NO301775B1 - DNA-sekvens som koder for nye former av kolonistimulerende faktor-1, vektor, ekspresjonssystem og rekombinant vertscelle - Google Patents
DNA-sekvens som koder for nye former av kolonistimulerende faktor-1, vektor, ekspresjonssystem og rekombinant vertscelle Download PDFInfo
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- NO301775B1 NO301775B1 NO882772A NO882772A NO301775B1 NO 301775 B1 NO301775 B1 NO 301775B1 NO 882772 A NO882772 A NO 882772A NO 882772 A NO882772 A NO 882772A NO 301775 B1 NO301775 B1 NO 301775B1
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- YPZRWBKMTBYPTK-UHFFFAOYSA-N oxidized gamma-L-glutamyl-L-cysteinylglycine Natural products OC(=O)C(N)CCC(=O)NC(C(=O)NCC(O)=O)CSSCC(C(=O)NCC(O)=O)NC(=O)CCC(N)C(O)=O YPZRWBKMTBYPTK-UHFFFAOYSA-N 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
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- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
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- 239000008247 solid mixture Substances 0.000 description 1
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- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
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- 229960001727 tretinoin Drugs 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 230000002476 tumorcidal effect Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pyrane Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92306786A | 1986-10-24 | 1986-10-24 | |
US3965787A | 1987-04-16 | 1987-04-16 | |
US3965487A | 1987-04-16 | 1987-04-16 | |
PCT/US1987/002679 WO1988003173A2 (en) | 1986-10-24 | 1987-10-16 | New forms of colony stimulating factor-1 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO882772D0 NO882772D0 (no) | 1988-06-22 |
NO882772L NO882772L (no) | 1988-08-22 |
NO301775B1 true NO301775B1 (no) | 1997-12-08 |
Family
ID=27365583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO882772A NO301775B1 (no) | 1986-10-24 | 1988-06-22 | DNA-sekvens som koder for nye former av kolonistimulerende faktor-1, vektor, ekspresjonssystem og rekombinant vertscelle |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0272779B1 (de) |
JP (1) | JP2644794B2 (de) |
AT (1) | ATE105869T1 (de) |
AU (2) | AU8007087A (de) |
CA (1) | CA1339032C (de) |
DE (1) | DE3789859T2 (de) |
DK (1) | DK174237B1 (de) |
ES (1) | ES2052580T3 (de) |
FI (1) | FI102190B (de) |
HU (1) | HU215241B (de) |
NO (1) | NO301775B1 (de) |
WO (1) | WO1988003173A2 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6156300A (en) * | 1985-02-05 | 2000-12-05 | Chiron Corporation | Point mutants of N∇2 CSF-1 and carboxy truncated fragments thereof |
US5837229A (en) * | 1985-02-05 | 1998-11-17 | Chiron Corporation | Uses of recombinant colony stimulating factor-1 |
US5422105A (en) * | 1985-02-05 | 1995-06-06 | Cetus Oncology Corporation | Use of recombinant colony stimulating factor 1 |
US5573930A (en) | 1985-02-05 | 1996-11-12 | Cetus Oncology Corporation | DNA encoding various forms of colony stimulating factor-1 |
US5556620A (en) * | 1985-02-05 | 1996-09-17 | Cetus Oncology Corporation | Use of recombinant colony stimulating factor-1 to enhance wound healing |
US5104650A (en) * | 1985-02-05 | 1992-04-14 | Cetus Corporation | Uses of recombinant colony stimulating factor-1 |
US6117422A (en) * | 1985-02-05 | 2000-09-12 | Chiron Corporation | N∇2-CSF-1(long form) and carboxy truncated fragments thereof |
AU595864B2 (en) * | 1986-03-14 | 1990-04-12 | Otsuka Pharmaceutical Co., Ltd. | Il-1 alpha derivatives and drugs |
EP0307402B1 (de) * | 1986-05-06 | 1993-08-11 | Genetics Institute, Inc. | Herstellung von m-csf |
JP2583829B2 (ja) * | 1986-09-17 | 1997-02-19 | 大塚製薬株式会社 | ヒトm−csf |
JP2583770B2 (ja) * | 1986-09-17 | 1997-02-19 | 大塚製薬株式会社 | 遺伝子 |
US5650297A (en) * | 1986-09-17 | 1997-07-22 | Otsuka Pharmaceutical Co., Ltd. | DNA encoding human colony-stimulating factors |
EP0276551B1 (de) * | 1986-12-07 | 1992-03-18 | Morinaga Milk Industry Co., Ltd. | Kolonie-stimulierender Faktor und Verfahren zu seiner Herstellung |
CA1339757C (en) * | 1987-04-16 | 1998-03-17 | Robert F. Halenbeck | Production of purified biologically active, bacterially produced recombinant human csf-1 |
US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
WO1989001038A1 (en) * | 1987-07-24 | 1989-02-09 | Cetus Corporation | PRODUCTION OF BIOLOGICALLY ACTIVE FORMS OF CSF USING A BACULOVIRUS (AcNPV)-INSECT CELL EXPRESSION SYSTEM |
