NO323231B1 - Soyaekstrakt, fremgangsmate for fremstilling derav og farmasoytisk blanding. - Google Patents
Soyaekstrakt, fremgangsmate for fremstilling derav og farmasoytisk blanding. Download PDFInfo
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- NO323231B1 NO323231B1 NO20000399A NO20000399A NO323231B1 NO 323231 B1 NO323231 B1 NO 323231B1 NO 20000399 A NO20000399 A NO 20000399A NO 20000399 A NO20000399 A NO 20000399A NO 323231 B1 NO323231 B1 NO 323231B1
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- Prior art keywords
- extract
- weight
- water
- treatment
- soy
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Classifications
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1997132866 DE19732866C2 (de) | 1997-07-30 | 1997-07-30 | Neue Soja-Extrakte, ihre Herstellung, auf ihnen basierende Formulierungen und deren Verwendung für die Prävention oder Behandlung von pre-menopausalen und post-menopausalen Symptomen |
DE1997132855 DE19732855C2 (de) | 1997-07-30 | 1997-07-30 | Spezieller Soja-Extrakt, dessen Herstellung, diesen enthaltende Formulierungen und deren Verwendung für die Prävention oder Behandlung von Krebs |
DE1997132822 DE19732822C2 (de) | 1997-07-30 | 1997-07-30 | Soja-Extrakt, dessen Herstellungsverfahren und diesen enthaltende pharmazeutische Zusammensetzungen und deren Verwendung für die Prävention oder Behandlung von Alkoholismus |
PCT/EP1998/004770 WO1999006057A1 (en) | 1997-07-30 | 1998-07-30 | Soya extract, process for its preparation and pharmaceutical composition |
Publications (3)
Publication Number | Publication Date |
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NO20000399D0 NO20000399D0 (no) | 2000-01-26 |
NO20000399L NO20000399L (no) | 2000-01-26 |
NO323231B1 true NO323231B1 (no) | 2007-02-05 |
Family
ID=27217588
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NO20000399A NO323231B1 (no) | 1997-07-30 | 2000-01-26 | Soyaekstrakt, fremgangsmate for fremstilling derav og farmasoytisk blanding. |
Country Status (20)
Country | Link |
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US (3) | US6280777B1 (zh) |
EP (1) | EP1001797B9 (zh) |
JP (2) | JP3570989B2 (zh) |
KR (1) | KR100388511B1 (zh) |
CN (1) | CN1089245C (zh) |
AT (1) | ATE297213T1 (zh) |
AU (1) | AU740356B2 (zh) |
CA (1) | CA2298142C (zh) |
CZ (1) | CZ298532B6 (zh) |
DE (1) | DE69830495T2 (zh) |
DK (1) | DK1001797T3 (zh) |
ES (1) | ES2243005T3 (zh) |
HK (1) | HK1025507A1 (zh) |
HU (1) | HU229444B1 (zh) |
NO (1) | NO323231B1 (zh) |
PL (1) | PL191191B1 (zh) |
PT (1) | PT1001797E (zh) |
RU (1) | RU2183964C2 (zh) |
SK (1) | SK283491B6 (zh) |
WO (1) | WO1999006057A1 (zh) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6261565B1 (en) * | 1996-03-13 | 2001-07-17 | Archer Daniels Midland Company | Method of preparing and using isoflavones |
JP3570989B2 (ja) * | 1997-07-30 | 2004-09-29 | インデナ エッセ ピ ア | 大豆抽出物、その調製方法および医薬組成物 |
ATE322903T1 (de) | 1999-07-09 | 2006-04-15 | Sun Farm Corp | Diätzusatz zur behandlung von malignitäten und virusinfektionen und verbesserung der immunfunktion |
JP4413464B2 (ja) * | 1999-12-17 | 2010-02-10 | 光則 小野 | 水溶性の豆ベース抽出物 |
ES2379055T3 (es) * | 2000-04-18 | 2012-04-20 | Medestea Internazionale S.P.A. | Una composición basada en extractos naturales útiles para la prevención y el tratamiento de las arrugas cutáneas |
CN1096456C (zh) * | 2000-06-08 | 2002-12-18 | 蒋宇扬 | 连续提取大豆异黄酮、低聚糖、皂甙的工艺 |
KR20010016220A (ko) * | 2000-11-17 | 2001-03-05 | 이광필 | 대두 배아로부터 생리활성 물질인 이소플라본의 분리정제방법 |
FR2818096B1 (fr) * | 2000-12-14 | 2004-05-07 | Daniel Chajuss | Composition phytochimique de soja |
IL148825A0 (en) * | 2002-03-21 | 2002-09-12 | Yeda Res & Dev | Derivatives of isoflavones |
US20040131749A1 (en) * | 2002-08-29 | 2004-07-08 | Archer-Daniels-Midland Company | Phytochemicals from edible bean process streams |
