NO321954B1 - Farmasoytisk preparat omfattende antisoppmiddel for intravenos administrering til en pasient, anvendelse av preparatet for fremstilling av intravenost medikament, fremgangsmate for fremstilling av det farmasoytiske preparatet og preparat som er fremstilt ved fremgangsmaten. - Google Patents
Farmasoytisk preparat omfattende antisoppmiddel for intravenos administrering til en pasient, anvendelse av preparatet for fremstilling av intravenost medikament, fremgangsmate for fremstilling av det farmasoytiske preparatet og preparat som er fremstilt ved fremgangsmaten. Download PDFInfo
- Publication number
- NO321954B1 NO321954B1 NO19984860A NO984860A NO321954B1 NO 321954 B1 NO321954 B1 NO 321954B1 NO 19984860 A NO19984860 A NO 19984860A NO 984860 A NO984860 A NO 984860A NO 321954 B1 NO321954 B1 NO 321954B1
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- compound
- pharmaceutically acceptable
- preparation according
- water
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 38
- 238000000034 method Methods 0.000 title claims description 12
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 8
- 239000003814 drug Substances 0.000 title claims description 7
- 229940079593 drug Drugs 0.000 title claims description 7
- 238000001990 intravenous administration Methods 0.000 title claims description 6
- 229940121375 antifungal agent Drugs 0.000 title description 5
- 239000003429 antifungal agent Substances 0.000 title description 5
- 239000008194 pharmaceutical composition Substances 0.000 title 2
- 150000001875 compounds Chemical class 0.000 claims description 34
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 30
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- 239000011521 glass Substances 0.000 description 5
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
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- DRSHXJFUUPIBHX-UHFFFAOYSA-N COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 Chemical compound COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 DRSHXJFUUPIBHX-UHFFFAOYSA-N 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
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- 150000007513 acids Chemical class 0.000 description 2
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 2
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- 239000012897 dilution medium Substances 0.000 description 2
- LTYMSROWYAPPGB-UHFFFAOYSA-N diphenyl sulfide Chemical compound C=1C=CC=CC=1SC1=CC=CC=C1 LTYMSROWYAPPGB-UHFFFAOYSA-N 0.000 description 2
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 2
- 229960004884 fluconazole Drugs 0.000 description 2
- -1 hydrochloric Chemical class 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
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- 229940095064 tartrate Drugs 0.000 description 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229930183010 Amphotericin Natural products 0.000 description 1
- QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 description 1
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- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 244000285963 Kluyveromyces fragilis Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
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- 239000003463 adsorbent Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229940009444 amphotericin Drugs 0.000 description 1
