NO326883B1 - Bredspektret 2-(amino)-benzoxazolsulfonamid HIV proteasehemmere - Google Patents

Info

Publication number

NO326883B1

NO326883B1 NO20034988A NO20034988A NO326883B1 NO 326883 B1 NO326883 B1 NO 326883B1 NO 20034988 A NO20034988 A NO 20034988A NO 20034988 A NO20034988 A NO 20034988A NO 326883 B1 NO326883 B1 NO 326883B1

Authority

NO

Norway

Prior art keywords

het

4alkyl

alkyl

aryl

optionally

Prior art date

2001-05-11

Links

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• 239000004030 hiv protease inhibitor Substances 0.000 title description 2
• STIGVXIBJPLPGH-UHFFFAOYSA-N 1,3-benzoxazole-2-sulfonohydrazide Chemical compound C1=CC=C2OC(S(=O)(=O)NN)=NC2=C1 STIGVXIBJPLPGH-UHFFFAOYSA-N 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 190
• -1 C1-4alkyloxycarbonyl Chemical group 0.000 claims description 99
• 125000000217 alkyl group Chemical group 0.000 claims description 88
• 239000000203 mixture Substances 0.000 claims description 65
• 125000003118 aryl group Chemical group 0.000 claims description 58
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 57
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 56
• 125000001424 substituent group Chemical group 0.000 claims description 52
• 241000725303 Human immunodeficiency virus Species 0.000 claims description 46
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 39
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 38
• 229910052739 hydrogen Inorganic materials 0.000 claims description 38
• 239000001257 hydrogen Substances 0.000 claims description 38
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 37
• 239000003814 drug Substances 0.000 claims description 33
• 229910052757 nitrogen Inorganic materials 0.000 claims description 31
• 229910052736 halogen Inorganic materials 0.000 claims description 30
• 150000002367 halogens Chemical class 0.000 claims description 30
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 28
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• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 26
• 125000005842 heteroatom Chemical group 0.000 claims description 26
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• 239000001301 oxygen Substances 0.000 claims description 26
• 150000002431 hydrogen Chemical class 0.000 claims description 25
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• 229910052717 sulfur Inorganic materials 0.000 claims description 23
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