NO315686B1 - Blanding for frigjöring av et medikament til kolon - Google Patents
Blanding for frigjöring av et medikament til kolon Download PDFInfo
- Publication number
- NO315686B1 NO315686B1 NO19965436A NO965436A NO315686B1 NO 315686 B1 NO315686 B1 NO 315686B1 NO 19965436 A NO19965436 A NO 19965436A NO 965436 A NO965436 A NO 965436A NO 315686 B1 NO315686 B1 NO 315686B1
- Authority
- NO
- Norway
- Prior art keywords
- drug
- capsule according
- capsule
- colon
- capsules
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9412394A GB9412394D0 (en) | 1994-06-21 | 1994-06-21 | Colonic drug delivery composition |
| PCT/GB1995/001458 WO1995035100A1 (en) | 1994-06-21 | 1995-06-21 | Colonic drug delivery composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO965436L NO965436L (no) | 1996-12-18 |
| NO965436D0 NO965436D0 (no) | 1996-12-18 |
| NO315686B1 true NO315686B1 (no) | 2003-10-13 |
Family
ID=10757052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19965436A NO315686B1 (no) | 1994-06-21 | 1996-12-18 | Blanding for frigjöring av et medikament til kolon |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6228396B1 (ja) |
| EP (1) | EP0810857B1 (ja) |
| JP (1) | JP2986217B2 (ja) |
| AT (1) | ATE204751T1 (ja) |
| AU (1) | AU688060B2 (ja) |
| CA (1) | CA2193481C (ja) |
| DE (1) | DE69522475T2 (ja) |
| DK (1) | DK0810857T3 (ja) |
| ES (1) | ES2162922T3 (ja) |
| FI (1) | FI118626B (ja) |
| GB (1) | GB9412394D0 (ja) |
| NO (1) | NO315686B1 (ja) |
| PT (1) | PT810857E (ja) |
| WO (1) | WO1995035100A1 (ja) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5686106A (en) * | 1995-05-17 | 1997-11-11 | The Procter & Gamble Company | Pharmaceutical dosage form for colonic delivery |
| GB9620709D0 (en) * | 1996-10-04 | 1996-11-20 | Danbiosyst Uk | Colonic delivery of weak acid drugs |
| CA2271560C (en) * | 1996-11-15 | 2003-09-23 | Mayo Foundation For Medical Education And Research | Pharmaceutical dosage form for colonic delivery |
| US5891474A (en) * | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
| DE19732903A1 (de) | 1997-07-30 | 1999-02-04 | Falk Pharma Gmbh | Pellet-Formulierung zur Behandlung des Intestinaltraktes |
| US8765177B2 (en) * | 1997-09-12 | 2014-07-01 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
| US7153845B2 (en) * | 1998-08-25 | 2006-12-26 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
| GB9800912D0 (en) * | 1998-01-17 | 1998-03-11 | Danbiosyst Uk | New composition |
| CN1149078C (zh) * | 1998-02-09 | 2004-05-12 | 乔尔·博朗尼克 | 治疗慢性胃肠道炎症的制剂 |
| US7022683B1 (en) | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
| KR100695562B1 (ko) * | 1998-09-28 | 2007-03-15 | 워너-램버트 캄파니 엘엘씨 | Ｈｐｍｃ 캡슐을 이용한 장 및 결장에의 전달방법 |
| DE19923817A1 (de) * | 1999-05-18 | 2000-11-23 | Roland Bodmeier | Kapsel mit kontrollierter Wirkstofffreisetzung |
| EP1184038B1 (en) * | 1999-06-09 | 2005-12-28 | Mochida Pharmaceutical Co., Ltd. | System for release in lower digestive tract |
| US6340473B1 (en) * | 1999-07-07 | 2002-01-22 | R.P. Scherer Technologies, Inc. | Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same |
| IT1318625B1 (it) * | 2000-07-14 | 2003-08-27 | Roberto Valducci | Formulazioni farmaceutiche solide orali a rilascio multifasicoph-dipendente. |
| US6908609B2 (en) | 2000-11-20 | 2005-06-21 | Dow Global Technologies Inc. | In vivo use of water absorbent polymers |
