NO323078B1 - Mifroemulsjonsforkonsentrat og mikroemulsjonssammensetning. - Google Patents
Mifroemulsjonsforkonsentrat og mikroemulsjonssammensetning. Download PDFInfo
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- NO323078B1 NO323078B1 NO19971898A NO971898A NO323078B1 NO 323078 B1 NO323078 B1 NO 323078B1 NO 19971898 A NO19971898 A NO 19971898A NO 971898 A NO971898 A NO 971898A NO 323078 B1 NO323078 B1 NO 323078B1
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- Prior art keywords
- composition according
- microemulsion
- preparations
- weight
- fatty acid
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- 239000004530 micro-emulsion Substances 0.000 title claims abstract description 42
- 239000000203 mixture Substances 0.000 title claims description 17
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- 108010036949 Cyclosporine Proteins 0.000 claims abstract description 22
- 239000003120 macrolide antibiotic agent Substances 0.000 claims abstract description 22
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- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 15
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61P37/02—Immunomodulators
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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GB9421613A GB9421613D0 (en) | 1994-10-26 | 1994-10-26 | Organic compounds |
GB9422084A GB9422084D0 (en) | 1994-11-02 | 1994-11-02 | Organic compounds |
GBGB9425353.1A GB9425353D0 (en) | 1994-12-15 | 1994-12-15 | Organic compounds |
GBGB9517133.6A GB9517133D0 (en) | 1995-08-22 | 1995-08-22 | Pharmaceutical compositions |
PCT/EP1995/004187 WO1996013273A1 (en) | 1994-10-26 | 1995-10-25 | Pharmaceutical compositions |
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NO971898D0 NO971898D0 (no) | 1997-04-24 |
NO971898L NO971898L (no) | 1997-06-24 |
NO323078B1 true NO323078B1 (no) | 2006-12-27 |
Family
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NO19971898A NO323078B1 (no) | 1994-10-26 | 1997-04-24 | Mifroemulsjonsforkonsentrat og mikroemulsjonssammensetning. |
NO20031901A NO323063B1 (no) | 1994-10-26 | 2003-04-28 | Farmasoytisk preparat og fremgangsmate for stabilisering av et makrolid mot nedbrytning i et farmasoytisk preparat. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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NO20031901A NO323063B1 (no) | 1994-10-26 | 2003-04-28 | Farmasoytisk preparat og fremgangsmate for stabilisering av et makrolid mot nedbrytning i et farmasoytisk preparat. |
Country Status (25)
Country | Link |
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EP (2) | EP0787011B1 (zh) |
JP (3) | JPH10509699A (zh) |
KR (2) | KR100518135B1 (zh) |
CN (3) | CN1124157C (zh) |
AT (1) | ATE411800T1 (zh) |
AU (1) | AU714360B2 (zh) |
BR (1) | BR9509496A (zh) |
CA (1) | CA2200967C (zh) |
CY (1) | CY2210B1 (zh) |
CZ (1) | CZ289838B6 (zh) |
DE (2) | DE69535869D1 (zh) |
ES (1) | ES2316150T3 (zh) |
FI (1) | FI119497B (zh) |
HU (1) | HU225535B1 (zh) |
IL (3) | IL115742A (zh) |
MY (1) | MY129435A (zh) |
NO (2) | NO323078B1 (zh) |
NZ (1) | NZ295655A (zh) |
PE (1) | PE52896A1 (zh) |
PL (1) | PL184368B1 (zh) |
PT (1) | PT787011E (zh) |
SK (2) | SK286178B6 (zh) |
TR (2) | TR199500299A2 (zh) |
TW (1) | TW308544B (zh) |
WO (1) | WO1996013273A1 (zh) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
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CH686761A5 (de) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
