EE200200553A - Uudne protsess N-[(S)-1-karboksübutüül]-(S)-alaniini estrite sünteesimiseks ning nende rakendamine perindopriili sünteesis - Google Patents

Uudne protsess N-[(S)-1-karboksübutüül]-(S)-alaniini estrite sünteesimiseks ning nende rakendamine perindopriili sünteesis

Info

Publication number
EE200200553A
EE200200553A EEP200200553A EEP200200553A EE200200553A EE 200200553 A EE200200553 A EE 200200553A EE P200200553 A EEP200200553 A EE P200200553A EE P200200553 A EEP200200553 A EE P200200553A EE 200200553 A EE200200553 A EE 200200553A
Authority
EE
Estonia
Prior art keywords
synthesis
carboxybutyl
perindopril
application
novel process
Prior art date
Application number
EEP200200553A
Other languages
English (en)
Inventor
Souvie Jean-Claude
Original Assignee
Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier filed Critical Laboratoires Servier
Publication of EE200200553A publication Critical patent/EE200200553A/et
Publication of EE05079B1 publication Critical patent/EE05079B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200200553A 2000-03-31 2001-03-30 Meetod N-[(S)-1-karboksbutl]-(S)-alaniini estrite snteesimiseks ning nende rakendamine perindopriili snteesis EE05079B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004112A FR2807037B1 (fr) 2000-03-31 2000-03-31 NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
PCT/FR2001/000959 WO2001056353A2 (fr) 2000-03-31 2001-03-30 Nouveau procede de synthese de esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (2)

Publication Number Publication Date
EE200200553A true EE200200553A (et) 2004-04-15
EE05079B1 EE05079B1 (et) 2008-10-15

Family

ID=8848711

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200553A EE05079B1 (et) 2000-03-31 2001-03-30 Meetod N-[(S)-1-karboksbutl]-(S)-alaniini estrite snteesimiseks ning nende rakendamine perindopriili snteesis

Country Status (36)

