NO319497B1 - Ekspresjonssystem for fremstilling av apolipoprotein AI-M - Google Patents
Ekspresjonssystem for fremstilling av apolipoprotein AI-M Download PDFInfo
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- NO319497B1 NO319497B1 NO19952297A NO952297A NO319497B1 NO 319497 B1 NO319497 B1 NO 319497B1 NO 19952297 A NO19952297 A NO 19952297A NO 952297 A NO952297 A NO 952297A NO 319497 B1 NO319497 B1 NO 319497B1
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- apo
- apolipoprotein
- cultivation
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- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004141 reverse cholesterol transport Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 108010087967 type I signal peptidase Proteins 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9203753A SE9203753D0 (sv) | 1992-12-11 | 1992-12-11 | Expression system for producing apolipoprotein ai-m |
| PCT/SE1993/001061 WO1994013819A1 (en) | 1992-12-11 | 1993-12-09 | Expression system for producing apolipoprotein ai-m |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO952297L NO952297L (no) | 1995-06-09 |
| NO952297D0 NO952297D0 (no) | 1995-06-09 |
| NO319497B1 true NO319497B1 (no) | 2005-08-22 |
Family
ID=20388112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19952297A NO319497B1 (no) | 1992-12-11 | 1995-06-09 | Ekspresjonssystem for fremstilling av apolipoprotein AI-M |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5721114A (hu) |
| EP (1) | EP0677109B1 (hu) |
| JP (1) | JP3899121B2 (hu) |
| AT (1) | ATE191930T1 (hu) |
| AU (1) | AU5663794A (hu) |
| CA (1) | CA2150928C (hu) |
| CZ (1) | CZ290865B6 (hu) |
| DE (1) | DE69328442T2 (hu) |
| DK (1) | DK0677109T3 (hu) |
| ES (1) | ES2146646T3 (hu) |
| FI (1) | FI952847A0 (hu) |
| GR (1) | GR3033966T3 (hu) |
| HU (1) | HU220193B (hu) |
| IL (1) | IL107896A (hu) |
| MX (1) | MX9307855A (hu) |
| NO (1) | NO319497B1 (hu) |
| PL (1) | PL175955B1 (hu) |
| PT (1) | PT677109E (hu) |
| SE (1) | SE9203753D0 (hu) |
| SK (1) | SK76695A3 (hu) |
| WO (1) | WO1994013819A1 (hu) |
| ZA (1) | ZA939266B (hu) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9500778D0 (sv) * | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
| EP0871713B1 (en) * | 1995-11-09 | 2007-02-14 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | The use of lecithin-cholesterol acyltransferase (lcat) in the treatment of atherosclerosis |
| SE9603068D0 (sv) | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603303D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603304D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a compound |
| US6306433B1 (en) | 1997-08-12 | 2001-10-23 | Pharmacia Ab | Method of preparing pharmaceutical compositions |
| US6046166A (en) | 1997-09-29 | 2000-04-04 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| US6518412B1 (en) | 1997-09-29 | 2003-02-11 | Jean-Louis Dasseux | Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| US6037323A (en) * | 1997-09-29 | 2000-03-14 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| US6004925A (en) | 1997-09-29 | 1999-12-21 | J. L. Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| CN1297932A (zh) * | 1999-11-30 | 2001-06-06 | 上海博容基因开发有限公司 | 一种新的多肽——人脂蛋白前体蛋白信号肽11和编码这种多肽的多核苷酸 |
| US20020064820A1 (en) * | 2000-03-13 | 2002-05-30 | Jean-Michel Dayer | Apo-A-I regulation of T-cell signaling |
| EP2343317A1 (en) | 2000-11-10 | 2011-07-13 | F. Hoffmann-La Roche Ltd. | Apolipoprotein analogues |
| US7217785B2 (en) * | 2001-05-09 | 2007-05-15 | The Regents Of The University Of California | Cysteine-containing peptides having antioxidant properties |
| IL161110A0 (en) * | 2001-09-28 | 2004-08-31 | Esperion Therapeutics Inc | Prevention and treatment of restenosis by local admistration of drug |
| AU2002360489A1 (en) * | 2001-12-07 | 2003-06-23 | The Regents Of The University Of California | Treatment for age-related macular degeneration |
| US7470659B2 (en) * | 2001-12-07 | 2008-12-30 | The Regents Of The University Of California | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) |
| US20030229062A1 (en) * | 2001-12-07 | 2003-12-11 | The Regents Of The University Of California | Treatments for age-related macular degeneration (AMD) |
| US7223726B2 (en) * | 2002-01-14 | 2007-05-29 | The Regents Of The University Of California | Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same |
| US20100204103A1 (en) * | 2002-05-08 | 2010-08-12 | The Regents Of The University Of California | Helical synthetic peptides that stimulate cellular cholesterol efflux |
| US7691965B2 (en) * | 2002-05-08 | 2010-04-06 | The Regents Of The University Of California | Helical synthetic peptides that stimulate cellular cholesterol efflux |
| WO2003097696A1 (en) * | 2002-05-17 | 2003-11-27 | Esperion Therapeutics, Inc. | Methods and copositions for the treatment of ischemic reperfusion |
| JP2006507223A (ja) | 2002-05-17 | 2006-03-02 | エスペリオン セラピューティクス，インコーポレイテッド | 脂質代謝異常疾患の治療方法 |
| SI2404890T1 (sl) | 2003-01-23 | 2017-12-29 | Esperion Therapeutics Inc. | Hidroksilne spojine in sestavki za uravnavanje holesterola in sorodne uporabe |
| WO2004078965A1 (ja) * | 2003-03-05 | 2004-09-16 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 大腸菌における異種蛋白質の製造方法 |
| WO2005097206A2 (en) * | 2004-04-06 | 2005-10-20 | Cedars-Sinai Medical Center | Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein a-i and apolipoprotein a-i milano |
| KR100560102B1 (ko) | 2004-06-25 | 2006-03-13 | 한국생명공학연구원 | 프로아포리포단백질 ａ－ⅰ 변이체와, 이를 포함하는고지혈증 또는 동맥경화증 예방 및 치료제 |
| CN1320119C (zh) * | 2004-12-09 | 2007-06-06 | 复旦大学 | 人载脂蛋白ApoAⅠ在毕赤氏酵母胞内表达的方法 |
| US7776870B2 (en) | 2005-08-22 | 2010-08-17 | Melior Pharmaceuticals I, Inc. | Methods for modulating Lyn kinase activity and treating related disorders |
| CA2619943A1 (en) * | 2005-08-26 | 2007-03-01 | Cerenis Therapeutics Holding Sa | Compositions and methods for producing apolipoprotein gene products in lactic acid bacteria |
| DE102006004871A1 (de) | 2006-02-02 | 2007-08-09 | Wacker Chemie Ag | Mikroorganismenstamm zur Produktion von rekombinanten Proteinen |
| US20070254832A1 (en) * | 2006-02-17 | 2007-11-01 | Pressler Milton L | Methods for the treatment of macular degeneration and related eye conditions |
| ES2402823T3 (es) | 2006-06-01 | 2013-05-09 | Institut De Cardiologie De Montreal | Compuesto para uso en el tratamiento de estenosis valvular |
| DE102006044841A1 (de) | 2006-09-22 | 2008-04-03 | Wacker Chemie Ag | Signalpeptid zur Produktion von rekombinanten Proteinen |
| DE502006009060D1 (de) | 2006-09-22 | 2011-04-21 | Wacker Chemie Ag | Verfahren zur fermentativen Herstellung von Antikörpern |
| DE102006050332A1 (de) | 2006-10-25 | 2008-04-30 | Wacker Chemie Ag | DNS-Konstrukt und Verfahren zur fermentativen Herstellung von Fusionsproteinen |
| CA2931881C (en) * | 2007-01-31 | 2018-12-11 | Nutrition 21, Inc. | Use of chromium histidinate for treatment of cardiometabolic disorders |
| CA2678813A1 (en) * | 2007-02-20 | 2008-08-28 | Melior Pharmaceuticals I, Inc. | Methods of identifying activators of lyn kinase |
| CA2681158C (en) | 2007-03-13 | 2018-09-18 | Nutrition 21, Inc. | Methods and compositions for the sustained release of chromium |
| WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
| CA2693809A1 (en) * | 2007-07-23 | 2009-01-29 | Melior Discovery, Inc. | Methods of activating irs-1 and akt |
| CN102177176B (zh) * | 2007-10-23 | 2014-05-07 | 克里夫兰临床基金会 | 氧化剂耐受性载脂蛋白a-1及模拟肽 |
| US8552184B2 (en) * | 2008-07-03 | 2013-10-08 | Melior Pharmaceuticals I, Inc. | Compounds and methods for treating disorders related to glucose metabolism |
| NO2355851T3 (hu) | 2008-11-10 | 2018-09-01 | ||
| EP3243504A1 (en) | 2009-01-29 | 2017-11-15 | Arbutus Biopharma Corporation | Improved lipid formulation |
| RU2532222C2 (ru) | 2009-02-16 | 2014-10-27 | Серенис Терапьютикс Холдинг С.А, | Миметики аполипопротеина а-i |
| CN102421900B (zh) | 2009-03-12 | 2015-07-22 | 阿尔尼拉姆医药品有限公司 | 用于抑制Eg5和VEGF基因表达的脂质配制的组合物以及方法 |
| WO2010129709A1 (en) | 2009-05-05 | 2010-11-11 | Alnylam Pharmaceuticals, Inc. | Lipid compositions |
| KR20230098713A (ko) | 2009-06-10 | 2023-07-04 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| AP3574A (en) | 2009-08-14 | 2016-02-08 | Alnylam Pharmaceuticals Inc | Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus |
| DE102009053566B4 (de) | 2009-11-11 | 2014-08-14 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Mikroorganismen mit gesteigerter Sucrosemutaseaktivität |
| EP3296398A1 (en) | 2009-12-07 | 2018-03-21 | Arbutus Biopharma Corporation | Compositions for nucleic acid delivery |
| US20130017223A1 (en) | 2009-12-18 | 2013-01-17 | The University Of British Columbia | Methods and compositions for delivery of nucleic acids |
| WO2011139911A2 (en) | 2010-04-29 | 2011-11-10 | Isis Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
| WO2011143362A1 (en) | 2010-05-11 | 2011-11-17 | Esperion Therapeutics, Inc. | Dimeric oxidation-resistant apolipoprotein a1 variants |
| WO2011150300A1 (en) | 2010-05-28 | 2011-12-01 | Melior Pharmaceuticals I, Inc. | Prevention of pancreatic beta cell degeneration |
| CA2800401C (en) | 2010-06-03 | 2020-09-15 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
| WO2012016184A2 (en) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
| WO2012016188A2 (en) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
| ES2558751T3 (es) * | 2010-08-30 | 2016-02-08 | F. Hoffmann-La Roche Ag | Alimento alcalino |
| CN110123830A (zh) | 2010-11-09 | 2019-08-16 | 阿尔尼拉姆医药品有限公司 | 用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法 |
| DK3202760T3 (da) | 2011-01-11 | 2019-11-25 | Alnylam Pharmaceuticals Inc | Pegylerede lipider og deres anvendelse til lægemiddelfremføring |
| CA2826158A1 (en) | 2011-02-07 | 2012-08-16 | Rose ACKERMANN | Lipoprotein complexes and manufacturing and uses thereof |
| WO2012119007A1 (en) | 2011-03-01 | 2012-09-07 | N21 Acquisition Holding, Llc | Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders |
| EP2760477B1 (en) | 2011-09-27 | 2018-08-08 | Alnylam Pharmaceuticals, Inc. | Di-aliphatic substituted pegylated lipids |
| EP2790704B1 (en) | 2011-12-12 | 2019-04-03 | Melior Pharmaceuticals I, Inc. | Treatment of type i diabetes |
| WO2014011908A1 (en) | 2012-07-11 | 2014-01-16 | Esperion Therapeutics, Inc. | Apolipoprotein mixtures |
| CN106488987A (zh) | 2014-05-02 | 2017-03-08 | 塞勒尼斯医疗控股公司 | Hdl疗法标志物 |
| CN109069532A (zh) | 2016-02-11 | 2018-12-21 | 营养21有限责任公司 | 含铬组合物用于改善健康和健身 |
| US10426817B2 (en) * | 2017-01-24 | 2019-10-01 | Macregen, Inc. | Treatment of age-related macular degeneration and other eye diseases with apolipoprotein mimetics |
| BR112019021140A2 (pt) | 2017-04-10 | 2020-05-19 | Univ Louisiana State | composição, método para reduzir os níveis de glicose no sangue, ganho de peso ou níveis de depósito de gordura, ou tratamento, método de indução do bege de adipócitos ou prevenção da degeneração das células beta do pâncreas, e, ativador de lyn cinase e agonista de trpm8 para uso na redução dos níveis de glicose no sangue, ganho de peso ou níveis de depósito de gordura, ou tratamento. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8625435D0 (en) * | 1986-10-23 | 1986-11-26 | Erba Farmitalia | Human apolipoprotein ai |
