HK1053301A1 - Novel method for synthesis of N-Ä(s)-1-carboxybutylÜ-(s)-alanine esters and use in synthesis of perindopril. - Google Patents
Novel method for synthesis of N-Ä(s)-1-carboxybutylÜ-(s)-alanine esters and use in synthesis of perindopril.Info
- Publication number
- HK1053301A1 HK1053301A1 HK03105541A HK03105541A HK1053301A1 HK 1053301 A1 HK1053301 A1 HK 1053301A1 HK 03105541 A HK03105541 A HK 03105541A HK 03105541 A HK03105541 A HK 03105541A HK 1053301 A1 HK1053301 A1 HK 1053301A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- synthesis
- perindopril
- carboxybutylü
- novel method
- alanine esters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0004112A FR2807037B1 (fr) | 2000-03-31 | 2000-03-31 | NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL |
| PCT/FR2001/000959 WO2001056353A2 (fr) | 2000-03-31 | 2001-03-30 | Nouveau procede de synthese de esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1053301A1 true HK1053301A1 (en) | 2003-10-17 |
Family
ID=8848711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK03105541A HK1053301A1 (en) | 2000-03-31 | 2003-08-01 | Novel method for synthesis of N-Ä(s)-1-carboxybutylÜ-(s)-alanine esters and use in synthesis of perindopril. |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6818788B2 (xx) |
| EP (1) | EP1268398B1 (xx) |
| JP (1) | JP3930322B2 (xx) |
| KR (1) | KR100498869B1 (xx) |
| CN (1) | CN1171855C (xx) |
| AP (1) | AP1483A (xx) |
| AR (1) | AR027754A1 (xx) |
| AT (1) | ATE297377T1 (xx) |
| AU (2) | AU4843301A (xx) |
| BG (1) | BG65832B1 (xx) |
| BR (1) | BRPI0109609B1 (xx) |
| CA (1) | CA2404700C (xx) |
| CZ (1) | CZ302840B6 (xx) |
| DE (1) | DE60111364T2 (xx) |
| DK (1) | DK1268398T3 (xx) |
| EA (1) | EA004314B1 (xx) |
| EE (1) | EE05079B1 (xx) |
| ES (1) | ES2242743T3 (xx) |
| FR (1) | FR2807037B1 (xx) |
| GE (1) | GEP20063796B (xx) |
| HK (1) | HK1053301A1 (xx) |
| HR (1) | HRP20020860B1 (xx) |
| HU (1) | HU229188B1 (xx) |
| ME (1) | ME00437B (xx) |
| MX (1) | MXPA02009378A (xx) |
| NO (1) | NO328064B1 (xx) |
| NZ (1) | NZ521324A (xx) |
| OA (1) | OA12324A (xx) |
| PL (1) | PL199714B1 (xx) |
| PT (1) | PT1268398E (xx) |
| RS (1) | RS50239B (xx) |
| SI (1) | SI1268398T1 (xx) |
| SK (1) | SK286851B6 (xx) |
| UA (1) | UA73562C2 (xx) |
| WO (1) | WO2001056353A2 (xx) |
| ZA (1) | ZA200207150B (xx) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2827860B1 (fr) | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
| CA2517205C (en) | 2003-02-28 | 2010-08-24 | Lupin Limited | Process for preparation of perindopril and salts thereof |
| PT1362845E (pt) * | 2003-09-01 | 2009-11-05 | Servier Lab | Novo processo de síntese dos ésteres da n-((s)-1- carboxibutil)-(s)-alanina e aplicação à síntese do perindopril |
| EP1400531B1 (fr) * | 2003-09-30 | 2006-01-04 | Les Laboratoires Servier | Procédé de synthèse de la N-[(S)-1-carbéthoxybutyl]-(S)-alanine et application à la synthèse du perindopril |
| DE60300806T2 (de) * | 2003-09-30 | 2006-03-23 | Les Laboratoires Servier | Verfahren zur Herstellung von N-((S)-1-(Ethoxycarbonyl)butyl)-(S)-alanin und Verwendung in der Synthese von Perindopril |
| JP4948392B2 (ja) * | 2004-03-29 | 2012-06-06 | レ ラボラトア セルビエ | 固形薬学的組成物を調製するためのプロセス |
| GB2413128A (en) * | 2004-04-13 | 2005-10-19 | Neopharma Ltd | Process for the preparation of perindopril |
| SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| WO2006006183A2 (en) * | 2004-07-12 | 2006-01-19 | Matrix Laboratories Ltd | An improved process for the preparation of n-[(s)-ethoxycarbonyl-l-butyl]-(s)-alanine |
| EP1792896A1 (en) | 2005-12-01 | 2007-06-06 | KRKA, tovarna zdravil, d.d., Novo mesto | Process for the preparation of perindopril and salts thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247716A (en) * | 1977-09-02 | 1981-01-27 | Mitsui Toatsu Chemicals, Inc. | Process for producing pyruvic acid |
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| FR2620699B1 (fr) * | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides |
| FR2807430B1 (fr) * | 2000-04-11 | 2002-05-17 | Adir | Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril |
-
2000
- 2000-03-31 FR FR0004112A patent/FR2807037B1/fr not_active Expired - Fee Related
-
2001
- 2001-03-20 PL PL346554A patent/PL199714B1/pl unknown
- 2001-03-30 AU AU4843301A patent/AU4843301A/xx active Pending
- 2001-03-30 US US10/221,973 patent/US6818788B2/en not_active Expired - Lifetime
- 2001-03-30 PT PT01921440T patent/PT1268398E/pt unknown
- 2001-03-30 KR KR10-2002-7012810A patent/KR100498869B1/ko not_active IP Right Cessation
- 2001-03-30 MX MXPA02009378A patent/MXPA02009378A/es active IP Right Grant
- 2001-03-30 JP JP2001556065A patent/JP3930322B2/ja not_active Expired - Fee Related
- 2001-03-30 OA OA1200200303A patent/OA12324A/en unknown
- 2001-03-30 NZ NZ521324A patent/NZ521324A/en not_active IP Right Cessation
- 2001-03-30 ME MEP-2008-664A patent/ME00437B/me unknown
- 2001-03-30 CZ CZ20023235A patent/CZ302840B6/cs not_active IP Right Cessation
- 2001-03-30 RS YUP73202 patent/RS50239B/sr unknown
- 2001-03-30 AP APAP/P/2002/002628A patent/AP1483A/en active
- 2001-03-30 UA UA2002108639A patent/UA73562C2/uk unknown
- 2001-03-30 ES ES01921440T patent/ES2242743T3/es not_active Expired - Lifetime
- 2001-03-30 CN CNB018074936A patent/CN1171855C/zh not_active Expired - Fee Related
- 2001-03-30 AU AU2001248433A patent/AU2001248433B2/en not_active Ceased
- 2001-03-30 AR ARP010101537 patent/AR027754A1/es not_active Application Discontinuation
- 2001-03-30 SI SI200130380T patent/SI1268398T1/xx unknown
- 2001-03-30 EP EP20010921440 patent/EP1268398B1/fr not_active Expired - Lifetime
- 2001-03-30 BR BRPI0109609-5A patent/BRPI0109609B1/pt not_active IP Right Cessation
- 2001-03-30 AT AT01921440T patent/ATE297377T1/de active
- 2001-03-30 GE GEAP20016674A patent/GEP20063796B/en unknown
- 2001-03-30 SK SK1405-2002A patent/SK286851B6/sk not_active IP Right Cessation
- 2001-03-30 WO PCT/FR2001/000959 patent/WO2001056353A2/fr active IP Right Grant
- 2001-03-30 CA CA 2404700 patent/CA2404700C/fr not_active Expired - Fee Related
- 2001-03-30 DE DE2001611364 patent/DE60111364T2/de not_active Expired - Lifetime
- 2001-03-30 DK DK01921440T patent/DK1268398T3/da active
- 2001-03-30 EA EA200201027A patent/EA004314B1/ru not_active IP Right Cessation
- 2001-03-30 HU HU0101335A patent/HU229188B1/hu not_active IP Right Cessation
- 2001-03-30 EE EEP200200553A patent/EE05079B1/xx unknown
-
2002
- 2002-09-05 ZA ZA200207150A patent/ZA200207150B/en unknown
- 2002-09-26 NO NO20024616A patent/NO328064B1/no not_active IP Right Cessation
- 2002-10-30 BG BG107234A patent/BG65832B1/bg unknown
- 2002-10-31 HR HR20020860A patent/HRP20020860B1/xx not_active IP Right Cessation
-
2003
- 2003-08-01 HK HK03105541A patent/HK1053301A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20180330 |