NO300732B1 - 1H-indol-3-acetamid sPLA2-inhibitorer, farmasöytiske preparater inneholdende forbindelsene samt anvendelse av forbindelsene for fremstilling av farmasöytiske preparater - Google Patents

1H-indol-3-acetamid sPLA2-inhibitorer, farmasöytiske preparater inneholdende forbindelsene samt anvendelse av forbindelsene for fremstilling av farmasöytiske preparater Download PDF

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Publication number
NO300732B1
NO300732B1 NO941361A NO941361A NO300732B1 NO 300732 B1 NO300732 B1 NO 300732B1 NO 941361 A NO941361 A NO 941361A NO 941361 A NO941361 A NO 941361A NO 300732 B1 NO300732 B1 NO 300732B1
Authority
NO
Norway
Prior art keywords
indole
methyl
phenylmethyl
amino
oxy
Prior art date
Application number
NO941361A
Other languages
English (en)
Norwegian (no)
Other versions
NO941361D0 (no
NO941361L (no
Inventor
Nicholas James Bach
Robert Delane Dillard
Richard Walter Schevitz
Susan Elizabeth Draheim
Robert Bell Hermann
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO941361D0 publication Critical patent/NO941361D0/no
Publication of NO941361L publication Critical patent/NO941361L/no
Publication of NO300732B1 publication Critical patent/NO300732B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO941361A 1993-04-16 1994-04-15 1H-indol-3-acetamid sPLA2-inhibitorer, farmasöytiske preparater inneholdende forbindelsene samt anvendelse av forbindelsene for fremstilling av farmasöytiske preparater NO300732B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4862993A 1993-04-16 1993-04-16
US20872194A 1994-03-15 1994-03-15

Publications (3)

Publication Number Publication Date
NO941361D0 NO941361D0 (no) 1994-04-15
NO941361L NO941361L (no) 1994-10-17
NO300732B1 true NO300732B1 (no) 1997-07-14

Family

ID=26726342

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941361A NO300732B1 (no) 1993-04-16 1994-04-15 1H-indol-3-acetamid sPLA2-inhibitorer, farmasöytiske preparater inneholdende forbindelsene samt anvendelse av forbindelsene for fremstilling av farmasöytiske preparater

Country Status (25)

Country Link
US (1) US5684034A (el)
EP (1) EP0620215B1 (el)
JP (1) JPH0725850A (el)
KR (1) KR100317755B1 (el)
CN (1) CN1068588C (el)
AT (1) ATE183503T1 (el)
AU (1) AU676884B2 (el)
BR (1) BR9401482A (el)
CA (1) CA2121323A1 (el)
CO (1) CO4230092A1 (el)
CZ (1) CZ289750B6 (el)
DE (1) DE69420068T2 (el)
DK (1) DK0620215T3 (el)
ES (1) ES2138648T3 (el)
FI (1) FI941767A (el)
GR (1) GR3031783T3 (el)
HU (1) HUT70836A (el)
IL (1) IL109311A0 (el)
NO (1) NO300732B1 (el)
NZ (1) NZ260298A (el)
PL (1) PL181319B1 (el)
RU (1) RU2162463C2 (el)
TW (1) TW268942B (el)
UA (1) UA44218C2 (el)
YU (1) YU20194A (el)

