NO316875B1 - Fettsyrederivater av gallesyrer og gallesyrederivater - Google Patents

Fettsyrederivater av gallesyrer og gallesyrederivater Download PDF

Info

Publication number
NO316875B1
NO316875B1 NO20004998A NO20004998A NO316875B1 NO 316875 B1 NO316875 B1 NO 316875B1 NO 20004998 A NO20004998 A NO 20004998A NO 20004998 A NO20004998 A NO 20004998A NO 316875 B1 NO316875 B1 NO 316875B1
Authority
NO
Norway
Prior art keywords
acid
bile
fatty acid
dihydroxy
cholan
Prior art date
Application number
NO20004998A
Other languages
English (en)
Norwegian (no)
Other versions
NO20004998D0 (no
NO20004998L (no
Inventor
Werner Kramer
Tuvia Gilat
Original Assignee
Galmed Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galmed Int Ltd filed Critical Galmed Int Ltd
Publication of NO20004998D0 publication Critical patent/NO20004998D0/no
Publication of NO20004998L publication Critical patent/NO20004998L/no
Publication of NO316875B1 publication Critical patent/NO316875B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
NO20004998A 1998-04-08 2000-10-04 Fettsyrederivater av gallesyrer og gallesyrederivater NO316875B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12399898A IL123998A (en) 1998-04-08 1998-04-08 Conjugates of bile salts and pharmaceutical preparations containing them
PCT/IL1999/000173 WO1999052932A1 (en) 1998-04-08 1999-03-25 Fatty acid derivatives of bile acids and bile acid derivatives

Publications (3)

Publication Number Publication Date
NO20004998D0 NO20004998D0 (no) 2000-10-04
NO20004998L NO20004998L (no) 2000-12-06
NO316875B1 true NO316875B1 (no) 2004-06-07

Family

ID=11071405

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20004998A NO316875B1 (no) 1998-04-08 2000-10-04 Fettsyrederivater av gallesyrer og gallesyrederivater

Country Status (25)