| DE68917379T2 (de) * | 1988-05-31 | 1994-12-01 | Mitsubishi Chem Ind | Verfahren zur Herstellung von Proteinen, die ähnlich dem natürlich-menschlichen Apolipoprotein-E sind. |
| DE3819463A1 (de) * | 1988-06-08 | 1989-12-14 | Behringwerke Ag | Expressionsvektoren zur herstellung unfusionierter proteine in mikroorganismen |
| US5223407A (en) * | 1988-08-31 | 1993-06-29 | Allelix Inc. | Excretion of heterologous proteins from e. coli |
| IT1229996B (it) * | 1989-04-20 | 1991-09-20 | Cesare Sirtori | Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine. |
| KR960013134B1 (ko) * | 1989-10-31 | 1996-09-30 | 쉐링 코포레이션 | 분비성 이.콜라이 균주, 이에 대한 플라스미드, 이의 제조 및 동정 방법 및 이를 이용하여 이질성 단백질을 제조하는 방법. |
| DE4009268A1 (de) * | 1990-03-22 | 1991-09-26 | Consortium Elektrochem Ind | Sekretion von hirudinderivaten |
| SE9103701D0 (sv) * | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
-
1992
- 1992-12-11 SE SE9203753A patent/SE9203753D0/xx unknown
-
1993
- 1993-12-06 IL IL10789693A patent/IL107896A/en not_active IP Right Cessation
- 1993-12-09 US US08/448,606 patent/US5721114A/en not_active Expired - Fee Related
- 1993-12-09 DK DK94902173T patent/DK0677109T3/da active
- 1993-12-09 WO PCT/SE1993/001061 patent/WO1994013819A1/en active IP Right Grant
- 1993-12-09 SK SK766-95A patent/SK76695A3/sk unknown
- 1993-12-09 EP EP94902173A patent/EP0677109B1/en not_active Expired - Lifetime
- 1993-12-09 DE DE69328442T patent/DE69328442T2/de not_active Expired - Fee Related
- 1993-12-09 AT AT94902173T patent/ATE191930T1/de not_active IP Right Cessation
- 1993-12-09 JP JP51405994A patent/JP3899121B2/ja not_active Expired - Fee Related
- 1993-12-09 CZ CZ19951487A patent/CZ290865B6/cs not_active IP Right Cessation
- 1993-12-09 ES ES94902173T patent/ES2146646T3/es not_active Expired - Lifetime
- 1993-12-09 CA CA002150928A patent/CA2150928C/en not_active Expired - Fee Related
- 1993-12-09 AU AU56637/94A patent/AU5663794A/en not_active Abandoned
- 1993-12-09 PL PL93309292A patent/PL175955B1/pl not_active IP Right Cessation
- 1993-12-09 PT PT94902173T patent/PT677109E/pt unknown
- 1993-12-09 HU HU9501680A patent/HU220193B/hu not_active IP Right Cessation
- 1993-12-10 MX MX9307855A patent/MX9307855A/es not_active IP Right Cessation
- 1993-12-10 ZA ZA939266A patent/ZA939266B/xx unknown
-
1995
- 1995-06-09 NO NO19952297A patent/NO319497B1/no unknown
- 1995-06-09 FI FI952847A patent/FI952847A0/fi unknown
-
2000
- 2000-07-17 GR GR20000401651T patent/GR3033966T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA939266B (en) | 1994-08-08 |
| US5721114A (en) | 1998-02-24 |
| NO952297L (no) | 1995-06-09 |
| DK0677109T3 (da) | 2000-07-17 |
| GR3033966T3 (en) | 2000-11-30 |
| ES2146646T3 (es) | 2000-08-16 |
| DE69328442T2 (de) | 2000-09-07 |
| HU220193B (hu) | 2001-11-28 |
| SK76695A3 (en) | 1996-02-07 |
| HU9501680D0 (en) | 1995-08-28 |
| IL107896A0 (en) | 1994-04-12 |
| FI952847A (fi) | 1995-06-09 |
| NO952297D0 (no) | 1995-06-09 |
| HUT71697A (en) | 1996-01-29 |
| IL107896A (en) | 2004-06-01 |
| PT677109E (pt) | 2000-07-31 |
| DE69328442D1 (de) | 2000-05-25 |
| ATE191930T1 (de) | 2000-05-15 |
| PL175955B1 (pl) | 1999-03-31 |
| JPH08506723A (ja) | 1996-07-23 |
| EP0677109A1 (en) | 1995-10-18 |
| CA2150928A1 (en) | 1994-06-23 |
| MX9307855A (es) | 1994-06-30 |
| AU5663794A (en) | 1994-07-04 |
| JP3899121B2 (ja) | 2007-03-28 |
| CZ290865B6 (cs) | 2002-11-13 |
| WO1994013819A1 (en) | 1994-06-23 |
| EP0677109B1 (en) | 2000-04-19 |
| CA2150928C (en) | 2005-02-08 |
| CZ148795A3 (en) | 1996-01-17 |
| SE9203753D0 (sv) | 1992-12-11 |
| FI952847A0 (fi) | 1995-06-09 |
| PL309292A1 (en) | 1995-10-02 |
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