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IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
US6252084B1 (en) 1994-03-15 2001-06-26 Eli Lilly And Company 1H-indole-3-acetamide sPLA2 inhibitors
ES2179088T3 (es) * 1994-04-01 2003-01-16 Lilly Co Eli Inhibidores de flsa2 1h-indol-3-glioxilamida.
US5641800A (en) * 1994-07-21 1997-06-24 Eli Lilly And Company 1H-indole-1-functional sPLA2 inhibitors
US6214876B1 (en) 1994-07-21 2001-04-10 Eli Lilly And Company Indene-1-acetamide sPLA2 inhibitors
US6630496B1 (en) 1996-08-26 2003-10-07 Genetics Institute Llc Inhibitors of phospholipase enzymes
CA2264020A1 (en) * 1996-08-26 1998-03-05 Jean Bemis Inhibitors of phospholipase enzymes
US6713645B1 (en) * 1996-10-30 2004-03-30 Eli Lilly And Company Substituted tricyclics
US6569539B2 (en) 1996-10-30 2003-05-27 Tetra Level Holdings & Finance S.A. Gas barrier packaging laminate method for production thereof and packaging containers
IL129481A0 (en) * 1996-10-30 2000-02-29 Lilly Co Eli Substituted tricyclics
US5919774A (en) * 1996-12-10 1999-07-06 Eli Lilly And Company Pyrroles as sPLA2 inhibitors
EP0987250A4 (en) * 1997-02-20 2000-12-06 Shionogi & Co INDOLDICARBONIC ACID DERIVATIVES
WO1999043654A2 (en) * 1998-02-25 1999-09-02 Genetics Institute, Inc. Inhibitors of phospholipase enzymes
EE200000522A (et) * 1998-02-25 2002-02-15 Genetics Institute, Inc. Fosfolipaas A2 ensüümi inhibiitor, seda sisaldav farmatseutiline kompositsioon ning meetod fosfolipaasensüümi toime pärssimiseks
US6828344B1 (en) 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6916841B2 (en) 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
JP2002504539A (ja) * 1998-02-25 2002-02-12 ジェネティックス・インスチチュート・インコーポレーテッド ホスホリパーゼ酵素の阻害剤
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
CA2326522A1 (en) 1998-03-31 1999-10-14 Shionogi & Co., Ltd. Pyrrolo[1,2-a]pyrazine spla2 inhibitor
ID23219A (id) * 1998-04-17 2000-03-30 Lilly Co Eli Trisiklik tersubstitusi
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CA2332528A1 (en) 1998-05-21 1999-11-25 Shionogi & Co., Ltd. Pyrrolo[1,2-b]pyridazine spla2 inhibitory
WO2000007590A1 (en) 1998-08-03 2000-02-17 Eli Lilly And Company INDOLE sPLA2 INHIBITORS
AU5331499A (en) 1998-08-03 2000-02-28 Eli Lilly And Company Indole spla2 inhibitors
WO2000010568A1 (en) 1998-08-24 2000-03-02 Draheim Susan E Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase a¿2?
WO2000021563A1 (fr) * 1998-10-14 2000-04-20 Shionogi & Co., Ltd. Moyens de traitement et de prevention contre les troubles ischemiques dus a la repercussion
AU1928800A (en) * 1998-12-22 2000-07-12 Eli Lilly And Company Substituted tricyclics
JP4636521B2 (ja) 1999-07-19 2011-02-23 塩野義製薬株式会社 ｓＰＬＡ２阻害作用を有する三環系化合物
US6706752B1 (en) 1999-07-19 2004-03-16 Eli Lilly And Company sPLA2 inhibitors
ATE350367T1 (de) * 1999-07-19 2007-01-15 Lilly Co Eli Spla2 inhibitoren
JP4636522B2 (ja) 1999-08-02 2011-02-23 塩野義製薬株式会社 ｓＰＬＡ２阻害作用を有する三環式化合物
US6787545B1 (en) 1999-08-23 2004-09-07 Shiongi & Co., Ltd. Pyrrolotriazine derivatives having spla2-inhibitory activities
AU7053700A (en) * 1999-09-20 2001-04-24 Eli Lilly And Company Novel spla2 inhibitors
US6831095B1 (en) 1999-09-20 2004-12-14 Eli Lilly And Company Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors
AU7559600A (en) * 1999-10-15 2001-04-23 Shionogi & Co., Ltd. V type and/or x type spla2 inhibitors
WO2001036420A1 (fr) 1999-11-15 2001-05-25 Shionogi & Co., Ltd. Derives d'aza-indolizine tricyclique ayant un effet inhibiteur sur spla¿2?
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Also Published As

Publication number Publication date
NO941361D0 (no) 1994-04-15
TW268942B (el) 1996-01-21
DE69420068D1 (de) 1999-09-23
EP0620215A1 (en) 1994-10-19
US5684034A (en) 1997-11-04
NO941361L (no) 1994-10-17
FI941767A (fi) 1994-10-17
ES2138648T3 (es) 2000-01-16
RU2162463C2 (ru) 2001-01-27
ATE183503T1 (de) 1999-09-15
CZ89394A3 (en) 1994-12-15
YU20194A (sh) 1997-09-30
BR9401482A (pt) 1994-10-18
CN1068588C (zh) 2001-07-18
KR100317755B1 (ko) 2002-08-09
GR3031783T3 (en) 2000-02-29
CN1098715A (zh) 1995-02-15
HU9401060D0 (en) 1994-07-28
NZ260298A (en) 1996-05-28
DK0620215T3 (da) 1999-12-06
CZ289750B6 (cs) 2002-03-13
AU676884B2 (en) 1997-03-27
IL109311A0 (en) 1994-07-31
DE69420068T2 (de) 1999-12-23
CO4230092A1 (es) 1995-10-19
AU5949294A (en) 1994-10-20
PL181319B1 (pl) 2001-07-31
HUT70836A (en) 1995-11-28
JPH0725850A (ja) 1995-01-27
UA44218C2 (uk) 2002-02-15
EP0620215B1 (en) 1999-08-18
FI941767A0 (fi) 1994-04-15
CA2121323A1 (en) 1994-10-17

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