Country Link
US (3) US6395722B1 (cs)
EP (1) EP1071702B1 (cs)
JP (1) JP5031942B2 (cs)
KR (1) KR100615560B1 (cs)
CN (1) CN100386339C (cs)
AT (1) ATE222923T1 (cs)
AU (1) AU742944B2 (cs)
BR (1) BRPI9909908B8 (cs)
CA (1) CA2325933C (cs)
CZ (1) CZ300824B6 (cs)
DE (1) DE69902647T2 (cs)
DK (1) DK1071702T3 (cs)
EA (1) EA003392B1 (cs)
ES (1) ES2183526T3 (cs)
HU (1) HU229513B1 (cs)
ID (1) ID26042A (cs)
IL (1) IL123998A (cs)
NO (1) NO316875B1 (cs)
NZ (1) NZ507309A (cs)
PL (1) PL199271B1 (cs)
PT (1) PT1071702E (cs)
SI (1) SI1071702T1 (cs)
TR (1) TR200002876T2 (cs)
UA (1) UA70318C2 (cs)
WO (1) WO1999052932A1 (cs)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL142650A (en) * 1998-04-08 2007-06-03 Galmed Int Ltd Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes
IL123998A (en) * 1998-04-08 2004-09-27 Galmed Int Ltd Conjugates of bile salts and pharmaceutical preparations containing them
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
US8975246B2 (en) 2001-04-17 2015-03-10 Galmed Research And Development Ltd. Bile acid or bile salt fatty acid conjugates
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
ITMI20021025A1 (it) * 2002-05-14 2003-11-14 Nicox Sa Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
US20080026077A1 (en) * 2002-11-12 2008-01-31 John Hilfinger Methods and compositions of gene delivery agents for systemic and local therapy
US7906137B2 (en) * 2004-05-21 2011-03-15 Mediplex Corporation, Korea Delivery agents for enhancing mucosal absorption of therapeutic agents
US20090035348A1 (en) * 2005-11-22 2009-02-05 Z & Z Medical Holdings, Inc. Dissolution of arterial plaque
WO2007084549A2 (en) * 2006-01-20 2007-07-26 Filiberto Zadini Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation
US8304383B2 (en) 2005-11-22 2012-11-06 Atheronova Operations, Inc. Dissolution of arterial plaque
US20070212470A1 (en) * 2006-03-13 2007-09-13 Nutracea Therapeutic uses of an anti-cancer composition derived from rice bran
US20080038385A1 (en) * 2006-03-13 2008-02-14 Nutracea Therapeutic uses of an anti-cancer composition derived from rice bran
EP2043451B1 (en) * 2006-07-18 2012-03-21 Symrise AG Cyclodextrin blends with crystal growth inhibitors
WO2008131419A2 (en) 2007-04-23 2008-10-30 Alnylam Pharmaceuticals, Inc. Glycoconjugates of rna interference agents
US20080287429A1 (en) * 2007-05-15 2008-11-20 Z & Z Medical Holdings, Inc. Dissolution of Arterial Cholesterol Plaques by Pharmacologically Induced Elevation of Endogenous Bile Salts
ES2709489T3 (es) * 2007-07-25 2019-04-16 Univ Graz Medizinische Uso de ácidos nor-biliares en el tratamiento de arteriosclerosis
CN101367859B (zh) * 2007-08-17 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 脂肪酸胆汁酸偶合物及其医药用途
CZ301037B6 (cs) * 2007-09-06 2009-10-21 Vysoká škola chemicko-technologická v Praze Amidové konjugáty steroidních a žlucových kyselin s D-glukosaminem a zpusob jejich prípravy
EP3156077B1 (en) 2007-12-04 2022-03-09 Arbutus Biopharma Corporation Targeting lipids
US8507455B2 (en) 2007-12-04 2013-08-13 Alnylam Pharmaceuticals, Inc. Folate conjugates
US20100021538A1 (en) * 2008-02-29 2010-01-28 Youngro Byun Pharmaceutical compositions containing heparin derivatives
CA3044980A1 (en) 2008-04-11 2009-10-15 Alnylam Pharmaceuticals, Inc. Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
WO2010062369A2 (en) * 2008-11-03 2010-06-03 Tufts University Methods and compositions for inhibiting clostridium difficile spore germination and outgrowth
WO2010086864A1 (en) * 2009-02-02 2010-08-05 Galmed International Ltd. Methods and compositions for treating alzheimer's disease
GB2480632A (en) 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
CN102115486B (zh) * 2009-12-30 2015-06-03 上海特化医药科技有限公司 一种3-β-花生酰胺基-7α,12α,5β-胆烷-24-羧酸的制备方法
WO2012174229A2 (en) * 2011-06-16 2012-12-20 Kythera Biopharmaceuticals, Inc. Methods for the synthesis and purification of deoxycholic acid
EP3030229B1 (en) * 2013-08-08 2019-03-13 Galmed Research and Development Ltd. Anti-acne compositions comprising bile acid-fatty acid conjugates
US11571431B2 (en) 2013-12-04 2023-02-07 Galmed Research And Development Ltd Aramchol salts
DK3077047T3 (da) * 2013-12-04 2019-07-15 Galmed Res & Development Ltd Aramcholsalte
AU2015270099A1 (en) * 2014-06-01 2016-12-15 Galmed Research And Development Ltd. Fatty acid bile acid conjugates for treatment of lipodystrophy
JOP20200092A1 (ar) 2014-11-10 2017-06-16 Alnylam Pharmaceuticals Inc تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
US10849911B2 (en) 2015-06-10 2020-12-01 Galmed Research And Development Ltd. Low dose compositions of Aramachol salts
IL243707A0 (en) 2016-01-20 2016-05-01 Galmed Res And Dev Ltd Treatment to regulate the microbiota in the intestine
CN106496300B (zh) * 2016-10-19 2018-05-18 上海博志研新药物技术有限公司 花生胆酸及其中间体的制备方法
US11197870B2 (en) 2016-11-10 2021-12-14 Galmed Research And Development Ltd Treatment for hepatic fibrosis
KR20190083660A (ko) * 2016-11-10 2019-07-12 갈메드 리서치 앤드 디벨롭먼트 리미티드 비-알코올성 지방 간질환 환자에 있어서 섬유증의 억제
US11324820B2 (en) 2017-04-18 2022-05-10 Alnylam Pharmaceuticals, Inc. Methods for the treatment of subjects having a hepatitis b virus (HBV) infection
EP3636655A4 (en) * 2017-06-07 2020-08-26 Crystal Pharmaceutical (Suzhou) Co., Ltd. CRYSTALLINE FORM OF A FATTY ACID - BILIARY ACID CONJUGATE, PROCESS OF PREPARATION AND APPLICATION
CN112673103B (zh) 2018-08-13 2024-08-09 阿尔尼拉姆医药品有限公司 乙型肝炎病毒(HBV)dsRNA剂组合物及其使用方法
IT202000000328A1 (it) 2020-01-10 2021-07-10 Ice S P A Metodo di preparazione dell'aramchol
CN114524857B (zh) * 2022-02-22 2023-06-30 中国科学院微生物研究所 胆酸衍生物及其应用
CN116687850A (zh) 2022-02-24 2023-09-05 甘莱制药有限公司 包含环状膦酸酯化合物的药物组合物及其制备方法与用途
WO2023227723A1 (en) * 2022-05-26 2023-11-30 Pharmazell Gmbh An improved process for the preparation of aramchol and salts thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856953A (en) * 1973-05-15 1974-12-24 Intellectual Property Dev Corp Method of treating fatty liver
IT1167479B (it) * 1981-07-24 1987-05-13 Carlo Scolastico Derivati dell'acido chenodesossicolico
IT1167478B (it) * 1981-07-24 1987-05-13 Carlo Scolastico Derivati dell'acido ursodesossicolico
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
IL123998A (en) * 1998-04-08 2004-09-27 Galmed Int Ltd Conjugates of bile salts and pharmaceutical preparations containing them
DE19824123A1 (de) * 1998-05-29 1999-12-02 Hoechst Marion Roussel De Gmbh Gallensäurederivat, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Also Published As

