NO306444B1 - Laminatkonstruksjon for transdermal administrering av fentanyl - Google Patents
Laminatkonstruksjon for transdermal administrering av fentanyl Download PDFInfo
- Publication number
- NO306444B1 NO306444B1 NO904317A NO904317A NO306444B1 NO 306444 B1 NO306444 B1 NO 306444B1 NO 904317 A NO904317 A NO 904317A NO 904317 A NO904317 A NO 904317A NO 306444 B1 NO306444 B1 NO 306444B1
- Authority
- NO
- Norway
- Prior art keywords
- fentanyl
- layer
- composition according
- composition
- reservoir
- Prior art date
Links
- 229960002428 fentanyl Drugs 0.000 title claims description 69
- 238000010276 construction Methods 0.000 title claims description 5
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 title claims 6
- 239000000203 mixture Substances 0.000 claims abstract description 40
- BHIZVZJETFVJMJ-UHFFFAOYSA-N 2-hydroxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)O BHIZVZJETFVJMJ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229940026235 propylene glycol monolaurate Drugs 0.000 claims abstract description 18
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 10
- 239000010410 layer Substances 0.000 claims description 62
- 150000001412 amines Chemical class 0.000 claims description 9
- 229920000642 polymer Polymers 0.000 claims description 9
- -1 polydimethylsiloxane Polymers 0.000 claims description 8
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 239000011247 coating layer Substances 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 5
- 239000004745 nonwoven fabric Substances 0.000 claims description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 5
- 239000012790 adhesive layer Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002998 adhesive polymer Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 abstract description 12
- 239000003814 drug Substances 0.000 abstract description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract description 6
- 239000002131 composite material Substances 0.000 abstract 3
- 241000761557 Lamina Species 0.000 abstract 1
- 229920001971 elastomer Polymers 0.000 abstract 1
- 239000000806 elastomer Substances 0.000 abstract 1
- 229920001600 hydrophobic polymer Polymers 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 description 65
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- 230000000202 analgesic effect Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000012530 fluid Substances 0.000 description 4
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 4
- 230000036470 plasma concentration Effects 0.000 description 4
- 229920000728 polyester Polymers 0.000 description 4
- 229920006267 polyester film Polymers 0.000 description 4
- 229920002545 silicone oil Polymers 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 230000004907 flux Effects 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- BOSAWIQFTJIYIS-UHFFFAOYSA-N 1,1,1-trichloro-2,2,2-trifluoroethane Chemical compound FC(F)(F)C(Cl)(Cl)Cl BOSAWIQFTJIYIS-UHFFFAOYSA-N 0.000 description 2
- 206010058019 Cancer Pain Diseases 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- UQDUPQYQJKYHQI-UHFFFAOYSA-N methyl laurate Chemical compound CCCCCCCCCCCC(=O)OC UQDUPQYQJKYHQI-UHFFFAOYSA-N 0.000 description 2
- 229960005181 morphine Drugs 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 229940005483 opioid analgesics Drugs 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000037317 transdermal delivery Effects 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 239000004821 Contact adhesive Substances 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000276498 Pollachius virens Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010038678 Respiratory depression Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229960004207 fentanyl citrate Drugs 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940127240 opiate Drugs 0.000 description 1
- 229940124636 opioid drug Drugs 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/179,423 US4906463A (en) | 1986-12-22 | 1988-04-08 | Transdermal drug-delivery composition |
US21137788A | 1988-06-24 | 1988-06-24 | |
PCT/US1989/001376 WO1989010108A1 (en) | 1988-04-08 | 1989-04-03 | Laminated composite for transdermal administration of fentanyl |
Publications (3)
Publication Number | Publication Date |
---|---|
NO904317D0 NO904317D0 (no) | 1990-10-04 |
NO904317L NO904317L (no) | 1990-11-28 |
NO306444B1 true NO306444B1 (no) | 1999-11-08 |
Family
ID=26875305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO904317A NO306444B1 (no) | 1988-04-08 | 1990-10-04 | Laminatkonstruksjon for transdermal administrering av fentanyl |
Country Status (15)
Country | Link |
---|---|
US (1) | US4906463A (ja) |
EP (1) | EP0409910B1 (ja) |
JP (1) | JPH03504977A (ja) |
KR (1) | KR950001968B1 (ja) |
AT (1) | ATE119019T1 (ja) |
AU (1) | AU633500B2 (ja) |
CA (1) | CA1325381C (ja) |
DE (1) | DE68921473T2 (ja) |
DK (1) | DK175375B1 (ja) |
FI (1) | FI904943A0 (ja) |
IE (1) | IE891070L (ja) |
NO (1) | NO306444B1 (ja) |
NZ (1) | NZ228637A (ja) |
PT (1) | PT90240B (ja) |
WO (1) | WO1989010108A1 (ja) |
Families Citing this family (151)
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-
1988
- 1988-04-08 US US07/179,423 patent/US4906463A/en not_active Expired - Lifetime
-
1989
- 1989-04-03 EP EP89907942A patent/EP0409910B1/en not_active Expired - Lifetime
- 1989-04-03 JP JP1507304A patent/JPH03504977A/ja active Granted
- 1989-04-03 DE DE68921473T patent/DE68921473T2/de not_active Expired - Lifetime
- 1989-04-03 KR KR1019890702283A patent/KR950001968B1/ko not_active IP Right Cessation
- 1989-04-03 WO PCT/US1989/001376 patent/WO1989010108A1/en active IP Right Grant
- 1989-04-03 AT AT89907942T patent/ATE119019T1/de not_active IP Right Cessation
- 1989-04-03 AU AU38530/89A patent/AU633500B2/en not_active Ceased
- 1989-04-04 IE IE891070A patent/IE891070L/xx unknown
- 1989-04-05 CA CA000595816A patent/CA1325381C/en not_active Expired - Lifetime
- 1989-04-06 NZ NZ228637A patent/NZ228637A/xx unknown
- 1989-04-10 PT PT90240A patent/PT90240B/pt not_active IP Right Cessation
-
1990
- 1990-10-04 NO NO904317A patent/NO306444B1/no unknown
- 1990-10-05 DK DK199002410A patent/DK175375B1/da not_active IP Right Cessation
- 1990-10-08 FI FI904943A patent/FI904943A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO904317L (no) | 1990-11-28 |
DE68921473D1 (de) | 1995-04-06 |
JPH0575727B2 (ja) | 1993-10-21 |
AU3853089A (en) | 1989-11-24 |
EP0409910A1 (en) | 1991-01-30 |
PT90240B (pt) | 1994-10-31 |
JPH03504977A (ja) | 1991-10-31 |
WO1989010108A1 (en) | 1989-11-02 |
ATE119019T1 (de) | 1995-03-15 |
EP0409910B1 (en) | 1995-03-01 |
PT90240A (pt) | 1989-11-10 |
DK175375B1 (da) | 2004-09-20 |
NO904317D0 (no) | 1990-10-04 |
IE891070L (en) | 1989-10-08 |
CA1325381C (en) | 1993-12-21 |
KR950001968B1 (ko) | 1995-03-08 |
EP0409910A4 (en) | 1991-08-21 |
DK241090D0 (da) | 1990-10-05 |
DE68921473T2 (de) | 1995-06-22 |
DK241090A (da) | 1990-10-05 |
KR900700064A (ko) | 1990-08-11 |
AU633500B2 (en) | 1993-02-04 |
US4906463A (en) | 1990-03-06 |
FI904943A0 (fi) | 1990-10-08 |
NZ228637A (en) | 1990-10-26 |
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