NO326822B1 - Anvendelse av cyklooksygenase-2 inhibitorer for fremstilling av et medikament for behandling av neoplasi - Google Patents
Anvendelse av cyklooksygenase-2 inhibitorer for fremstilling av et medikament for behandling av neoplasi Download PDFInfo
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- NO326822B1 NO326822B1 NO19991793A NO991793A NO326822B1 NO 326822 B1 NO326822 B1 NO 326822B1 NO 19991793 A NO19991793 A NO 19991793A NO 991793 A NO991793 A NO 991793A NO 326822 B1 NO326822 B1 NO 326822B1
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- Norway
- Prior art keywords
- pyrazol
- cancer
- trifluoromethyl
- difluoromethyl
- compound
- Prior art date
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
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US2849496P | 1996-10-15 | 1996-10-15 | |
PCT/US1997/018670 WO1998016227A1 (en) | 1996-10-15 | 1997-10-14 | Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia |
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NO991793D0 NO991793D0 (no) | 1999-04-15 |
NO991793L NO991793L (no) | 1999-04-15 |
NO326822B1 true NO326822B1 (no) | 2009-02-23 |
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NO19991793A NO326822B1 (no) | 1996-10-15 | 1999-04-15 | Anvendelse av cyklooksygenase-2 inhibitorer for fremstilling av et medikament for behandling av neoplasi |
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EP (3) | EP1977749A1 (ru) |
JP (1) | JP2001503395A (ru) |
KR (1) | KR20000049138A (ru) |
CN (2) | CN100558356C (ru) |
AT (2) | ATE271385T1 (ru) |
AU (1) | AU742645B2 (ru) |
BR (1) | BR9712314A (ru) |
CA (1) | CA2267186C (ru) |
CZ (1) | CZ298022B6 (ru) |
DE (2) | DE69729946T2 (ru) |
DK (2) | DK1479385T3 (ru) |
ES (2) | ES2308068T3 (ru) |
HK (1) | HK1025518A1 (ru) |
HU (1) | HU227564B1 (ru) |
IL (3) | IL128568A0 (ru) |
NO (1) | NO326822B1 (ru) |
NZ (3) | NZ506515A (ru) |
PT (2) | PT932402E (ru) |
RO (1) | RO120172B1 (ru) |
RU (1) | RU2239429C2 (ru) |
SK (1) | SK284788B6 (ru) |
TR (1) | TR199900827T2 (ru) |
TW (1) | TWI235060B (ru) |
UA (1) | UA67732C2 (ru) |
WO (1) | WO1998016227A1 (ru) |
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NZ333399A (en) | 1997-12-24 | 2000-05-26 | Sankyo Co | Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis |
US6727238B2 (en) | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
US6294558B1 (en) | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
US20040053900A1 (en) * | 1998-12-23 | 2004-03-18 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an aromatase inhibitor as a combination therapy |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US20020103141A1 (en) * | 1998-12-23 | 2002-08-01 | Mckearn John P. | Antiangiogenic combination therapy for the treatment of cancer |
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AU2593600A (en) * | 1998-12-23 | 2000-07-12 | G.D. Searle & Co. | Method of using a cyclooxygenase-2 inhibitor and a matrix metalloproteinase inhibitor as a combination therapy in the treatment of neoplasia |
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JP2003503360A (ja) * | 1999-06-24 | 2003-01-28 | ファルマシア コーポレイション | 炎症性疾患の処置のための併用療法 |
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EP1232153B1 (en) | 1999-11-22 | 2004-11-03 | SmithKline Beecham plc | Imidazole derivatives and their use as raf kinase inhibitors |
WO2001054688A1 (en) * | 2000-01-28 | 2001-08-02 | Merck & Co., Inc. | Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug |
GB0003224D0 (en) | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
GB0005357D0 (en) | 2000-03-06 | 2000-04-26 | Smithkline Beecham Plc | Compounds |
WO2001091856A2 (en) * | 2000-06-01 | 2001-12-06 | Pharmacia Corporation | Use of cox2 inhibitors for treating skin injury from exposure to ultraviolet radiation |
GB0021494D0 (en) | 2000-09-01 | 2000-10-18 | Glaxo Group Ltd | Chemical comkpounds |
ATE300529T1 (de) | 2000-09-21 | 2005-08-15 | Smithkline Beecham Plc | Imidazolderivate als raf-kinase-inhibitoren |
AU2002234165A1 (en) | 2000-11-03 | 2002-05-27 | Tularik, Inc. | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents |
CA2440017A1 (en) | 2001-05-03 | 2002-11-14 | Cornell Research Foundation, Inc. | Treatment of hpv caused diseases |
GB0112802D0 (en) | 2001-05-25 | 2001-07-18 | Glaxo Group Ltd | Pyrimidine derivatives |
GB0112810D0 (en) | 2001-05-25 | 2001-07-18 | Glaxo Group Ltd | Pyrimidine derivatives |
GB0119477D0 (en) | 2001-08-09 | 2001-10-03 | Glaxo Group Ltd | Pyrimidine derivatives |
JP2005506366A (ja) * | 2001-10-25 | 2005-03-03 | ノバルティス アクチエンゲゼルシャフト | 選択的シクロオキシゲナーゼ−2阻害剤を含む組合せ剤 |
FR2835433B1 (fr) * | 2002-02-01 | 2006-02-17 | Richard Lab M | Utilisation de la 1-(-4-chlorobenzoyl)-5methoxy-2-methyl-1h- indole-3acetic 4-(acetylamino)phenylester pour la fabrication d'un medicament destine a inhiber exclusivement la cox2 |
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DE60305053T2 (de) | 2002-08-19 | 2006-08-31 | Glaxo Group Ltd., Greenford | Pyrimidinderivate als selektive cox-2-inhibitoren |
GB0221443D0 (en) | 2002-09-16 | 2002-10-23 | Glaxo Group Ltd | Pyridine derivates |
KR100484525B1 (ko) * | 2002-10-15 | 2005-04-20 | 씨제이 주식회사 | 이소티아졸 유도체, 그 제조방법 및 약제학적 조성물 |
GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
PE20040844A1 (es) | 2002-11-26 | 2004-12-30 | Novartis Ag | Acidos fenilaceticos y derivados como inhibidores de la cox-2 |
MXPA05008335A (es) * | 2003-02-11 | 2006-05-04 | Vernalis Cambridge Ltd | Compuestos de isoxazol como inhibidores de las proteinas de choque por calor. |
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BRPI0607688A2 (pt) | 2005-02-17 | 2009-09-22 | Synta Pharmaceuticals Corp | método para inibir a polimerização de tubulina em uma célula; método para tratar ou prevenir um distúrbio proliferativo em um indivìduo; método para bloquear, ocluir ou de outro modo romper o fluxo sangüìneo na neovasculatura; composto; composição farmacêutica e uso do referido método e composto |
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1997
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- 1997-10-14 DK DK97911746T patent/DK0932402T3/da active
- 1997-10-14 BR BR9712314-5A patent/BR9712314A/pt not_active Application Discontinuation
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1999
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