NO20025405D0 - Modulatorer for TNF-alfa-signalisering - Google Patents
Modulatorer for TNF-alfa-signaliseringInfo
- Publication number
- NO20025405D0 NO20025405D0 NO20025405A NO20025405A NO20025405D0 NO 20025405 D0 NO20025405 D0 NO 20025405D0 NO 20025405 A NO20025405 A NO 20025405A NO 20025405 A NO20025405 A NO 20025405A NO 20025405 D0 NO20025405 D0 NO 20025405D0
- Authority
- NO
- Norway
- Prior art keywords
- tnf
- modulators
- alpha signaling
- alpha
- signaling
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20378400P | 2000-05-12 | 2000-05-12 | |
US20521300P | 2000-05-18 | 2000-05-18 | |
PCT/US2001/015027 WO2001087849A2 (en) | 2000-05-12 | 2001-05-10 | Modulators of tnf- alpha signaling |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20025405D0 true NO20025405D0 (no) | 2002-11-11 |
NO20025405L NO20025405L (no) | 2003-01-09 |
NO324693B1 NO324693B1 (no) | 2007-12-03 |
Family
ID=26898898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20025405A NO324693B1 (no) | 2000-05-12 | 2002-11-11 | 2-acetamidoacetamidderivater, anvendelse av slike forbindelser til fremstilling av preparater for behandling av sykdommer samt preparater omfattende slike forbindelser |
Country Status (13)
Country | Link |
---|---|
US (5) | US6969728B2 (no) |
EP (1) | EP1294699B1 (no) |
JP (3) | JP4960565B2 (no) |
KR (1) | KR100840816B1 (no) |
CN (1) | CN100494182C (no) |
AU (2) | AU2001259691B2 (no) |
BR (1) | BR0111158A (no) |
CA (3) | CA2408408C (no) |
HK (1) | HK1051186A1 (no) |
IL (2) | IL152450A0 (no) |
MX (1) | MXPA02010993A (no) |
NO (1) | NO324693B1 (no) |
WO (1) | WO2001087849A2 (no) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA02010993A (es) | 2000-05-12 | 2003-03-10 | Genzyme Corp | Reguladores de transmision de la tnf-alfa. |
DE10108481A1 (de) * | 2001-02-22 | 2002-10-24 | Bayer Ag | Pyridylpyrimidine |
ES2283532T3 (es) * | 2001-04-10 | 2007-11-01 | Pfizer, Inc. | Derivados de pirazol para tratar el vih. |
CA2478183C (en) * | 2002-03-12 | 2010-02-16 | Merck & Co. Inc. | Substituted amides |
JP4914008B2 (ja) * | 2002-11-21 | 2012-04-11 | ジェンザイム・コーポレーション | 免疫寛容を誘導するためのジアミド誘導体と免疫抑制剤との組み合わせ |
DE60335652D1 (de) * | 2002-11-21 | 2011-02-17 | Genzyme Corp | Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung |
EP1572647B1 (en) * | 2002-12-20 | 2016-09-21 | Basf Se | Synthesis of amines and intermediates for the synthesis thereof |
JP2006517213A (ja) * | 2003-02-11 | 2006-07-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規な抗コリン作用剤とTNFα合成又は作用阻害剤に基づく新規な医薬組成物 |
WO2005037213A2 (en) * | 2003-10-14 | 2005-04-28 | Cornell Research Foundation, Inc. | Antiinflammatory inhibitors of respiratory burst in adherent neutrophils |
EP1765347A4 (en) * | 2004-06-04 | 2008-10-01 | Univ California | COMPOUNDS WITH ION TRANSPORTER HEALING EFFECT BY MUTANT CFTR AND ITS USE |
EA200801591A1 (ru) * | 2005-12-30 | 2008-12-30 | Рэнбакси Лабораториз Лимитед | Антагонисты мускаринового рецептора |
WO2008005429A2 (en) | 2006-07-03 | 2008-01-10 | Charles David Adair | Composition for modulating the expression of cell adhesion molecules |
TW200831491A (en) | 2006-10-10 | 2008-08-01 | Amgen Inc | N-aryl pyrazole compounds, compositions, and methods for their use |
WO2009026579A1 (en) * | 2007-08-23 | 2009-02-26 | Cornell Research Foundation, Inc. | Proteasome inhibitors and their use in treating pathogen infection and cancer |
