NO314264B1 - Etylenglykolestere av monohydrobenzoporfyrinderivater, anvendelse derav samt farmasöytisk blanding - Google Patents
Etylenglykolestere av monohydrobenzoporfyrinderivater, anvendelse derav samt farmasöytisk blanding Download PDFInfo
- Publication number
- NO314264B1 NO314264B1 NO19995436A NO995436A NO314264B1 NO 314264 B1 NO314264 B1 NO 314264B1 NO 19995436 A NO19995436 A NO 19995436A NO 995436 A NO995436 A NO 995436A NO 314264 B1 NO314264 B1 NO 314264B1
- Authority
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- Norway
- Prior art keywords
- bpd
- compound according
- cells
- vinyl
- compounds
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Links
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical class OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 title description 10
- PLVAJLBZYYGQNL-UHFFFAOYSA-N C12CC=C(N1)C=C1C=CC(=N1)C=C1C=CC(N1)=CC=1C3=C(C(N=1)=C2)C=CC=C3 Chemical class C12CC=C(N1)C=C1C=CC(=N1)C=C1C=CC(N1)=CC=1C3=C(C(N=1)=C2)C=CC=C3 PLVAJLBZYYGQNL-UHFFFAOYSA-N 0.000 title description 3
- 239000008194 pharmaceutical composition Substances 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 54
- 238000002428 photodynamic therapy Methods 0.000 claims description 25
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 9
- 229920002554 vinyl polymer Polymers 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 150000002367 halogens Chemical class 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 4
- 229910021645 metal ion Inorganic materials 0.000 claims description 4
- 230000003647 oxidation Effects 0.000 claims description 4
- 238000007254 oxidation reaction Methods 0.000 claims description 4
- 238000001212 derivatisation Methods 0.000 claims description 2
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
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- LOTKRQAVGJMPNV-UHFFFAOYSA-N 1-fluoro-2,4-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(F)C([N+]([O-])=O)=C1 LOTKRQAVGJMPNV-UHFFFAOYSA-N 0.000 description 3
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- UJKPHYRXOLRVJJ-MLSVHJFASA-N CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C Chemical compound CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C UJKPHYRXOLRVJJ-MLSVHJFASA-N 0.000 description 2
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- HXYIQMHXZZPHNJ-UHFFFAOYSA-N protoporphyrin xiii Chemical compound N1C(C=C2C(=C(C=C)C(C=C3C(=C(CCC(=O)OC)C(=C4)N3)C)=N2)C)=C(C)C(C=C)=C1C=C1C(C)=C(CCC(=O)OC)C4=N1 HXYIQMHXZZPHNJ-UHFFFAOYSA-N 0.000 description 2
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- 229920006395 saturated elastomer Polymers 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 125000000143 2-carboxyethyl group Chemical group [H]OC(=O)C([H])([H])C([H])([H])* 0.000 description 1
- MHIITNFQDPFSES-UHFFFAOYSA-N 25,26,27,28-tetrazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1(25),2,4,6,8(27),9,11,13,15,17,19,21,23-tridecaene Chemical class N1C(C=C2C3=CC=CC=C3C(C=C3NC(=C4)C=C3)=N2)=CC=C1C=C1C=CC4=N1 MHIITNFQDPFSES-UHFFFAOYSA-N 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 description 1
- 108010045100 HSP27 Heat-Shock Proteins Proteins 0.000 description 1
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- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 1
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- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
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- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 1
- 102100023132 Transcription factor Jun Human genes 0.000 description 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
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- 125000003545 alkoxy group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
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- 229910052738 indium Inorganic materials 0.000 description 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
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- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
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- 239000012044 organic layer Substances 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
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- 125000005493 quinolyl group Chemical group 0.000 description 1
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- 208000037803 restenosis Diseases 0.000 description 1