NZ280689A (en) * | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
US5958876A (en) * | 1996-06-19 | 1999-09-28 | Novartis Ag | Cyclosporin-containing pharmaceutical compositions |
EP0978288A4 (en) * | 1997-04-11 | 2006-07-12 | Astellas Pharma Inc | DRUG COMPOSITION |
US6008191A (en) * | 1997-09-08 | 1999-12-28 | Panacea Biotec Limited | Pharmaceutical compositions containing cyclosporin |
US6346511B1 (en) | 1997-09-08 | 2002-02-12 | Panacea Biotec Limited | Pharmaceutical composition comprising cyclosporin |
IN188719B (zh) * | 1997-09-08 | 2002-11-02 | Panacea Biotec Ltd | |
US6187747B1 (en) | 1997-09-08 | 2001-02-13 | Panacea Biotech Limited | Pharmaceutical composition comprising cyclosporin |
CA2313024C (en) | 1997-12-10 | 2008-06-03 | Severson, Mary L. | Pharmaceutical compositions containing an omega-3 fatty acid oil |
ID25908A (id) * | 1998-03-06 | 2000-11-09 | Novartis Ag | Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida |
GB2380674B (en) * | 1998-03-06 | 2003-05-28 | Novartis Ag | Emulsion preconcentrates containing cyclosporin or a macrolide |
WO1999056727A2 (en) * | 1998-05-07 | 1999-11-11 | Elan Corporation, Plc | Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems |
TWI241915B (en) * | 1998-05-11 | 2005-10-21 | Ciba Sc Holding Ag | A method of preparing a pharmaceutical end formulation using a nanodispersion |
SE9804192D0 (sv) * | 1998-12-03 | 1998-12-03 | Scotia Lipidteknik Ab | New formulation |
GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
EP1143962B1 (en) * | 1999-01-28 | 2004-11-24 | Dinesh Shantilal Patel | Parenteral solution of propofol (2,6-diisoprophylphenol) and 2.5-di-0-methyl-1.4;3.6-dianhydro-d-glucitol as a solvent |
GB9903547D0 (en) | 1999-02-16 | 1999-04-07 | Novartis Ag | Organic compounds |
US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
ATE474590T1 (de) | 1999-05-10 | 2010-08-15 | Paolo Brenner | Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen |
GB9912476D0 (en) | 1999-05-28 | 1999-07-28 | Novartis Ag | Organic compounds |
DE19925001A1 (de) * | 1999-05-31 | 2000-12-07 | Pharma Concepts Gmbh & Co Kg | Flüssiges Konzentrat |
TR200200562T2 (tr) * | 1999-06-14 | 2002-05-21 | Cosmo S.P.A | Vücutta kontrollü şekilde salgılanabilen ve nahoş tadı önleyebilen ağızdan alınmaya mahsus farmasötik bileşimler |
US8895064B2 (en) | 1999-06-14 | 2014-11-25 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
KR100342942B1 (ko) * | 1999-07-05 | 2002-07-02 | 민경윤 | 카르두스 마리아누스 추출물 또는 이로부터 정제된 실리빈을함유하는 경구용 마이크로에멀젼 조성물 |
US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US7919113B2 (en) | 1999-12-30 | 2011-04-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Dispersible concentrate lipospheres for delivery of active agents |
GB0008785D0 (en) | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
DE10024451A1 (de) * | 2000-05-18 | 2001-11-29 | Asta Medica Ag | Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung |
AU2545901A (en) * | 2000-09-18 | 2002-03-26 | Rpg Life Sciences Ltd | Selfemulsifiable formulation having enhanced bioabsorption and immunosuppressionactivities |
JP2002193790A (ja) * | 2000-12-27 | 2002-07-10 | Lion Corp | 水難溶性薬剤含有水中油型エマルジョン及びその製造方法 |
SK288546B6 (sk) | 2001-02-19 | 2018-03-05 | Novartis Ag | 40-O-(2-hydroxyetyl)rapamycín v kombinácii s exemestánom alebo letrozolom na použitie pri liečení nádoru prsníka |
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