Country Link
US (1) US6818788B2 (et)
EP (1) EP1268398B1 (et)
JP (1) JP3930322B2 (et)
KR (1) KR100498869B1 (et)
CN (1) CN1171855C (et)
AP (1) AP1483A (et)
AR (1) AR027754A1 (et)
AT (1) ATE297377T1 (et)
AU (2) AU2001248433B2 (et)
BG (1) BG65832B1 (et)
BR (1) BRPI0109609B1 (et)
CA (1) CA2404700C (et)
CZ (1) CZ302840B6 (et)
DE (1) DE60111364T2 (et)
DK (1) DK1268398T3 (et)
EA (1) EA004314B1 (et)
EE (1) EE05079B1 (et)
ES (1) ES2242743T3 (et)
FR (1) FR2807037B1 (et)
GE (1) GEP20063796B (et)
HK (1) HK1053301A1 (et)
HR (1) HRP20020860B1 (et)
HU (1) HU229188B1 (et)
ME (1) ME00437B (et)
MX (1) MXPA02009378A (et)
NO (1) NO328064B1 (et)
NZ (1) NZ521324A (et)
OA (1) OA12324A (et)
PL (1) PL199714B1 (et)
PT (1) PT1268398E (et)
RS (1) RS50239B (et)
SI (1) SI1268398T1 (et)
SK (1) SK286851B6 (et)
UA (1) UA73562C2 (et)
WO (1) WO2001056353A2 (et)
ZA (1) ZA200207150B (et)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
DE60321233D1 (de) 2003-02-28 2008-07-03 Servier S A Lab Verfahren zur herstellung von perindopril
PT1362845E (pt) * 2003-09-01 2009-11-05 Servier Lab Novo processo de síntese dos ésteres da n-((s)-1- carboxibutil)-(s)-alanina e aplicação à síntese do perindopril
SI1403278T1 (en) * 2003-09-30 2005-10-31 Les Laboratoires Servier Process for the synthesis of N-((S)-1-(ethoxycarbonyl)butyl)-(S)-alanine and use in the synthese of perindopril
ATE315046T1 (de) * 2003-09-30 2006-02-15 Servier Lab Verfahren zur herstellung von n-((s)-1- (etoxycarbonyl)butyl)-(s)-alanin und verwendung in der synthese von perindopril
HUE031058T2 (en) * 2004-03-29 2017-06-28 Servier Lab A method of producing a solid pharmaceutical composition
GB2413128A (en) 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
WO2006006183A2 (en) * 2004-07-12 2006-01-19 Matrix Laboratories Ltd An improved process for the preparation of n-[(s)-ethoxycarbonyl-l-butyl]-(s)-alanine
EP1792896A1 (en) * 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247716A (en) * 1977-09-02 1981-01-27 Mitsui Toatsu Chemicals, Inc. Process for producing pyruvic acid
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
JP3930322B2 (ja) 2007-06-13
HRP20020860A2 (en) 2004-02-29
UA73562C2 (uk) 2005-08-15
RS50239B (sr) 2009-07-15
WO2001056353A2 (fr) 2001-08-09
EE05079B1 (et) 2008-10-15
BRPI0109609B1 (pt) 2015-04-14
PT1268398E (pt) 2005-09-30
BG65832B1 (bg) 2010-02-26
MXPA02009378A (es) 2003-02-12
AP2002002628A0 (en) 2002-09-30
EA004314B1 (ru) 2004-02-26
CA2404700C (fr) 2007-02-20
AU4843301A (en) 2001-08-14
NO20024616L (no) 2002-09-26
GEP20063796B (en) 2006-04-25
YU73202A (sh) 2006-03-03
SI1268398T1 (en) 2005-10-31
HUP0101335A3 (en) 2002-11-28
BG107234A (bg) 2003-07-31
ATE297377T1 (de) 2005-06-15
EA200201027A1 (ru) 2003-02-27
KR100498869B1 (ko) 2005-07-04
WO2001056353A3 (fr) 2002-04-18
PL199714B1 (pl) 2008-10-31
EP1268398B1 (fr) 2005-06-08
DE60111364D1 (de) 2005-07-14
HUP0101335A2 (hu) 2001-11-28
FR2807037A1 (fr) 2001-10-05
HU0101335D0 (en) 2001-06-28
AU2001248433B2 (en) 2004-10-28
ME00437B (me) 2011-10-10
US6818788B2 (en) 2004-11-16
OA12324A (en) 2006-05-12
CA2404700A1 (fr) 2001-08-09
CZ302840B6 (cs) 2011-12-07
HRP20020860B1 (en) 2011-02-28
PL346554A1 (en) 2001-09-10
SK14052002A3 (sk) 2003-02-04
HU229188B1 (hu) 2013-09-30
SK286851B6 (sk) 2009-06-05
FR2807037B1 (fr) 2002-05-10
AP1483A (en) 2005-10-31
CN1420862A (zh) 2003-05-28
HK1053301A1 (en) 2003-10-17
NO328064B1 (no) 2009-11-16
US20030045744A1 (en) 2003-03-06
JP2003534241A (ja) 2003-11-18
ES2242743T3 (es) 2005-11-16
AR027754A1 (es) 2003-04-09
DK1268398T3 (da) 2005-10-03
NZ521324A (en) 2004-03-26
DE60111364T2 (de) 2006-03-16
BR0109609A (pt) 2004-01-13
CN1171855C (zh) 2004-10-20
EP1268398A2 (fr) 2003-01-02
KR20030017484A (ko) 2003-03-03
ZA200207150B (en) 2003-09-05
NO20024616D0 (no) 2002-09-26

Similar Documents

Publication Publication Date Title
EE200200553A (et) Uudne protsess N-[(S)-1-karboksübutüül]-(S)-alaniini estrite sünteesimiseks ning nende rakendamine perindopriili sünteesis
EG24152A (en) Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in synthesis of perindopril
NO20024811D0 (no) Fremgangsmåte ved syntese av N-[(S)-1-karboksybutyl]-(S)- alaninestere og anvendelse i syntesen av perindopril
EE200400107A (et) Protsess kõrgpuhta perindopriili ning sünteesis kasulike vaheühendite valmistamiseks
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AU2001250467A1 (en) Method for synthesis of N-[(S)-1-carboxybutyl]-(S)-alanine esters and use in synthesis of perindopril
AU2001248433A1 (en) Novel method for synthesis of N-((S)-1-carboxybutyl)-(S)-alanine esters and use in synthesis of perindopril
HK1118285A1 (en) Intermediate for synthesizing esters of n-[(s)-1-carboxybutyl]-(s)-alanine and use thereof for synthesizing perindopril
DK1400531T3 (da) Fremgangsmåde til fremstilling af N-[(S)-1-ethoxycarbonyl-butyl]-(S)-alanin og anvendelse heraf ved syntese af perindopril
SI1272454T1 (sl) Postopek za sintezo estrov n-((s)-karboksibutil)-(s)-alanina in uporaba pri sintezi perindoprila
DK1403278T3 (da) Syntesefremgangsmåde for N-[(S)-1-ethoxycarbonylbutyl]-(S)-alanin og anvendelse heraf ved syntesen af perindopril

Legal Events

Date Code Title Description
HK1A Erratum in gazette
KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231