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- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85249497A | 1997-05-07 | 1997-05-07 | |
| PCT/CA1998/000468 WO1998050387A1 (en) | 1997-05-07 | 1998-05-06 | Ethylene glycol esters of monohydrobenzoporphyrin derivatives as photoactive agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO995436D0 NO995436D0 (no) | 1999-11-05 |
| NO995436L NO995436L (no) | 2000-01-04 |
| NO314264B1 true NO314264B1 (no) | 2003-02-24 |
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| NO19995436A NO314264B1 (no) | 1997-05-07 | 1999-11-05 | Etylenglykolestere av monohydrobenzoporfyrinderivater, anvendelse derav samt farmasöytisk blanding |
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|---|---|
| US (2) | US5929105A (de) |
| EP (2) | EP0983273B8 (de) |
| JP (1) | JP3378889B2 (de) |
| KR (1) | KR100397131B1 (de) |
| CN (1) | CN1113882C (de) |
| AR (1) | AR012673A1 (de) |
| AT (1) | ATE211473T1 (de) |
| AU (1) | AU741070B2 (de) |
| CA (1) | CA2284879C (de) |
| CZ (1) | CZ294715B6 (de) |
| DE (1) | DE69803376T2 (de) |
| DK (1) | DK0983273T3 (de) |
| ES (2) | ES2437790T3 (de) |
| HK (1) | HK1042439B (de) |
| HU (1) | HU221754B1 (de) |
| IL (1) | IL132066A (de) |
| NO (1) | NO314264B1 (de) |
| NZ (1) | NZ338031A (de) |
| PL (1) | PL202341B1 (de) |
| PT (1) | PT983273E (de) |
| WO (1) | WO1998050387A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756396B1 (en) * | 1997-05-07 | 2004-06-29 | Qlt Inc. | Ethylene glycol esters as photoactive agents |
| US6364907B1 (en) | 1998-10-09 | 2002-04-02 | Qlt Inc. | Method to prevent xenograft transplant rejection |
| US6331235B1 (en) * | 1998-12-11 | 2001-12-18 | The University Of British Columbia | Chiral separation of benzoporphyrin derivative mono-and di-acids by laser-induced fluorescence capillary electrophoresis |
| US6344050B1 (en) | 1998-12-21 | 2002-02-05 | Light Sciences Corporation | Use of pegylated photosensitizer conjugated with an antibody for treating abnormal tissue |
| CA2356532A1 (en) * | 1999-01-15 | 2000-07-20 | Light Sciences Corporation | Noninvasive vascular therapy |
| US6602274B1 (en) * | 1999-01-15 | 2003-08-05 | Light Sciences Corporation | Targeted transcutaneous cancer therapy |
| AU2789900A (en) * | 1999-02-26 | 2000-09-21 | Qlt Phototherapeutics, Inc. | Photodynamic therapy in combination with apoptosis inducing factors |
| GB9905911D0 (en) | 1999-03-15 | 1999-05-05 | Photocure As | Method |
| US6609014B1 (en) | 1999-04-14 | 2003-08-19 | Qlt Inc. | Use of PDT to inhibit intimal hyperplasia |
| US20020022032A1 (en) * | 1999-04-23 | 2002-02-21 | Curry Patrick Mark | Immuno-adjuvant PDT treatment of metastatic tumors |
| US7122568B1 (en) | 1999-11-17 | 2006-10-17 | Qlt, Inc. | Use of low-dose PDT to inhibit restenosis |
| US20040208855A1 (en) * | 1999-11-17 | 2004-10-21 | Allison Beth Anne | Use of PDT to inhibit intimal hyperplasia |
| WO2001051087A2 (en) * | 2000-01-12 | 2001-07-19 | Light Sciences Corporation | Novel treatment for eye disease |
| WO2001085213A2 (en) | 2000-05-08 | 2001-11-15 | The University Of British Columbia | Supports for photosensitizer formulations |
| AU2001258095A1 (en) | 2000-05-08 | 2001-11-20 | The University Of British Columbia | Drug delivery systems for photodynamic therapy |
| AU2002220853B2 (en) * | 2000-11-29 | 2007-06-28 | Pci Biotech As | Photochemical internalization for delivery of molecules into the cytosol |
| AU2002222104B2 (en) * | 2000-11-29 | 2007-06-28 | Pci Biotech As | Photochemical internalization for virus-mediated molecule delivery into the cyosol |
| US6984395B2 (en) * | 2001-04-11 | 2006-01-10 | Qlt, Inc. | Drug delivery system for hydrophobic drugs |
| EP1401506A4 (de) * | 2001-05-31 | 2005-02-16 | Miravant Pharm Inc | Lichtsensibilisierende metallotetrapyrrol-mittel zur verwendung in der photodynamischen therapie |
| EP1424942B1 (de) * | 2001-08-22 | 2008-12-31 | Montana State University-Bozeman | Porphyrine mit verbesserten multi-photonen-absorptionsquerschnitten für die photodynamische therapie |
| EP1465590B1 (de) * | 2001-11-02 | 2008-03-26 | The Governors Of The University Of Alberta | Micelle-zusammensetzungen enthaltend pegylierten phospholipide und einen photosensibilisator |
| US7264629B2 (en) | 2001-11-09 | 2007-09-04 | Qlt, Inc. | Photodynamic therapy for the treatment of hair loss |
| WO2003039596A1 (en) * | 2001-11-09 | 2003-05-15 | Qlt Inc. | Photodynamic therapy for the treatment of hair loss |
| CA2437638A1 (en) * | 2003-08-20 | 2005-02-20 | John Robert North | Photodynamic therapy |
| CA2457214A1 (en) | 2004-02-06 | 2005-08-06 | Qlt Inc. | Photodynamic therapy for the treatment of acne |
| US20110070154A1 (en) * | 2008-08-13 | 2011-03-24 | Hyde Roderick A | Artificial cells |
| EP2451796B1 (de) | 2009-07-08 | 2013-04-17 | Dermira (Canada), Inc. | Tofa-analoga zur behandlung von hauterkrankungen oder -störungen |
| DK2531206T3 (en) | 2010-02-04 | 2017-09-11 | Morphotek Inc | CHLOROTOXIN POLYPEPTIDES AND CONJUGATES AND USE THEREOF |
| EP2663285A2 (de) | 2011-01-13 | 2013-11-20 | Qlt Inc. | Pharmazeutische zusammensetzungen für die topische verabreichung von photosensibilisatoren und ihre verwendung |
| WO2013003507A1 (en) | 2011-06-27 | 2013-01-03 | Morphotek, Inc. | Multifunctional agents |
| CA2853705C (en) | 2011-10-25 | 2021-10-12 | Memorial Sloan-Kettering Cancer Center | Free psa antibodies as diagnostics, prognostics and therapeutics for prostate cancer |
| BR112015000383A2 (pt) | 2012-07-11 | 2017-06-27 | Dermira Inc | composição farmacêutica, e, métodos para preparação de uma composição farmacêutica, para reduzir a taxa de excreção de sebo das glândulas sebáceas na pele de um indivíduo e para tratamento da acne |
| AU2013334102B2 (en) | 2012-10-26 | 2018-08-16 | Memorial Sloan-Kettering Cancer Center | Modulators of resistant androgen receptor |
| EP3087182B1 (de) | 2013-12-23 | 2019-03-20 | Memorial Sloan-Kettering Cancer Center | Verfahren und zusammensetzungen zur behandlung von krebs unter verwendung von peptidnukleinsäurebasiertem wirkstoff |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4920143A (en) * | 1987-04-23 | 1990-04-24 | University Of British Columbia | Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents |
| US5095030A (en) * | 1987-01-20 | 1992-03-10 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| US5171749A (en) | 1987-01-20 | 1992-12-15 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| US4883790A (en) | 1987-01-20 | 1989-11-28 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| US5283255A (en) * | 1987-01-20 | 1994-02-01 | The University Of British Columbia | Wavelength-specific cytotoxic agents |
| CA2056431A1 (en) * | 1989-06-07 | 1990-12-08 | David Dolphin | Photosensitizing diels-alder porphyrin derivatives |
| US5498710A (en) * | 1994-04-22 | 1996-03-12 | Health Research, Inc. | Alkyl ether analogues of benzoporphyrin derivatives |
| PL202340B1 (pl) * | 1997-05-07 | 2009-06-30 | Univ British Columbia | Pochodna benzoporfiryny, sposób jej wytwarzania, kompozycja farmaceutyczna ją zawierająca oraz jej zastosowanie jako czynnika fotoaktywnego |
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1998
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- 1998-05-06 HU HU0003604A patent/HU221754B1/hu not_active IP Right Cessation
- 1998-05-06 CN CN98804737A patent/CN1113882C/zh not_active Expired - Fee Related
- 1998-05-06 CA CA002284879A patent/CA2284879C/en not_active Expired - Fee Related
- 1998-05-06 DE DE69803376T patent/DE69803376T2/de not_active Expired - Lifetime
- 1998-05-06 EP EP01121719.7A patent/EP1177795B1/de not_active Expired - Lifetime
- 1998-05-06 AT AT98921294T patent/ATE211473T1/de active
- 1998-05-06 NZ NZ338031A patent/NZ338031A/en not_active IP Right Cessation
- 1998-05-06 WO PCT/CA1998/000468 patent/WO1998050387A1/en active IP Right Grant
- 1998-05-06 JP JP54758598A patent/JP3378889B2/ja not_active Expired - Fee Related
- 1998-05-06 PT PT98921294T patent/PT983273E/pt unknown
- 1998-05-06 KR KR10-1999-7010283A patent/KR100397131B1/ko not_active IP Right Cessation
- 1998-05-06 ES ES01121719.7T patent/ES2437790T3/es not_active Expired - Lifetime
- 1998-05-06 PL PL336790A patent/PL202341B1/pl unknown
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- 1998-05-06 IL IL132066A patent/IL132066A/en not_active IP Right Cessation
- 1998-05-06 AU AU74207/98A patent/AU741070B2/en not_active Ceased
- 1998-05-06 DK DK98921294T patent/DK0983273T3/da active
- 1998-05-07 AR ARP980102133A patent/AR012673A1/es active IP Right Grant
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1999
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- 1999-11-05 NO NO19995436A patent/NO314264B1/no not_active IP Right Cessation
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Owner name: THE UNIVERSITY OF BRITISH COLUMBIA, CA |
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| MM1K | Lapsed by not paying the annual fees |