NO312510B1 - Bifenylsulfonamid matriksmetalloproteinase-inhibitorer, anvendelse derav, samt farmasöytiske formuleringer omfattende dem - Google Patents
Bifenylsulfonamid matriksmetalloproteinase-inhibitorer, anvendelse derav, samt farmasöytiske formuleringer omfattende dem Download PDFInfo
- Publication number
- NO312510B1 NO312510B1 NO19985326A NO985326A NO312510B1 NO 312510 B1 NO312510 B1 NO 312510B1 NO 19985326 A NO19985326 A NO 19985326A NO 985326 A NO985326 A NO 985326A NO 312510 B1 NO312510 B1 NO 312510B1
- Authority
- NO
- Norway
- Prior art keywords
- biphenyl
- sulfonylamino
- methyl
- butyric acid
- acid
- Prior art date
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- -1 their use Substances 0.000 title abstract description 12
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/42—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1746096P | 1996-05-17 | 1996-05-17 | |
| PCT/US1997/006801 WO1997044315A1 (en) | 1996-05-17 | 1997-04-24 | Biphenylsulfonamide matrix metalloproteinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO985326D0 NO985326D0 (no) | 1998-11-16 |
| NO985326L NO985326L (no) | 1999-01-14 |
| NO312510B1 true NO312510B1 (no) | 2002-05-21 |
Family
ID=21782716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19985326A NO312510B1 (no) | 1996-05-17 | 1998-11-16 | Bifenylsulfonamid matriksmetalloproteinase-inhibitorer, anvendelse derav, samt farmasöytiske formuleringer omfattende dem |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0901466B1 (zh) |
| JP (1) | JP2000511175A (zh) |
| KR (1) | KR20000011095A (zh) |
| CN (1) | CN1077885C (zh) |
| AT (1) | ATE207891T1 (zh) |
| BG (1) | BG63940B1 (zh) |
| BR (1) | BR9710841A (zh) |
| CA (1) | CA2253342A1 (zh) |
| CZ (1) | CZ294063B6 (zh) |
| DE (1) | DE69707865T2 (zh) |
| DK (1) | DK0901466T3 (zh) |
| EA (1) | EA001561B1 (zh) |
| EE (1) | EE03965B1 (zh) |
| ES (1) | ES2167733T3 (zh) |
| HK (1) | HK1019585A1 (zh) |
| IL (1) | IL126832A0 (zh) |
| NO (1) | NO312510B1 (zh) |
| NZ (1) | NZ332711A (zh) |
| PL (1) | PL186416B1 (zh) |
| PT (1) | PT901466E (zh) |
| SK (1) | SK282863B6 (zh) |
| WO (1) | WO1997044315A1 (zh) |
| ZA (1) | ZA974223B (zh) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ288298A (en) * | 1994-06-22 | 1998-12-23 | British Biotech Pharm | Hydroxamic acid and carboxylic acid derivatives; medicaments containing such derivatives that are metalloproteinase inhibitors |
| US6124333A (en) * | 1995-06-22 | 2000-09-26 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
| JP2001526631A (ja) * | 1996-12-09 | 2001-12-18 | ワーナー−ランバート・コンパニー | 心不全および心拡張症の治療および予防方法 |
| ES2212142T3 (es) * | 1996-12-17 | 2004-07-16 | Warner-Lambert Company Llc | Uso de inhibidores de metaloproteinasas de la matriz para promover la curacion de heridas. |
| EP1366765A1 (en) * | 1996-12-17 | 2003-12-03 | Warner-Lambert Company Llc | Use of matrix metalloproteinase inhibitors for treating neurological disorders and promoting wound healing |
| GB9706255D0 (en) | 1997-03-26 | 1997-05-14 | Smithkline Beecham Plc | Novel compounds |
| DE19719621A1 (de) * | 1997-05-09 | 1998-11-12 | Hoechst Ag | Sulfonylaminocarbonsäuren |
| ID29293A (id) * | 1997-07-22 | 1999-01-28 | Shionogi & Co | KOMPOSISI UNTUK MENGOBATI ATAU MENCEGAH GLOMERULOPATI (Pecahan dari No. W20000054) |
| IL135428A0 (en) * | 1997-12-23 | 2001-05-20 | Warner Lambert Co | Ace inhibitor-mmp inhibitor combinations |
| US6410580B1 (en) | 1998-02-04 | 2002-06-25 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
| HUP0101176A3 (en) * | 1998-02-04 | 2002-06-28 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases, process for their preparation and pharmaceutical compositions containing them |
| BR9815745A (pt) * | 1998-03-17 | 2000-11-14 | Warner Lambert Co | Combinações de inibidor de metaloproteinase de matriz estatina |
| EP0967201A1 (en) * | 1998-05-20 | 1999-12-29 | Roche Diagnostics GmbH | Pharmaceutical agents containing sulfonamids as matrix metalloproteinase inhibitors |
| WO2000004030A1 (de) | 1998-07-16 | 2000-01-27 | Aventis Pharma Deutschland Gmbh | Phosphin- und phosphonsäurederivate als arzneimittel |
| KR20010083134A (ko) * | 1998-07-21 | 2001-08-31 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 아테롬성 동맥경화증 병소의 치료를 위한 ａｃａｔ 및ｍｍｐ 억제제의 병용 투여 |
| DE19851184A1 (de) * | 1998-11-06 | 2000-05-11 | Aventis Pharma Gmbh | N-Arylsulfonyl-aminosäure-omega-amide |
