NO309636B1 - Fremgangsmåte for fremstilling av et krystallinsk amifostinpreparat samt doseringsformer av krystallinsk amifostin - Google Patents
Fremgangsmåte for fremstilling av et krystallinsk amifostinpreparat samt doseringsformer av krystallinsk amifostin Download PDFInfo
- Publication number
- NO309636B1 NO309636B1 NO950343A NO950343A NO309636B1 NO 309636 B1 NO309636 B1 NO 309636B1 NO 950343 A NO950343 A NO 950343A NO 950343 A NO950343 A NO 950343A NO 309636 B1 NO309636 B1 NO 309636B1
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- Prior art keywords
- amifostine
- solution
- crystalline
- temperature
- water
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 42
- 238000009472 formulation Methods 0.000 claims description 30
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 26
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Classifications
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92292992A | 1992-07-31 | 1992-07-31 | |
| US08/099,298 US5424471A (en) | 1992-07-31 | 1993-07-29 | Crystalline amifostine compositions and methods of the preparation and use of same |
| PCT/US1993/007222 WO1994003179A1 (en) | 1992-07-31 | 1993-07-30 | Crystalline amifostine compositions and methods for the preparation and use of same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO950343D0 NO950343D0 (no) | 1995-01-30 |
| NO950343L NO950343L (no) | 1995-03-22 |
| NO309636B1 true NO309636B1 (no) | 2001-03-05 |
Family
ID=26795942
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO950343A NO309636B1 (no) | 1992-07-31 | 1995-01-30 | Fremgangsmåte for fremstilling av et krystallinsk amifostinpreparat samt doseringsformer av krystallinsk amifostin |
| NO20005775A NO315691B1 (no) | 1992-07-31 | 2000-11-15 | Doseringsform omfattende krystallinsk amifostin |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20005775A NO315691B1 (no) | 1992-07-31 | 2000-11-15 | Doseringsform omfattende krystallinsk amifostin |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5591731A (is) |
| EP (1) | EP0655917B1 (is) |
| JP (1) | JP3503943B2 (is) |
| CN (2) | CN1070370C (is) |
| AT (1) | ATE261729T1 (is) |
| AU (1) | AU681858B2 (is) |
| CA (1) | CA2120133C (is) |
| CZ (1) | CZ284417B6 (is) |
| DE (1) | DE69333453T2 (is) |
| DK (1) | DK0655917T3 (is) |
| ES (1) | ES2215992T3 (is) |
| HK (1) | HK1010692A1 (is) |
| HU (1) | HU227122B1 (is) |
| IL (1) | IL106540A (is) |
| IS (1) | IS1843B (is) |
| MX (1) | MX9304627A (is) |
| NO (2) | NO309636B1 (is) |
| NZ (1) | NZ255182A (is) |
| PL (1) | PL178463B1 (is) |
| PT (1) | PT655917E (is) |
| RU (1) | RU2125880C1 (is) |
| SG (1) | SG47101A1 (is) |
| SK (1) | SK283318B6 (is) |
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| US6384259B1 (en) | 1998-11-16 | 2002-05-07 | Medimmune Oncology, Inc. | Stable amorphous amifostine compositions and dosage form |
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| SG11202004799TA (en) | 2017-12-11 | 2020-06-29 | Tonix Pharma Holdings Ltd | Cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions |
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| CN110607552B (zh) * | 2018-10-30 | 2024-02-20 | 中国科学院化学研究所 | 一种利用水溶液制备单晶或无定型物的方法 |
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| CN110606868A (zh) * | 2018-10-30 | 2019-12-24 | 中国科学院化学研究所 | 一种制备多肽或蛋白质单晶或无定型物的方法 |
| CN110735176B (zh) * | 2018-10-30 | 2024-03-22 | 中国科学院化学研究所 | 一种制备配位化合物单晶或无定型物的方法 |
| EP3824880A1 (en) * | 2019-11-25 | 2021-05-26 | Clevexel Pharma | Freeze-dried powder containing 2-[(3-aminopropyl)amino]ethanethiol and its use for preparing a thermogel |
| KR20240041506A (ko) * | 2022-09-23 | 2024-04-01 | 주식회사 경보제약 | 아비박탐 나트륨 염의 안정한 일수화물 형태 및 그의 제조 방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3892824A (en) * | 1968-12-16 | 1975-07-01 | Southern Res Inst | S-{107 -({107 -aminoalkylamino)alkyl dihydrogen phosphorothioates |
| JPS6041676B2 (ja) * | 1977-09-21 | 1985-09-18 | 山之内製薬株式会社 | Ｓ−２−（３−アミノプロピルアミノ）エチルジハイドロジエンホスホロチオエ−ト１水和結晶の新規製法 |
| US4424216A (en) * | 1979-07-31 | 1984-01-03 | The Rockefeller University | Method for the reduction of mucin viscosity |
| DE3586845T2 (de) * | 1984-08-08 | 1993-04-01 | Survival Technology | Absorptionsverbesserer. |
| WO1990014007A1 (en) * | 1989-05-24 | 1990-11-29 | U.S. Bioscience | Method for protection from azt side effects and toxicity |
-
1993
- 1993-06-30 SG SG1996007320A patent/SG47101A1/en unknown
- 1993-07-30 PL PL93307298A patent/PL178463B1/pl unknown
- 1993-07-30 ES ES93918552T patent/ES2215992T3/es not_active Expired - Lifetime
- 1993-07-30 NZ NZ255182A patent/NZ255182A/en not_active IP Right Cessation
- 1993-07-30 AT AT93918552T patent/ATE261729T1/de active
- 1993-07-30 AU AU47966/93A patent/AU681858B2/en not_active Expired
- 1993-07-30 SK SK113-95A patent/SK283318B6/sk not_active IP Right Cessation
- 1993-07-30 MX MX9304627A patent/MX9304627A/es unknown
- 1993-07-30 DK DK93918552T patent/DK0655917T3/da active
- 1993-07-30 CA CA002120133A patent/CA2120133C/en not_active Expired - Lifetime
- 1993-07-30 JP JP50547994A patent/JP3503943B2/ja not_active Expired - Lifetime
- 1993-07-30 EP EP93918552A patent/EP0655917B1/en not_active Expired - Lifetime
- 1993-07-30 IL IL10654093A patent/IL106540A/xx not_active IP Right Cessation
- 1993-07-30 IS IS4060A patent/IS1843B/is unknown
- 1993-07-30 RU RU95105441A patent/RU2125880C1/ru active
- 1993-07-30 PT PT93918552T patent/PT655917E/pt unknown
- 1993-07-30 CZ CZ95230A patent/CZ284417B6/cs not_active IP Right Cessation
- 1993-07-30 DE DE69333453T patent/DE69333453T2/de not_active Expired - Lifetime
- 1993-07-30 HU HU9500277A patent/HU227122B1/hu unknown
- 1993-07-31 CN CN93117436A patent/CN1070370C/zh not_active Expired - Lifetime
-
1995
- 1995-01-30 NO NO950343A patent/NO309636B1/no not_active IP Right Cessation
- 1995-02-16 US US08/389,386 patent/US5591731A/en not_active Expired - Lifetime
-
1998
- 1998-10-29 HK HK98111596A patent/HK1010692A1/xx not_active IP Right Cessation
-
2000
- 2000-11-15 NO NO20005775A patent/NO315691B1/no not_active IP Right Cessation
- 2000-12-01 CN CNB00128097XA patent/CN1146428C/zh not_active Expired - Lifetime
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| MK1K | Patent expired |