NO317801B1 - DNA-molekyl, kimaert DNA-molekyl eller vektor som koder for BMP12 eller BMP12-relaterte proteiner, og vertceller, fremgangsmater, proteiner, sammensetninger og anvendelse derav. - Google Patents
DNA-molekyl, kimaert DNA-molekyl eller vektor som koder for BMP12 eller BMP12-relaterte proteiner, og vertceller, fremgangsmater, proteiner, sammensetninger og anvendelse derav. Download PDFInfo
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- NO317801B1 NO317801B1 NO19962304A NO962304A NO317801B1 NO 317801 B1 NO317801 B1 NO 317801B1 NO 19962304 A NO19962304 A NO 19962304A NO 962304 A NO962304 A NO 962304A NO 317801 B1 NO317801 B1 NO 317801B1
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- bmp
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- dna
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/386—Ligaments, tendons
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
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- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Rehabilitation Therapy (AREA)
- Vascular Medicine (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16410393A | 1993-12-07 | 1993-12-07 | |
| US21778094A | 1994-03-25 | 1994-03-25 | |
| US08/333,576 US6027919A (en) | 1993-12-07 | 1994-11-02 | BMP-12 and BMP-13 proteins and DNA encoding them |
| PCT/US1994/014030 WO1995016035A2 (en) | 1993-12-07 | 1994-12-06 | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO962304D0 NO962304D0 (no) | 1996-06-04 |
| NO962304L NO962304L (no) | 1996-06-04 |
| NO317801B1 true NO317801B1 (no) | 2004-12-13 |
Family
ID=27388970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19962304A NO317801B1 (no) | 1993-12-07 | 1996-06-04 | DNA-molekyl, kimaert DNA-molekyl eller vektor som koder for BMP12 eller BMP12-relaterte proteiner, og vertceller, fremgangsmater, proteiner, sammensetninger og anvendelse derav. |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US5658882A (fi) |
| EP (1) | EP0733109B9 (fi) |
| JP (3) | JP3717930B2 (fi) |
| KR (1) | KR100353182B1 (fi) |
| AT (1) | ATE319823T1 (fi) |
| AU (1) | AU689184B2 (fi) |
| CA (1) | CA2176942C (fi) |
| DE (1) | DE69434651T2 (fi) |
| DK (1) | DK0733109T3 (fi) |
| ES (1) | ES2255059T3 (fi) |
| FI (1) | FI119816B (fi) |
| NO (1) | NO317801B1 (fi) |
| OA (1) | OA10582A (fi) |
| PT (1) | PT733109E (fi) |
| WO (1) | WO1995016035A2 (fi) |
Families Citing this family (147)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US20070166353A1 (en) * | 1988-04-08 | 2007-07-19 | Stryker Corporation | Osteogenic proteins |
| US6586388B2 (en) | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
| US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
| KR100259827B1 (ko) | 1991-11-04 | 2000-06-15 | 브루스 엠. 에이센, 토마스 제이 데스로저 | 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법 |
| DE19525416A1 (de) * | 1995-07-12 | 1997-01-16 | Bioph Biotech Entw Pharm Gmbh | Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems |
| US20080233170A1 (en) * | 1992-02-21 | 2008-09-25 | Stryker Corporation | Osteogenic Proteins |
| EP0804214A4 (en) * | 1993-07-09 | 1998-05-20 | Univ Johns Hopkins Med | FACTOR 6 OF CELL GROWTH AND DIFFERENTIATION |
| CA2165778A1 (en) * | 1993-07-09 | 1995-01-19 | Se-Jin Lee | Growth differentiation factor-7 |
| US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| AU689184B2 (en) * | 1993-12-07 | 1998-03-26 | Genetics Institute, Llc | BMP-12, BMP-13 and tendon-inducing compositions thereof |
| US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
| US5906827A (en) † | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
| WO1996014335A1 (en) * | 1994-11-07 | 1996-05-17 | The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services | Cartilage-derived morphogenetic proteins |
| US20010011131A1 (en) * | 1997-07-28 | 2001-08-02 | Luyten Frank P. | DNA molecules encoding cartilage-derived morphogenetic proteins |
| US5846770A (en) * | 1994-11-22 | 1998-12-08 | Genetics Institute, Inc. | DNA molecules encoding human chordin |
| US7235527B2 (en) * | 1995-04-19 | 2007-06-26 | Biopharm Gesellschaft Zur Biotechnologieschen Entwicklung Von Pharmaka Mbh | Protein and process for producing the same |
| HU222664B1 (hu) * | 1995-06-05 | 2003-09-29 | Genetics Institute, Llc | Csont morfogenetikus protein (BMP) alkalmazása csont és ín vagy szalag funkcionális összeköttetésének regenerálására |
| US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
| ZA966489B (en) * | 1995-08-03 | 1997-02-26 | Bioph Biotech Entw Pharm Gmbh | New protein human MP52 Arg. |
| US6048964A (en) * | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
| US7026292B1 (en) | 1995-12-12 | 2006-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
| DE19548476A1 (de) * | 1995-12-22 | 1997-06-26 | Bioph Biotech Entw Pharm Gmbh | Zielgerichtete Verbindungen mit knorpel- und/oder knocheninduzierender Aktivität |
| US5700774A (en) * | 1996-03-26 | 1997-12-23 | Genetics Institute, Inc. | Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same |
| US5965403A (en) | 1996-09-18 | 1999-10-12 | Genetics Institute, Inc. | Nucleic acids encoding bone morphogenic protein-16 (BMP-16) |
| JPH11335398A (ja) * | 1998-05-22 | 1999-12-07 | Hoechst Marion Roussel Kk | 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬 |
| EP1074620A1 (en) * | 1999-08-06 | 2001-02-07 | HyGene AG | Monomeric protein of the TGF-beta family |
| JP4388602B2 (ja) | 1997-02-07 | 2009-12-24 | ストライカー コーポレイション | マトリクスを含まない骨形成デバイス、移植片、およびその使用方法 |
| US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
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1994
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- 1994-12-06 AT AT95904255T patent/ATE319823T1/de active
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- 1994-12-06 EP EP95904255A patent/EP0733109B9/en not_active Expired - Lifetime
- 1994-12-06 DK DK95904255T patent/DK0733109T3/da active
- 1994-12-06 WO PCT/US1994/014030 patent/WO1995016035A2/en active IP Right Grant
- 1994-12-06 CA CA2176942A patent/CA2176942C/en not_active Expired - Lifetime
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1996
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1997
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1999
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