DK54589A (da) * | 1988-02-08 | 1989-08-09 | Otsuka Pharma Co Ltd | Humane kolonistmulerende faktorer |
JPH0610137B2 (ja) * | 1988-02-29 | 1994-02-09 | 新技術事業団 | ヒト単球−マクロファージコロニー刺激因子を有効成分とする造血器疾患治療剤 |
US5171675A (en) * | 1988-07-28 | 1992-12-15 | Cerretti Douglas P | Macrophage colony stimulating factor-γ |
WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
DE69026440T2 (de) * | 1989-07-27 | 1996-10-17 | Denki Kagaku Kogyo Kk | Für M-CSF kodierendes Gen und dazu gehörende rekombinante Systeme |
KR920701253A (ko) * | 1989-11-07 | 1992-08-11 | 오오쓰까 아끼히꼬 | M-csf 유도체, 그 유도체의 발현 벡터, 그 벡터를 갖는 형질 전환체 및 이들의 제조방법 |
US5714140A (en) * | 1989-12-13 | 1998-02-03 | Otsuka Pharmaceutical Co., Ltd. | Method for inhibiting the production of bioactive IL-1 by administering M-CSF |
DE4014750A1 (de) * | 1990-05-08 | 1991-11-14 | Boehringer Mannheim Gmbh | Muteine des granulozyten-stimulierenden faktors (g-csf) |
AU639091B2 (en) * | 1991-04-24 | 1993-07-15 | Otsuka Pharmaceutical Co., Ltd. | M-csf derivatives, expression vectors for said derivatives, transformants carrying said vectors and production of these |
WO1993025687A1 (en) | 1992-06-09 | 1993-12-23 | Chiron Corporation | Crystallization of m-csf |
AU6125294A (en) * | 1993-01-13 | 1994-08-15 | Genetics Institute Inc. | Process for producing m-csf 223 |
GB2355791B (en) | 1999-10-28 | 2004-10-20 | Molecular Light Tech Res Ltd | Detection of mRNA expression using chemiluminescent labelled probes |
KR100371264B1 (ko) * | 2000-01-25 | 2003-02-05 | 양문식 | 무라인 그래뉼로사이트-매크로파지 콜로니 자극 인자를포함하는 재조합 벡터와 그것을 발현하는 재조합아스퍼질러스 나이거 |
DK3417701T3 (da) | 2009-10-06 | 2022-03-14 | Regeneron Pharma | Genmodificerede mus og indpodning |
CN111808879A (zh) | 2011-02-15 | 2020-10-23 | 再生元制药公司 | 人源化m-csf小鼠 |
KR102287541B1 (ko) | 2012-09-07 | 2021-08-10 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
DK3556206T3 (da) | 2012-11-05 | 2021-08-09 | Regeneron Pharma | Genmodificerede ikke-humane dyr og fremgangsmåder til anvendelse deraf |
DK3145307T3 (en) | 2014-05-19 | 2019-04-15 | Regeneron Pharma | RE-MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO |
US10123518B2 (en) | 2015-04-13 | 2018-11-13 | Regeneron Pharmaceuticals, Inc | Genetically modified non-human animals and methods of use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0209601B1 (de) * | 1985-02-05 | 1993-12-15 | Cetus Oncology Corporation | Rekombinanter koloniestimulierender faktor-1 |
JP2583770B2 (ja) * | 1986-09-17 | 1997-02-19 | 大塚製薬株式会社 | 遺伝子 |
-
1987
- 1987-10-16 JP JP62507123A patent/JP2644794B2/ja not_active Expired - Lifetime
- 1987-10-16 WO PCT/US1987/002679 patent/WO1988003173A2/en active IP Right Grant
- 1987-10-16 HU HU876048A patent/HU215241B/hu not_active IP Right Cessation
- 1987-10-23 DE DE3789859T patent/DE3789859T2/de not_active Expired - Fee Related
- 1987-10-23 AT AT87309409T patent/ATE105869T1/de not_active IP Right Cessation
- 1987-10-23 EP EP87309409A patent/EP0272779B1/de not_active Expired - Lifetime
- 1987-10-23 ES ES87309409T patent/ES2052580T3/es not_active Expired - Lifetime
- 1987-10-23 CA CA000550127A patent/CA1339032C/en not_active Expired - Fee Related
- 1987-10-23 AU AU80070/87A patent/AU8007087A/en not_active Abandoned
-
1988
- 1988-06-22 NO NO882772A patent/NO301775B1/no not_active IP Right Cessation
- 1988-06-23 FI FI883056A patent/FI102190B/fi not_active IP Right Cessation
- 1988-06-24 DK DK198803501A patent/DK174237B1/da not_active IP Right Cessation
-
1991
- 1991-07-30 AU AU81494/91A patent/AU646277B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU646277B2 (en) | 1994-02-17 |
WO1988003173A3 (en) | 1988-07-28 |
FI102190B1 (fi) | 1998-10-30 |
HUT47635A (en) | 1989-03-28 |
HU215241B (hu) | 1998-11-30 |
DE3789859D1 (de) | 1994-06-23 |
WO1988003173A2 (en) | 1988-05-05 |
EP0272779A2 (de) | 1988-06-29 |
DE3789859T2 (de) | 1994-09-15 |
JP2644794B2 (ja) | 1997-08-25 |
EP0272779A3 (en) | 1988-08-03 |
FI102190B (fi) | 1998-10-30 |
NO882772D0 (no) | 1988-06-22 |
JPH01501283A (ja) | 1989-05-11 |
AU8149491A (en) | 1991-10-31 |
CA1339032C (en) | 1997-04-01 |
DK350188D0 (da) | 1988-06-24 |
DK174237B1 (da) | 2002-10-07 |
DK350188A (da) | 1988-08-19 |
FI883056A0 (fi) | 1988-06-23 |
ES2052580T3 (es) | 1994-07-16 |
NO882772L (no) | 1988-08-22 |
AU8007087A (en) | 1988-04-28 |
FI883056A (fi) | 1988-06-23 |
ATE105869T1 (de) | 1994-06-15 |
EP0272779B1 (de) | 1994-05-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |