NO324693B1 - 2-acetamidoacetamidderivater, anvendelse av slike forbindelser til fremstilling av preparater for behandling av sykdommer samt preparater omfattende slike forbindelser - Google Patents

2-acetamidoacetamidderivater, anvendelse av slike forbindelser til fremstilling av preparater for behandling av sykdommer samt preparater omfattende slike forbindelser Download PDF

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Publication number
NO324693B1
NO324693B1 NO20025405A NO20025405A NO324693B1 NO 324693 B1 NO324693 B1 NO 324693B1 NO 20025405 A NO20025405 A NO 20025405A NO 20025405 A NO20025405 A NO 20025405A NO 324693 B1 NO324693 B1 NO 324693B1
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NO
Norway
Prior art keywords
alkyl
phenyl
group
substituted
methyl
Prior art date
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NO20025405A
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English (en)
Norwegian (no)
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NO20025405D0 (no
NO20025405L (no
Inventor
Scott F Sneddon
John L Kane
Bradford H Hirth
Fred Vinick
Shuang Qiao
Sharon R Nahill
John M Williams
Hans-Peter Biemann
Andrew Janjigian
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Genzyme Corp
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Publication of NO20025405D0 publication Critical patent/NO20025405D0/no
Publication of NO20025405L publication Critical patent/NO20025405L/no
Publication of NO324693B1 publication Critical patent/NO324693B1/no

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/02Immunomodulators
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    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P5/00Drugs for disorders of the endocrine system
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
NO20025405A 2000-05-12 2002-11-11 2-acetamidoacetamidderivater, anvendelse av slike forbindelser til fremstilling av preparater for behandling av sykdommer samt preparater omfattende slike forbindelser NO324693B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20378400P 2000-05-12 2000-05-12
US20521300P 2000-05-18 2000-05-18
PCT/US2001/015027 WO2001087849A2 (en) 2000-05-12 2001-05-10 Modulators of tnf- alpha signaling

Publications (3)

Publication Number Publication Date
NO20025405D0 NO20025405D0 (no) 2002-11-11
NO20025405L NO20025405L (no) 2003-01-09
NO324693B1 true NO324693B1 (no) 2007-12-03

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NO20025405A NO324693B1 (no) 2000-05-12 2002-11-11 2-acetamidoacetamidderivater, anvendelse av slike forbindelser til fremstilling av preparater for behandling av sykdommer samt preparater omfattende slike forbindelser

Country Status (13)

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US (5) US6969728B2 (de)
EP (1) EP1294699B1 (de)
JP (3) JP4960565B2 (de)
KR (1) KR100840816B1 (de)
CN (1) CN100494182C (de)
AU (2) AU5969101A (de)
BR (1) BR0111158A (de)
CA (3) CA2408408C (de)
HK (1) HK1051186A1 (de)
IL (2) IL152450A0 (de)
MX (1) MXPA02010993A (de)
NO (1) NO324693B1 (de)
WO (1) WO2001087849A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2408408C (en) * 2000-05-12 2013-07-09 Genzyme Corporation Modulators of tnf- alpha signaling
DE10108481A1 (de) * 2001-02-22 2002-10-24 Bayer Ag Pyridylpyrimidine
CZ305099B6 (cs) * 2001-04-10 2015-05-06 Pfizer Inc. Derivát pyrazolu, způsoby a meziprodukty pro výrobu, farmaceutická kompozice s jeho obsahem a jeho lékařské aplikace, zejména k léčení infekcí HIV
NZ534757A (en) * 2002-03-12 2006-07-28 Merck & Co Inc Substituted amides
PT1567138E (pt) * 2002-11-21 2011-04-11 Genzyme Corp Utilização de derivados de diamida para inibição de rejeição crónica de transplante
JP4914008B2 (ja) * 2002-11-21 2012-04-11 ジェンザイム・コーポレーション 免疫寛容を誘導するためのジアミド誘導体と免疫抑制剤との組み合わせ
JP4897221B2 (ja) * 2002-12-20 2012-03-14 チバ ホールディング インコーポレーテッド アミン類の合成及びその合成のための中間体
WO2004071383A2 (en) * 2003-02-11 2004-08-26 Boehringer Ingelheim International Gmbh New pharmaceutical compositions based on anticholinergics and inhibitors of tnf alpha synthesis or action
US7977366B2 (en) * 2003-10-14 2011-07-12 Cornell Research Foundation, Inc. Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation
EP1765347A4 (de) * 2004-06-04 2008-10-01 Univ California Verbindungen mit ionentransporterhöhender wirkung durch mutanten cftr und ihre verwendung
KR20080089461A (ko) * 2005-12-30 2008-10-06 랜박시 래보러터리스 리미티드 무스카린 수용체 길항제
US20080003230A1 (en) 2006-07-03 2008-01-03 Adair Charles D Composition for modulating the expression of cell adhesion molecules
EP2079728B1 (de) 2006-10-10 2013-09-25 Amgen Inc. N-arylpyrazolverbindungen zur verwendung gegen diabetes
WO2009026579A1 (en) * 2007-08-23 2009-02-26 Cornell Research Foundation, Inc. Proteasome inhibitors and their use in treating pathogen infection and cancer
WO2009073146A2 (en) * 2007-11-29 2009-06-11 Celgene Corporation Use of immunomodulatory compounds for the treatment of transverse myelitis, multiple sclerosis, and other disorders
EP2827861A4 (de) * 2012-03-19 2016-03-16 Aposignal Bioscience Llc Zusammensetzung und verfahren zur zellmodulation
UY36034A (es) 2014-03-18 2015-09-30 Astrazeneca Ab Derivados de 3,5-diamino-6-cloro-pirazina-2-carboxamida y sales farmaceuticamente aceptables de estos

