NO328064B1 - Ny fremgangsmate ved syntese av N-[(S)-1-karboksybutyl]-(S)-alaninestere og anvendelse i syntese av perindopril - Google Patents

Ny fremgangsmate ved syntese av N-[(S)-1-karboksybutyl]-(S)-alaninestere og anvendelse i syntese av perindopril Download PDF

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Publication number
NO328064B1
NO328064B1 NO20024616A NO20024616A NO328064B1 NO 328064 B1 NO328064 B1 NO 328064B1 NO 20024616 A NO20024616 A NO 20024616A NO 20024616 A NO20024616 A NO 20024616A NO 328064 B1 NO328064 B1 NO 328064B1
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NO
Norway
Prior art keywords
formula
synthesis
compound
perindopril
synthesis method
Prior art date
Application number
NO20024616A
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English (en)
Norwegian (no)
Other versions
NO20024616D0 (no
NO20024616L (no
Inventor
Jean-Claude Souvie
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of NO20024616D0 publication Critical patent/NO20024616D0/no
Publication of NO20024616L publication Critical patent/NO20024616L/no
Publication of NO328064B1 publication Critical patent/NO328064B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30Preparation of optical isomers
    • C07C227/32Preparation of optical isomers by stereospecific synthesis

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20024616A 2000-03-31 2002-09-26 Ny fremgangsmate ved syntese av N-[(S)-1-karboksybutyl]-(S)-alaninestere og anvendelse i syntese av perindopril NO328064B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004112A FR2807037B1 (fr) 2000-03-31 2000-03-31 NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
PCT/FR2001/000959 WO2001056353A2 (fr) 2000-03-31 2001-03-30 Nouveau procede de synthese de esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (3)

Publication Number Publication Date
NO20024616D0 NO20024616D0 (no) 2002-09-26
NO20024616L NO20024616L (no) 2002-09-26
NO328064B1 true NO328064B1 (no) 2009-11-16

Family

ID=8848711

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20024616A NO328064B1 (no) 2000-03-31 2002-09-26 Ny fremgangsmate ved syntese av N-[(S)-1-karboksybutyl]-(S)-alaninestere og anvendelse i syntese av perindopril

Country Status (36)

Country Link
US (1) US6818788B2 (et)
EP (1) EP1268398B1 (et)
JP (1) JP3930322B2 (et)
KR (1) KR100498869B1 (et)
CN (1) CN1171855C (et)
AP (1) AP1483A (et)
AR (1) AR027754A1 (et)
AT (1) ATE297377T1 (et)
AU (2) AU2001248433B2 (et)
BG (1) BG65832B1 (et)
BR (1) BRPI0109609B1 (et)
CA (1) CA2404700C (et)
CZ (1) CZ302840B6 (et)
DE (1) DE60111364T2 (et)
DK (1) DK1268398T3 (et)
EA (1) EA004314B1 (et)
EE (1) EE05079B1 (et)
ES (1) ES2242743T3 (et)
FR (1) FR2807037B1 (et)
GE (1) GEP20063796B (et)
HK (1) HK1053301A1 (et)
HR (1) HRP20020860B1 (et)
HU (1) HU229188B1 (et)
ME (1) ME00437B (et)
MX (1) MXPA02009378A (et)
NO (1) NO328064B1 (et)
NZ (1) NZ521324A (et)
OA (1) OA12324A (et)
PL (1) PL199714B1 (et)
PT (1) PT1268398E (et)
RS (1) RS50239B (et)
SI (1) SI1268398T1 (et)
SK (1) SK286851B6 (et)
UA (1) UA73562C2 (et)
WO (1) WO2001056353A2 (et)
ZA (1) ZA200207150B (et)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
ATE395913T1 (de) 2003-02-28 2008-06-15 Servier S A Lab Verfahren zur herstellung von perindopril
ES2334900T3 (es) * 2003-09-01 2010-03-17 Les Laboratoires Servier Nuevo procedimiento de sintesis de esteres de n-((s)-1-carboxibutil)-(s)-alanina y su aplicacion a la sintesis de perindopril.
ES2256693T3 (es) * 2003-09-30 2006-07-16 Les Laboratoires Servier Procedimiento de sintesis de n-((s)-1-(etoxicarbonil)butil)-(s)-alanina y su utilizacion en la sintesis de perindopril.
SI1403278T1 (en) * 2003-09-30 2005-10-31 Les Laboratoires Servier Process for the synthesis of N-((S)-1-(ethoxycarbonyl)butyl)-(S)-alanine and use in the synthese of perindopril
DK1729739T3 (en) * 2004-03-29 2016-10-31 Servier Lab PROCESS FOR THE PREPARATION OF A solid pharmaceutical composition.
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
WO2006006183A2 (en) * 2004-07-12 2006-01-19 Matrix Laboratories Ltd An improved process for the preparation of n-[(s)-ethoxycarbonyl-l-butyl]-(s)-alanine
EP1792896A1 (en) * 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247716A (en) * 1977-09-02 1981-01-27 Mitsui Toatsu Chemicals, Inc. Process for producing pyruvic acid
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
DE60111364D1 (de) 2005-07-14
BG107234A (bg) 2003-07-31
US20030045744A1 (en) 2003-03-06
JP2003534241A (ja) 2003-11-18
PT1268398E (pt) 2005-09-30
KR20030017484A (ko) 2003-03-03
SK286851B6 (sk) 2009-06-05
CA2404700C (fr) 2007-02-20
BR0109609A (pt) 2004-01-13
AU2001248433B2 (en) 2004-10-28
YU73202A (sh) 2006-03-03
EE05079B1 (et) 2008-10-15
EP1268398A2 (fr) 2003-01-02
ZA200207150B (en) 2003-09-05
PL199714B1 (pl) 2008-10-31
BRPI0109609B1 (pt) 2015-04-14
SK14052002A3 (sk) 2003-02-04
ES2242743T3 (es) 2005-11-16
SI1268398T1 (en) 2005-10-31
AP1483A (en) 2005-10-31
ME00437B (me) 2011-10-10
HUP0101335A3 (en) 2002-11-28
HRP20020860B1 (en) 2011-02-28
AP2002002628A0 (en) 2002-09-30
EE200200553A (et) 2004-04-15
CN1420862A (zh) 2003-05-28
WO2001056353A3 (fr) 2002-04-18
NZ521324A (en) 2004-03-26
NO20024616D0 (no) 2002-09-26
HUP0101335A2 (hu) 2001-11-28
GEP20063796B (en) 2006-04-25
EA200201027A1 (ru) 2003-02-27
AU4843301A (en) 2001-08-14
HRP20020860A2 (en) 2004-02-29
BG65832B1 (bg) 2010-02-26
EP1268398B1 (fr) 2005-06-08
FR2807037B1 (fr) 2002-05-10
KR100498869B1 (ko) 2005-07-04
PL346554A1 (en) 2001-09-10
CZ302840B6 (cs) 2011-12-07
AR027754A1 (es) 2003-04-09
DK1268398T3 (da) 2005-10-03
DE60111364T2 (de) 2006-03-16
HU0101335D0 (en) 2001-06-28
RS50239B (sr) 2009-07-15
WO2001056353A2 (fr) 2001-08-09
NO20024616L (no) 2002-09-26
EA004314B1 (ru) 2004-02-26
ATE297377T1 (de) 2005-06-15
FR2807037A1 (fr) 2001-10-05
MXPA02009378A (es) 2003-02-12
HU229188B1 (hu) 2013-09-30
OA12324A (en) 2006-05-12
US6818788B2 (en) 2004-11-16
CN1171855C (zh) 2004-10-20
CA2404700A1 (fr) 2001-08-09
JP3930322B2 (ja) 2007-06-13
HK1053301A1 (en) 2003-10-17
UA73562C2 (uk) 2005-08-15

Similar Documents

Publication Publication Date Title
NO328064B1 (no) Ny fremgangsmate ved syntese av N-[(S)-1-karboksybutyl]-(S)-alaninestere og anvendelse i syntese av perindopril
US6774259B2 (en) Method for synthesis of n-[(s)]-1-carboxybutyl-(s)-alanine esters and use in synthesis of perindopril
NO333957B1 (no) Fremgangsmåte for syntesen av perindopril og dens farmasøytiske akseptable salter
EA007948B1 (ru) НОВЫЙ СПОСОБ СИНТЕЗА (2S,3aS,7aS )-ПЕРГИДРОИНДОЛ-2-КАРБОНОВОЙ КИСЛОТЫ И ЕЁ СЛОЖНЫХ ЭФИРОВ, А ТАКЖЕ ИХ ПРИМЕНЕНИЕ ДЛЯ СИНТЕЗА ПЕРИНДОПРИЛА
ZA200600480B (en) Novel method for the synthesis of perindopril and pharmaceutically acceptable salts thereof
WO2006006183A2 (en) An improved process for the preparation of n-[(s)-ethoxycarbonyl-l-butyl]-(s)-alanine

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