- 229960003942 amphotericin b Drugs 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000884 anti-protozoa Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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- VFRSADQPWYCXDG-LEUCUCNGSA-N ethyl (2s,5s)-5-methylpyrrolidine-2-carboxylate;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CCOC(=O)[C@@H]1CC[C@H](C)N1 VFRSADQPWYCXDG-LEUCUCNGSA-N 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
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- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- OJVZUXCPPHYAGF-UHFFFAOYSA-N phenylsulfanylbenzene;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=CC=CC=1SC1=CC=CC=C1 OJVZUXCPPHYAGF-UHFFFAOYSA-N 0.000 description 1
- VBOGDLCGFBSZKS-UHFFFAOYSA-N phenylsulfanylbenzene;trifluoromethanesulfonic acid Chemical compound [O-]S(=O)(=O)C(F)(F)F.C=1C=CC=CC=1[SH+]C1=CC=CC=C1 VBOGDLCGFBSZKS-UHFFFAOYSA-N 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
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- 235000017281 sodium acetate Nutrition 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000011123 type I (borosilicate glass) Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1563896P | 1996-04-19 | 1996-04-19 | |
| GBGB9611006.9A GB9611006D0 (en) | 1996-05-24 | 1996-05-24 | Antifungal compositions |
| PCT/US1997/006284 WO1997039763A1 (fr) | 1996-04-19 | 1997-04-15 | Compositions contenant un agent antifongique et un tampon acetate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO984860D0 NO984860D0 (no) | 1998-10-16 |
| NO984860L NO984860L (no) | 1998-12-18 |
| NO321954B1 true NO321954B1 (no) | 2006-07-31 |
Family
ID=26309400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19984860A NO321954B1 (no) | 1996-04-19 | 1998-10-16 | Farmasoytisk preparat omfattende antisoppmiddel for intravenos administrering til en pasient, anvendelse av preparatet for fremstilling av intravenost medikament, fremgangsmate for fremstilling av det farmasoytiske preparatet og preparat som er fremstilt ved fremgangsmaten. |
Country Status (36)
| Country | Link |
|---|---|
| EP (1) | EP0904098B1 (fr) |
| JP (1) | JP3258672B2 (fr) |
| CN (1) | CN1132624C (fr) |
| AR (1) | AR006598A1 (fr) |
| AT (1) | ATE241999T1 (fr) |
| AU (1) | AU706250B2 (fr) |
| BG (1) | BG64272B1 (fr) |
| BR (2) | BRPI9708706C8 (fr) |
| CA (1) | CA2251928C (fr) |
| CO (1) | CO4940486A1 (fr) |
| CY (1) | CY2374B1 (fr) |
| CZ (1) | CZ289361B6 (fr) |
| DE (1) | DE69722615T2 (fr) |
| DK (1) | DK0904098T3 (fr) |
| DZ (1) | DZ2205A1 (fr) |
| EA (1) | EA001386B1 (fr) |
| EE (1) | EE04265B1 (fr) |
| ES (1) | ES2198569T3 (fr) |
| HK (1) | HK1020873A1 (fr) |
| HR (1) | HRP970201B1 (fr) |
| HU (1) | HU228296B1 (fr) |
| ID (1) | ID16643A (fr) |
| IL (1) | IL126479A (fr) |
| IS (1) | IS2159B (fr) |
| MY (1) | MY126305A (fr) |
| NO (1) | NO321954B1 (fr) |
| NZ (1) | NZ332156A (fr) |
| PE (1) | PE63998A1 (fr) |
| PL (1) | PL187294B1 (fr) |
| PT (1) | PT904098E (fr) |
| RS (1) | RS49566B (fr) |
| SA (1) | SA97180104B1 (fr) |
| SK (1) | SK281969B6 (fr) |
| TR (1) | TR199802102T2 (fr) |
| UA (1) | UA55409C2 (fr) |
| WO (1) | WO1997039763A1 (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU776782C (en) * | 1999-03-03 | 2005-04-07 | Eli Lilly And Company | Echinocandin pharmaceutical formulations containing micelle-forming surfactants |
