NO304519B1 - Fremstilling av (1)-(-)-2-(aminokarbonyl)-N-(4-amino-2,6-diklorfenyl)-4-[5,5-bis(4-fluorfenyl)pentyl]-1-piperazinacetamid - Google Patents
Fremstilling av (1)-(-)-2-(aminokarbonyl)-N-(4-amino-2,6-diklorfenyl)-4-[5,5-bis(4-fluorfenyl)pentyl]-1-piperazinacetamid Download PDFInfo
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- NO304519B1 NO304519B1 NO912511A NO912511A NO304519B1 NO 304519 B1 NO304519 B1 NO 304519B1 NO 912511 A NO912511 A NO 912511A NO 912511 A NO912511 A NO 912511A NO 304519 B1 NO304519 B1 NO 304519B1
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- Prior art keywords
- formula
- bis
- fluorophenyl
- compound
- aminocarbonyl
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- 229950005499 carbon tetrachloride Drugs 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 230000036459 cardiodepression Effects 0.000 description 1
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- 230000015556 catabolic process Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000007665 chronic toxicity Effects 0.000 description 1
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- 235000001727 glucose Nutrition 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical group 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 230000000297 inotrophic effect Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 229960001317 isoprenaline Drugs 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
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- 235000010355 mannitol Nutrition 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
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- 239000012528 membrane Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000003680 myocardial damage Effects 0.000 description 1
- LVJYSFUNASCGCN-HOTGVXAUSA-N n,n'-bis[(1s)-1-phenylethyl]ethane-1,2-diamine Chemical compound C1([C@H](C)NCCN[C@@H](C)C=2C=CC=CC=2)=CC=CC=C1 LVJYSFUNASCGCN-HOTGVXAUSA-N 0.000 description 1
- AJFDBNQQDYLMJN-UHFFFAOYSA-N n,n-diethylacetamide Chemical compound CCN(CC)C(C)=O AJFDBNQQDYLMJN-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- UNHKSXOTUHOTAB-UHFFFAOYSA-N sodium;sulfane Chemical compound [Na].S UNHKSXOTUHOTAB-UHFFFAOYSA-N 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 description 1
- 229960005001 ticlopidine Drugs 0.000 description 1
- YONPGGFAJWQGJC-UHFFFAOYSA-K titanium(iii) chloride Chemical compound Cl[Ti](Cl)Cl YONPGGFAJWQGJC-UHFFFAOYSA-K 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44014289A | 1989-11-22 | 1989-11-22 | |
PCT/EP1990/001985 WO1991007967A2 (fr) | 1989-11-22 | 1990-11-19 | Procede pour empecher ou limiter les lesions liees a la reperfusion |
SG118494A SG118494G (en) | 1989-11-22 | 1994-08-20 | Method of preventing or limiting reperfusion damage |
Publications (3)
Publication Number | Publication Date |
---|---|
NO912511D0 NO912511D0 (no) | 1991-06-26 |
NO912511L NO912511L (no) | 1991-08-26 |
NO304519B1 true NO304519B1 (no) | 1999-01-04 |
Family
ID=26664237
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO912511A NO304519B1 (no) | 1989-11-22 | 1991-06-26 | Fremstilling av (1)-(-)-2-(aminokarbonyl)-N-(4-amino-2,6-diklorfenyl)-4-[5,5-bis(4-fluorfenyl)pentyl]-1-piperazinacetamid |
NO19982078A NO311701B1 (no) | 1989-11-22 | 1998-05-07 | Fremgangsmåte for beskyttelse av et donorhjerte for transplantering samt anvendelse av en N-aryl-piperazinalkanamidforbindelse for dette formål |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19982078A NO311701B1 (no) | 1989-11-22 | 1998-05-07 | Fremgangsmåte for beskyttelse av et donorhjerte for transplantering samt anvendelse av en N-aryl-piperazinalkanamidforbindelse for dette formål |
Country Status (22)
Country | Link |
---|---|
EP (2) | EP0455789B1 (fr) |
JP (1) | JP2574585B2 (fr) |
KR (1) | KR0165686B1 (fr) |
AT (2) | ATE102831T1 (fr) |
AU (1) | AU632888B2 (fr) |
CA (1) | CA2044143C (fr) |
CY (1) | CY1869A (fr) |
DE (2) | DE69007471T2 (fr) |
DK (2) | DK0577171T3 (fr) |
ES (2) | ES2053208T3 (fr) |
FI (1) | FI109694B (fr) |
HK (1) | HK115095A (fr) |
HU (1) | HU215847B (fr) |
IE (1) | IE65121B1 (fr) |
IL (1) | IL96390A (fr) |
NO (2) | NO304519B1 (fr) |
NZ (1) | NZ236168A (fr) |
PT (2) | PT95959B (fr) |
RU (1) | RU2093156C1 (fr) |
SG (1) | SG118494G (fr) |
WO (1) | WO1991007967A2 (fr) |
ZA (1) | ZA909345B (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9202266D0 (sv) * | 1992-07-31 | 1992-07-31 | Kabi Pharmacia Ab | Novel piperazine carboxamides |
SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
US6683100B2 (en) | 1999-01-19 | 2004-01-27 | Novartis Ag | Organic compounds |
US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
SE9904674D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
SE0001209D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
ES2319876T3 (es) | 2001-05-18 | 2009-05-14 | Astrazeneca Ab | Derivados de 4 (fenil-piperazinil-metil) benzamida y su uso para el tratamiento de la ansiedad o trastornos gastrointestinales. |
SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
CA2575975A1 (fr) * | 2003-11-12 | 2005-05-26 | Dr. Reddy's Laboratories, Inc. | Preparation d'escitaloprame |
MX2007001240A (es) | 2004-08-02 | 2007-03-23 | Astrazeneca Ab | Derivados de diarilmetil-piperazina, preparaciones y usos de las mismas. |
FR2946340B1 (fr) | 2009-06-05 | 2011-06-24 | Galderma Res & Dev | Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
KR101900124B1 (ko) | 2014-06-25 | 2018-09-18 | 전남대학교산학협력단 | 전복 박리용 조성물 |
KR101644299B1 (ko) | 2014-07-22 | 2016-08-02 | 주식회사 엔바이로젠 | 오미자 및 삼채 추출물을 유효성분으로 포함하는 전복 박리용 조성물 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4766125A (en) * | 1981-06-23 | 1988-08-23 | Janssen Pharmaceutica N.V. | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia |
NZ223847A (en) * | 1987-04-01 | 1989-12-21 | Janssen Pharmaceutica Nv | Substituted piperazine derivatives and pharmaceutical compositions |
-
1990
- 1990-11-19 DK DK93201656T patent/DK0577171T3/da active
- 1990-11-19 ES ES90917677T patent/ES2053208T3/es not_active Expired - Lifetime
- 1990-11-19 DE DE69007471T patent/DE69007471T2/de not_active Expired - Fee Related
- 1990-11-19 AT AT90917677T patent/ATE102831T1/de not_active IP Right Cessation
- 1990-11-19 CA CA002044143A patent/CA2044143C/fr not_active Expired - Fee Related
- 1990-11-19 KR KR1019910700758A patent/KR0165686B1/ko not_active IP Right Cessation
- 1990-11-19 WO PCT/EP1990/001985 patent/WO1991007967A2/fr active IP Right Grant
- 1990-11-19 IL IL9639090A patent/IL96390A/en not_active IP Right Cessation
- 1990-11-19 EP EP90917677A patent/EP0455789B1/fr not_active Expired - Lifetime
- 1990-11-19 AT AT93201656T patent/ATE213943T1/de not_active IP Right Cessation
- 1990-11-19 DK DK90917677.8T patent/DK0455789T3/da active
- 1990-11-19 AU AU68763/91A patent/AU632888B2/en not_active Ceased
- 1990-11-19 DE DE69033926T patent/DE69033926T2/de not_active Expired - Fee Related
- 1990-11-19 ES ES93201656T patent/ES2173883T3/es not_active Expired - Lifetime
- 1990-11-19 HU HU2436/91A patent/HU215847B/hu not_active IP Right Cessation
- 1990-11-19 EP EP19930201656 patent/EP0577171B1/fr not_active Expired - Lifetime
- 1990-11-19 RU SU905001085A patent/RU2093156C1/ru active
- 1990-11-19 JP JP3500097A patent/JP2574585B2/ja not_active Expired - Fee Related
- 1990-11-20 NZ NZ236168A patent/NZ236168A/xx unknown
- 1990-11-21 ZA ZA909345A patent/ZA909345B/xx unknown
- 1990-11-21 IE IE420990A patent/IE65121B1/en not_active IP Right Cessation
- 1990-11-22 PT PT95959A patent/PT95959B/pt not_active IP Right Cessation
-
1991
- 1991-06-26 NO NO912511A patent/NO304519B1/no unknown
- 1991-07-16 FI FI913433A patent/FI109694B/fi active
-
1994
- 1994-08-20 SG SG118494A patent/SG118494G/en unknown
-
1995
- 1995-07-13 HK HK115095A patent/HK115095A/xx not_active IP Right Cessation
-
1996
- 1996-04-05 CY CY186996A patent/CY1869A/xx unknown
-
1998
- 1998-04-20 PT PT102145A patent/PT102145B/pt not_active IP Right Cessation
- 1998-05-07 NO NO19982078A patent/NO311701B1/no unknown
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