NO313517B1 - 6-Fenylpyridyl-2-aminderivater, anvendelse av disse og farmasöytiske preparater inneholdende dem - Google Patents
6-Fenylpyridyl-2-aminderivater, anvendelse av disse og farmasöytiske preparater inneholdende dem Download PDFInfo
- Publication number
- NO313517B1 NO313517B1 NO19992725A NO992725A NO313517B1 NO 313517 B1 NO313517 B1 NO 313517B1 NO 19992725 A NO19992725 A NO 19992725A NO 992725 A NO992725 A NO 992725A NO 313517 B1 NO313517 B1 NO 313517B1
- Authority
- NO
- Norway
- Prior art keywords
- phenyl
- ylamine
- pyridin
- alkyl
- methyl
- Prior art date
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- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 89
- -1 hydroxy, methyl Chemical group 0.000 claims description 51
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 26
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
- 125000001424 substituent group Chemical group 0.000 claims description 23
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 22
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- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims description 19
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 7
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- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 claims description 7
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 6
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- 239000000126 substance Substances 0.000 claims description 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 5
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- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims description 3
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- 125000004093 cyano group Chemical group *C#N 0.000 claims description 3
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- 125000006678 phenoxycarbonyl group Chemical group 0.000 claims description 3
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 2
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- ZOMWHUFJIVHYTM-UHFFFAOYSA-N 3-[(6-aminopyridin-2-yl)-phenylmethyl]-1-methyl-3h-indol-2-one Chemical compound C12=CC=CC=C2N(C)C(=O)C1C(C=1N=C(N)C=CC=1)C1=CC=CC=C1 ZOMWHUFJIVHYTM-UHFFFAOYSA-N 0.000 claims description 2
- AFXPRGRPBFUARV-UHFFFAOYSA-N 3-[(6-aminopyridin-2-yl)-phenylmethylidene]-1-[2-(dimethylamino)ethyl]indol-2-one Chemical compound C12=CC=CC=C2N(CCN(C)C)C(=O)C1=C(C=1N=C(N)C=CC=1)C1=CC=CC=C1 AFXPRGRPBFUARV-UHFFFAOYSA-N 0.000 claims description 2
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 2
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- JEIONJSEBLCOJW-UHFFFAOYSA-N 6-[4-[1-(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]phenyl]pyridin-2-amine Chemical compound NC1=CC=CC(C=2C=CC(=CC=2)C2CCN(CC=3C=C4OCOC4=CC=3)CC2)=N1 JEIONJSEBLCOJW-UHFFFAOYSA-N 0.000 claims 1
- ULNUZJQBLXAHCQ-UHFFFAOYSA-N 8-[4-(6-aminopyridin-2-yl)phenyl]-3-(2-methylpropyl)-3-azabicyclo[3.2.1]octan-8-ol Chemical compound C1N(CC(C)C)CC2CCC1C2(O)C(C=C1)=CC=C1C1=CC=CC(N)=N1 ULNUZJQBLXAHCQ-UHFFFAOYSA-N 0.000 claims 1
- IREJNWMYFOEDGE-UHFFFAOYSA-N 8-[4-(6-aminopyridin-2-yl)phenyl]-3-(furan-2-ylmethyl)-3-azabicyclo[3.2.1]octan-8-ol Chemical compound NC1=CC=CC(C=2C=CC(=CC=2)C2(O)C3CCC2CN(CC=2OC=CC=2)C3)=N1 IREJNWMYFOEDGE-UHFFFAOYSA-N 0.000 claims 1
- MXNCJGDSGDBEBK-UHFFFAOYSA-N 8-[4-(6-aminopyridin-2-yl)phenyl]-3-benzyl-3-azabicyclo[3.2.1]octan-8-ol Chemical compound NC1=CC=CC(C=2C=CC(=CC=2)C2(O)C3CCC2CN(CC=2C=CC=CC=2)C3)=N1 MXNCJGDSGDBEBK-UHFFFAOYSA-N 0.000 claims 1
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
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- Engineering & Computer Science (AREA)
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- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Biomedical Technology (AREA)
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- Addiction (AREA)
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- Immunology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3279396P | 1996-12-06 | 1996-12-06 | |
| PCT/IB1997/001446 WO1998024766A1 (en) | 1996-12-06 | 1997-11-17 | 6-phenylpyridyl-2-amine derivatives useful as nos inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO992725D0 NO992725D0 (no) | 1999-06-04 |
| NO992725L NO992725L (no) | 1999-06-04 |
| NO313517B1 true NO313517B1 (no) | 2002-10-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19992725A NO313517B1 (no) | 1996-12-06 | 1999-06-04 | 6-Fenylpyridyl-2-aminderivater, anvendelse av disse og farmasöytiske preparater inneholdende dem |
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| CN (1) | CN1117077C (pt) |
| AP (1) | AP848A (pt) |
| AR (1) | AR010331A1 (pt) |
| AT (1) | ATE251612T1 (pt) |
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| BR (1) | BR9714381A (pt) |
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| PE (1) | PE46499A1 (pt) |
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| PT (1) | PT946512E (pt) |
| SI (1) | SI0946512T1 (pt) |
| SK (1) | SK70899A3 (pt) |
| TN (1) | TNSN97198A1 (pt) |
| TR (1) | TR199901259T2 (pt) |
| TW (1) | TW491840B (pt) |
| UA (1) | UA59379C2 (pt) |
| UY (1) | UY24799A1 (pt) |
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| YU (1) | YU25399A (pt) |
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Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE261942T1 (de) * | 1996-03-29 | 2004-04-15 | Pfizer | 6-phenylpyridinderivate |
| HN1998000118A (es) * | 1997-08-27 | 1999-02-09 | Pfizer Prod Inc | 2 - aminopiridinas que contienen sustituyentes de anillos condensados. |
| US20010049379A1 (en) | 1997-08-27 | 2001-12-06 | Lowe John Adams | 2-aminopyridines containing fused ring substituents |
| HN1998000125A (es) * | 1997-08-28 | 1999-02-09 | Pfizer Prod Inc | 2-aminopiridinas con sustituyentes alcoxi ramificados |
| FR2780971B1 (fr) * | 1998-07-08 | 2001-09-28 | Sod Conseils Rech Applic | Nouveaux derives de 2-aminopyridines, leur application en tant que medicaments et compositions pharmaceutiques les contenant |
| FR2791674A1 (fr) * | 1999-04-02 | 2000-10-06 | Sod Conseils Rech Applic | Nouveaux derives de 2-aminopyridines, leur utilisation en tant que medicaments et compositions pharmaceutiques les contenant |
| AR019190A1 (es) * | 1998-07-08 | 2001-12-26 | Sod Conseils Rech Applic | Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos |
| AU749439B2 (en) * | 1998-08-11 | 2002-06-27 | Pfizer Products Inc. | New pharmaceutical uses for nos inhibitors |
| US7115557B2 (en) | 1998-09-25 | 2006-10-03 | Sciaticon Ab | Use of certain drugs for treating nerve root injury |
| SE9803710L (sv) | 1998-09-25 | 2000-03-26 | A & Science Invest Ab | Användning av vissa substanser för behandling av nervrotsskador |
| PT1155000E (pt) | 1999-02-25 | 2003-10-31 | Pfizer Prod Inc | 2-aminopiridinas contendo aneis fundidos substituintes |
| TR200200099T2 (tr) * | 1999-07-23 | 2002-06-21 | Shionogi &Co., Ltd. | Th2 farklılaşma inhibitörleri |
| FR2804429B1 (fr) * | 2000-01-31 | 2003-05-09 | Adir | Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6790845B2 (en) * | 2001-04-09 | 2004-09-14 | Bristol-Myers Squibb Pharma Company | Fused heterocyclic inhibitors of factor Xa |
| US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
| BRPI0409307A (pt) * | 2003-04-14 | 2006-04-25 | Pfizer Prod Inc | derivados de 3-azabiciclo[3.2.1]octano |
| CN1295216C (zh) * | 2003-07-04 | 2007-01-17 | 中国人民解放军军事医学科学院毒物药物研究所 | 吲哚酮类衍生物及其用于制备抗肿瘤药物的用途 |
| US20080070952A1 (en) * | 2005-02-21 | 2008-03-20 | Proximagen Ltd., | Inhibition or Treatment of Dyskinesia |
| WO2006105795A1 (en) * | 2005-04-08 | 2006-10-12 | Leo Pharma A/S | Novel indolinone derivatives |
| WO2008021849A2 (en) | 2006-08-09 | 2008-02-21 | Smithkline Beecham Corporation | Novel compounds as antagonists or inverse agonists at opioid receptors |
| US8981094B2 (en) | 2007-06-08 | 2015-03-17 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| US8835437B2 (en) | 2007-06-08 | 2014-09-16 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| EP2152269B1 (en) | 2007-06-08 | 2014-04-23 | Janssen Pharmaceutica, N.V. | Piperidine/piperazine derivatives |
| PE20140572A1 (es) | 2008-06-05 | 2014-05-16 | Janssen Pharmaceutica Nv | Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
| EP2404902A1 (en) * | 2009-03-05 | 2012-01-11 | Shionogi&Co., Ltd. | Piperidine and pyrrolidine derivatives having npy y5 receptor antagonism |
| US11013844B2 (en) * | 2014-11-20 | 2021-05-25 | City Of Hope | Treatment device for plasma virus inactivation |
| US10213435B2 (en) | 2016-08-12 | 2019-02-26 | Athenex, Inc. | Biaryl compositions and methods for modulating a kinase cascade |
| CA3073656C (en) | 2017-09-22 | 2024-03-05 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| CN111225915B (zh) | 2017-10-18 | 2023-03-07 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的咪唑并吡啶化合物 |
| EP3707135A1 (en) | 2017-11-06 | 2020-09-16 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation |
| BR112020010322A2 (pt) | 2017-11-24 | 2020-11-17 | Jubilant Episcribe Llc | composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer |
| SG11202008950PA (en) | 2018-03-13 | 2020-10-29 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| WO2020252383A2 (en) * | 2019-06-14 | 2020-12-17 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| US20220193058A1 (en) * | 2020-12-16 | 2022-06-23 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992014780A1 (en) | 1991-02-19 | 1992-09-03 | Akzo N.V. | Stabilized carbon monoxide-olefin copolymers |
| WO1994014780A1 (en) * | 1992-12-18 | 1994-07-07 | The Wellcome Foundation Limited | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
| US5621004A (en) | 1994-06-03 | 1997-04-15 | Robert W. Dunn | Method for treating emesis |
| AU4515696A (en) * | 1994-12-12 | 1996-07-03 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| ATE261942T1 (de) * | 1996-03-29 | 2004-04-15 | Pfizer | 6-phenylpyridinderivate |
| US6093743A (en) | 1998-06-23 | 2000-07-25 | Medinox Inc. | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor |
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