NO313961B1 - IL-8-reseptor-antagonister, anvendelse derav samt farmasöytiske preparater - Google Patents
IL-8-reseptor-antagonister, anvendelse derav samt farmasöytiske preparater Download PDFInfo
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- NO313961B1 NO313961B1 NO19993586A NO993586A NO313961B1 NO 313961 B1 NO313961 B1 NO 313961B1 NO 19993586 A NO19993586 A NO 19993586A NO 993586 A NO993586 A NO 993586A NO 313961 B1 NO313961 B1 NO 313961B1
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- Prior art keywords
- urea
- cyano
- bromophenyl
- benzimidazolin
- mmol
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Classifications
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- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3599197P | 1997-01-23 | 1997-01-23 | |
| US4282997P | 1997-04-08 | 1997-04-08 | |
| PCT/US1998/001291 WO1998032439A1 (en) | 1997-01-23 | 1998-01-23 | Il-8 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO993586D0 NO993586D0 (no) | 1999-07-22 |
| NO993586L NO993586L (no) | 1999-09-21 |
| NO313961B1 true NO313961B1 (no) | 2003-01-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19993586A NO313961B1 (no) | 1997-01-23 | 1999-07-22 | IL-8-reseptor-antagonister, anvendelse derav samt farmasöytiske preparater |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6300325B1 (hu) |
| EP (1) | EP0991406A4 (hu) |
| JP (1) | JP2001511130A (hu) |
| KR (1) | KR20000070368A (hu) |
| CN (1) | CN1217660C (hu) |
| AU (1) | AU726858B2 (hu) |
| BR (1) | BR9807083A (hu) |
| CA (1) | CA2278504A1 (hu) |
| HU (1) | HUP0001943A3 (hu) |
| IL (1) | IL131004A0 (hu) |
| NO (1) | NO313961B1 (hu) |
| NZ (1) | NZ336861A (hu) |
| PL (1) | PL334756A1 (hu) |
| TR (1) | TR199901710T2 (hu) |
| WO (1) | WO1998032439A1 (hu) |
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| JP2000513360A (ja) | 1996-06-27 | 2000-10-10 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ―８レセプターアンタゴニスト |
| JP2002518300A (ja) * | 1998-06-17 | 2002-06-25 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体アンタゴニスト |
| DE19842363A1 (de) * | 1998-09-16 | 2000-03-30 | Forssmann Wolf Georg | Verwendung von Chemokinen zur Stammzellmobilisation und von Chemokin-Antagonisten zur Vermeidung von Tumormetastasierung |
| CA2359244C (en) | 1999-01-13 | 2013-10-08 | Bayer Corporation | .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| AR029637A1 (es) * | 1999-05-28 | 2003-07-10 | Smithkline Beecham Corp | Compuestos de guanidina, antagonistas de los receptores de la il-8, una composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de un medicamento |
| CO5190696A1 (es) * | 1999-06-16 | 2002-08-29 | Smithkline Beecham Corp | Antagonistas de los receptores il-8 |
| DE10038709A1 (de) * | 2000-08-09 | 2002-02-28 | Aventis Pharma Gmbh | Substituierte und unsubstituierte Benzooxathiazole sowie daraus abgeleitete Verbindungen |
| US20030204085A1 (en) * | 2001-02-02 | 2003-10-30 | Taveras Arthur G. | 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists |
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US7132445B2 (en) * | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| EP1598339B1 (en) | 2001-04-18 | 2009-06-24 | Euro-Celtique S.A. | 1-(4-amino-cyclohexyl)-1,3-dihydro-2h-benzimidazole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain |
| MXPA04003439A (es) * | 2001-10-12 | 2004-07-08 | Schering Corp | Compuestos de maleimida 3,4 disustituidos como antagonistas de receptor de quimiocina cxc. |
| US6878709B2 (en) * | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
| WO2003068229A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
| DK1478358T3 (da) | 2002-02-11 | 2013-10-07 | Bayer Healthcare Llc | Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese |
| NZ535314A (en) * | 2002-03-18 | 2007-08-31 | Schering Corp | Combination treatments for chemokine-mediated diseases |
| US7115644B2 (en) * | 2002-09-13 | 2006-10-03 | Boehringer Ingelheim Pharmaceuticals Inc. | Heterocyclic compounds |
| ATE422203T1 (de) * | 2002-10-09 | 2009-02-15 | Schering Corp | Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden |
| TW200418812A (en) * | 2002-10-29 | 2004-10-01 | Smithkline Beecham Corp | IL-8 receptor antagonists |