US20090155207A1 (en) * | 2007-11-29 | 2009-06-18 | Hariri Robert J | Use of Immunomodulatory Compounds for the Treatment of Transverse Myelitis, Multiple Sclerosis, and Other Disorders |
US20150038541A1 (en) * | 2012-03-19 | 2015-02-05 | Aposignal Bioscience Llc | Composition and methods for cell modulation |
UY36034A (es) | 2014-03-18 | 2015-09-30 | Astrazeneca Ab | Derivados de 3,5-diamino-6-cloro-pirazina-2-carboxamida y sales farmaceuticamente aceptables de estos |
Family Cites Families (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE372326C (de) | 1922-04-22 | 1923-03-26 | Adam Thierauf | Turbinenanlage |
DE748704C (de) | 1938-02-26 | 1944-11-08 | Einrichtung zum federnden Begrenzen des Laengsspiels der in Gleitlagern laufenden Ankerwelle von Elektrokleinmotoren | |
US3935263A (en) * | 1971-12-10 | 1976-01-27 | Eastman Kodak Company | Oxichromic compounds, stabilized oxichromic compounds and processes for preparing same |
CA996119A (en) | 1971-12-10 | 1976-08-31 | Eastman Kodak Company | Oxichromic compounds, stabilized oxichromic compounds and processes for preparing same |
DE2937698A1 (de) * | 1979-09-18 | 1981-04-02 | A. Nattermann & Cie GmbH, 5000 Köln | N-propionylsarcosinanilide, deren herstellungsverfahren und arzneimittel auf deren basis |
US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
EP0246749A3 (en) | 1986-05-17 | 1988-08-31 | AgrEvo UK Limited | Triazole herbicides |
JPH01101456A (ja) * | 1987-10-15 | 1989-04-19 | Honda Electron Co Ltd | 超音波顕微鏡装置 |
DE3825867A1 (de) | 1988-03-04 | 1989-09-14 | Bayer Ag | Heterocyclisch substituierte sulfonylaminoazole und ihre verwendung als herbizide |
DE3813886A1 (de) | 1988-04-20 | 1989-11-02 | Schering Ag | 1-triazinyl-1h-1,2,4-triazol-3- sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider, fungizider und pflanzenwachstumsregulierender wirkung |
US4944796A (en) * | 1988-11-14 | 1990-07-31 | Ici Americas Inc. | Certain 2-(disubstituted amino) acetanilide herbicides |
DE3841086A1 (de) | 1988-12-07 | 1990-06-21 | Bayer Ag | Sulfonylaminoazine, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
US5540931A (en) * | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
US4997950A (en) * | 1989-04-20 | 1991-03-05 | Richard Finbar Murphy | Novel C-terminal gastrin antagonists |
US5100899A (en) | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
DE3928605A1 (de) | 1989-08-30 | 1991-03-07 | Bayer Ag | Substituierte sulfonylaminoazole |
JPH0686378B2 (ja) * | 1990-05-31 | 1994-11-02 | 田辺製薬株式会社 | 免疫調節剤 |
US5958413A (en) * | 1990-11-01 | 1999-09-28 | Celltech Limited | Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor |
US6420374B1 (en) * | 1990-11-30 | 2002-07-16 | Fred Hutchinson Cancer Research Center | Use of xanthines as immunosuppressants and to inhibit allograft reactions |
WO1992017456A1 (en) * | 1991-03-26 | 1992-10-15 | Fujisawa Pharmaceutical Co., Ltd. | Amino acid derivative and salt thereof |
EP0520573A1 (en) | 1991-06-27 | 1992-12-30 | Glaxo Inc. | Cyclic imide derivatives |
EP0629622B1 (en) | 1992-02-28 | 1998-11-11 | Zenyaku Kogyo Kabushikikaisha | S-triazine derivative and remedy for estrogen-dependent diseases containing the same as active ingredient |