| TWI233805B (en) * | 1999-07-01 | 2005-06-11 | Fujisawa Pharmaceutical Co | Stabilized pharmaceutical composition in lyophilized form as antifungal agent |
| CN101516387B (zh) * | 2006-07-26 | 2014-06-04 | 桑多斯股份公司 | 卡泊芬净制剂 |
| WO2008012310A1 (fr) * | 2006-07-26 | 2008-01-31 | Sandoz Ag | Préparations à base de caspofungine |
| AU2008269140A1 (en) | 2007-06-26 | 2008-12-31 | Merck Sharp & Dohme Corp. | Lyophilized anti-fungal composition |
| US8048853B2 (en) | 2008-06-13 | 2011-11-01 | Xellia Pharmaceuticals Aps | Process for preparing pharmaceutical compound and intermediates thereof |
| US20100256074A1 (en) * | 2008-06-25 | 2010-10-07 | Chaim Eidelman | Processes for preparing high purity aza cyclohexapeptides |
| WO2010108637A1 (fr) * | 2009-03-27 | 2010-09-30 | Axellia Pharmaceuticals Aps | Composé cristallisé |
| CN102219832B (zh) * | 2010-04-15 | 2013-08-21 | 上海天伟生物制药有限公司 | 一种氮杂环六肽或其盐的纯化方法 |
| CN102367269B (zh) * | 2010-11-10 | 2013-11-06 | 上海天伟生物制药有限公司 | 一种卡泊芬净类似物及其制备方法和用途 |
| CN102367268B (zh) * | 2010-11-10 | 2013-11-06 | 上海天伟生物制药有限公司 | 一种卡泊芬净类似物及其用途 |
| CN102367267B (zh) * | 2010-11-10 | 2013-09-04 | 上海天伟生物制药有限公司 | 一种卡泊芬净的制备方法 |
| CN102614493B (zh) * | 2011-01-31 | 2013-12-11 | 上海天伟生物制药有限公司 | 一种含有棘白菌素类抗真菌剂卡泊芬净的液体药用组合物 |
| CN102488887B (zh) * | 2011-01-31 | 2014-06-18 | 上海天伟生物制药有限公司 | 一种含有棘白菌素类抗真菌剂卡泊芬净的药用组合物及其制备方法和用途 |
| CN102488888B (zh) * | 2011-01-31 | 2014-07-30 | 上海天伟生物制药有限公司 | 一种含有棘白菌素类抗真菌剂的药用组合物及其制备方法和用途 |
| CN102166186A (zh) * | 2011-04-18 | 2011-08-31 | 深圳市健元医药科技有限公司 | 一种更加稳定的氮杂环己肽类制剂 |
| CN103315969B (zh) * | 2011-09-26 | 2016-05-18 | 上海天伟生物制药有限公司 | 一种低杂质含量的卡泊芬净制剂及其制备方法和用途 |
| CN103386117B (zh) * | 2011-09-26 | 2015-09-30 | 上海天伟生物制药有限公司 | 一种低杂质含量的卡泊芬净制剂及其制备方法和用途 |
| CN103212059A (zh) * | 2012-01-18 | 2013-07-24 | 江苏恒瑞医药股份有限公司 | 含有抗真菌药物和乳酸盐缓冲液的组合物 |
| HUE063336T2 (hu) * | 2012-03-19 | 2024-01-28 | Cidara Therapeutics Inc | Adagolási rend echinokandin osztályba tartozó vegyületekhez |
| EP2992003B1 (fr) | 2013-05-02 | 2017-01-25 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Procédé pour isoler la caspofungine |
| PL3058958T3 (pl) | 2015-02-23 | 2019-02-28 | Selectchemie Ag | Kompozycja anidulafunginy |
| JP7224916B2 (ja) | 2016-03-16 | 2023-02-20 | シダラ セラピューティクス インコーポレーテッド | 真菌感染の処置のための投薬レジメン |
| CA3069423A1 (fr) | 2017-07-12 | 2019-01-17 | Cidara Therapeutics, Inc. | Formulations pour le traitement des infections fongiques |
| CN109721641B (zh) * | 2017-10-31 | 2021-08-03 | 鲁南制药集团股份有限公司 | 一种卡泊芬净的合成方法 |
| CN113801202A (zh) * | 2020-06-15 | 2021-12-17 | 杭州中美华东制药有限公司 | 一种醋酸卡泊芬净杂质g的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1234383A (en) * | 1982-03-17 | 1983-09-22 | Inter-Yeda Ltd. | Interferon stabilised with polyvinyl-pyrrolidone |
| JPH03504605A (ja) * | 1988-05-27 | 1991-10-09 | セントカー・インコーポレーテツド | 抗体産生物の凍結乾燥した配合物 |
| US5939384A (en) * | 1991-10-01 | 1999-08-17 | Merck & Co., Inc. | Cyclohexapeptidyl propanolamine compounds |
| DE4305225A1 (de) * | 1993-02-19 | 1994-08-25 | Asta Medica Ag | Neues Herstellverfahren für Cetrorelix Lyophilisat |
| US5378804A (en) * | 1993-03-16 | 1995-01-03 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
| IL109350A (en) * | 1993-05-12 | 2001-01-28 | Genentech Inc | Stable liquid preparations of gamma interferon |
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