NO320296B1 - Oral suspensjon - Google Patents
Oral suspensjon Download PDFInfo
- Publication number
- NO320296B1 NO320296B1 NO20015755A NO20015755A NO320296B1 NO 320296 B1 NO320296 B1 NO 320296B1 NO 20015755 A NO20015755 A NO 20015755A NO 20015755 A NO20015755 A NO 20015755A NO 320296 B1 NO320296 B1 NO 320296B1
- Authority
- NO
- Norway
- Prior art keywords
- suspension
- ziprasidone
- acid
- polysorbate
- silicon dioxide
- Prior art date
Links
- 229940100692 oral suspension Drugs 0.000 title description 5
- 239000000725 suspension Substances 0.000 description 35
- 150000003839 salts Chemical class 0.000 description 26
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 24
- 239000003795 chemical substances by application Substances 0.000 description 23
- 229960000607 ziprasidone Drugs 0.000 description 22
- ZCBZSCBNOOIHFP-UHFFFAOYSA-N ziprasidone hydrochloride hydrate Chemical compound [H+].O.[Cl-].C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 ZCBZSCBNOOIHFP-UHFFFAOYSA-N 0.000 description 21
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 19
- 239000002253 acid Substances 0.000 description 17
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 229960003474 ziprasidone hydrochloride Drugs 0.000 description 16
- 230000001939 inductive effect Effects 0.000 description 15
- 229920000136 polysorbate Polymers 0.000 description 15
- 239000012458 free base Substances 0.000 description 12
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- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
- Colloid Chemistry (AREA)
- Cosmetics (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13626899P | 1999-05-27 | 1999-05-27 | |
| PCT/IB2000/000593 WO2000072847A1 (en) | 1999-05-27 | 2000-05-08 | Ziprasidone suspension |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20015755D0 NO20015755D0 (no) | 2001-11-26 |
| NO20015755L NO20015755L (no) | 2002-01-23 |
| NO320296B1 true NO320296B1 (no) | 2005-11-21 |
Family
ID=22472103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20015755A NO320296B1 (no) | 1999-05-27 | 2001-11-26 | Oral suspensjon |
Country Status (50)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7175855B1 (en) | 1999-05-27 | 2007-02-13 | Pfizer Inc. | Ziprasidone suspension |
| ATE526950T1 (de) | 1999-10-29 | 2011-10-15 | Euro Celtique Sa | Hydrocodon-formulierungen mit gesteuerter freisetzung |
| US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
| WO2002036099A1 (en) | 2000-10-30 | 2002-05-10 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
| PL212421B1 (pl) * | 2002-03-12 | 2012-09-28 | Bristol Myers Squibb Co | Kompozycja farmaceutyczna w postaci zawiesiny kwasowego leku i sposób jej wytwarzania oraz sposób maskowania gorzkiego lub innego nieprzyjemnego smaku leku |
| EP1575616A2 (en) * | 2002-10-25 | 2005-09-21 | Pfizer Products Inc. | Novel injectable depot formulations |
| RU2292207C2 (ru) * | 2002-10-25 | 2007-01-27 | Пфайзер Продактс Инк. | Депо-препараты арилгетероциклических активных веществ в виде суспензии |
| EP1418492B1 (en) | 2002-11-05 | 2017-09-20 | LG Electronics, Inc. | Touch screen mounting assembly for LCD monitor |
| CA2543805A1 (en) | 2003-10-24 | 2005-05-06 | Gideon Pilarsky | Processes for preparation of ziprasidone |
| WO2005107719A2 (en) * | 2004-05-06 | 2005-11-17 | Sandoz Ag | Pharmaceutical composition comprising hydrophobic drug having improved solubility |
| EP1753400A4 (en) * | 2004-06-11 | 2012-11-28 | Reddys Lab Ltd Dr | PHARMACEUTICAL FOR ZIPRASIDONE |
| WO2006085168A2 (en) * | 2005-01-07 | 2006-08-17 | Ranbaxy Laboratories Limited | Solid oral dosage forms of ziprasidone containing colloidal silicone dioxide |
| CA2613474A1 (en) * | 2005-06-20 | 2007-03-08 | Elan Pharma International Limited | Nanoparticulate and controlled release compositions comprising aryl-heterocyclic compounds |
| EP1906937B1 (en) | 2005-07-22 | 2016-10-19 | Rubicon Research Pvt Ltd. | Novel dispersible tablet composition |
| CN100391458C (zh) * | 2006-02-07 | 2008-06-04 | 上海医药工业研究院 | 齐拉西酮或其盐包合物制备方法 |
| KR20080076667A (ko) * | 2007-02-15 | 2008-08-20 | 주식회사 중외제약 | 요변성 약학 조성물 |
| JP4336380B1 (ja) * | 2008-11-06 | 2009-09-30 | 塩野義製薬株式会社 | 水懸濁性を向上させた細粒剤 |
| JP6272730B2 (ja) * | 2014-05-21 | 2018-01-31 | 救急薬品工業株式会社 | 速溶性フィルム剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
| US5312925A (en) * | 1992-09-01 | 1994-05-17 | Pfizer Inc. | Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride |
| US6150366A (en) * | 1998-06-15 | 2000-11-21 | Pfizer Inc. | Ziprasidone formulations |
-
2000
- 2000-05-08 AU AU41385/00A patent/AU777413B2/en not_active Ceased
- 2000-05-08 IL IL14595000A patent/IL145950A0/xx active IP Right Grant
- 2000-05-08 MX MXPA01012124A patent/MXPA01012124A/es active IP Right Grant
- 2000-05-08 SK SK1678-2001A patent/SK284590B6/sk not_active IP Right Cessation
- 2000-05-08 RS YUP-767/01A patent/RS50089B/sr unknown
- 2000-05-08 DK DK00920981T patent/DK1181018T3/da active
- 2000-05-08 TR TR2001/03392T patent/TR200103392T2/xx unknown
- 2000-05-08 OA OA1200100304A patent/OA11946A/en unknown
- 2000-05-08 GE GEAP20006213A patent/GEP20033113B/en unknown
- 2000-05-08 EA EA200101131A patent/EA003907B1/ru not_active IP Right Cessation
- 2000-05-08 KR KR10-2001-7015090A patent/KR100477782B1/ko not_active IP Right Cessation
- 2000-05-08 DE DE60001649T patent/DE60001649T2/de not_active Expired - Lifetime
- 2000-05-08 CN CNB008081204A patent/CN1196486C/zh not_active Expired - Fee Related
- 2000-05-08 CA CA002371550A patent/CA2371550C/en not_active Expired - Lifetime
- 2000-05-08 WO PCT/IB2000/000593 patent/WO2000072847A1/en active IP Right Grant
- 2000-05-08 EE EEP200100633A patent/EE04704B1/xx not_active IP Right Cessation
- 2000-05-08 NZ NZ514764A patent/NZ514764A/en unknown
- 2000-05-08 AT AT00920981T patent/ATE234097T1/de not_active IP Right Cessation
- 2000-05-08 JP JP2000620959A patent/JP3942827B2/ja not_active Expired - Lifetime
- 2000-05-08 EP EP00920981A patent/EP1181018B1/en not_active Expired - Lifetime
- 2000-05-08 PL PL352826A patent/PL196867B1/pl not_active IP Right Cessation
- 2000-05-08 BR BR0010990-8A patent/BR0010990A/pt not_active Application Discontinuation
- 2000-05-08 HU HU0201297A patent/HUP0201297A3/hu unknown
- 2000-05-08 SI SI200030060T patent/SI1181018T1/xx unknown
- 2000-05-08 CZ CZ20014230A patent/CZ20014230A3/cs unknown
- 2000-05-08 AP APAP/P/2001/002346A patent/AP1409A/en active
- 2000-05-08 ES ES00920981T patent/ES2191618T3/es not_active Expired - Lifetime
- 2000-05-10 HN HN2000000071A patent/HN2000000071A/es unknown
- 2000-05-19 PA PA20008495801A patent/PA8495801A1/es unknown
- 2000-05-22 PE PE2000000480A patent/PE20010127A1/es not_active Application Discontinuation
- 2000-05-23 GC GCP2000670 patent/GC0000190A/en active
- 2000-05-23 TW TW089109949A patent/TWI263498B/zh active
- 2000-05-24 MA MA25991A patent/MA26741A1/fr unknown
- 2000-05-24 CO CO00038317A patent/CO5170458A1/es not_active Application Discontinuation
- 2000-05-24 TN TNTNSN00112A patent/TNSN00112A1/fr unknown
- 2000-05-24 DZ DZ000093A patent/DZ3049A1/xx active
- 2000-05-24 MY MYPI20002273A patent/MY127891A/en unknown
- 2000-05-25 UY UY26166A patent/UY26166A1/es not_active Application Discontinuation
- 2000-05-25 GT GT200000081A patent/GT200000081A/es unknown
- 2000-05-26 SV SV2000000085A patent/SV2001000085A/es not_active Application Discontinuation
- 2000-05-26 AR ARP000102585A patent/AR022643A1/es active IP Right Grant
- 2000-08-05 UA UA2001118094A patent/UA59491C2/uk unknown
-
2001
- 2001-10-15 IL IL145950A patent/IL145950A/en unknown
- 2001-10-30 IS IS6134A patent/IS2396B/is unknown
- 2001-11-19 CU CU20010266A patent/CU23223B7/es not_active IP Right Cessation
- 2001-11-23 CR CR6506A patent/CR6506A/es not_active Application Discontinuation
- 2001-11-26 NO NO20015755A patent/NO320296B1/no unknown
- 2001-11-26 BG BG106153A patent/BG65367B1/bg unknown
- 2001-11-26 HR HR20010878A patent/HRP20010878B1/xx not_active IP Right Cessation
- 2001-11-26 ZA ZA200109692A patent/ZA200109692B/en unknown
-
2002
- 2002-10-30 HK HK02107882.4A patent/HK1046366B/zh not_active IP Right Cessation
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