NO304728B1 - Fremgangsmaate for fremstilling av et cyklodekstrinbasert erytropoietinprepat - Google Patents
Fremgangsmaate for fremstilling av et cyklodekstrinbasert erytropoietinprepat Download PDFInfo
- Publication number
- NO304728B1 NO304728B1 NO922990A NO922990A NO304728B1 NO 304728 B1 NO304728 B1 NO 304728B1 NO 922990 A NO922990 A NO 922990A NO 922990 A NO922990 A NO 922990A NO 304728 B1 NO304728 B1 NO 304728B1
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- NO
- Norway
- Prior art keywords
- erythropoietin
- cyclodextrin
- aqueous solution
- epo
- dried
- Prior art date
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- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- 229960001915 hexamidine Drugs 0.000 description 1
- 229960004867 hexetidine Drugs 0.000 description 1
- 102000044890 human EPO Human genes 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000009851 immunogenic response Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- ODLHGICHYURWBS-FOSILIAISA-N molport-023-220-444 Chemical compound CC(O)COC[C@@H]([C@@H]([C@H]([C@@H]1O)O)O[C@@H]2O[C@H]([C@H](O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O3)[C@@H](O)[C@@H]2O)COCC(O)C)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O)[C@H]3O[C@H]1COCC(C)O ODLHGICHYURWBS-FOSILIAISA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229940067107 phenylethyl alcohol Drugs 0.000 description 1
- 229940096825 phenylmercury Drugs 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 230000000581 polycythemic effect Effects 0.000 description 1
- 210000004896 polypeptide structure Anatomy 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009450 sialylation Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 239000004324 sodium propionate Substances 0.000 description 1
- 235000010334 sodium propionate Nutrition 0.000 description 1
- 229960003212 sodium propionate Drugs 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229960004906 thiomersal Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- WHGYBXFWUBPSRW-FEYSZYNQSA-N β-dextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)C(O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FEYSZYNQSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nanotechnology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polyurethanes Or Polyureas (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909001987A GB9001987D0 (en) | 1990-01-29 | 1990-01-29 | Improved cyclodextrin based erythropietin formulation |
| PCT/EP1991/000173 WO1991011200A1 (fr) | 1990-01-29 | 1991-01-25 | Composition d'erythropoïetine amelioree a base de cyclodextrine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO922990D0 NO922990D0 (no) | 1992-07-29 |
| NO922990L NO922990L (no) | 1992-07-29 |
| NO304728B1 true NO304728B1 (no) | 1999-02-08 |
Family
ID=10670074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO922990A NO304728B1 (no) | 1990-01-29 | 1992-07-29 | Fremgangsmaate for fremstilling av et cyklodekstrinbasert erytropoietinprepat |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5376632A (fr) |
| EP (1) | EP0513072B1 (fr) |
| JP (1) | JP2997052B2 (fr) |
| KR (1) | KR0183445B1 (fr) |
| AT (1) | ATE107518T1 (fr) |
| AU (1) | AU648061B2 (fr) |
| CA (1) | CA2074820C (fr) |
| DE (1) | DE69102627T2 (fr) |
| DK (1) | DK0513072T3 (fr) |
| ES (1) | ES2059115T3 (fr) |
| FI (1) | FI105012B (fr) |
| GB (1) | GB9001987D0 (fr) |
| HU (1) | HU218213B (fr) |
| IE (1) | IE65209B1 (fr) |
| IL (1) | IL97019A (fr) |
| NO (1) | NO304728B1 (fr) |
| NZ (1) | NZ236938A (fr) |
| PT (1) | PT96593B (fr) |
| WO (1) | WO1991011200A1 (fr) |
