IL146105A - 5-pyridyl-1, 3-azole compounds, process for producing the same and use therefor - Google Patents

5-pyridyl-1, 3-azole compounds, process for producing the same and use therefor

Info

Publication number
IL146105A
IL146105A IL14610500A IL14610500A IL146105A IL 146105 A IL146105 A IL 146105A IL 14610500 A IL14610500 A IL 14610500A IL 14610500 A IL14610500 A IL 14610500A IL 146105 A IL146105 A IL 146105A
Authority
IL
Israel
Prior art keywords
pyridyl
producing
same
azole compounds
use therefor
Prior art date
Application number
IL14610500A
Other languages
English (en)
Other versions
IL146105A0 (en
Original Assignee
Tadeda Pharmaceutical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tadeda Pharmaceutical Company filed Critical Tadeda Pharmaceutical Company
Publication of IL146105A0 publication Critical patent/IL146105A0/xx
Publication of IL146105A publication Critical patent/IL146105A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
IL14610500A 1999-04-23 2000-04-20 5-pyridyl-1, 3-azole compounds, process for producing the same and use therefor IL146105A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11668699 1999-04-23
JP22465099 1999-08-06
PCT/JP2000/002575 WO2000064894A1 (fr) 1999-04-23 2000-04-20 Composes 5-pyridyle-1,3-azole, leur procede de fabrication et leur utilisation

Publications (2)

Publication Number Publication Date
IL146105A0 IL146105A0 (en) 2002-07-25
IL146105A true IL146105A (en) 2005-09-25

Family

ID=26454974

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14610500A IL146105A (en) 1999-04-23 2000-04-20 5-pyridyl-1, 3-azole compounds, process for producing the same and use therefor

Country Status (24)

Country Link
US (3) US7101899B1 (cs)
EP (1) EP1180518B1 (cs)
KR (2) KR100558123B1 (cs)
CN (1) CN1156471C (cs)
AU (1) AU765473B2 (cs)
BR (1) BR0009952A (cs)
CA (1) CA2370264A1 (cs)
CZ (1) CZ300709B6 (cs)
DE (1) DE60033028T2 (cs)
DK (1) DK1180518T3 (cs)
ES (1) ES2275500T3 (cs)
HK (1) HK1044338B (cs)
HU (1) HUP0203766A3 (cs)
IL (1) IL146105A (cs)
MX (1) MXPA01010675A (cs)
MY (1) MY126736A (cs)
NO (1) NO320588B1 (cs)
NZ (1) NZ515215A (cs)
PL (1) PL351148A1 (cs)
PT (1) PT1180518E (cs)
RU (1) RU2237062C2 (cs)
SI (1) SI1180518T1 (cs)
SK (1) SK286666B6 (cs)
WO (1) WO2000064894A1 (cs)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2237062C2 (ru) * 1999-04-23 2004-09-27 Такеда Кемикал Индастриз, Лтд. Производные 5-пиридил-1,3-азола, способ их получения, их пролекарство, фармацевтическая композиция, способ антагонизации аденозинового а3-рецептора, способ ингибирования р38 мар-киназы, способ ингибирования продуцирования tnf-альфа и способ профилактики или лечения ряда заболеваний с их использованием
US7122666B2 (en) 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
DE60024480T2 (de) 1999-10-27 2006-07-27 Novartis Ag Thiazol und imidazo[4,5-b]pyridin verbindungen und ihre verwendung als pharmazeutika
CA2404384A1 (en) * 2000-03-30 2001-10-11 Takeda Chemical Industries, Ltd. Substituted 1,3-thiazole compounds, their production and use
CA2431171A1 (en) 2000-12-08 2002-06-13 Takeda Chemical Industries, Ltd. Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
WO2002051442A1 (fr) * 2000-12-26 2002-07-04 Takeda Chemical Industries, Ltd. Co-prescriptions
EP1364949A4 (en) 2001-02-02 2005-11-23 Takeda Pharmaceutical JNK INHIBITOR
DE60212836T2 (de) * 2001-05-16 2007-01-25 Gpc Biotech Ag Pyridylpyrimidin-derivate als wirksame verbindungen gegen prionen-krankheiten
CA2448561C (en) * 2001-05-31 2011-07-19 Sanofi-Synthelabo Aminoquinoline derivatives and their use as adenosine a3 ligands
US20050080113A1 (en) * 2001-06-11 2005-04-14 Shigenori Ohkawa Medicinal compositions
MXPA04003729A (es) * 2001-10-22 2004-07-23 Tanabe Seiyaku Co Compuestos de 4-imidazolin-2-ona.
US7473695B2 (en) 2001-10-22 2009-01-06 Mitsubishi Tanabe Pharma Corporation 4-imidazolin-2-one compounds
US7064139B2 (en) * 2001-10-29 2006-06-20 Uniroyal Chemical Company, Inc. Method for treating retroviral infections
AU2003246927A1 (en) * 2002-07-03 2004-01-23 Astex Technology Limited 3-`(hetero) arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors
CA2491895C (en) * 2002-07-09 2011-01-18 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
MXPA05002082A (es) 2002-08-23 2005-06-08 Rigel Pharmaceuticals Inc Heterociclos subtituidos con piridilo, utiles para tratar o evitar infeccion hcv.
AR044519A1 (es) * 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
WO2004099165A2 (en) 2003-05-02 2004-11-18 Rigel Pharmaceuticals, Inc. Heterocyclic compounds and hydro isomers thereof
US7410979B2 (en) 2003-11-19 2008-08-12 Rigel Pharmaceuticals, Inc. Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
BRPI0418082B8 (pt) 2003-12-26 2021-05-25 Kyowa Hakko Kirin Co Ltd derivados de tiazol úteis como antagonistas de receptor de adenosina a2a
US7514434B2 (en) 2004-02-23 2009-04-07 Rigel Pharmaceuticals, Inc. Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
MY146532A (en) * 2004-03-05 2012-08-15 Taisho Pharmaceutical Co Ltd Thiazole derivative
JP2007223903A (ja) * 2004-07-09 2007-09-06 Takeda Chem Ind Ltd 新規な固体分散体およびその製造方法
ATE542817T1 (de) * 2004-11-10 2012-02-15 Ono Pharmaceutical Co Stickstoffhaltige heterocyclische verbindung und deren pharmazeutische verwendung
WO2007027230A2 (en) 2005-05-02 2007-03-08 Rigel Pharmaceuticals, Inc. Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses
KR100848205B1 (ko) * 2005-06-20 2008-07-24 주식회사 동부하이텍 면역 억제 및 염증 억제 활성을 갖는 신규한 치환된1,3-티아졸 유도체 또는 이의 약학적으로 허용가능한 염,중간체 화합물 또는 이의 약학적으로 허용가능한 염, 이의제조방법, 및 이를 포함하는 약학적 조성물
