NO315050B1 - Kapsiddannende og cysteinmodifisert kim¶rt MS2-kappeprotein - Google Patents
Kapsiddannende og cysteinmodifisert kim¶rt MS2-kappeprotein Download PDFInfo
- Publication number
- NO315050B1 NO315050B1 NO19934842A NO934842A NO315050B1 NO 315050 B1 NO315050 B1 NO 315050B1 NO 19934842 A NO19934842 A NO 19934842A NO 934842 A NO934842 A NO 934842A NO 315050 B1 NO315050 B1 NO 315050B1
- Authority
- NO
- Norway
- Prior art keywords
- coat protein
- modified
- protein according
- cysteine
- cysteine residue
- Prior art date
Links
- 101710132601 Capsid protein Proteins 0.000 title claims abstract description 65
- 101710094648 Coat protein Proteins 0.000 title claims abstract description 65
- 101710125418 Major capsid protein Proteins 0.000 title claims abstract description 65
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- 101710083689 Probable capsid protein Proteins 0.000 title claims abstract description 65
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- 125000006850 spacer group Chemical group 0.000 claims description 7
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- JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919114003A GB9114003D0 (en) | 1991-06-28 | 1991-06-28 | Chimaeric protein |
| PCT/GB1992/001159 WO1993000434A1 (en) | 1991-06-28 | 1992-06-26 | Capsid forming and cystein modified chimaeric ms2-coat protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO934842D0 NO934842D0 (no) | 1993-12-27 |
| NO934842L NO934842L (no) | 1994-02-28 |
| NO315050B1 true NO315050B1 (no) | 2003-06-30 |
Family
ID=10697502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19934842A NO315050B1 (no) | 1991-06-28 | 1993-12-27 | Kapsiddannende og cysteinmodifisert kim¶rt MS2-kappeprotein |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5698424A (de) |
| EP (1) | EP0591369B1 (de) |
| JP (1) | JP3514755B2 (de) |
| KR (1) | KR100222163B1 (de) |
| AT (1) | ATE205880T1 (de) |
| AU (1) | AU657560B2 (de) |
| CA (1) | CA2111683A1 (de) |
| DE (1) | DE69232069T2 (de) |
| FI (1) | FI110613B (de) |
| GB (2) | GB9114003D0 (de) |
| IE (1) | IE922085A1 (de) |
| NO (1) | NO315050B1 (de) |
| NZ (1) | NZ243330A (de) |
| WO (1) | WO1993000434A1 (de) |
| ZA (1) | ZA924774B (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9213601D0 (en) * | 1992-06-26 | 1992-08-12 | Mastico Robert A | Protein based delivery system |
| DE19618797C2 (de) * | 1996-05-10 | 2000-03-23 | Bertling Wolf | Vehikel zum Transport molekularer Substanz |
| DE69929232T2 (de) * | 1998-10-21 | 2006-08-31 | The United States Government As Represented By The Department Of Health And Human Services | Virusähnliche partikel zur induktion von autoantikörpern |
| PL192016B1 (pl) * | 1998-11-30 | 2006-08-31 | Cytos Biotechnology Ag | Kompozycja, sposób wytwarzania sztucznego, uporządkowanego i powtarzalnego układu antygenu, zastosowanie kompozycji oraz kompozycja szczepionki |
| DE19916224C1 (de) | 1999-04-10 | 2000-06-21 | November Ag Molekulare Medizin | Synthetisches biologisch aktives Molekül |
| PT1144607E (pt) * | 1999-07-20 | 2009-04-22 | Morphosys Ag | Novos métodos para apresentar (poli)peptídeos/ proteínas em partículas bacteriofágicas através de ligações dissulfureto |
| AU2001252458A1 (en) | 2000-05-05 | 2001-11-20 | Martin Bachmann | Molecular antigen arrays and vaccines |
| US7094409B2 (en) * | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| AU2007202761B2 (en) * | 2001-01-19 | 2010-01-21 | Kuros Biosciences Ag | Molecular antigen array |
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| CA2492823A1 (en) * | 2001-09-14 | 2003-03-27 | Martin F. Bachmann | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| WO2003024481A2 (en) | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
| BR0213117A (pt) | 2001-10-05 | 2004-09-21 | Cytos Biotechnology Ag | Conjugados peptìdeo angiotensina-veìculo e seus usos |
| US7115266B2 (en) * | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| MXPA04003900A (es) * | 2001-11-07 | 2004-07-08 | Cytos Biotechnology Ag | Disposiciones de antigenos para el tratamiento de enfermedades oseas. |
| US20030219459A1 (en) * | 2002-01-18 | 2003-11-27 | Cytos Biotechnology Ag | Prion protein carrier-conjugates |
| CN1662253A (zh) * | 2002-06-20 | 2005-08-31 | 赛托斯生物技术公司 | 用作佐剂的包装的病毒样颗粒:制备方法与用途 |