| ZA (1) | ZA91620B (fr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4126984A1 (de) * | 1991-08-15 | 1993-02-18 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von humanprotein-enthaltenden, gut vertraeglichen arzneimitteln fuer infusions- oder injektionszwecke |
| US5661125A (en) * | 1992-08-06 | 1997-08-26 | Amgen, Inc. | Stable and preserved erythropoietin compositions |
| US5494901A (en) * | 1993-01-05 | 1996-02-27 | Javitt; Jonathan C. | Topical compositions for the eye comprising a β-cyclodextrin derivative and a therapeutic agent |
| IL116085A (en) | 1994-12-16 | 1999-12-31 | Ortho Pharma Corp | Spray dried erythropoietin |
| DE19539574A1 (de) * | 1995-10-25 | 1997-04-30 | Boehringer Mannheim Gmbh | Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren |
| WO1997039761A1 (fr) | 1996-04-19 | 1997-10-30 | Alpha Therapeutic Corporation | Procede d'inactivation de virus dans des proteines sanguines lyophilisees |
| US5754937A (en) | 1996-05-15 | 1998-05-19 | Stackpole Limited | Hi-density forming process |
| PT977582E (pt) * | 1997-03-18 | 2002-12-31 | Roche Diagnostics Gmbh | Preparacoes farmaceuticas associadas contendo eritropoietina e preparacoes de ferro |
| US6683100B2 (en) | 1999-01-19 | 2004-01-27 | Novartis Ag | Organic compounds |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| JP2002523475A (ja) * | 1998-09-02 | 2002-07-30 | アラーガン・セイルズ・インコーポレイテッド | 防腐したシクロデキストリン含有組成物 |
| US20040152664A1 (en) * | 1998-09-02 | 2004-08-05 | Allergan, Inc. | Prednisolone compositions |
| CA2369444C (fr) * | 1999-04-09 | 2009-08-18 | Ortho-Mcneil Pharmaceutical, Inc. | Composition pharmaceutique d'erythropoietine |
| AU2001276737A1 (en) * | 2000-08-04 | 2002-02-18 | Chugai Seiyaku Kabushiki Kaisha | Protein injection preparations |
| US20060235366A1 (en) * | 2000-12-20 | 2006-10-19 | Fox Hollow Technologies, Inc. | Method of evaluating a treatment for vascular disease |
| US20020146409A1 (en) * | 2001-01-30 | 2002-10-10 | Herring Steven W. | Methods for stabilizing lyophilized blood proteins |
| US20040142043A1 (en) * | 2001-07-09 | 2004-07-22 | Atsushi Maeda | Sustained-release compositions for injection and process for producing the same |
| DE10228049A1 (de) * | 2002-06-24 | 2004-01-15 | Merck Patent Gmbh | Flüssige Zubereitung enthaltend Oligopeptide |
| US7459435B2 (en) * | 2002-08-29 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
| US7459436B2 (en) * | 2002-11-22 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
| EP1641486B1 (fr) * | 2003-06-10 | 2012-04-18 | LG Life Sciences Ltd. | Solutions aqueuses stables d'erythropoietine humaine ne contenant pas d'albumine serique |
| EP1537876A1 (fr) * | 2003-12-01 | 2005-06-08 | BioGeneriX AG | Formulation d'une solution d'érythropoiétine |
| US7772182B2 (en) * | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| US20110236902A1 (en) * | 2004-12-13 | 2011-09-29 | Tyco Healthcare Group Lp | Testing a patient population having a cardiovascular condition for drug efficacy |
| US7794413B2 (en) * | 2005-04-19 | 2010-09-14 | Ev3, Inc. | Libraries and data structures of materials removed by debulking catheters |
| CU23317A1 (es) * | 2005-07-22 | 2008-10-22 | Ct De Investigacia N Y Desarro | Formulaciones nasales de eporh con bajo contenido de ã cido siã lico para el tratamiento de enfermedades del sistema nervioso central |
| BRPI0717460A2 (pt) | 2006-10-20 | 2013-12-24 | Icos Corp | Composições de inibidores de chk1 |
| ES2632164T3 (es) * | 2010-07-06 | 2017-09-11 | Augustinus Bader | Aplicación tópica de eritropoyetina para uso en el tratamiento de lesiones de la córnea |
| US10328152B2 (en) | 2011-06-16 | 2019-06-25 | Nayan Patel | Method for stabilization and delivery of therapeutic molecules |