| PT1626714E (pt) | 2003-05-20 | 2007-08-24 | Bayer Pharmaceuticals Corp | Diarilureias para doenças mediadas por pdgfr |
| ES2297490T3 (es) | 2003-07-23 | 2008-05-01 | Bayer Pharmaceuticals Corporation | Omega-carboxiarildifenilurea fluoro sustituida para el tratamiento y prevencion de enfermadades y afecciones. |
| MXPA06007076A (es) * | 2003-12-19 | 2006-08-31 | Pharmacopeia Drug Discovery | Tiadiazoles como ligandos del receptor cxc y cc-quimiocina. |
| JP4851943B2 (ja) * | 2003-12-22 | 2012-01-11 | シェーリング コーポレイション | Ｃｘｃ−ケモカインレセプターリガンドおよびｃｃ−ケモカインレセプターリガンドとしてのイソチアゾールジオキシド |
| GB0403038D0 (en) | 2004-02-11 | 2004-03-17 | Novartis Ag | Organic compounds |
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| JP2008517930A (ja) * | 2004-10-21 | 2008-05-29 | トランス テック ファーマ，インコーポレイテッド | ＧａｌＲ１のアゴニストとしてのビススルホンアミド化合物、組成物、及び使用法 |
| JP2009500328A (ja) * | 2005-06-29 | 2009-01-08 | シェーリング コーポレイション | Ｃｘｃ−ケモカインレセプターリガンドとしての５，６−ジ−置換オキサジアゾロピラジンおよびチアジアゾロピラジン |
| EP1912971A2 (en) * | 2005-06-29 | 2008-04-23 | Shering Corporation | Di-substituted oxadiazoles as cxc-chemokine receptor ligands |
| AU2007240364A1 (en) * | 2006-04-21 | 2007-11-01 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| UA98456C2 (en) * | 2006-04-21 | 2012-05-25 | Смитклайн Бичам Корпорейшн | Il-8 receptor antagonists |
| AR061571A1 (es) * | 2006-06-23 | 2008-09-03 | Smithkline Beecham Corp | Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un |
| RU2009103999A (ru) * | 2006-07-07 | 2010-08-20 | Шеринг Корпорейшн (US) | 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс-хемокиновых рецепторов |
| BR112012003462A2 (pt) | 2009-08-24 | 2016-02-23 | Ascepion Pharmaceuticals Inc | "composto, composição farmacêutica, e, método para tratar um paciente tendo uma condição mediada pela proteína quinase." |
| CN111362878B (zh) * | 2020-03-18 | 2023-09-19 | 湖南复瑞生物医药技术有限责任公司 | 一种4-氨基-1,3-二氢-苯并咪唑-2-酮的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK160941C (da) * | 1988-06-28 | 1991-10-21 | Novo Nordisk As | Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar |
| JPH11503110A (ja) * | 1995-02-17 | 1999-03-23 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体拮抗剤 |
| WO1997049287A1 (en) | 1996-06-27 | 1997-12-31 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| EP0907362A4 (en) * | 1996-06-27 | 1999-12-01 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
-
1998
- 1998-01-23 EP EP98905988A patent/EP0991406A4/en not_active Withdrawn
- 1998-01-23 CN CN988035650A patent/CN1217660C/zh not_active Expired - Fee Related
- 1998-01-23 JP JP53213898A patent/JP2001511130A/ja not_active Ceased
- 1998-01-23 IL IL13100498A patent/IL131004A0/xx unknown
- 1998-01-23 CA CA002278504A patent/CA2278504A1/en not_active Abandoned
- 1998-01-23 WO PCT/US1998/001291 patent/WO1998032439A1/en not_active Application Discontinuation
- 1998-01-23 PL PL98334756A patent/PL334756A1/xx unknown
- 1998-01-23 KR KR1019997006601A patent/KR20000070368A/ko not_active Application Discontinuation
- 1998-01-23 US US09/341,378 patent/US6300325B1/en not_active Expired - Fee Related
- 1998-01-23 TR TR1999/01710T patent/TR199901710T2/xx unknown
- 1998-01-23 AU AU61339/98A patent/AU726858B2/en not_active Ceased
- 1998-01-23 BR BR9807083-5A patent/BR9807083A/pt not_active Application Discontinuation
- 1998-01-23 NZ NZ336861A patent/NZ336861A/xx unknown
- 1998-01-23 HU HU0001943A patent/HUP0001943A3/hu unknown
-
1999
- 1999-07-22 NO NO19993586A patent/NO313961B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU6133998A (en) | 1998-08-18 |
| EP0991406A1 (en) | 2000-04-12 |
| EP0991406A4 (en) | 2000-12-13 |
| US6300325B1 (en) | 2001-10-09 |
| TR199901710T2 (xx) | 1999-09-21 |
| HUP0001943A2 (hu) | 2001-01-29 |
| KR20000070368A (ko) | 2000-11-25 |
| AU726858B2 (en) | 2000-11-23 |
| CA2278504A1 (en) | 1998-07-30 |
| PL334756A1 (en) | 2000-03-13 |
| NZ336861A (en) | 2001-01-26 |
| CN1217660C (zh) | 2005-09-07 |
| WO1998032439A1 (en) | 1998-07-30 |
| BR9807083A (pt) | 2000-04-18 |
| IL131004A0 (en) | 2001-01-28 |
| CN1251038A (zh) | 2000-04-19 |
| JP2001511130A (ja) | 2001-08-07 |
| NO993586L (no) | 1999-09-21 |
| NO993586D0 (no) | 1999-07-22 |
| HUP0001943A3 (en) | 2002-12-28 |
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