Publication number Publication date
BRPI9909908B8 (pt) 2021-05-25
ATE222923T1 (de) 2002-09-15
CZ300824B6 (cs) 2009-08-19
NO20004998D0 (no) 2000-10-04
PT1071702E (pt) 2003-01-31
IL123998A (en) 2004-09-27
KR20010042342A (ko) 2001-05-25
CN100386339C (zh) 2008-05-07
PL199271B1 (pl) 2008-09-30
WO1999052932A1 (en) 1999-10-21
EA003392B1 (ru) 2003-04-24
NZ507309A (en) 2003-06-30
JP5031942B2 (ja) 2012-09-26
DE69902647T2 (de) 2003-04-24
AU3051599A (en) 1999-11-01
US20020091111A1 (en) 2002-07-11
US6589946B2 (en) 2003-07-08
SI1071702T1 (en) 2003-04-30
HU229513B1 (en) 2014-01-28
BR9909908B1 (pt) 2014-03-18
EP1071702B1 (en) 2002-08-28
AU742944B2 (en) 2002-01-17
CA2325933C (en) 2008-06-10
ES2183526T3 (es) 2003-03-16
US6395722B1 (en) 2002-05-28
EA200000888A1 (ru) 2001-04-23
HUP0101653A2 (hu) 2001-12-28
PL343360A1 (en) 2001-08-13
CN1296492A (zh) 2001-05-23
BR9909908A (pt) 2000-12-26
CA2325933A1 (en) 1999-10-21
US6384024B1 (en) 2002-05-07
KR100615560B1 (ko) 2006-08-25
DK1071702T3 (da) 2002-12-30
UA70318C2 (uk) 2004-10-15
HUP0101653A3 (en) 2002-02-28
DE69902647D1 (de) 2002-10-02
ID26042A (id) 2000-11-16
TR200002876T2 (tr) 2000-12-21
NO20004998L (no) 2000-12-06
EP1071702A1 (en) 2001-01-31
CZ20003625A3 (cs) 2001-01-17
JP2002511482A (ja) 2002-04-16

Similar Documents

Publication Publication Date Title
NO316875B1 (no) Fettsyrederivater av gallesyrer og gallesyrederivater
CA2656320C (en) Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated diseases or conditions
EP1113785B1 (en) Clear aqueous solutions of bile acids
CA1246544A (en) Tigogenin-cellobioside for treating hypercholesterolemia and arteriosclerosis
US20030153538A1 (en) Antitumor agent
Olson The effect of bile and bile salts on the uptake and cleavage of β-carotene into retinol ester (vitamin A ester) by intestinal slices
EP0676410B1 (en) Bile acids derivatives useful in the therapy of the biliary calculosis from cholesterol and of the pathologies caused by cholestasis
GB2039217A (en) Anti-inflammatory medicaments comprising glycosides of sterols or spiroketal steroids or esters thereof
US4939134A (en) 26-aminocholesterol and derivatives and analogs thereof in the regulation of cholesterol accumulation in body tissue
Roda et al. New 6-substituted bile acids: physico-chemical and biological properties of 6 alpha-methyl ursodeoxycholic acid and 6 alpha-methyl-7-epicholic acid.
PL98710B1 (pl) Sposob wytwarzania nowych d-homosteroidow
MXPA00009863A (en) Fatty acid derivatives of bile acids and bile acid derivatives
IL43287A (en) Fusidic acid conjugates their preparation and pharmaceutical compositions containing them
EP0100983A1 (en) Steroid compounds with choleretic activity, a process for their preparation, and therapeutic compounds which contain them as active principle
JPS6363698A (ja) 胆汁酸誘導体およびその塩ならびにその製造法
NZ207413A (en) Steroid intermediates in the preparation of 24,24-difluoro-25-hydroxy-vitamin d3
EP2255813A1 (en) Derivatives of ursodeoxycholic acid for the treatment of diarrhoea
Roda et al. New 6-substituted bile acids: physico-chemical and biological properties of 6~ methyl ursodeoxycholic acid and 6a-methylg% epicholic acid
SHIMIZU et al. Hypocholesterolemic effect of ursodeoxycholylcysteic acid in hamsters fed a high cholesterol diet
Xu Importance of gallbladder and small intestine motility in cholesterol gallstone formation
SHIMIZU et al. Hypocholesterolemic Effect of 5β-Cholane-3α, 7β, 24-triol-24-sulfate in Hamsters
JPH0797400A (ja) カルシトニン誘導体

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: GALMED RESEARCH AND DEVELOPMENT LTD, IL

MK1K Patent expired