NO300499B1 - Komplekse salter av hematoporfyrin og av derivater derav, blandinger av slike salter samt terapeutisk middel for detektering og/eller behandling av neoplasmer - Google Patents

Komplekse salter av hematoporfyrin og av derivater derav, blandinger av slike salter samt terapeutisk middel for detektering og/eller behandling av neoplasmer Download PDF

Info

Publication number
NO300499B1
NO300499B1 NO924151A NO924151A NO300499B1 NO 300499 B1 NO300499 B1 NO 300499B1 NO 924151 A NO924151 A NO 924151A NO 924151 A NO924151 A NO 924151A NO 300499 B1 NO300499 B1 NO 300499B1
Authority
NO
Norway
Prior art keywords
carboxy
salts
formula
mixture
salt
Prior art date
Application number
NO924151A
Other languages
English (en)
Norwegian (no)
Other versions
NO924151L (no
NO924151D0 (no
Inventor
Alfreda Graczyk
Jerzy Konarski
Original Assignee
Wojskowa Akad Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wojskowa Akad Tech filed Critical Wojskowa Akad Tech
Publication of NO924151D0 publication Critical patent/NO924151D0/no
Publication of NO924151L publication Critical patent/NO924151L/no
Publication of NO300499B1 publication Critical patent/NO300499B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
NO924151A 1991-10-29 1992-10-28 Komplekse salter av hematoporfyrin og av derivater derav, blandinger av slike salter samt terapeutisk middel for detektering og/eller behandling av neoplasmer NO300499B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL91292220A PL165249B1 (pl) 1991-10-29 1991-10-29 Sposób otrzymywania soli kompleksowych hematoporfiryny i jej pochodnych PL PL PL PL PL PL PL

Publications (3)

Publication Number Publication Date
NO924151D0 NO924151D0 (no) 1992-10-28
NO924151L NO924151L (no) 1993-04-30
NO300499B1 true NO300499B1 (no) 1997-06-09

Family

ID=20055985

Family Applications (1)

Application Number Title Priority Date Filing Date
NO924151A NO300499B1 (no) 1991-10-29 1992-10-28 Komplekse salter av hematoporfyrin og av derivater derav, blandinger av slike salter samt terapeutisk middel for detektering og/eller behandling av neoplasmer

Country Status (18)

Country Link
US (1) US5451599A (cs)
EP (1) EP0539960B1 (cs)
JP (1) JP3020759B2 (cs)
CN (1) CN1040328C (cs)
BG (1) BG61648B1 (cs)
CA (1) CA2081605C (cs)
CZ (1) CZ281694B6 (cs)
DE (1) DE69217819T2 (cs)
DK (1) DK0539960T3 (cs)
FI (1) FI100243B (cs)
HR (1) HRP921337B1 (cs)
LV (1) LV11952B (cs)
NO (1) NO300499B1 (cs)
PL (1) PL165249B1 (cs)
RU (1) RU2122003C1 (cs)
SI (1) SI9200286B (cs)
UA (1) UA40568C2 (cs)
YU (1) YU48961B (cs)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223600B2 (en) 2000-11-29 2007-05-29 The Norwegian Radium Hospital Research Foundation Photochemical internalization for delivery of molecules into the cytosol
US7521239B2 (en) 2000-11-29 2009-04-21 Pci Biotech As Photochemical internalization for virus-mediated molecule delivery into the cyosol

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO180167C (no) 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
US5948771A (en) * 1996-01-31 1999-09-07 The Trustees Of Columbia University In The City Of New York Method for treating heart failure using tetrapyrroles and metallotetrapyrroles
GB9606293D0 (en) * 1996-03-26 1996-05-29 William Harvey Research Limite Treatment of cancers and other tumours
RU2164136C2 (ru) * 1998-09-09 2001-03-20 Государственный научный центр РФ "НИОПИК" Фотосенсибилизатор для фотодинамической терапии
RU2236411C2 (ru) * 2002-06-06 2004-09-20 Московская государственная академия тонкой химической технологии им. М.В. Ломоносова Металлокомплексы карборанилпорфиринов, обладающие противоопухолевой активностью
RU2278119C1 (ru) * 2004-12-06 2006-06-20 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" Тетраазахлорины как фотосенсибилизаторы для фотодинамической терапии
RU2282647C1 (ru) * 2005-05-31 2006-08-27 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Фотосенсибилизаторы для антимикробной фотодинамической терапии
RU2282646C1 (ru) * 2005-05-31 2006-08-27 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Фотосенсибилизаторы для фотодинамической терапии
CN104130266A (zh) * 2013-05-02 2014-11-05 中国医学科学院生物医学工程研究所 一种新型原卟啉衍生物及制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2912M (fr) * 1963-07-24 1964-11-09 Rech S Pharma E R P H A R Soc Dichlorhydrate d'hématoporphyrinate de procaine.
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
JPS60152487A (ja) * 1984-01-18 1985-08-10 Sato Yakugaku Kenkyusho:Kk デユウテロポルフイリン誘導体及びその塩
US4675338A (en) * 1984-07-18 1987-06-23 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
GB8429845D0 (en) * 1984-11-26 1985-01-03 Efamol Ltd Porphyrins & cancer treatment
US4977177A (en) * 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
JPH0764728B2 (ja) * 1985-04-30 1995-07-12 日本石油化学株式会社 新規なテトラピロ−ル医薬用組成物
US4849207A (en) * 1985-10-23 1989-07-18 Nihon Medi-Physics Co., Ltd. Porphyrin derivatives
US4882234A (en) * 1986-11-12 1989-11-21 Healux, Inc. Storage-stable porphin compositions and a method for their manufacture
US4861876A (en) * 1986-11-26 1989-08-29 Wayne State University Hematoporphyrin derivative and method of preparation and purification
JPH0786109B2 (ja) * 1987-12-21 1995-09-20 浜理薬品工業株式会社 フェオフォルバイド誘導体
GB8805849D0 (en) * 1988-03-11 1988-04-13 Efamol Holdings Porphyrins & cancer treatment
US5190966A (en) * 1988-07-06 1993-03-02 Health Research, Inc. Purified hematoporphyrin dimers and trimers useful in photodynamic therapy
US4968715A (en) * 1988-07-06 1990-11-06 Health Research, Inc. Use of purified hematoporphyrin trimers in photodynamic therapy
US4961920A (en) * 1988-12-08 1990-10-09 Luminis Pty, Ltd. Phototherapeutic monovinyl and divinyl ether-linked dimers
US5059619A (en) * 1989-06-14 1991-10-22 Quadra Logic Technologies, Inc. Stable freeze-dried polyhematoporphyrin ether/ester
US4965054A (en) * 1989-08-01 1990-10-23 Henkel Corporation Process of extraction of gallium from aqueous solutions thereof
CN102565846B (zh) * 2011-12-30 2014-05-14 清华大学 蜂窝型热中子探测器

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223600B2 (en) 2000-11-29 2007-05-29 The Norwegian Radium Hospital Research Foundation Photochemical internalization for delivery of molecules into the cytosol
US7521239B2 (en) 2000-11-29 2009-04-21 Pci Biotech As Photochemical internalization for virus-mediated molecule delivery into the cyosol
US8008077B2 (en) 2000-11-29 2011-08-30 Pci Biotech As Photochemical internalization for delivery of molecules into the cytosol

Also Published As

Publication number Publication date
SI9200286B (en) 2001-06-30
YU48961B (sh) 2003-01-31
DK0539960T3 (da) 1997-09-15
FI100243B (fi) 1997-10-31
NO924151L (no) 1993-04-30
HRP921337A2 (en) 1994-10-31
UA40568C2 (uk) 2001-08-15
JPH05262775A (ja) 1993-10-12
EP0539960A2 (en) 1993-05-05
US5451599A (en) 1995-09-19
CN1071914A (zh) 1993-05-12
CZ281694B6 (cs) 1996-12-11
DE69217819T2 (de) 1997-09-04
DE69217819D1 (de) 1997-04-10
BG97030A (bg) 1994-03-24
CN1040328C (zh) 1998-10-21
CZ325292A3 (en) 1993-09-15
PL165249B1 (pl) 1994-11-30
BG61648B1 (bg) 1998-02-27
RU2122003C1 (ru) 1998-11-20
FI924856A0 (fi) 1992-10-26
LV11952A (lv) 1998-01-20
SI9200286A (en) 1993-06-30
CA2081605C (en) 2002-02-26
YU94592A (sh) 1995-12-04
CA2081605A1 (en) 1993-04-30
EP0539960B1 (en) 1997-03-05
LV11952B (en) 1998-06-20
NO924151D0 (no) 1992-10-28
HRP921337B1 (en) 2000-02-29
JP3020759B2 (ja) 2000-03-15
FI924856A7 (fi) 1993-04-30
PL292220A1 (en) 1993-09-20
EP0539960A3 (en) 1993-06-16

Similar Documents

Publication Publication Date Title
DE3686683T2 (de) Tetrapyrrolpolyaminomonocarbonsaeure-therapiemittel.
NO169290B (no) Analogifremgangsmaate for fremstilling av et terapeutisk aktivt tetrapyrrol-amino-dicarboxylsyreaddukt
KR20010108130A (ko) 치환된 포르피린
NO169291B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktivt tetrapyrrol-amino-dicarboxylsyreaddukt
NO300499B1 (no) Komplekse salter av hematoporfyrin og av derivater derav, blandinger av slike salter samt terapeutisk middel for detektering og/eller behandling av neoplasmer
JP7043260B2 (ja) 新規なジヒドロポルフィンｅ６誘導体及びその薬学的に許容される塩、その調製方法並びに使用
US8067404B2 (en) Phthalocyanine derivatives, process for their preparation, pharmaceutical compositions containing them and their use
CN101885736B (zh) 5-氨基乙酰丙酸盐、其制备方法及其用途
CA2423252C (en) Photosensitisers
US7195772B2 (en) Amino-acid iodine complex
NO173319B (no) Anvendelse av et olefyrin for paavisning av tumorer
Reshetnickov et al. Novel drug form of chlorin e6
JP2833740B2 (ja) 易水溶性クロロフィルの製造方法
CA2133284A1 (en) Octacarboxy substituted tetra(2,3-pyrazino)porphyrazines and their derivatives
KR101620577B1 (ko) 클로린 유도체를 함유하는 여드름 치료제 및 피지분비 억제제, 및 이를 포함하는 광역학적 치료용 키트
JPH03271268A (ja) ２，６―ジメトキシヒドロキノン―３―メルカプトプロピオン酸および２，６―ジメトキシヒドロキノン―３―メルカプト酢酸およびその抗癌用途
SK280098B6 (sk) Spôsob prípravy acetátu zinočnatého s fenazónom
JPH03190880A (ja) ２―メチルチオエチルオキサゾピロロキノリン類

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees