NO302301B1 - Fremgangsmåte til fremstilling av terapeutisk aktivt HSA fra en metylotrof gjær av slekten Pichia, samt ekspresjonsvektorer og gjærstammer deri - Google Patents
Fremgangsmåte til fremstilling av terapeutisk aktivt HSA fra en metylotrof gjær av slekten Pichia, samt ekspresjonsvektorer og gjærstammer deri Download PDFInfo
- Publication number
- NO302301B1 NO302301B1 NO891716A NO891716A NO302301B1 NO 302301 B1 NO302301 B1 NO 302301B1 NO 891716 A NO891716 A NO 891716A NO 891716 A NO891716 A NO 891716A NO 302301 B1 NO302301 B1 NO 302301B1
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- hsa
- gene
- dna
- vector
- pichia pastoris
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/765—Serum albumin, e.g. HSA
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N1/14—Fungi; Culture media therefor
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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| FR2649991B2 (fr) * | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| JPH0669365B2 (ja) * | 1989-05-22 | 1994-09-07 | 株式会社ミドリ十字 | アルブミン遺伝子を含むプラスミド、形質転換体、形質転換体の製造方法、アルブミンの製造方法 |
| WO1992013951A1 (en) * | 1991-02-04 | 1992-08-20 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Production of human serum albumin in methylotrophic yeast cells |
| JPH0671432B2 (ja) * | 1991-03-20 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
| CA2063890C (en) * | 1991-03-27 | 2007-03-13 | Masami Miura | Mutant aox2 promoter, microorganism carrying same, method of preparation thereof and production of heterologous protein using such microorganism |
| CA2058820C (en) * | 1991-04-25 | 2003-07-15 | Kotikanyad Sreekrishna | Expression cassettes and vectors for the secretion of human serum albumin in pichia pastoris cells |
| US5330901A (en) * | 1991-04-26 | 1994-07-19 | Research Corporation Technologies, Inc. | Expression of human serum albumin in Pichia pastoris |
| FR2686620B1 (fr) * | 1992-01-27 | 1995-06-23 | Rhone Poulenc Rorer Sa | Serum-albumine humaine, preparation et utilisation. |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| FR2693207B1 (fr) * | 1992-07-03 | 1994-09-30 | Orsan | Souche de levure permettant la co-expression d'une activité mono-oxygénase de cytochrome P450 hétérologue et d'une NADPH-cytochrome P450-réductase endogène ou hétérologue et son utilisation à des fins de bioconversion. |
| JPH06209763A (ja) * | 1993-01-13 | 1994-08-02 | Green Cross Corp:The | 変異株 |
| JPH07308199A (ja) | 1994-05-18 | 1995-11-28 | Green Cross Corp:The | ヒト血清アルブミンの製造方法 |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| FR2746109B1 (fr) | 1996-03-12 | 1998-04-17 | Rhone Poulenc Rorer Sa | Milieu pour la conservation de materiel biologique |
| MX9605082A (es) * | 1996-10-24 | 1998-04-30 | Univ Autonoma De Nuevo Leon | Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano. |
| CN1105727C (zh) * | 1998-06-17 | 2003-04-16 | 上海海济医药生物工程有限公司 | 重组人血清白蛋白的生产方法 |
| IL128757A0 (en) * | 1999-02-28 | 2000-01-31 | Yissum Res Dev Co | GCN4-derived expression of heterologous coding sequences and different uses thereof |
| CN1103373C (zh) * | 1999-03-04 | 2003-03-19 | 上海贸基生物工程科技有限公司 | 人血清白蛋白改构基因、表达载体及其宿主 |
| CN1103374C (zh) * | 1999-03-04 | 2003-03-19 | 上海贸基生物工程科技有限公司 | 重组dna技术生产人血清白蛋白的方法 |
| US20040010134A1 (en) | 2000-04-12 | 2004-01-15 | Rosen Craig A. | Albumin fusion proteins |
| US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| DK1463751T3 (da) | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Albuminfusionsproteiner. |