US5861382A (en) * | 1992-05-01 | 1999-01-19 | Yeda Research And Development Co. Ltd. | Methods for regulation of active TNF-α |
US6270766B1 (en) * | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
WO1994008619A1 (en) | 1992-10-08 | 1994-04-28 | The Kennedy Institute Of Rheumatology | Treatment of autoimmune and inflammatory disorders |
US6080407A (en) * | 1993-05-17 | 2000-06-27 | The Picower Institute For Medical Research | Diagnostic assays for MIF |
JPH09510952A (ja) | 1993-10-06 | 1997-11-04 | ザ ケネディー インスティチュート オブ リューマトロジー | 自己免疫疾患および炎症性疾患の治療 |
DE4337600A1 (de) * | 1993-11-01 | 1995-05-04 | Diagnostikforschung Inst | N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen |
NZ278607A (en) * | 1994-02-07 | 1999-05-28 | Knoll Ag | Use of tnf antagonists for treating disorders involving elevated serum levels of il-6 wherein the serum levels are 500pg/ml or above |
DE4430128A1 (de) * | 1994-08-25 | 1996-02-29 | Hoechst Ag | Kombinationspräparat mit immunsuppressiven, kardiovaskulären und cerebralen Wirkungen |
DE4430127A1 (de) * | 1994-08-25 | 1996-03-14 | Hoechst Ag | Kombinationspräparat, enthaltend Cyclosporin A oder FK506 und ein Xanthinderivat |
AU3993795A (en) * | 1994-12-02 | 1996-06-19 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compounds for prevention and/or treatment of no-mediated diseases |
US5632367A (en) | 1995-01-23 | 1997-05-27 | Mars, Incorporated | Validation housing for a bill validator made by a two shot molding process |
US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
FR2730411B1 (fr) * | 1995-02-14 | 1997-03-28 | Centre Nat Rech Scient | Association medicamenteuse utile pour la transfection et l'expression in vivo d'exogenes |
ATE226641T1 (de) | 1995-04-08 | 2002-11-15 | Lg Chemical Ltd | Humaner 4-1bb spezifischer humaner antikörper und diesen produzierende zellinie |
US6110896A (en) | 1995-05-10 | 2000-08-29 | Darwin Discovery, Ltd. | Peptidyl compounds and their therapeutic use |
SE510202C2 (sv) | 1995-05-19 | 1999-04-26 | Stroemsholmen Ab | Anordning vid ett hydraulsystem |
US5654312A (en) * | 1995-06-07 | 1997-08-05 | Andrulis Pharmaceuticals | Treatment of inflammatory and/or autoimmune dermatoses with thalidomide alone or in combination with other agents |
EP0754459B1 (en) * | 1995-07-20 | 2004-02-11 | Cellena (Cell Engineering) A.G. | Composition containing glycans corresponding to transferrin glycans as an active principle for the induction of immune tolerance against antigens |
IL115245A (en) * | 1995-09-11 | 2002-12-01 | Yissum Res Dev Co | Tumor necrosis factor inhibiting pharmaceuticals |
JP2000500482A (ja) | 1995-11-22 | 2000-01-18 | ダーウィン・ディスカバリー・リミテッド | イミダゾール置換基を有するメルカプトアルキルペプチジル化合物並びにマトリックス金属プロテイナーゼ(mmp)および/または腫瘍壊死因子(tnf)のインヒビターとしての該化合物の使用 |
US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
ATE230740T1 (de) * | 1996-04-12 | 2003-01-15 | Sumitomo Pharma | Piperidinylpyrimidine derivate |
US6211160B1 (en) * | 1996-09-06 | 2001-04-03 | The Trustees Of The University Of Pennsylvania | Method for tolerizing a mammalian patient to administration of gene therapy virus vectors |
AR038955A1 (es) * | 1996-12-05 | 2005-02-02 | Amgen Inc | Compuestos de pirimidinona y piridona sustituidos y metodos para su uso |
EP0942740B1 (en) * | 1996-12-06 | 2003-08-27 | Amgen Inc., | Combination therapy using a tnf binding protein for treating tnf-mediated diseases |
WO1998030241A1 (en) | 1997-01-10 | 1998-07-16 | Biogen, Inc. | Methods of therapeutic administration of anti-cd40l compounds |
US6294170B1 (en) * | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
AU5623398A (en) | 1997-03-07 | 1998-09-22 | Biogen, Inc. | Methods of therapeutic administration of anti-cd40l compounds |
US5801193A (en) * | 1997-04-15 | 1998-09-01 | Immune Modulation, Inc. | Compositions and methods for immunosuppressing |
US6506569B1 (en) * | 1997-05-30 | 2003-01-14 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor TR10 |
GB9713732D0 (en) | 1997-06-27 | 1997-09-03 | Pharmacia & Upjohn Spa | Substituted triazinic compounds |
AU8672198A (en) | 1997-07-31 | 1999-02-22 | Chiron Corporation | Method enabling readministration of aav vector via immunosuppression of host |
US6503184B1 (en) * | 1997-10-21 | 2003-01-07 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
US6022884A (en) * | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
US6407218B1 (en) * | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
DE69837621T2 (de) | 1997-12-03 | 2007-12-27 | Mid-America Commercialization Corp., Manhattan | Substituierte pyrimidine und pyridine als unkrautbekämpfungsmittel |
WO1999050246A1 (en) * | 1998-03-30 | 1999-10-07 | Repligen Corporation | Protein-carbohydrate binding antagonists |
CA2329065A1 (en) * | 1998-05-05 | 1999-11-11 | Francisco Xavier Talamas | Pyrazole derivatives as p-38 map kinase inhibitors |
FR2780891A1 (fr) | 1998-07-10 | 2000-01-14 | Univ Paris Curie | Echange de lymphocytes t |
AU6476599A (en) | 1998-11-03 | 2000-05-22 | Novartis Ag | Anti-inflammatory 4-phenyl-5-pyrimidinyl-imidazoles |
US6359061B1 (en) | 1999-03-19 | 2002-03-19 | Isis Pharmaceuticals, Inc. | Amide compound libraries |
JP2002541138A (ja) * | 1999-04-02 | 2002-12-03 | デュポン ファーマシューティカルズ カンパニー | マトリックスメタロプロテアーゼ、TNF−α、およびアグレカナーゼの阻害剤としての新規アミド誘導体 |
US6365617B1 (en) | 1999-06-29 | 2002-04-02 | Ortho-Mcneil Pharmaceutical, Inc. | Indole and indazole urea-peptoids as thrombin receptor antagonists |
US6204245B1 (en) * | 1999-09-17 | 2001-03-20 | The Regents Of The University Of California | Treatment of narcolepsy with immunosuppressants |
AU1590201A (en) | 1999-11-09 | 2001-06-06 | Chiron Corporation | Compositions and methods for treating autoimmune diseases and transplant rejections |
CA2388686A1 (en) | 1999-12-07 | 2001-06-14 | Sompong Wattanasin | Vla-4 integrin antagonists |
DE10019755A1 (de) | 2000-04-20 | 2001-11-08 | Bayer Ag | Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten |
MXPA02010993A (es) * | 2000-05-12 | 2003-03-10 | Genzyme Corp | Reguladores de transmision de la tnf-alfa. |
RU2270194C2 (ru) * | 2000-05-22 | 2006-02-20 | Лео Фарма А/С | Бензофеноны как ингибиторы il-1бета и tnf-альфа, фармацевтическая композиция и способ лечения |
AU2003280429A1 (en) * | 2002-06-26 | 2004-01-19 | The Trustees Of Columbia Uninersity In The City Of New York | Use of streptavidin to inhibit transplant rejection |
DE60335652D1 (de) * | 2002-11-21 | 2011-02-17 | Genzyme Corp | Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung |
JP4914008B2 (ja) * | 2002-11-21 | 2012-04-11 | ジェンザイム・コーポレーション | 免疫寛容を誘導するためのジアミド誘導体と免疫抑制剤との組み合わせ |
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