| US7494669B2 (en) * | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
| US6777000B2 (en) * | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
| US7012068B2 (en) | 2001-03-27 | 2006-03-14 | Pro-Pharmaceuticals, Inc. | Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer |
| US6645946B1 (en) | 2001-03-27 | 2003-11-11 | Pro-Pharmaceuticals, Inc. | Delivery of a therapeutic agent in a formulation for reduced toxicity |
| US20040077540A1 (en) * | 2002-06-28 | 2004-04-22 | Nastech Pharmaceutical Company Inc. | Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds |
| US11116782B2 (en) | 2002-10-15 | 2021-09-14 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| US8404716B2 (en) * | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| US8404717B2 (en) * | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes using lenalidomide |
| TWI355276B (en) * | 2003-01-14 | 2012-01-01 | Akira Tsuji | Gastrointestinal absorption enhancer mediated by p |
| JP2006525351A (ja) * | 2003-04-30 | 2006-11-09 | ナステック・ファーマシューティカル・カンパニー・インコーポレーテッド | ガンを診断および治療するための方法 |
| JP2007531697A (ja) * | 2003-07-11 | 2007-11-08 | プロ−ファーマシューティカルズ，インコーポレイティド | 疎水性薬剤のデリバリーのための組成物と方法 |
| US7737133B2 (en) | 2003-09-03 | 2010-06-15 | Agi Therapeutics Ltd. | Formulations and methods of treating inflammatory bowel disease |
| US7825106B2 (en) | 2003-09-03 | 2010-11-02 | Agi Therapeutics Ltd. | Modified release formulations and methods of treating inflammatory bowel disease |
| US20050053664A1 (en) * | 2003-09-08 | 2005-03-10 | Eliezer Zomer | Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer |
| US20050129679A1 (en) * | 2003-12-15 | 2005-06-16 | Nastech Pharmaceutical Company Inc. | Method for opening tight junctions |
| US20070078109A1 (en) * | 2004-02-13 | 2007-04-05 | David Platt | Compositions and methods used to treat acne and candida |
| US20040224019A1 (en) * | 2004-03-03 | 2004-11-11 | Adi Shefer | Oral controlled release system for targeted drug delivery into the cell and its nucleus for gene therapy, DNA vaccination, and administration of gene based drugs |
| US20080286251A1 (en) * | 2004-08-02 | 2008-11-20 | Propharmaceuticals, Inc. | Compositions and Methods for the Enhancement of Chemotherapy with Microbial Cytotoxins |
| GB0421121D0 (en) * | 2004-09-22 | 2004-10-27 | Natrocell Technologies Ltd | Composite rodenticide |
| GB0517957D0 (en) | 2005-09-03 | 2005-10-12 | Morvus Technology Ltd | Method of combating infection |
| GB0526552D0 (en) | 2005-12-29 | 2006-02-08 | Morvus Technology Ltd | New use |
| US7964215B1 (en) | 2006-01-24 | 2011-06-21 | Emet Pharmaceuticals, LLC | Delayed release dosage form |
| GB0607534D0 (en) * | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
| WO2008028193A2 (en) * | 2006-09-01 | 2008-03-06 | Pharmion Corporation | Colon-targeted oral formulations of cytidine analogs |
| RU2009116271A (ru) * | 2006-09-29 | 2010-11-10 | Конинклейке Филипс Электроникс, Н.В. (Nl) | Миниатюрные пороговые датчики |
| GB2442202A (en) | 2006-09-30 | 2008-04-02 | Morvus Technology Ltd | Vermin poison |
| EP2380564B1 (en) | 2007-04-04 | 2014-10-22 | Sigmoid Pharma Limited | An oral pharmaceutical composition |
| US20090036414A1 (en) * | 2007-08-02 | 2009-02-05 | Mutual Pharmaceutical Company, Inc. | Mesalamine Formulations |
| WO2009126742A2 (en) * | 2008-04-08 | 2009-10-15 | Appian Labs, Llc | Enzyme mediated delivery system |
| GB0808537D0 (en) | 2008-05-12 | 2008-06-18 | Archimedes Dev Ltd | Compositions |
| DK3692983T3 (da) | 2008-05-15 | 2021-09-20 | Celgene Corp | Orale formuleringer af cytidinanaloger og fremgangsmåder til anvendelse deraf |
| DK2365802T3 (da) | 2008-11-11 | 2017-11-13 | Univ Texas | Mikrokapsler af rapamycin og anvendelse til behandling af cancer |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| US20170079962A1 (en) | 2009-11-11 | 2017-03-23 | Rapamycin Holdings, Llc | Oral Rapamycin Preparation and Use for Stomatitus |
| US11974971B2 (en) | 2011-01-07 | 2024-05-07 | Anji Pharmaceuticals Inc. | Compositions and methods for treating metabolic disorders |
| US11759441B2 (en) | 2011-01-07 | 2023-09-19 | Anji Pharmaceuticals Inc. | Biguanide compositions and methods of treating metabolic disorders |
| US20120276056A1 (en) * | 2011-04-26 | 2012-11-01 | Wieslaw Janusz Bochenek | Method for Use of Biologic Agents Including Live or Dormant Forms of Bacteria and other organisms in Treating Infections, Inflammation and Other Diseases of Distal Small Intestine and Large Intestine |
| CA2862533C (en) | 2012-01-06 | 2021-05-04 | Elcelyx Therapeutics, Inc. | Biguanide compositions and methods of treating metabolic disorders |
| EP3461477B1 (en) * | 2012-03-29 | 2021-06-30 | Therabiome, Llc | Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix |
| US20140066837A1 (en) | 2012-07-26 | 2014-03-06 | Ronald L. Moy | Skin care compositions and methods |
| DK2968281T3 (da) | 2013-03-13 | 2020-11-02 | Univ Texas | Mtor-hæmmere til forebyggelse af vækst af tarmpolyp |
| AU2014239883B2 (en) | 2013-03-14 | 2019-01-17 | Therabiome, Llc | Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents |
| KR20150144743A (ko) * | 2013-04-05 | 2015-12-28 | 폴리켐 에스.에이. | 염증성 장 질환을 치료하기 위한 피도티모드의 사용 |
| US9446027B2 (en) | 2013-04-05 | 2016-09-20 | Polichem Sa | Use of pidotimod to treat irritable bowel syndrome |
| DK3089737T3 (da) | 2013-12-31 | 2021-12-13 | Rapamycin Holdings Llc | Orale rapamycin-nanopartikelpræparater og anvendelse. |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| AU2015218769B2 (en) * | 2014-02-20 | 2020-09-17 | Vaxart, Inc. | Formulations for small intestinal delivery |
| AU2015305449B2 (en) | 2014-08-22 | 2021-05-06 | Celgene Corporation | Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies |
| AU2016274599B2 (en) | 2015-06-12 | 2021-09-02 | Vaxart, Inc. | Formulations for small intestinal delivery of RSV and norovirus antigens |
| TN2018000069A1 (en) | 2015-09-01 | 2019-07-08 | First Wave Biopharma | Methods and compositions for treating conditions associated with an abnormal inflammatory responses |
| US10588864B2 (en) | 2016-03-11 | 2020-03-17 | Gateway Pharmaceuticals LLC | Pharmaceutical compositions for colon-specific delivery |
| CN106380636B (zh) * | 2016-08-30 | 2019-05-14 | 华南理工大学 | 一种壳聚糖接枝的抗消化淀粉载体材料及其制备方法和应用 |
| CN108201531A (zh) * | 2016-12-19 | 2018-06-26 | 湖南尔康湘药制药有限公司 | 高溶解性磺苄西林钠结肠靶向淀粉胶囊及其制备方法 |
| US11596607B2 (en) | 2017-04-18 | 2023-03-07 | Actorious Innovations And Research Pvt. Ltd. | Polymer based formulation for release of drugs and bioactives at specific GIT sites |
| WO2019211419A1 (en) * | 2018-05-03 | 2019-11-07 | M.W. Encap Limited | Dosage forms for delivery of medicines to the lower gastrointestinal tract |