| GB0217033D0 (en) | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
| JP2009298783A (ja) | 2008-05-15 | 2009-12-24 | R Tec Ueno:Kk | ドライアイおよび／または角結膜障害処置のための医薬組成物 |
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| US4855231A (en) * | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
| US4885242A (en) * | 1984-10-30 | 1989-12-05 | Phillips Petroleum Company | Genes from pichia histidine pathway and uses thereof |
| US4837148A (en) * | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
| KR870000428A (ko) * | 1985-06-17 | 1987-02-18 | . | 인체혈청 알부민의 제조방법 |
| US4882279A (en) * | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
| US4895800A (en) * | 1985-11-26 | 1990-01-23 | Phillips Petroleum Company | Yeast production of hepatitis B surface antigen |
| JPS62215393A (ja) * | 1986-01-13 | 1987-09-22 | ジエネツクス・コ−ポレ−シヨン | バチルス中でのヒト血清アルブミンの製造 |
| GB8613388D0 (en) * | 1986-06-03 | 1986-07-09 | Delta Biotechnology Ltd | Induction of galactose regulated gene expression in yeast |
| GB8615701D0 (en) * | 1986-06-27 | 1986-08-06 | Delta Biotechnology Ltd | Stable gene integration vector |
| IL82935A0 (en) * | 1986-08-12 | 1987-12-20 | Phillips Petroleum Co | Secretion of heterologous proteins from yeast |
| GB8620926D0 (en) * | 1986-08-29 | 1986-10-08 | Delta Biotechnology Ltd | Yeast promoter |
-
1989
- 1989-04-17 IL IL89992A patent/IL89992A0/xx unknown
- 1989-04-21 AU AU33279/89A patent/AU605691B2/en not_active Expired
- 1989-04-25 KR KR1019890005444A patent/KR970002914B1/ko not_active IP Right Cessation
- 1989-04-25 MX MX2671489A patent/MX26714A/es unknown
- 1989-04-25 IE IE134889A patent/IE81153B1/en not_active IP Right Cessation
- 1989-04-25 CA CA000597721A patent/CA1328838C/en not_active Expired - Lifetime
- 1989-04-25 ES ES89107459T patent/ES2108681T3/es not_active Expired - Lifetime
- 1989-04-25 DK DK198901995A patent/DK175792B1/da not_active IP Right Cessation
- 1989-04-25 AT AT89107459T patent/ATE159297T1/de not_active IP Right Cessation
- 1989-04-25 DE DE68928380T patent/DE68928380T2/de not_active Expired - Fee Related
- 1989-04-25 JP JP1105730A patent/JP2580036B2/ja not_active Expired - Lifetime
- 1989-04-25 IE IE19980173A patent/IE980173A1/en not_active IP Right Cessation
- 1989-04-25 EP EP89107459A patent/EP0344459B1/en not_active Expired - Lifetime
- 1989-04-25 NO NO891716A patent/NO302301B1/no not_active IP Right Cessation
- 1989-04-25 EP EP97101044A patent/EP0771871A3/en not_active Withdrawn
-
1997
- 1997-11-13 GR GR970403026T patent/GR3025382T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK199589A (da) | 1989-10-26 |
| IE891348L (en) | 1989-10-25 |
| DK199589D0 (da) | 1989-04-25 |
| DK175792B1 (da) | 2005-02-21 |
| NO891716L (no) | 1989-10-26 |
| MX26714A (es) | 1993-10-01 |
| JPH02104290A (ja) | 1990-04-17 |
| EP0344459B1 (en) | 1997-10-15 |
| EP0344459A2 (en) | 1989-12-06 |
| CA1328838C (en) | 1994-04-26 |
| KR970002914B1 (ko) | 1997-03-12 |
| EP0771871A3 (en) | 1997-05-28 |
| EP0344459A3 (en) | 1989-12-27 |
| EP0771871A2 (en) | 1997-05-07 |
| IL89992A0 (en) | 1989-12-15 |
| ATE159297T1 (de) | 1997-11-15 |
| NO891716D0 (no) | 1989-04-25 |
| KR890016176A (ko) | 1989-11-28 |
| IE81153B1 (en) | 2000-05-03 |
| AU605691B2 (en) | 1991-01-17 |
| JP2580036B2 (ja) | 1997-02-12 |
| DE68928380D1 (de) | 1997-11-20 |
| ES2108681T3 (es) | 1998-01-01 |
| AU3327989A (en) | 1989-10-26 |
| GR3025382T3 (en) | 1998-02-27 |
| DE68928380T2 (de) | 1998-02-26 |
| IE980173A1 (en) | 2000-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |