NO309320B1 - Forbedret lagring av parenteralt administrerbare produkter - Google Patents
Forbedret lagring av parenteralt administrerbare produkter Download PDFInfo
- Publication number
- NO309320B1 NO309320B1 NO951690A NO951690A NO309320B1 NO 309320 B1 NO309320 B1 NO 309320B1 NO 951690 A NO951690 A NO 951690A NO 951690 A NO951690 A NO 951690A NO 309320 B1 NO309320 B1 NO 309320B1
- Authority
- NO
- Norway
- Prior art keywords
- helium
- product
- products
- casing
- foaming
- Prior art date
Links
- 238000003860 storage Methods 0.000 title claims description 21
- 239000001307 helium Substances 0.000 claims abstract description 60
- 229910052734 helium Inorganic materials 0.000 claims abstract description 60
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims abstract description 60
- 238000000034 method Methods 0.000 claims abstract description 13
- 239000002960 lipid emulsion Substances 0.000 claims abstract description 12
- 238000005187 foaming Methods 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 13
- 239000000463 material Substances 0.000 claims description 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 10
- 239000001301 oxygen Substances 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 239000011261 inert gas Substances 0.000 claims description 9
- 238000007911 parenteral administration Methods 0.000 claims description 9
- 235000021476 total parenteral nutrition Nutrition 0.000 claims description 9
- 150000001413 amino acids Chemical class 0.000 claims description 7
- 235000013619 trace mineral Nutrition 0.000 claims description 7
- 239000011573 trace mineral Substances 0.000 claims description 7
- 239000003792 electrolyte Substances 0.000 claims description 6
- 238000005189 flocculation Methods 0.000 claims description 6
- 230000016615 flocculation Effects 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 5
- 239000008103 glucose Substances 0.000 claims description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 3
- 230000007774 longterm Effects 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 229920001282 polysaccharide Polymers 0.000 claims description 3
- 239000005017 polysaccharide Substances 0.000 claims description 3
- 230000002829 reductive effect Effects 0.000 claims description 3
- 238000007666 vacuum forming Methods 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- 239000011888 foil Substances 0.000 claims description 2
- 229920006254 polymer film Polymers 0.000 claims description 2
- 239000003570 air Substances 0.000 claims 1
- 239000012080 ambient air Substances 0.000 claims 1
- 239000007789 gas Substances 0.000 abstract description 16
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 21
- 239000000839 emulsion Substances 0.000 description 19
- 239000012298 atmosphere Substances 0.000 description 15
- 239000003925 fat Substances 0.000 description 13
- 229910052757 nitrogen Inorganic materials 0.000 description 9
- 239000000243 solution Substances 0.000 description 7
- 239000012530 fluid Substances 0.000 description 6
- 150000002632 lipids Chemical class 0.000 description 5
- 235000016236 parenteral nutrition Nutrition 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 229940123973 Oxygen scavenger Drugs 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 4
- 239000003978 infusion fluid Substances 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000004581 coalescence Methods 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 229910001873 dinitrogen Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 238000011179 visual inspection Methods 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 2
- 238000002144 chemical decomposition reaction Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000009189 diving Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000003182 parenteral nutrition solution Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940003953 helium / oxygen Drugs 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000012858 packaging process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000009516 primary packaging Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000006903 response to temperature Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
- B65D81/20—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas
- B65D81/2069—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas in a special atmosphere
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
- B65D81/20—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas
- B65D81/2069—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas in a special atmosphere
- B65D81/2084—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas in a special atmosphere in a flexible container
- B65D81/2092—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas in a special atmosphere in a flexible container with one or several rigid inserts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2565/00—Wrappers or flexible covers; Packaging materials of special type or form