| US11583584B1 (en) * | 2015-10-28 | 2023-02-21 | Coherus Biosciences, Inc. | Stable protein compositions and methods of their use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3346123A1 (de) * | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| JPS60258125A (ja) * | 1984-06-06 | 1985-12-20 | Hayashibara Biochem Lab Inc | 蛋白性生理活性物質を含有する水溶性乾燥物 |
| JPS6191131A (ja) * | 1984-10-09 | 1986-05-09 | Chugai Pharmaceut Co Ltd | 医薬品の吸着防止方法および組成物 |
| JPS6197229A (ja) * | 1984-10-18 | 1986-05-15 | Chugai Pharmaceut Co Ltd | 安定なエリトロポエチン製剤 |
| US4920214A (en) * | 1986-04-16 | 1990-04-24 | American Maize-Products Company | Process for producing modified cyclodextrins |
| PT88490B (pt) * | 1987-09-14 | 1992-11-30 | Novo Nordisk As | Processo para a preparacao de composicoes farmaceuticas para libertacao nao-enterica trans-mucosa contendo monossacaridos ou oligossacaridos |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| US5997856A (en) * | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
| US5068227A (en) * | 1989-01-18 | 1991-11-26 | Cyclex, Inc. | Cyclodextrins as carriers |
-
1990
- 1990-01-29 GB GB909001987A patent/GB9001987D0/en active Pending
-
1991
- 1991-01-24 IL IL97019A patent/IL97019A/xx active IP Right Grant
- 1991-01-25 WO PCT/EP1991/000173 patent/WO1991011200A1/fr not_active Application Discontinuation
- 1991-01-25 EP EP91902955A patent/EP0513072B1/fr not_active Revoked
- 1991-01-25 ES ES91902955T patent/ES2059115T3/es not_active Expired - Lifetime
- 1991-01-25 AU AU71497/91A patent/AU648061B2/en not_active Ceased
- 1991-01-25 JP JP3503095A patent/JP2997052B2/ja not_active Expired - Fee Related
- 1991-01-25 DK DK91902955.3T patent/DK0513072T3/da active
- 1991-01-25 CA CA002074820A patent/CA2074820C/fr not_active Expired - Fee Related
- 1991-01-25 AT AT91902955T patent/ATE107518T1/de not_active IP Right Cessation
- 1991-01-25 HU HU9202432A patent/HU218213B/hu unknown
- 1991-01-25 DE DE69102627T patent/DE69102627T2/de not_active Revoked
- 1991-01-28 IE IE28691A patent/IE65209B1/en not_active IP Right Cessation
- 1991-01-28 ZA ZA91620A patent/ZA91620B/xx unknown
- 1991-01-29 NZ NZ236938A patent/NZ236938A/en unknown
- 1991-01-29 PT PT96593A patent/PT96593B/pt not_active IP Right Cessation
-
1992
- 1992-06-30 US US07/906,780 patent/US5376632A/en not_active Expired - Lifetime
- 1992-07-24 KR KR1019920701755A patent/KR0183445B1/ko not_active IP Right Cessation
- 1992-07-28 FI FI923402A patent/FI105012B/fi not_active IP Right Cessation
- 1992-07-29 NO NO922990A patent/NO304728B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT96593B (pt) | 2001-06-29 |
| IL97019A0 (en) | 1992-03-29 |
| AU648061B2 (en) | 1994-04-14 |
| KR0183445B1 (en) | 1999-05-01 |
| EP0513072A1 (fr) | 1992-11-19 |
| HU218213B (hu) | 2000-06-28 |
| JP2997052B2 (ja) | 2000-01-11 |
| NO922990D0 (no) | 1992-07-29 |
| CA2074820A1 (fr) | 1991-07-30 |
| JPH05503700A (ja) | 1993-06-17 |
| IL97019A (en) | 1997-07-13 |
| AU7149791A (en) | 1991-08-21 |
| ES2059115T3 (es) | 1994-11-01 |
| IE910286A1 (en) | 1991-07-31 |
| FI923402A (fi) | 1992-07-28 |
| PT96593A (pt) | 1991-10-15 |
| GB9001987D0 (en) | 1990-03-28 |
| DE69102627T2 (de) | 1994-11-03 |
| DE69102627D1 (de) | 1994-07-28 |
| FI923402A0 (fi) | 1992-07-28 |
| EP0513072B1 (fr) | 1994-06-22 |
| IE65209B1 (en) | 1995-10-04 |
| CA2074820C (fr) | 2003-10-14 |
| ZA91620B (en) | 1992-10-28 |
| ATE107518T1 (de) | 1994-07-15 |
| US5376632A (en) | 1994-12-27 |
| WO1991011200A1 (fr) | 1991-08-08 |
| FI105012B (fi) | 2000-05-31 |
| NO922990L (no) | 1992-07-29 |
| HUT62198A (en) | 1993-04-28 |
| NZ236938A (en) | 1992-07-28 |
| DK0513072T3 (da) | 1994-08-01 |
| HU9202432D0 (en) | 1992-10-28 |
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