ITMI20022723A1 (it) * | 2002-12-20 | 2004-06-21 | Marfarma S R L Ora Marfarma Holding Spa | Composizioni per il trattamento della sindrome post-menopausa. |
JP4442422B2 (ja) * | 2002-12-24 | 2010-03-31 | 不二製油株式会社 | 高濃度かつ高溶解性のイソフラボン含有組成物及びその製造法 |
GB0317020D0 (en) * | 2003-07-21 | 2003-08-27 | Sahajanand Biotech Private Ltd | Herbo-mineral formulation for refractory leukemias and lymphomas |
US7718813B2 (en) | 2003-08-15 | 2010-05-18 | Nature Pure Labs Sw, Inc. | Hydrolysis and purification of active plant compounds suitable for topical application |
ATE532525T1 (de) | 2003-09-08 | 2011-11-15 | Genyous Biomed Internat Inc | Zusammensetzungen von botanischen extrakten für die krebstherapie |
RU2006113703A (ru) * | 2003-09-22 | 2007-11-10 | Джиниус Байомед Интернэшнл Инк. (Us) | Композиции hippophae rhamnoides для терапии рака |
KR100449887B1 (ko) | 2003-10-31 | 2004-09-22 | 주식회사 렉스진바이오텍 | 이소플라본을 함유하는 괴각 추출물의 제조방법 |
MD2518G2 (ro) * | 2003-12-09 | 2005-06-30 | Элеонора ВАТАМАН | Preparat medicamentos pentru reducerea concentratiei colesterolului in sange |
JP2005232032A (ja) * | 2004-02-17 | 2005-09-02 | Kikkoman Corp | 敗血症の予防・治療剤 |
US7658955B2 (en) * | 2004-03-03 | 2010-02-09 | Bio-Botanica, Inc. | Pueraria candollei var. mirifica A Shaw. & Suvat. extract |
WO2005107780A2 (en) * | 2004-05-10 | 2005-11-17 | Instituto Tecnológico Y De Estudios Superiores De Monterrey (Itesm) | Cancer cell growth inhibition by black bean (phaseolus vulgarisl) extracts |
AU2005203059B2 (en) * | 2004-07-16 | 2011-11-24 | Johnson & Johnson Consumer Companies, Inc. | Use of legume products for the treatment and prevention of radiotherapy-induced skin damage |
AU2005229653B2 (en) * | 2004-11-02 | 2006-06-08 | Finocchiaro, Rosario Salvatore Antonio | Wood cutting tool |
CN100345505C (zh) * | 2004-12-21 | 2007-10-31 | 山东理工大学 | 提取大豆异黄酮、皂甙、低聚糖的挤压加工方法和装置 |
EP1860956A1 (en) * | 2005-03-09 | 2007-12-05 | Cargill, Incorporated | A method for extracting oilseed and use of the resultant product |
BRPI0708893A2 (pt) * | 2006-03-15 | 2011-06-28 | Univ Rutgers | composição, processos para aumentar a proporção de pmfs hidroxiladas para pmfs não hidroxiladas em um extrato de planta, e para preparar o extrato de planta, usos de uma pmf hidroxilada, e de uma composição, e, métodos para inibir a proliferação de uma célula cancerosa, para induzir apoptose em uma célula cancerosa, para reduzir a produção de nitrito em um macrófago, e para inibir a ativação de inos e/ou cox-2 em um macrófago |
US20110117121A1 (en) * | 2006-10-27 | 2011-05-19 | James Dao | Compositions for treatment and inhibition of pain |
EP2049131A2 (de) * | 2006-11-02 | 2009-04-22 | Dr. Willmar Schwabe GmbH & Co. KG | Verfahren zur herstellung von pflanzenextrakten mit vermindertem gehalt an umweltbedingten unpolaren fremdstoffen |
BRPI0719164A8 (pt) * | 2006-11-03 | 2017-11-07 | Corn Products Int Inc | Processo para fabricar extratos de soja encapsulados, extrato de soja encapsulado, e, material encapsulado |
US20110136745A1 (en) * | 2008-01-03 | 2011-06-09 | Monsanto Technology Llc. | Method of selecting soybeans with enhanced bioactivity and compositions for reducing cancer cell viability |
US8217165B2 (en) * | 2008-06-17 | 2012-07-10 | Pawan Kumar Goel | Process for the extraction of furostanolic saponins from fenugreek seeds |
CN101477098B (zh) * | 2009-01-08 | 2012-07-18 | 上海交通大学 | 利用大豆天然提取物检测大豆抗蚜性的方法 |
CN102548565A (zh) * | 2009-10-22 | 2012-07-04 | 株式会社益力多本社 | 癌症发病风险降低剂 |
CN102977066A (zh) * | 2012-12-07 | 2013-03-20 | 山东大学 | 大豆中异黄酮的提取与纯化方法 |
CN106028795B (zh) * | 2013-12-13 | 2020-03-03 | 庆尚大学校产学协力团 | 具有高含量异黄酮衍生物的豆叶或豆茎及其制备方法 |
KR101834764B1 (ko) * | 2014-09-26 | 2018-03-08 | 대한민국 | 유효성분의 함량이 향상된 콩 유래 추출물 |
KR101834766B1 (ko) * | 2014-09-26 | 2018-03-08 | 대한민국 | 향상된 색택을 가지는 콩 유래 추출물 |
US10543243B2 (en) | 2016-06-06 | 2020-01-28 | Charsire Biotechnology Corp. | Soybeam seed extract, method for producing the same and uses thereof |
RU2664148C1 (ru) * | 2017-09-11 | 2018-08-15 | Павел Павлович Хорошутин | Способ производства сухих экстрактов из сырья растительного происхождения |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4501734A (en) * | 1981-03-06 | 1985-02-26 | Wakunaga Yakuhin Kabushiki Kaisha | Promotion of absorption of drugs administered through the alimentary system |
JPS5933232A (ja) | 1982-08-19 | 1984-02-23 | Tokiwa Kanpou Seiyaku:Kk | マメ科植物からサポニン類およびフラボン類の分離方法 |
JPS5988064A (ja) | 1982-11-10 | 1984-05-21 | Osaka Chem Lab | 美容食品 |
JPS59175496A (ja) | 1983-03-23 | 1984-10-04 | Osaka Chem Lab | ソ−ヤサポニンの単離法 |
JPS6136225A (ja) * | 1984-07-30 | 1986-02-20 | Airin:Kk | サポニン類の単離法 |
JPS625917A (ja) * | 1985-07-03 | 1987-01-12 | Airin:Kk | 大豆胚芽よりのイソフラボン類を含有しないサポニンの製造法 |
JPS63245648A (ja) * | 1987-04-01 | 1988-10-12 | Ajinomoto Co Inc | 大豆食品素材の製法 |
CH679584A5 (zh) * | 1989-11-10 | 1992-03-13 | Nestle Sa | |
JPH0436242A (ja) * | 1990-05-30 | 1992-02-06 | Fuji Oil Co Ltd | 大豆サポニンの製造法 |
US5204369A (en) * | 1991-07-01 | 1993-04-20 | The Endowment For Research In Human Biology | Method for the inhibition of aldh-i useful in the treatment of alcohol dependence or alcohol abuse |
USRE40792E1 (en) * | 1992-05-19 | 2009-06-23 | Novogen Research Pty Ltd | Health supplements containing phyto-oestrogens, analogues or metabolites thereof |
JPH06136225A (ja) | 1992-10-29 | 1994-05-17 | Sanyo Chem Ind Ltd | 水溶性高分子化合物の水分散液 |
JP3078694B2 (ja) * | 1993-12-17 | 2000-08-21 | キッコーマン株式会社 | ゲニステインの製造法 |
WO1996010341A1 (en) | 1994-10-03 | 1996-04-11 | Schouten Industries B.V. | Food and health products |
JPH08291191A (ja) * | 1995-04-24 | 1996-11-05 | Kikkoman Corp | アセチルイソフラボン配糖体の製造法 |
IT1274481B (it) | 1995-05-12 | 1997-07-17 | Indena Spa | Composizioni farmaceutiche per il trattamento della alcol-dipendenza |
IT1275436B (it) | 1995-05-19 | 1997-08-07 | Indena Spa | Uso della forskolina e di estratti che la contengono per il trattamento della alcol-dipendenza |
US6020471A (en) * | 1996-09-13 | 2000-02-01 | Abbott Laboratories | Process for isolating phytoestrogens from plant protein |
JP3570989B2 (ja) * | 1997-07-30 | 2004-09-29 | インデナ エッセ ピ ア | 大豆抽出物、その調製方法および医薬組成物 |
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- 1998-07-30 ES ES98942659T patent/ES2243005T3/es not_active Expired - Lifetime
- 1998-07-30 CN CN98807664A patent/CN1089245C/zh not_active Expired - Fee Related
- 1998-07-30 CZ CZ20000223A patent/CZ298532B6/cs not_active IP Right Cessation
- 1998-07-30 CA CA002298142A patent/CA2298142C/en not_active Expired - Fee Related
- 1998-07-30 DK DK98942659T patent/DK1001797T3/da active
- 1998-07-30 DE DE69830495T patent/DE69830495T2/de not_active Expired - Lifetime
- 1998-07-30 AT AT98942659T patent/ATE297213T1/de active
- 1998-07-30 EP EP98942659A patent/EP1001797B9/en not_active Expired - Lifetime
- 1998-07-30 WO PCT/EP1998/004770 patent/WO1999006057A1/en active IP Right Grant
- 1998-07-30 KR KR10-2000-7001016A patent/KR100388511B1/ko not_active IP Right Cessation
- 1998-07-30 AU AU90711/98A patent/AU740356B2/en not_active Ceased
- 1998-07-30 RU RU2000105259/14A patent/RU2183964C2/ru not_active IP Right Cessation
- 1998-07-30 PL PL337520A patent/PL191191B1/pl unknown
- 1998-07-30 PT PT98942659T patent/PT1001797E/pt unknown
- 1998-07-30 HU HU0003058A patent/HU229444B1/hu not_active IP Right Cessation
- 1998-07-30 SK SK104-2000A patent/SK283491B6/sk not_active IP Right Cessation
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2000
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- 2000-01-28 US US09/492,921 patent/US6280777B1/en not_active Expired - Lifetime
- 2000-07-04 HK HK00104037A patent/HK1025507A1/xx not_active IP Right Cessation
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