US7494519B2 (en) * 2005-07-28 2009-02-24 3M Innovative Properties Company Abrasive agglomerate polishing method
ES2643340T3 (es) * 2005-08-02 2017-11-22 Kyowa Hakko Kirin Co., Ltd. Agentes para tratar y/o prevenir trastornos del sueño
US20090005568A1 (en) * 2005-08-18 2009-01-01 Pharmacopeia Drug Discovery, Inc. Substituted 2-aminothiazoles for treating neurodegenerative diseases
WO2007040208A1 (ja) * 2005-10-03 2007-04-12 Ono Pharmaceutical Co., Ltd. 含窒素複素環化合物およびその医薬用途
CA2627497C (en) 2005-10-28 2014-10-14 Takeda Pharmaceutical Company Limited Heterocyclic amide compound and use thereof
EP1985283A4 (en) * 2006-01-18 2011-08-03 Next21 Kk GELPENDING COMPOSITION FOR USE IN MEDICINE, APPARATUS FOR THE APPLICATION OF THE COMPOSITION, AND MEDICAMENT-RELATED TAX CARRIER
EP2044957A4 (en) * 2006-06-28 2011-01-05 Aska Pharm Co Ltd AGENT FOR THE TREATMENT OF INFLAMMATORY ENDURANCE
CN101528158B (zh) * 2006-08-21 2011-10-05 21世纪国际新技术株式会社 骨模型、骨填充材以及骨填充材的制造方法
CA2677842C (en) 2007-02-16 2014-09-16 Aska Pharmaceutical Co., Ltd. Pharmaceutical composition comprising microparticle oily suspension
WO2008133102A1 (ja) 2007-04-20 2008-11-06 Daido Chemical Corporation 新規乾式固体分散体用基剤、該基剤を含有する固体分散体及び該分散体を含有する組成物
EP2198710A1 (de) * 2008-12-19 2010-06-23 Bayer CropScience AG Verwendung von 5-Pyridin-4yl-(1,3)Thiazole zur Bekämpfung phytopathogener Pilze
WO2011105534A1 (ja) 2010-02-26 2011-09-01 日新化成株式会社 硬カプセルおよびその製造方法
JP6225113B2 (ja) 2012-09-26 2017-11-01 武田薬品工業株式会社 固体粒子の製造方法
CN103288817A (zh) * 2013-07-02 2013-09-11 天津理工大学 一种基于1,3,4-噻二唑和1,3,4-噁二唑的希夫碱衍生物及其制备方法和应用
ES2578363B1 (es) 2015-01-22 2017-01-31 Palobiofarma, S.L. Moduladores de los receptores A3 de adenosina
KR101851972B1 (ko) 2015-10-21 2018-06-11 주식회사 제이아이바이오팜 청호, 구절초, 애엽, 인진호, 괴각, 대계, 및 목향을 포함하는 한약 추출물이 함유된 탈모개선 및 탈모방지용 복합조성물 및 그 제조방법
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
EP3238711B1 (en) 2016-04-26 2023-07-12 Mitsubishi Chemical Corporation Base for solid dispersion, production method for solid dispersion using same, and solid dispersion
ES2676535B1 (es) * 2017-01-20 2019-04-29 Palobiofarma Sl Moduladores de los receptores a3 de adenosina
CN108017584B (zh) * 2017-06-20 2021-03-23 南开大学 A3腺苷受体的小分子拮抗剂
CN109293652B (zh) * 2017-07-24 2021-10-22 四川科伦博泰生物医药股份有限公司 一种取代的噻唑衍生物及其用途
CA3128468A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
TW202112368A (zh) 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合
CN119015281A (zh) * 2023-05-25 2024-11-26 中国医学科学院药物研究所 一种苯甲酰胺类化合物防治恶性肿瘤恶病质的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3486009T2 (de) 1983-09-09 1993-04-15 Takeda Chemical Industries Ltd 5-pyridyl-1,3-thiazol-derivate, ihre herstellung und anwendung.
JPH0570446A (ja) 1991-09-13 1993-03-23 Taisho Pharmaceut Co Ltd Ｎ−チアゾリルスルホンアミド誘導体
EA001203B1 (ru) * 1995-10-06 2000-12-25 Мерк Энд Ко., Инк. Замещенные имидазолы, обладающие антиканцерогенной и цитокин-ингибирующей активностью
US5684439A (en) * 1995-10-10 1997-11-04 Motorola, Inc. Half wave ceramic filter with open circuit at both ends
MY128323A (en) * 1996-09-30 2007-01-31 Otsuka Pharma Co Ltd Thiazole derivatives for inhibition of cytokine production and of cell adhesion
GB9713726D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
AU9648098A (en) 1997-10-27 1999-05-17 Takeda Chemical Industries Ltd. Adenosine a3 receptor antagonists
RU2237062C2 (ru) * 1999-04-23 2004-09-27 Такеда Кемикал Индастриз, Лтд. Производные 5-пиридил-1,3-азола, способ их получения, их пролекарство, фармацевтическая композиция, способ антагонизации аденозинового а3-рецептора, способ ингибирования р38 мар-киназы, способ ингибирования продуцирования tnf-альфа и способ профилактики или лечения ряда заболеваний с их использованием
US20040097555A1 (en) * 2000-12-26 2004-05-20 Shinegori Ohkawa Concomitant drugs
US20050080113A1 (en) * 2001-06-11 2005-04-14 Shigenori Ohkawa Medicinal compositions

