NO309768B1 - Isoksazolin- og isoksazolfibrinogenreseptorantagonister, prodrugs derav, farmasöytiske preparater samt forbindelsenes anvendelse - Google Patents

Info

Publication number

NO309768B1

NO309768B1 NO962096A NO962096A NO309768B1 NO 309768 B1 NO309768 B1 NO 309768B1 NO 962096 A NO962096 A NO 962096A NO 962096 A NO962096 A NO 962096A NO 309768 B1 NO309768 B1 NO 309768B1

Authority

NO

Norway

Prior art keywords

isoxazolin

acetyl

phenyl

diaminopropanoic acid

acid

Prior art date

1993-11-24

Links

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• 150000001875 compounds Chemical class 0.000 title claims abstract description 218
• 239000000651 prodrug Substances 0.000 title claims description 21
• 229940002612 prodrug Drugs 0.000 title claims description 21
• 239000000825 pharmaceutical preparation Substances 0.000 title claims description 10
• WEQPBCSPRXFQQS-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole Chemical compound C1CC=NO1 WEQPBCSPRXFQQS-UHFFFAOYSA-N 0.000 title description 5
• CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 title description 3
• 239000002319 fibrinogen receptor antagonist Substances 0.000 title 1
• 239000003814 drug Substances 0.000 claims abstract description 37
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• 230000002537 thrombolytic effect Effects 0.000 claims abstract description 10
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• -1 4-benzyl-1-piperazinylcarbonyl Chemical group 0.000 claims description 153
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 74
• 125000000217 alkyl group Chemical group 0.000 claims description 48
• 229910052736 halogen Inorganic materials 0.000 claims description 44
• 150000002367 halogens Chemical class 0.000 claims description 44
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 44
• 239000002253 acid Substances 0.000 claims description 43
• 125000001424 substituent group Chemical group 0.000 claims description 37
• 150000003839 salts Chemical class 0.000 claims description 35
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 31
• 125000004076 pyridyl group Chemical group 0.000 claims description 23
• 230000015572 biosynthetic process Effects 0.000 claims description 21
• 229910052739 hydrogen Inorganic materials 0.000 claims description 20
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 18
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 18
• 125000000842 isoxazolyl group Chemical group 0.000 claims description 18
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• PECYZEOJVXMISF-REOHCLBHSA-N 3-amino-L-alanine Chemical compound [NH3+]C[C@H](N)C([O-])=O PECYZEOJVXMISF-REOHCLBHSA-N 0.000 claims description 2
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• 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims 1
• XMIIGOLPHOKFCH-UHFFFAOYSA-N beta-phenylpropanoic acid Natural products OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims 1
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