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE372326C (de) 1922-04-22 1923-03-26 Adam Thierauf Turbinenanlage
DE748704C (de) 1938-02-26 1944-11-08 Einrichtung zum federnden Begrenzen des Laengsspiels der in Gleitlagern laufenden Ankerwelle von Elektrokleinmotoren
CA996119A (en) 1971-12-10 1976-08-31 Eastman Kodak Company Oxichromic compounds, stabilized oxichromic compounds and processes for preparing same
US3935263A (en) * 1971-12-10 1976-01-27 Eastman Kodak Company Oxichromic compounds, stabilized oxichromic compounds and processes for preparing same
DE2937698A1 (de) 1979-09-18 1981-04-02 A. Nattermann & Cie GmbH, 5000 Köln N-propionylsarcosinanilide, deren herstellungsverfahren und arzneimittel auf deren basis
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
EP0246749A3 (de) 1986-05-17 1988-08-31 AgrEvo UK Limited Herbizide Triazole
JPH01101456A (ja) * 1987-10-15 1989-04-19 Honda Electron Co Ltd 超音波顕微鏡装置
DE3825867A1 (de) 1988-03-04 1989-09-14 Bayer Ag Heterocyclisch substituierte sulfonylaminoazole und ihre verwendung als herbizide
DE3813886A1 (de) 1988-04-20 1989-11-02 Schering Ag 1-triazinyl-1h-1,2,4-triazol-3- sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider, fungizider und pflanzenwachstumsregulierender wirkung
US4944796A (en) * 1988-11-14 1990-07-31 Ici Americas Inc. Certain 2-(disubstituted amino) acetanilide herbicides
DE3841086A1 (de) 1988-12-07 1990-06-21 Bayer Ag Sulfonylaminoazine, verfahren zu ihrer herstellung und ihre verwendung als herbizide
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US4997950A (en) * 1989-04-20 1991-03-05 Richard Finbar Murphy Novel C-terminal gastrin antagonists
US5100899A (en) 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
DE3928605A1 (de) 1989-08-30 1991-03-07 Bayer Ag Substituierte sulfonylaminoazole
JPH0686378B2 (ja) * 1990-05-31 1994-11-02 田辺製薬株式会社 免疫調節剤
US5958413A (en) * 1990-11-01 1999-09-28 Celltech Limited Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor
US6420374B1 (en) * 1990-11-30 2002-07-16 Fred Hutchinson Cancer Research Center Use of xanthines as immunosuppressants and to inhibit allograft reactions
WO1992017456A1 (en) * 1991-03-26 1992-10-15 Fujisawa Pharmaceutical Co., Ltd. Amino acid derivative and salt thereof
EP0520573A1 (de) 1991-06-27 1992-12-30 Glaxo Inc. Derivate von cyclischen Imiden
WO1993017009A1 (en) 1992-02-28 1993-09-02 Zenyaku Kogyo Kabushiki Kaisha s-TRIAZINE DERIVATIVE AND REMEDY FOR ESTROGEN-DEPENDENT DISEASES CONTAINING THE SAME AS ACTIVE INGREDIENT
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
WO1995009652A1 (en) 1993-10-06 1995-04-13 The Kennedy Institute For Rheumatology Treatment of autoimmune and inflammatory disorders
US6270766B1 (en) * 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
AU5152293A (en) 1992-10-08 1994-05-09 Kennedy Institute Of Rheumatology, The Treatment of autoimmune and inflammatory disorders
US6030615A (en) * 1993-05-17 2000-02-29 The Picower Institute For Medical Research Combination method for treating diseases caused by cytokine-mediated toxicity
DE4337600A1 (de) * 1993-11-01 1995-05-04 Diagnostikforschung Inst N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen
NZ278607A (en) * 1994-02-07 1999-05-28 Knoll Ag Use of tnf antagonists for treating disorders involving elevated serum levels of il-6 wherein the serum levels are 500pg/ml or above
DE4430127A1 (de) * 1994-08-25 1996-03-14 Hoechst Ag Kombinationspräparat, enthaltend Cyclosporin A oder FK506 und ein Xanthinderivat
DE4430128A1 (de) * 1994-08-25 1996-02-29 Hoechst Ag Kombinationspräparat mit immunsuppressiven, kardiovaskulären und cerebralen Wirkungen
US5932737A (en) * 1994-12-02 1999-08-03 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds for treatment of no-mediated diseases
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
US5632367A (en) 1995-01-23 1997-05-27 Mars, Incorporated Validation housing for a bill validator made by a two shot molding process
FR2730411B1 (fr) * 1995-02-14 1997-03-28 Centre Nat Rech Scient Association medicamenteuse utile pour la transfection et l'expression in vivo d'exogenes
ATE226641T1 (de) 1995-04-08 2002-11-15 Lg Chemical Ltd Humaner 4-1bb spezifischer humaner antikörper und diesen produzierende zellinie
CA2217857A1 (en) 1995-05-10 1996-11-14 Darwin Discovery Limited Peptide compounds which inhibit metalloproteinase and tnf liberation and their therapeutic uses
SE510202C2 (sv) 1995-05-19 1999-04-26 Stroemsholmen Ab Anordning vid ett hydraulsystem
US5654312A (en) * 1995-06-07 1997-08-05 Andrulis Pharmaceuticals Treatment of inflammatory and/or autoimmune dermatoses with thalidomide alone or in combination with other agents
ATE259235T1 (de) * 1995-07-20 2004-02-15 Cell Eng Ag Zubereitung enthaltend glykane übereinstimmend mit transferrin glykaner als aktives prinzip für die induktion der immuntoleranz gegen antigene
IL115245A (en) * 1995-09-11 2002-12-01 Yissum Res Dev Co Tumor necrosis factor inhibiting pharmaceuticals
CZ291337B6 (cs) 1995-11-22 2003-02-12 Darwin Discovery Limited Merkaptoalkylpeptidylová sloučenina, její použití pro výrobu přípravku pro léčení nebo prevenci stavu souvisejícího s metalloproteinázou nebo TNFalfa a farmaceutický přípravek ji obsahující
US6090382A (en) * 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
AU2521597A (en) * 1996-04-12 1997-11-07 Sumitomo Pharmaceuticals Company, Limited Piperidinylpyramidine derivatives
US6211160B1 (en) * 1996-09-06 2001-04-03 The Trustees Of The University Of Pennsylvania Method for tolerizing a mammalian patient to administration of gene therapy virus vectors
TW520362B (en) * 1996-12-05 2003-02-11 Amgen Inc Substituted pyrimidine compounds and pharmaceutical composition comprising same
DE69724451T2 (de) * 1996-12-06 2004-03-18 Amgen Inc., Thousand Oaks Kombinationtherapie mit einem tnf-bindendem protein zür behandlung von durch tnf verursachten erkrangungen
DE69837322T2 (de) 1997-01-10 2007-11-22 Biogen Idec Ma Inc., Cambridge Verfahren zur therapeutischen verabreichung von anti-cd40l-mitteln
US6294170B1 (en) * 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
WO1998039026A2 (en) 1997-03-07 1998-09-11 Biogen, Inc. Methods of therapeutic administration of anti-cd40l compounds
US5801193A (en) * 1997-04-15 1998-09-01 Immune Modulation, Inc. Compositions and methods for immunosuppressing
US6506569B1 (en) * 1997-05-30 2003-01-14 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor TR10
GB9713732D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Substituted triazinic compounds
AU8672198A (en) 1997-07-31 1999-02-22 Chiron Corporation Method enabling readministration of aav vector via immunosuppression of host
US6503184B1 (en) * 1997-10-21 2003-01-07 Human Genome Sciences, Inc. Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
US6407218B1 (en) * 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
EP1036066B1 (de) 1997-12-03 2007-04-18 Mid-America Commercialization Corporation Substituierte pyrimidine und pyridine als unkrautbekämpfungsmittel
AU3368899A (en) * 1998-03-30 1999-10-18 Cambridge Neuroscience, Inc. Protein-carbohydrate binding antagonists
NZ507558A (en) * 1998-05-05 2003-08-29 F Pyrazole derivatives as P-38 map kinase inhibitors
FR2780891A1 (fr) 1998-07-10 2000-01-14 Univ Paris Curie Echange de lymphocytes t
AU6476599A (en) 1998-11-03 2000-05-22 Novartis Ag Anti-inflammatory 4-phenyl-5-pyrimidinyl-imidazoles
US6359061B1 (en) 1999-03-19 2002-03-19 Isis Pharmaceuticals, Inc. Amide compound libraries
EP1165500A1 (de) * 1999-04-02 2002-01-02 Du Pont Pharmaceuticals Company Amidderivate als inhibitoren von matrix metalloproteinasen, tnf-alpha und aggrecanase
US6365617B1 (en) 1999-06-29 2002-04-02 Ortho-Mcneil Pharmaceutical, Inc. Indole and indazole urea-peptoids as thrombin receptor antagonists
US6204245B1 (en) * 1999-09-17 2001-03-20 The Regents Of The University Of California Treatment of narcolepsy with immunosuppressants
WO2001034649A2 (en) 1999-11-09 2001-05-17 Chiron Corporation Compositions and methods for treating autoimmune diseases and transplant rejections
JP2003516380A (ja) 1999-12-07 2003-05-13 ノバルティス アクチエンゲゼルシャフト Vla−4インテグリンアンタゴニスト
DE10019755A1 (de) 2000-04-20 2001-11-08 Bayer Ag Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten
CA2408408C (en) 2000-05-12 2013-07-09 Genzyme Corporation Modulators of tnf- alpha signaling
RU2270194C2 (ru) * 2000-05-22 2006-02-20 Лео Фарма А/С Бензофеноны как ингибиторы il-1бета и tnf-альфа, фармацевтическая композиция и способ лечения
AU2003280429A1 (en) * 2002-06-26 2004-01-19 The Trustees Of Columbia Uninersity In The City Of New York Use of streptavidin to inhibit transplant rejection
JP4914008B2 (ja) 2002-11-21 2012-04-11 ジェンザイム・コーポレーション 免疫寛容を誘導するためのジアミド誘導体と免疫抑制剤との組み合わせ
PT1567138E (pt) * 2002-11-21 2011-04-11 Genzyme Corp Utilização de derivados de diamida para inibição de rejeição crónica de transplante

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US8921547B2 (en) 2014-12-30
US20060173010A1 (en) 2006-08-03
US20150126512A1 (en) 2015-05-07
JP2012051917A (ja) 2012-03-15
CA2781858C (en) 2015-03-31
HK1051186A1 (zh) 2003-07-25
WO2001087849A3 (en) 2002-06-06
AU5969101A (en) 2001-11-26
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KR100840816B1 (ko) 2008-06-23
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US9579325B2 (en) 2017-02-28
CA2781858A1 (en) 2001-11-22
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US6969728B2 (en) 2005-11-29
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