| NZ538083A (en) * | 2002-07-17 | 2006-08-31 | Cytos Biotechnology Ag | Molecular antigen arrays using a virus like particle derived from the AP205 coat protein |
| BR0312297A (pt) * | 2002-07-18 | 2005-04-12 | Cytos Biotechnology Ag | Conjugados veìculos de hapteno e seu uso |
| BR0312792A (pt) * | 2002-07-19 | 2005-05-03 | Cytos Biotechnology Ag | Composições de vacinas contendo séries antigênicas de amilóide beta1-6 |
| US20060210588A1 (en) * | 2003-03-26 | 2006-09-21 | Cytos Biotechnology Ag | Hiv-peptide-carrier-conjugates |
| AU2004224762B2 (en) * | 2003-03-26 | 2009-12-24 | Kuros Us Llc | Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use |
| US7537767B2 (en) * | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| US20050191317A1 (en) * | 2004-01-20 | 2005-09-01 | Cytos Biotechnology Ag | Ghrelin-carrier conjugates |
| MXPA06013854A (es) * | 2004-06-02 | 2007-03-02 | Cytos Biotechnology Ag | Usos medicos de conjugados portadores de peptidos del factor de necrosis tumoral, no humanos. |
| EP1812051A2 (de) * | 2004-10-05 | 2007-08-01 | Cytos Biotechnology AG | Vlp-antigen-konjugate und ihre verwendung als vakzine |
| KR20070073896A (ko) * | 2004-10-25 | 2007-07-10 | 사이토스 바이오테크놀로지 아게 | 위 억제 폴리펩티드(ｇｉｐ) 항원 어레이 및 그의 용도 |
| GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| EP1855723B1 (de) * | 2005-03-08 | 2013-05-22 | Ramot at Tel-Aviv University Ltd. | Zielgerichtete arzneistofftragende bakteriophagen |
| ZA200707413B (en) * | 2005-03-18 | 2009-01-28 | Cytos Biotechnology Ag | Cat allergen fusion proteins and uses thereof |
| AU2006298767B2 (en) | 2005-09-28 | 2013-01-10 | Cytos Biotechnology Ag | Interleukin-1 conjugates and uses thereof |
| CA2636139A1 (en) | 2005-12-14 | 2007-06-21 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| RU2476595C2 (ru) | 2006-06-12 | 2013-02-27 | Цитос Биотехнологи Аг | Способы упаковки олигонуклеотидов в вирусоподобные частицы рнк-содержащих бактериофагов |
| JP2011504722A (ja) * | 2007-08-21 | 2011-02-17 | モルフォシス・アー・ゲー | ジスルフィド結合形成のための改良された方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9101550D0 (en) * | 1991-01-24 | 1991-03-06 | Mastico Robert A | Antigen-presenting chimaeric protein |
-
1991
- 1991-06-28 GB GB919114003A patent/GB9114003D0/en active Pending
-
1992
- 1992-06-26 AU AU21955/92A patent/AU657560B2/en not_active Ceased
- 1992-06-26 JP JP50123093A patent/JP3514755B2/ja not_active Expired - Fee Related
- 1992-06-26 NZ NZ243330A patent/NZ243330A/en unknown
- 1992-06-26 KR KR1019930703986A patent/KR100222163B1/ko not_active IP Right Cessation
- 1992-06-26 CA CA002111683A patent/CA2111683A1/en not_active Abandoned
- 1992-06-26 GB GB9213644A patent/GB2257431B/en not_active Revoked
- 1992-06-26 ZA ZA924774A patent/ZA924774B/xx unknown
- 1992-06-26 DE DE69232069T patent/DE69232069T2/de not_active Expired - Fee Related
- 1992-06-26 WO PCT/GB1992/001159 patent/WO1993000434A1/en active IP Right Grant
- 1992-06-26 AT AT92913894T patent/ATE205880T1/de not_active IP Right Cessation
- 1992-06-26 US US08/167,982 patent/US5698424A/en not_active Expired - Fee Related
- 1992-06-26 EP EP92913894A patent/EP0591369B1/de not_active Expired - Lifetime
- 1992-07-01 IE IE208592A patent/IE922085A1/en not_active Application Discontinuation
-
1993
- 1993-12-27 FI FI935877A patent/FI110613B/fi active
- 1993-12-27 NO NO19934842A patent/NO315050B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI110613B (fi) | 2003-02-28 |
| AU2195592A (en) | 1993-01-25 |
| JP3514755B2 (ja) | 2004-03-31 |
| ZA924774B (en) | 1993-04-22 |
| CA2111683A1 (en) | 1993-01-07 |
| DE69232069T2 (de) | 2002-01-31 |
| WO1993000434A1 (en) | 1993-01-07 |
| FI935877A0 (fi) | 1993-12-27 |
| AU657560B2 (en) | 1995-03-16 |
| NO934842L (no) | 1994-02-28 |
| ATE205880T1 (de) | 2001-10-15 |
| DE69232069D1 (de) | 2001-10-25 |
| US5698424A (en) | 1997-12-16 |
| EP0591369A1 (de) | 1994-04-13 |
| GB9114003D0 (en) | 1991-08-14 |
| JPH06509223A (ja) | 1994-10-20 |
| GB2257431B (en) | 1995-04-19 |
| GB2257431A (en) | 1993-01-13 |
| IE922085A1 (en) | 1992-12-30 |
| KR940701447A (ko) | 1994-05-28 |
| EP0591369B1 (de) | 2001-09-19 |
| FI935877A (fi) | 1993-12-27 |
| NZ243330A (en) | 1994-06-27 |
| KR100222163B1 (ko) | 1999-10-01 |
| NO934842D0 (no) | 1993-12-27 |
| GB9213644D0 (en) | 1992-08-12 |
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