Also Published As

Publication number Publication date
CZ20013805A3 (cs) 2002-04-17
MXPA01010675A (es) 2002-06-04
HUP0203766A3 (en) 2008-01-28
AU765473B2 (en) 2003-09-18
BR0009952A (pt) 2002-03-26
KR20010111314A (ko) 2001-12-17
CN1353710A (zh) 2002-06-12
KR100558123B1 (ko) 2006-03-07
NO20015156D0 (no) 2001-10-22
EP1180518A1 (en) 2002-02-20
AU3840100A (en) 2000-11-10
SI1180518T1 (sl) 2007-06-30
KR100449215B1 (ko) 2004-09-18
PL351148A1 (en) 2003-03-24
ES2275500T3 (es) 2007-06-16
HK1044338B (en) 2007-06-29
EP1180518A4 (en) 2004-09-15
KR20020059453A (ko) 2002-07-12
NZ515215A (en) 2003-07-25
NO320588B1 (no) 2005-12-27
US20060135566A1 (en) 2006-06-22
DE60033028D1 (de) 2007-03-08
DK1180518T3 (da) 2007-05-21
HUP0203766A2 (hu) 2003-03-28
WO2000064894A1 (fr) 2000-11-02
IL146105A0 (en) 2002-07-25
CZ300709B6 (cs) 2009-07-22
SK14952001A3 (sk) 2002-04-04
NO20015156L (no) 2001-12-18
HK1044338A1 (en) 2002-10-18
US7101899B1 (en) 2006-09-05
CN1156471C (zh) 2004-07-07
US20090048307A1 (en) 2009-02-19
US7276527B2 (en) 2007-10-02
EP1180518B1 (en) 2007-01-17
MY126736A (en) 2006-10-31
SK286666B6 (sk) 2009-03-05
PT1180518E (pt) 2007-02-28
DE60033028T2 (de) 2007-11-15
CA2370264A1 (en) 2000-11-02
RU2237062C2 (ru) 2004-09-27

Similar Documents

Publication Publication Date Title
IL146105A (en) 5-pyridyl-1, 3-azole compounds, process for producing the same and use therefor
TWI315741B (en) A-isomaltosyltransferase, process for producing the same and use thereof
AU2856499A (en) Novel substances kf-1040t4a, kf-1040t4b, kf-1040t5a and kf-1040t5b and process for producing the same
GB9928977D0 (en) Process
HUP0101192A3 (en) Cycloalkene derivatives, process for producing the same, and use
AU2001294228A1 (en) Benzimidazole compounds, process for producing the same and use thereof
ZA200300743B (en) DDS compound and process for the preparation thereof.
AU1306601A (en) Chemically modified supports and process for producing the same
PL351616A1 (en) Polyolefin compositions, method for the production and use thereof
IL139023A0 (en) Process for the preparation of 2,3,5-trimethyl-p- benzoquinone
GB9905512D0 (en) Process
GB9908814D0 (en) Process
AU2796602A (en) Coniosetin and derivatives thereof, method for producing the same and use thereof
GB9904162D0 (en) Process
HUP0105166A3 (en) Substances wk-5344a and wk-5344b and process for producing the same
GB9914600D0 (en) Novel,process
GB9905418D0 (en) Process
HU0000208D0 (en) Process producing the secondary-alkoxy-1-alkenes
GB9903087D0 (en) Process
HU9901547D0 (en) Process for producing n,n-dimethyl-cyclohexyl-amine
AU4951000A (en) Microliposomes and process for producing the same
AU2002221114A1 (en) Novel ss-lactam compounds and process for preparing the same
EP1295940A4 (en) POLYPEPTIDES, THE APPLICATION THEREOF AND METHOD FOR THE PRODUCTION THEREOF
GB9909973D0 (en) Process
GB9911181D0 (en) Process

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed