면역 조절제와 조합된 rar 선택적 작용제 |
US11793835B2 (en) * | 2021-11-23 | 2023-10-24 | Io Therapeutics, Inc. | Methods of using RARγ agonists for cancer treatment |
CN115073394A (zh) * | 2022-06-29 | 2022-09-20 | 上海中医药大学 | 一种高烯丙基类化合物及其制备方法和应用 |
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DE3202100A1 (de) * | 1982-01-23 | 1983-08-04 | Basf Ag, 6700 Ludwigshafen | Substituierte benzoesaeure-4-hydroxyanilide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
US5527945A (en) | 1989-02-10 | 1996-06-18 | Basf Aktiengesellschaft | Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom |
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CA2129773C (en) * | 1993-09-02 | 2007-05-01 | Michael Klaus | Aromatic carboxylic acid derivatives |
AU2823395A (en) | 1994-06-07 | 1996-01-04 | Sri International | Novel compounds useful in modulating gene expression of retinoid responsive genes and/or having anti-ap-1 activity |
ATE223713T1 (de) | 1995-04-10 | 2002-09-15 | Taiho Pharmaceutical Co Ltd | Inhibitor der krebsmetastasierung |
US5965606A (en) * | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
FR2746098B1 (fr) | 1996-03-14 | 1998-04-30 | Composes propynyl biaromatiques | |
FR2753091B1 (fr) | 1996-09-09 | 2001-03-16 | Oreal | Utilisation d'un agoniste des recepteurs des retinoides de type rxr pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute |
US5998486A (en) * | 1997-07-08 | 1999-12-07 | Georgetown University School Of Medicine | Treatment of emphysema with retinoic acid or other retinoids by inducing formation of gas-exchange units (alveoli) |
TWI281911B (en) * | 2000-04-04 | 2007-06-01 | Allergan Inc | Treatment of tumors with RARalpha selective retinoid compounds in combination with other anti-tumor agents |
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- 2001-10-01 US US09/968,425 patent/US6777418B2/en not_active Expired - Lifetime
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