NO320588B1 - 5-pyridyl-1,3-azolforbindelser, fremgangsmate for fremstilling av disse, farmasoytisk preparat omfattende disse og anvendelse av disse. - Google Patents

Info

Publication number

NO320588B1

NO320588B1 NO20015156A NO20015156A NO320588B1 NO 320588 B1 NO320588 B1 NO 320588B1 NO 20015156 A NO20015156 A NO 20015156A NO 20015156 A NO20015156 A NO 20015156A NO 320588 B1 NO320588 B1 NO 320588B1

Authority

NO

Norway

Prior art keywords

pyridyl

thiazol

methylphenyl

compound

formula

Prior art date

1999-04-23

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• 238000000034 method Methods 0.000 title claims description 37
• 238000002360 preparation method Methods 0.000 title claims description 37
• 239000008194 pharmaceutical composition Substances 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 457
• 238000006243 chemical reaction Methods 0.000 claims description 191
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 80
• 150000003839 salts Chemical class 0.000 claims description 76
• -1 alkyl hydrogen peroxide Chemical compound 0.000 claims description 59
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 52
• 229910052736 halogen Inorganic materials 0.000 claims description 43
• 125000004076 pyridyl group Chemical group 0.000 claims description 42
• 239000003795 chemical substances by application Substances 0.000 claims description 41
• 229910052717 sulfur Inorganic materials 0.000 claims description 38
• 125000000217 alkyl group Chemical group 0.000 claims description 37
• 230000002401 inhibitory effect Effects 0.000 claims description 33
• 125000004434 sulfur atom Chemical group 0.000 claims description 32
• 125000003277 amino group Chemical group 0.000 claims description 31
• 125000002252 acyl group Chemical group 0.000 claims description 24
• 125000005843 halogen group Chemical group 0.000 claims description 23
• 108010060261 Adenosine A3 Receptor Proteins 0.000 claims description 22
• 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims description 22
• 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 claims description 22
• 125000004430 oxygen atom Chemical group O* 0.000 claims description 21
• 125000001624 naphthyl group Chemical group 0.000 claims description 20
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 19
• 238000002560 therapeutic procedure Methods 0.000 claims description 19
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 18
• 125000004043 oxo group Chemical group O=* 0.000 claims description 18
• 102000008161 Adenosine A3 Receptor Human genes 0.000 claims description 17
• 238000004519 manufacturing process Methods 0.000 claims description 17
• 125000001544 thienyl group Chemical group 0.000 claims description 16
• 125000003545 alkoxy group Chemical group 0.000 claims description 14
• 150000001412 amines Chemical class 0.000 claims description 14
• 230000002265 prevention Effects 0.000 claims description 14
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 13
• 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 13
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 13
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
• 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 12
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• 125000002947 alkylene group Chemical group 0.000 claims description 11
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