NO319115B1 - Arylfusjonerte azapolycykliske forbindelser, anvendelse derav samt farmasoytiske sammensetninger. - Google Patents
Arylfusjonerte azapolycykliske forbindelser, anvendelse derav samt farmasoytiske sammensetninger. Download PDFInfo
- Publication number
- NO319115B1 NO319115B1 NO20003422A NO20003422A NO319115B1 NO 319115 B1 NO319115 B1 NO 319115B1 NO 20003422 A NO20003422 A NO 20003422A NO 20003422 A NO20003422 A NO 20003422A NO 319115 B1 NO319115 B1 NO 319115B1
- Authority
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- Norway
- Prior art keywords
- mmol
- formula
- compound
- aza
- alkyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 210
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 35
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 239000001257 hydrogen Substances 0.000 claims description 26
- -1 hydroxy, nitro, amino Chemical group 0.000 claims description 20
- 229910052757 nitrogen Inorganic materials 0.000 claims description 17
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- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims description 4
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 2
- ZABMHLDQFJHDSC-UHFFFAOYSA-N 2,3-dihydro-1,3-oxazole Chemical group C1NC=CO1 ZABMHLDQFJHDSC-UHFFFAOYSA-N 0.000 claims description 2
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- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 2
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims description 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims description 2
- 125000004043 oxo group Chemical group O=* 0.000 claims description 2
- 125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims description 2
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 255
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- YUKQRDCYNOVPGJ-UHFFFAOYSA-N thioacetamide Chemical compound CC(N)=S YUKQRDCYNOVPGJ-UHFFFAOYSA-N 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229940055764 triaz Drugs 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical group [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- NHDIQVFFNDKAQU-UHFFFAOYSA-N tripropan-2-yl borate Chemical compound CC(C)OB(OC(C)C)OC(C)C NHDIQVFFNDKAQU-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Classifications
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- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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- C07—ORGANIC CHEMISTRY
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7024597P | 1997-12-31 | 1997-12-31 | |
| PCT/IB1998/001813 WO1999035131A1 (en) | 1997-12-31 | 1998-11-13 | Aryl fused azapolycyclic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20003422D0 NO20003422D0 (no) | 2000-06-30 |
| NO20003422L NO20003422L (no) | 2000-08-29 |
| NO319115B1 true NO319115B1 (no) | 2005-06-20 |
Family
ID=22094096
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003422A NO319115B1 (no) | 1997-12-31 | 2000-06-30 | Arylfusjonerte azapolycykliske forbindelser, anvendelse derav samt farmasoytiske sammensetninger. |
| NO2006016C NO2006016I1 (no) | 1997-12-31 | 2006-11-17 | 7,8,9,10-tetrahydro-6H-6,10-metanoazepinoÄ4,5-gÜkinoksalintartrat |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2006016C NO2006016I1 (no) | 1997-12-31 | 2006-11-17 | 7,8,9,10-tetrahydro-6H-6,10-metanoazepinoÄ4,5-gÜkinoksalintartrat |
Country Status (52)
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| ES2301210T5 (es) * | 1997-12-31 | 2015-05-07 | Pfizer Products Inc. | Compuestos azapolicíclicos condensados con un arilo |
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| CA2380072C (en) | 1999-07-28 | 2007-07-10 | John Cooke | Nicotine in therapeutic angiogenesis and vasculogenesis |
| US8188043B2 (en) | 1999-07-28 | 2012-05-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
| IL137937A0 (en) * | 1999-08-27 | 2001-10-31 | Pfizer Prod Inc | A pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
| US20020010192A1 (en) * | 2000-06-02 | 2002-01-24 | Coe Jotham Wadsworth | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
| US20020016334A1 (en) * | 2000-07-31 | 2002-02-07 | Coe Jotham Wadsworth | Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD) |
| IL157881A0 (en) * | 2001-04-20 | 2004-03-28 | Pfizer Prod Inc | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds |
| OA12600A (en) * | 2001-05-14 | 2006-06-09 | Pfizer Prod Inc | The citrate salt of 5,8,14-triazatetracyclo 10.3.1.o2,11.o49)-hexadeca-2(11)3,5,7,9-pentaene and pharmaceutical compositions thereof. |
| ME00466B (me) * | 2001-05-14 | 2011-10-10 | Pfizer Prod Inc | Tartaratne soli 5,8,14-triazatetraciklo( 10.3.1.02,11.04,9)-heksadeka-2 (11),3,5,7,9-pentaena |
| AU2002341327A1 (en) | 2001-11-29 | 2003-06-10 | Pfizer Products Inc. | Succinic acid salts of 5,8,14-triazatetracyclo'10.3.1.0<2,11>.0<4,9>-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof |
| DE60228478D1 (de) | 2001-11-30 | 2008-10-02 | Pfizer Prod Inc | Aryl-annellierte azapolyzyklische verbindungen |
| IL161857A0 (en) * | 2001-11-30 | 2005-11-20 | Pfizer Prod Inc | Pharmaceutical compositions of 5,7,14-triazatetracycloÄ10.3.1.0(2,11).0(4,9)Ü-hexadeca-2(11)3,5,7,9-pentaene |
| US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| DK1572127T4 (da) * | 2002-02-14 | 2014-11-24 | Univ Leland Stanford Junior | Enzymbehandling af fødevarer til cøliaki |
| US7320788B2 (en) * | 2002-02-14 | 2008-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
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| WO2004045392A2 (en) * | 2002-11-20 | 2004-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic method for celiac sprue |
| BR0316392A (pt) * | 2002-11-20 | 2005-09-27 | Pfizer Prod Inc | Processo para preparar ácido indan-1,3-dicarboxìlico |
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