NO316171B1 - Arylkarboksylsyre- og tetrazolderivater, farmasöytisk preparat samt fremgangsmåte for fremstilling og anvendelse derav - Google Patents
Arylkarboksylsyre- og tetrazolderivater, farmasöytisk preparat samt fremgangsmåte for fremstilling og anvendelse derav Download PDFInfo
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- NO316171B1 NO316171B1 NO19996366A NO996366A NO316171B1 NO 316171 B1 NO316171 B1 NO 316171B1 NO 19996366 A NO19996366 A NO 19996366A NO 996366 A NO996366 A NO 996366A NO 316171 B1 NO316171 B1 NO 316171B1
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- Prior art keywords
- acetic acid
- compound according
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- acid
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- 238000002360 preparation method Methods 0.000 title claims description 85
- 238000000034 method Methods 0.000 title claims description 40
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 16
- -1 Aryl Carboxylic Acid Chemical class 0.000 title description 59
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- 150000001875 compounds Chemical class 0.000 claims description 190
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- 150000002367 halogens Chemical class 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 20
- 125000002947 alkylene group Chemical group 0.000 claims description 18
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- 239000001257 hydrogen Substances 0.000 claims description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 14
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- VCTVPGPDKHRWMQ-UHFFFAOYSA-N 2-[3-[3-(diphenylcarbamoyloxy)propyl]phenyl]acetic acid Chemical compound OC(=O)CC1=CC=CC(CCCOC(=O)N(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 VCTVPGPDKHRWMQ-UHFFFAOYSA-N 0.000 claims description 5
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- ZXGQEZNIBUOWSJ-UHFFFAOYSA-N tert-butyl 2-(3-formyl-2-methylphenoxy)acetate Chemical compound CC1=C(OCC(=O)OC(C)(C)C)C=CC=C1C=O ZXGQEZNIBUOWSJ-UHFFFAOYSA-N 0.000 description 1
- RHHVCZIHNBRUCK-UHFFFAOYSA-N tert-butyl 2-[3-(3-hydroxyprop-1-ynyl)phenyl]propanoate Chemical compound CC(C)(C)OC(=O)C(C)C1=CC=CC(C#CCO)=C1 RHHVCZIHNBRUCK-UHFFFAOYSA-N 0.000 description 1
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- NNIANPBPWHBFBO-UHFFFAOYSA-N tert-butyl 2-[3-[3-(diphenylcarbamoyloxy)propyl]phenyl]acetate Chemical compound CC(C)(C)OC(=O)CC1=CC=CC(CCCOC(=O)N(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 NNIANPBPWHBFBO-UHFFFAOYSA-N 0.000 description 1
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- RVURXEOJGRPZDA-UHFFFAOYSA-N tert-butyl 3-[3-(3-hydroxyprop-1-ynyl)phenyl]propanoate Chemical compound CC(C)(C)OC(=O)CCC1=CC=CC(C#CCO)=C1 RVURXEOJGRPZDA-UHFFFAOYSA-N 0.000 description 1
- PMHAODQGWVSIKE-UHFFFAOYSA-N tert-butyl 4-(3-bromophenyl)butanoate Chemical compound CC(C)(C)OC(=O)CCCC1=CC=CC(Br)=C1 PMHAODQGWVSIKE-UHFFFAOYSA-N 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- XTOWSCXECRARHA-UHFFFAOYSA-N tert-butylazanium;propanoate Chemical compound CCC([O-])=O.CC(C)(C)[NH3+] XTOWSCXECRARHA-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11344698P | 1998-12-23 | 1998-12-23 | |
| US15181499P | 1999-08-30 | 1999-08-30 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO996366D0 NO996366D0 (no) | 1999-12-21 |
| NO996366L NO996366L (no) | 2000-06-26 |
| NO316171B1 true NO316171B1 (no) | 2003-12-22 |
Family
ID=26811078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19996366A NO316171B1 (no) | 1998-12-23 | 1999-12-21 | Arylkarboksylsyre- og tetrazolderivater, farmasöytisk preparat samt fremgangsmåte for fremstilling og anvendelse derav |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6335459B1 (zh) |
| EP (1) | EP1013639B1 (zh) |
| JP (1) | JP3415085B2 (zh) |
| KR (1) | KR100378335B1 (zh) |
| CN (1) | CN1167670C (zh) |
| AR (1) | AR029320A1 (zh) |
| AT (1) | ATE251125T1 (zh) |
| AU (1) | AU735640B2 (zh) |
| BR (1) | BR9905974A (zh) |
| CA (1) | CA2292921C (zh) |
| DE (1) | DE69911726T2 (zh) |
| DK (1) | DK1013639T3 (zh) |
| ES (1) | ES2207108T3 (zh) |
| HR (1) | HRP990394A2 (zh) |
| HU (1) | HUP9904659A3 (zh) |
| ID (1) | ID25983A (zh) |
| IL (1) | IL133578A (zh) |
| MA (1) | MA26713A1 (zh) |
| NO (1) | NO316171B1 (zh) |
| NZ (1) | NZ501891A (zh) |
| PE (1) | PE20001368A1 (zh) |
| PL (1) | PL337419A1 (zh) |
| PT (1) | PT1013639E (zh) |
| RU (1) | RU2179969C2 (zh) |
| SG (1) | SG90086A1 (zh) |
| TR (1) | TR199903310A2 (zh) |
| TW (1) | TWI221834B (zh) |
| UY (1) | UY25876A1 (zh) |
| YU (1) | YU69699A (zh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9828442D0 (en) | 1998-12-24 | 1999-02-17 | Karobio Ab | Novel thyroid receptor ligands and method II |
| SE0100158D0 (sv) * | 2001-01-19 | 2001-01-19 | Synphora Ab | Novel method and composition for local treatment of Meniere´s disease and tinnitus |
| MXPA03007864A (es) * | 2001-03-02 | 2003-12-04 | Hoffmann La Roche | Derivados del acido alcoxicarbonilamino-heteroaril carboxilico como antagonistas ip. |
| CN100477995C (zh) | 2003-05-09 | 2009-04-15 | 东丽株式会社 | 增强剂 |
| UA93548C2 (uk) | 2006-05-05 | 2011-02-25 | Айерем Елелсі | Сполуки та композиції як модулятори хеджхогівського сигнального шляху |
| US9669381B2 (en) | 2007-06-27 | 2017-06-06 | Hrd Corporation | System and process for hydrocracking |
| KR20200034831A (ko) | 2008-03-18 | 2020-03-31 | 아레나 파마슈티칼스, 인크. | 프로스타시클린 （ｐｇｉ２） 수용체와 관련된 장애의 치료에 유용한 상기 수용체의 조절제 |
| MX2011000897A (es) | 2008-07-23 | 2011-03-30 | Toray Industries | Agente terapeutico para falla renal cronica. |
| EP2580218B1 (en) | 2010-06-11 | 2015-02-25 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
| EP2580201B1 (en) | 2010-06-11 | 2017-08-02 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| JP7023559B2 (ja) | 2017-03-01 | 2022-02-22 | アレーナ ファーマシューティカルズ，インク． | Ｐｇｉ２－受容体アゴニストを含む組成物、およびその調製のためのプロセス |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1079414A (en) | 1965-06-30 | 1967-08-16 | Smith & Nephew | Derivatives of acetic acid and a process for their preparation |
| GB1185539A (en) | 1967-11-03 | 1970-03-25 | Smith & Nephew | Substituted Tetrazoles |
| DE2432560A1 (de) | 1974-07-06 | 1976-01-22 | Boehringer Mannheim Gmbh | Neue phenoxyalkylcarbonsaeurederivate und verfahren zur herstellung derselben |
| JPS5832859A (ja) | 1981-08-20 | 1983-02-25 | Dainippon Pharmaceut Co Ltd | Ｎ，ｎ−ジメチルカルバミン酸ベンジルエステル誘導体 |
| JPH0725725B2 (ja) | 1987-07-23 | 1995-03-22 | 保土谷化学工業株式会社 | ベンズアミド誘導体 |
| US5084466A (en) | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
| CA2090283A1 (en) | 1992-02-28 | 1993-08-29 | Nobuyuki Hamanaka | Phenoxyacetic acid derivatives |
| JP3692536B2 (ja) | 1994-02-10 | 2005-09-07 | 小野薬品工業株式会社 | プロスタグランジンｉ２受容体 |
| EP0749424B1 (en) | 1994-03-10 | 2001-09-12 | Fujisawa Pharmaceutical Co., Ltd. | Naphthalene derivatives as prostaglandin i2 agonists |
| US5753700A (en) | 1994-12-28 | 1998-05-19 | Ono Pharmaceutical Co., Ltd. | Naphthyloxyacetic acid derivatives |
| TW401408B (en) | 1995-07-21 | 2000-08-11 | Fujisawa Pharmaceutical Co | Heterocyclic compounds having prostaglandin I2 agonism |
| US6018068A (en) | 1995-07-26 | 2000-01-25 | Ono Pharmaceutical Co., Ltd. | Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients |
| AUPP029197A0 (en) | 1997-11-10 | 1997-12-04 | Fujisawa Pharmaceutical Co., Ltd. | Benzocycloheptene derivatives |
| AUPP109097A0 (en) | 1997-12-22 | 1998-01-22 | Fujisawa Pharmaceutical Co., Ltd. | Napthalene derivatives |
-
1999
- 1999-12-07 US US09/456,167 patent/US6335459B1/en not_active Expired - Fee Related
- 1999-12-15 EP EP99125027A patent/EP1013639B1/en not_active Expired - Lifetime
- 1999-12-15 PT PT99125027T patent/PT1013639E/pt unknown
- 1999-12-15 ES ES99125027T patent/ES2207108T3/es not_active Expired - Lifetime
- 1999-12-15 AT AT99125027T patent/ATE251125T1/de not_active IP Right Cessation
- 1999-12-15 DK DK99125027T patent/DK1013639T3/da active
- 1999-12-15 DE DE69911726T patent/DE69911726T2/de not_active Expired - Fee Related
- 1999-12-17 NZ NZ501891A patent/NZ501891A/en unknown
- 1999-12-17 AU AU65340/99A patent/AU735640B2/en not_active Ceased
- 1999-12-17 SG SG9906425A patent/SG90086A1/en unknown
- 1999-12-17 IL IL13357899A patent/IL133578A/en not_active IP Right Cessation
- 1999-12-20 HR HR990394A patent/HRP990394A2/hr not_active Application Discontinuation
- 1999-12-20 HU HU9904659A patent/HUP9904659A3/hu unknown
- 1999-12-20 MA MA25866A patent/MA26713A1/fr unknown
- 1999-12-21 PE PE1999001307A patent/PE20001368A1/es not_active Application Discontinuation
- 1999-12-21 AR ARP990106638A patent/AR029320A1/es not_active Application Discontinuation
- 1999-12-21 NO NO19996366A patent/NO316171B1/no unknown
- 1999-12-22 ID IDP991169D patent/ID25983A/id unknown
- 1999-12-22 UY UY25876A patent/UY25876A1/es unknown
- 1999-12-22 JP JP36452099A patent/JP3415085B2/ja not_active Expired - Fee Related
- 1999-12-22 RU RU99127329/04A patent/RU2179969C2/ru not_active IP Right Cessation
- 1999-12-22 CA CA002292921A patent/CA2292921C/en not_active Expired - Fee Related
- 1999-12-22 KR KR10-1999-0060163A patent/KR100378335B1/ko not_active IP Right Cessation
- 1999-12-23 PL PL99337419A patent/PL337419A1/xx not_active Application Discontinuation
- 1999-12-23 YU YU69699A patent/YU69699A/sh unknown
- 1999-12-23 TR TR1999/03310A patent/TR199903310A2/xx unknown
- 1999-12-23 TW TW088122774A patent/TWI221834B/zh not_active IP Right Cessation
- 1999-12-23 CN CNB991277953A patent/CN1167670C/zh not_active Expired - Fee Related
- 1999-12-23 BR BR9905974-6A patent/BR9905974A/pt not_active IP Right Cessation
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