- B65D2565/38—Packaging materials of special type or form
- B65D2565/381—Details of packaging materials of special type or form
- B65D2565/388—Materials used for their gas-permeability
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Vending Machines For Individual Products (AREA)
- Fats And Perfumes (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Edible Oils And Fats (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9203250A SE9203250D0 (sv) | 1992-11-03 | 1992-11-03 | Improved storage of oxygen sensitive materials |
| PCT/SE1993/000915 WO1994010064A1 (en) | 1992-11-03 | 1993-11-02 | Improved storage of parenterally administerable products |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO951690D0 NO951690D0 (no) | 1995-05-02 |
| NO951690L NO951690L (no) | 1995-06-26 |
| NO309320B1 true NO309320B1 (no) | 2001-01-15 |
Family
ID=20387668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO951690A NO309320B1 (no) | 1992-11-03 | 1995-05-02 | Forbedret lagring av parenteralt administrerbare produkter |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5690943A (de) |
| EP (1) | EP0666822B1 (de) |
| AT (1) | ATE157618T1 (de) |
| AU (1) | AU678564B2 (de) |
| CA (1) | CA2148472A1 (de) |
| DE (1) | DE69313656T2 (de) |
| DK (1) | DK0666822T3 (de) |
| ES (1) | ES2108302T3 (de) |
| FI (1) | FI952086A (de) |
| GR (1) | GR3025416T3 (de) |
| NO (1) | NO309320B1 (de) |
| NZ (1) | NZ257675A (de) |
| SE (1) | SE9203250D0 (de) |
| WO (1) | WO1994010064A1 (de) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1263217A (en) * | 1970-06-02 | 1972-02-09 | American Cyanamid Co | Storage stable package for absorbable polyglycolic acid sutures, and method for preparing same |
| FR2344008A1 (fr) * | 1976-03-11 | 1977-10-07 | Scal Gp Condit Aluminium | Procede de conservation de produits mettant en jeu un test d'etancheite totale |
| FR2406567A1 (fr) * | 1977-10-24 | 1979-05-18 | Dubois Jacques | Procede et dispositif destines a l'emballage etanche sous film thermoplastique et thermoformable de produits exigeant une protection absolue |
| JPS58192552A (ja) * | 1982-05-06 | 1983-11-10 | テルモ株式会社 | 薬液を収容してなる合成樹脂製医療用バッグを収納した包装容器 |
| US4515266A (en) * | 1984-03-15 | 1985-05-07 | St. Regis Corporation | Modified atmosphere package and process |
| JPS61280230A (ja) * | 1985-06-03 | 1986-12-10 | ウイルソン・フ−ズ・コ−ポレ−シヨン | 生豚肉の包装出荷法 |
| GB2178702A (en) * | 1985-08-07 | 1987-02-18 | Deimos Limited | Crawler |
| SE8505047L (sv) * | 1985-10-25 | 1987-04-26 | Nutritional Int Res Inst | Fettemulsion |
| GB8606223D0 (en) * | 1986-03-13 | 1986-04-16 | Ives D C A | Food packaging |
| US4709819A (en) * | 1986-07-23 | 1987-12-01 | Environmental Diagnostics, Inc. | Method for preserving plated media and product |
| DE3625081A1 (de) * | 1986-07-24 | 1988-02-04 | Lieder Maschinenbau Gmbh & Co | Verfahren und vorrichtung zur konservierung von in einem behaelter eingeschlossener ware |
| EP0510687B1 (de) * | 1991-04-26 | 2002-10-16 | Mitsubishi Pharma Corporation | Infustionspräparat |
-
1992
- 1992-11-03 SE SE9203250A patent/SE9203250D0/xx unknown
-
1993
- 1993-11-02 WO PCT/SE1993/000915 patent/WO1994010064A1/en active IP Right Grant
- 1993-11-02 AT AT93924869T patent/ATE157618T1/de not_active IP Right Cessation
- 1993-11-02 DE DE69313656T patent/DE69313656T2/de not_active Expired - Fee Related
- 1993-11-02 NZ NZ257675A patent/NZ257675A/en unknown
- 1993-11-02 CA CA002148472A patent/CA2148472A1/en not_active Abandoned
- 1993-11-02 AU AU54375/94A patent/AU678564B2/en not_active Ceased
- 1993-11-02 ES ES93924869T patent/ES2108302T3/es not_active Expired - Lifetime
- 1993-11-02 EP EP93924869A patent/EP0666822B1/de not_active Expired - Lifetime
- 1993-11-02 DK DK93924869.6T patent/DK0666822T3/da active
- 1993-11-02 US US08/428,178 patent/US5690943A/en not_active Expired - Fee Related
-
1995
- 1995-05-02 NO NO951690A patent/NO309320B1/no unknown
- 1995-05-02 FI FI952086A patent/FI952086A/fi unknown
-
1997
- 1997-11-19 GR GR970403061T patent/GR3025416T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI952086A (fi) | 1995-06-21 |
| ATE157618T1 (de) | 1997-09-15 |
| FI952086A0 (fi) | 1995-05-02 |
| DK0666822T3 (da) | 1998-04-20 |
| AU5437594A (en) | 1994-05-24 |
| DE69313656T2 (de) | 1998-02-26 |
| US5690943A (en) | 1997-11-25 |
| GR3025416T3 (en) | 1998-02-27 |
| CA2148472A1 (en) | 1994-05-11 |
| EP0666822B1 (de) | 1997-09-03 |
| SE9203250D0 (sv) | 1992-11-03 |
| NO951690L (no) | 1995-06-26 |
| NO951690D0 (no) | 1995-05-02 |
| WO1994010064A1 (en) | 1994-05-11 |
| DE69313656D1 (de) | 1997-10-09 |
| EP0666822A1 (de) | 1995-08-16 |
| ES2108302T3 (es) | 1997-12-16 |
| AU678564B2 (en) | 1997-06-05 |
| NZ257675A (en) | 1996-06-25 |
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