| US20230102999A1 (en) | 2020-01-10 | 2023-03-30 | First Wave Bio, Inc. | Deuterated niclosamide |
| WO2021188564A1 (en) | 2020-03-16 | 2021-09-23 | First Wave Bio, Inc. | Methods of treating covid-19 with a niclosamide compound |
| US10980756B1 (en) | 2020-03-16 | 2021-04-20 | First Wave Bio, Inc. | Methods of treatment |
| EP4327806A1 (en) | 2021-04-20 | 2024-02-28 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Capsule for specific drug delivery and preparation method therefor |
| US11896719B2 (en) | 2022-01-24 | 2024-02-13 | Calliditas Therapeutics Ab | Pharmaceutical compositions |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA825384B (en) * | 1981-07-31 | 1983-05-25 | Tillott J B Ltd | Orally administrable pharmaceutical compositions |
| US4738724A (en) * | 1983-11-04 | 1988-04-19 | Warner-Lambert Company | Method for forming pharmaceutical capsules from starch compositions |
| US4673438A (en) * | 1984-02-13 | 1987-06-16 | Warner-Lambert Company | Polymer composition for injection molding |
| US4663308A (en) | 1984-07-18 | 1987-05-05 | Medical College Of Ohio | Method of use of polymers containing cross-linked azo bonds for releasing therapeutic agents into the lower gastrointestinal tract |
| US4627851A (en) | 1984-10-26 | 1986-12-09 | Alza Corporation | Colonic-therapeutic delivery system |
| US4668517A (en) | 1985-04-04 | 1987-05-26 | Norwich Eaton Pharmaceuticals, Inc. | Furazolidone dosage form |
| IL77186A0 (en) * | 1985-11-29 | 1986-04-29 | Touitou Elka | Pharmaceutical insulin composition |
| US4945080A (en) * | 1987-05-26 | 1990-07-31 | Eli Lilly And Company | Dirithromycin metabolite |
| JP2782691B2 (ja) * | 1987-09-29 | 1998-08-06 | ワーナー−ランバート・コンパニー | 腸溶製剤の安定化 |
| ATE73643T1 (de) * | 1987-11-20 | 1992-04-15 | Greither Peter | Kapsel und verfahren zu ihrer herstellung. |
| DE8715583U1 (de) * | 1987-11-24 | 1988-01-28 | Greither, Peter, Kirchberg | Kapsel |
| DE3812799A1 (de) | 1988-04-16 | 1989-10-26 | Sanol Arznei Schwarz Gmbh | Oral zu verabreichende pharmazeutische zubereitung mit kontrollierter wirkstofffreisetzung und verfahren zu deren herstellung |
| GB8812490D0 (en) | 1988-05-26 | 1988-06-29 | Agricultural & Food Res | Delayed release formulations |
| US5342624A (en) * | 1989-02-16 | 1994-08-30 | British Technology Group Ltd. | Dispensing device |
| WO1990013286A1 (fr) | 1989-05-11 | 1990-11-15 | Chugai Seiyaku Kabushiki Kaisha | Preparation orale pouvant etre liberee dans une region appropriee de l'intestin |
| US5032405A (en) * | 1989-09-27 | 1991-07-16 | Warner-Lambert Company | Oral pharmaceutical composition for acid sensitive proteinaceous agents |
| BE1003677A3 (nl) * | 1990-01-29 | 1992-05-19 | Schacht Etienne | Werkwijze voor het bereiden van azobevattende polymeren en het gebruik ervan als geneesmiddelafgiftesystemen. |
| IL98087A (en) * | 1990-05-04 | 1996-11-14 | Perio Prod Ltd | Preparation for dispensing drugs in the colon |
| WO1992018147A1 (en) * | 1991-04-19 | 1992-10-29 | Affinity Biotech, Inc. | Convertible microemulsion formulations |
| CZ282760B6 (cs) * | 1991-11-22 | 1997-09-17 | Procter And Gamble Pharmaceuticals, Inc. | Risedronátové prostředky se zpožděným uvolňováním |
| DE4236025A1 (de) | 1992-10-24 | 1994-04-28 | Merck Patent Gmbh | Orale Arzneiformen |
| US5656290A (en) | 1993-02-26 | 1997-08-12 | The Procter & Gamble Company | Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery |
| US5651983A (en) * | 1993-02-26 | 1997-07-29 | The Procter & Gamble Company | Bisacodyl dosage form for colonic delivery |
| US5686105A (en) | 1993-10-19 | 1997-11-11 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| JP3725539B2 (ja) | 1993-02-26 | 2005-12-14 | 大正製薬株式会社 | ビサコジル剤形 |
| PT621032E (pt) | 1993-04-23 | 2001-01-31 | Novartis Ag | Dispositivo de distribuicao de libertacao controlada de farmaco |
| DE4329503A1 (de) | 1993-09-01 | 1995-03-02 | Galenik Labor Freiburg Gmbh | Pharmazeutische Präparate zur gezielten Behandlung von Morbus Crohn und Colitis Ulcerosa |
| US5514663A (en) | 1993-10-19 | 1996-05-07 | The Procter & Gamble Company | Senna dosage form |
| AU7961094A (en) | 1993-10-19 | 1995-05-08 | Procter & Gamble Company, The | Picosulphate dosage form |
| WO1995014037A1 (en) * | 1993-11-17 | 1995-05-26 | Ibah, Inc. | Transparent liquid for encapsulated drug delivery |
| US5482718A (en) | 1994-03-23 | 1996-01-09 | Hoffmann-La Roche Inc. | Colon-targeted delivery system |
| US5686106A (en) | 1995-05-17 | 1997-11-11 | The Procter & Gamble Company | Pharmaceutical dosage form for colonic delivery |
| US5891474A (en) * | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
-
1994
- 1994-06-21 GB GB9412394A patent/GB9412394D0/en active Pending
-
1995
- 1995-06-21 EP EP95922632A patent/EP0810857B1/en not_active Expired - Lifetime
- 1995-06-21 JP JP8501842A patent/JP2986217B2/ja not_active Expired - Lifetime
- 1995-06-21 ES ES95922632T patent/ES2162922T3/es not_active Expired - Lifetime
- 1995-06-21 US US08/765,347 patent/US6228396B1/en not_active Expired - Lifetime
- 1995-06-21 DE DE69522475T patent/DE69522475T2/de not_active Expired - Lifetime
- 1995-06-21 CA CA002193481A patent/CA2193481C/en not_active Expired - Lifetime
- 1995-06-21 WO PCT/GB1995/001458 patent/WO1995035100A1/en active IP Right Grant
- 1995-06-21 PT PT95922632T patent/PT810857E/pt unknown
- 1995-06-21 AU AU27460/95A patent/AU688060B2/en not_active Expired
- 1995-06-21 AT AT95922632T patent/ATE204751T1/de active
- 1995-06-21 DK DK95922632T patent/DK0810857T3/da active
-
1996
- 1996-12-18 NO NO19965436A patent/NO315686B1/no not_active IP Right Cessation
- 1996-12-20 FI FI965154A patent/FI118626B/fi not_active IP Right Cessation
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2000
- 2000-12-27 US US09/749,152 patent/US20010026807A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20010026807A1 (en) | 2001-10-04 |
| US6228396B1 (en) | 2001-05-08 |
| ES2162922T3 (es) | 2002-01-16 |
| PT810857E (pt) | 2001-12-28 |
| AU688060B2 (en) | 1998-03-05 |
| EP0810857A1 (en) | 1997-12-10 |
| WO1995035100A1 (en) | 1995-12-28 |
| GB9412394D0 (en) | 1994-08-10 |
| CA2193481C (en) | 2001-03-20 |
| DE69522475T2 (de) | 2002-05-08 |
| NO965436L (no) | 1996-12-18 |
| FI118626B (fi) | 2008-01-31 |
| NO965436D0 (no) | 1996-12-18 |
| JPH09510478A (ja) | 1997-10-21 |
| ATE204751T1 (de) | 2001-09-15 |
| FI965154A (fi) | 1997-02-20 |
| CA2193481A1 (en) | 1995-12-28 |
| DK0810857T3 (da) | 2001-10-08 |
| DE69522475D1 (de) | 2001-10-04 |
| AU2746095A (en) | 1996-01-15 |
| FI965154A0 (fi) | 1996-12-20 |
| JP2986217B2 (ja) | 1999-12-06 |
| EP0810857B1 (en) | 2001-08-29 |
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| MK1K | Patent expired |