| PL351374A1 (en) * | 1999-04-19 | 2003-04-07 | Shionogi & Co | Sulfonamide derivatives having oxadiazole rings |
| GB9918684D0 (en) | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
| DK1249233T3 (da) | 1999-11-26 | 2008-11-17 | Shionogi & Co | NPYY5-antagonister |
| AU2001292285A1 (en) * | 2000-09-29 | 2002-04-15 | Shionogi And Co., Ltd. | Thiazole or oxazole derivatives |
| GB0103303D0 (en) | 2001-02-09 | 2001-03-28 | Novartis Ag | Organic compounds |
| MXPA01013326A (es) * | 2001-02-14 | 2002-08-26 | Warner Lambert Co | Bifenil sulfonamidas utiles como inhibisdores de metaloproteinasa de matriz. |
| WO2003035610A1 (fr) * | 2001-10-26 | 2003-05-01 | Shionogi & Co., Ltd. | Derive de sulfonamide a effet inhibiteur sur les mmp |
| GB0314488D0 (en) * | 2003-06-20 | 2003-07-23 | Glaxo Group Ltd | Therapeutically useful compounds |
| BR0318625A (pt) | 2003-12-04 | 2006-10-31 | Wyeth Corp | biaril sulfonamidas e métodos para usar as mesmas |
| CN101001834B (zh) | 2004-03-22 | 2011-06-29 | 南方研究院 | 基质金属蛋白酶的非肽抑制剂 |
| CN101279956B (zh) * | 2008-04-25 | 2011-06-15 | 南昌大学 | 一种基质金属蛋白酶抑制剂及合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| NZ288298A (en) * | 1994-06-22 | 1998-12-23 | British Biotech Pharm | Hydroxamic acid and carboxylic acid derivatives; medicaments containing such derivatives that are metalloproteinase inhibitors |
-
1997
- 1997-04-24 SK SK1577-98A patent/SK282863B6/sk unknown
- 1997-04-24 AT AT97918788T patent/ATE207891T1/de not_active IP Right Cessation
- 1997-04-24 BR BR9710841A patent/BR9710841A/pt not_active IP Right Cessation
- 1997-04-24 CN CN97194719A patent/CN1077885C/zh not_active Expired - Fee Related
- 1997-04-24 EP EP97918788A patent/EP0901466B1/en not_active Expired - Lifetime
- 1997-04-24 ES ES97918788T patent/ES2167733T3/es not_active Expired - Lifetime
- 1997-04-24 DK DK97918788T patent/DK0901466T3/da active
- 1997-04-24 NZ NZ332711A patent/NZ332711A/en unknown
- 1997-04-24 DE DE69707865T patent/DE69707865T2/de not_active Expired - Fee Related
- 1997-04-24 WO PCT/US1997/006801 patent/WO1997044315A1/en not_active Application Discontinuation
- 1997-04-24 IL IL12683297A patent/IL126832A0/xx unknown
- 1997-04-24 KR KR1019980709253A patent/KR20000011095A/ko not_active Application Discontinuation
- 1997-04-24 CA CA002253342A patent/CA2253342A1/en not_active Abandoned
- 1997-04-24 JP JP09542377A patent/JP2000511175A/ja not_active Abandoned
- 1997-04-24 PL PL97329929A patent/PL186416B1/pl not_active IP Right Cessation
- 1997-04-24 CZ CZ19983668A patent/CZ294063B6/cs not_active IP Right Cessation
- 1997-04-24 EE EE9800397A patent/EE03965B1/xx not_active IP Right Cessation
- 1997-04-24 PT PT97918788T patent/PT901466E/pt unknown
- 1997-04-24 EA EA199800988A patent/EA001561B1/ru not_active IP Right Cessation
- 1997-05-15 ZA ZA9704223A patent/ZA974223B/xx unknown
-
1998
- 1998-11-12 BG BG102918A patent/BG63940B1/bg unknown
- 1998-11-16 NO NO19985326A patent/NO312510B1/no not_active IP Right Cessation
-
1999
- 1999-10-27 HK HK99104791A patent/HK1019585A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL186416B1 (pl) | 2004-01-30 |
| EA199800988A1 (ru) | 1999-04-29 |
| CZ366898A3 (cs) | 1999-02-17 |
| SK282863B6 (sk) | 2002-12-03 |
| KR20000011095A (ko) | 2000-02-25 |
| EE03965B1 (et) | 2003-02-17 |
| CN1077885C (zh) | 2002-01-16 |
| BG102918A (en) | 1999-09-30 |
| EP0901466B1 (en) | 2001-10-31 |
| NO985326D0 (no) | 1998-11-16 |
| DK0901466T3 (da) | 2002-02-18 |
| EP0901466A1 (en) | 1999-03-17 |
| EA001561B1 (ru) | 2001-04-23 |
| EE9800397A (et) | 1999-06-15 |
| BR9710841A (pt) | 1999-08-17 |
| CA2253342A1 (en) | 1997-11-27 |
| SK157798A3 (en) | 1999-04-13 |
| CN1219166A (zh) | 1999-06-09 |
| NO985326L (no) | 1999-01-14 |
| NZ332711A (en) | 2000-06-23 |
| ATE207891T1 (de) | 2001-11-15 |
| IL126832A0 (en) | 1999-08-17 |
| ES2167733T3 (es) | 2002-05-16 |
| BG63940B1 (bg) | 2003-07-31 |
| AU713286B2 (en) | 1999-11-25 |
| DE69707865D1 (de) | 2001-12-06 |
| DE69707865T2 (de) | 2002-05-02 |
| CZ294063B6 (cs) | 2004-09-15 |
| ZA974223B (en) | 1997-12-10 |
| JP2000511175A (ja) | 2000-08-29 |
| HK1019585A1 (en) | 2000-02-18 |
| PL329929A1 (en) | 1999-04-26 |
| AU2680397A (en) | 1997-12-09 |
| WO1997044315A1 (en) | 1997-11-27 |
| PT901466E (pt) | 2002-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |