NO2681244T3 - - Google Patents
Info
- Publication number
- NO2681244T3 NO2681244T3 NO12707732A NO12707732A NO2681244T3 NO 2681244 T3 NO2681244 T3 NO 2681244T3 NO 12707732 A NO12707732 A NO 12707732A NO 12707732 A NO12707732 A NO 12707732A NO 2681244 T3 NO2681244 T3 NO 2681244T3
- Authority
- NO
- Norway
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11156665 | 2011-03-02 | ||
| EP12707732.9A EP2681244B1 (fr) | 2011-03-02 | 2012-02-29 | Anticorps anti-cea |
| PCT/EP2012/053390 WO2012117002A1 (fr) | 2011-03-02 | 2012-02-29 | Anticorps anti-cea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO2681244T3 true NO2681244T3 (fr) | 2018-04-28 |
Family
ID=45811481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO12707732A NO2681244T3 (fr) | 2011-03-02 | 2012-02-29 |
Country Status (35)
| Country | Link |
|---|---|
| US (7) | US8642742B2 (fr) |
| EP (2) | EP2681244B1 (fr) |
| JP (1) | JP6046642B2 (fr) |
| KR (1) | KR101981342B1 (fr) |
| CN (1) | CN103403029B (fr) |
| AR (1) | AR085591A1 (fr) |
| AU (1) | AU2012222463B9 (fr) |
| BR (1) | BR112013021460B1 (fr) |
| CA (1) | CA2827722C (fr) |
| CL (1) | CL2013002203A1 (fr) |
| CO (1) | CO6781491A2 (fr) |
| CR (1) | CR20130359A (fr) |
| DK (1) | DK2681244T3 (fr) |
| EA (1) | EA029300B1 (fr) |
| EC (1) | ECSP13012859A (fr) |
| ES (1) | ES2657856T3 (fr) |
| HK (1) | HK1187056A1 (fr) |
| HR (1) | HRP20180147T1 (fr) |
| HU (1) | HUE036229T2 (fr) |
| IL (1) | IL227482B (fr) |
| LT (1) | LT2681244T (fr) |
| MA (1) | MA34927B1 (fr) |
| MX (1) | MX347590B (fr) |
| MY (1) | MY164647A (fr) |
| NO (1) | NO2681244T3 (fr) |
| PE (1) | PE20141017A1 (fr) |
| PL (1) | PL2681244T3 (fr) |
| PT (1) | PT2681244T (fr) |
| RS (1) | RS56793B1 (fr) |
| SG (1) | SG192972A1 (fr) |
| SI (1) | SI2681244T1 (fr) |
| TW (1) | TWI553016B (fr) |
| UA (1) | UA115030C2 (fr) |
| WO (1) | WO2012117002A1 (fr) |
| ZA (1) | ZA201305323B (fr) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010288469A1 (en) * | 2009-08-31 | 2012-03-01 | Roche Glycart Ag | Affinity-matured humanized anti CEA monoclonal antibodies |
| RS62238B1 (sr) | 2011-02-10 | 2021-09-30 | Roche Glycart Ag | Mutantni interleukin-2 polipeptidi |
| JP6046642B2 (ja) | 2011-03-02 | 2016-12-21 | ロシュ グリクアート アーゲー | Ｃｅａ抗体 |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
| ME02928B (fr) | 2012-02-24 | 2018-04-20 | Abbvie Stemcentrx Llc | Modulateurs de dll3 et leurs procédés d'utilisation |
| TWI664192B (zh) | 2012-11-20 | 2019-07-01 | 法商賽諾菲公司 | 抗ｃｅａｃａｍ５抗體及其用途 |
| EP2925782B1 (fr) | 2012-12-03 | 2020-01-22 | NovImmune SA | Anticorps anti-cd47 et leurs procédés d'utilisation |
| BR112015019909A2 (pt) | 2013-02-22 | 2017-08-29 | Abbvie Stemcentrx Llc | Conjugados anticorpo-fármaco, composição farmacêutica, usos dos mesmos, e kit |
| EP2961770A1 (fr) * | 2013-02-26 | 2016-01-06 | Roche Glycart AG | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t |
| EP3708584A1 (fr) | 2013-02-26 | 2020-09-16 | Roche Glycart AG | Molécules bispécifiques de liaison à l'antigène activant des lymphocytes t |
| JP2014161283A (ja) * | 2013-02-26 | 2014-09-08 | Shizuoka Prefecture | Ｃｅａｃａｍ５遺伝子のスプライシングバリアント |
| PE20160674A1 (es) | 2013-08-28 | 2016-07-21 | Stemcentrx Inc | Metodos de conjugacion de anticuerpos especificos de sitio y composiciones |
| CA2922529A1 (fr) | 2013-08-28 | 2015-03-05 | Stemcentrx, Inc. | Nouveaux modulateurs sez6 et procedes d'utilisation |
| EP3065776A4 (fr) | 2013-11-06 | 2017-04-19 | AbbVie Stemcentrx LLC | Nouveaux anticorps anti-claudine et leurs méthodes d'utilisation |
| US9753036B2 (en) | 2014-04-29 | 2017-09-05 | Edp Biotech Corporation | Methods and compositions for screening and detecting biomarkers |
| AR100271A1 (es) * | 2014-05-19 | 2016-09-21 | Lilly Co Eli | Compuestos de vegfr2 / ang2 |
| BR112016030462A2 (pt) | 2014-08-04 | 2018-01-16 | F. Hoffmann-La Roche Ag | moléculas de ligação, um ou mais polinucleotídeos isolados, um ou mais vetores, célula hospedeira, método de produção de uma molécula de ligação, composição farmacêutica, uso da molécula de ligação, método de tratamento de doenças e de indução da lise de células alvo |
| TW201617368A (zh) | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | 新穎抗ｍｆｉ２抗體及使用方法 |
| CA2990755A1 (fr) | 2015-10-02 | 2017-04-06 | F. Hoffman-La Roche Ag | Molecules bispecifiques de liaison a l'antigene activant les lymphocytes t anti-ceaxcd3 |
| CN106065032B (zh) * | 2015-11-30 | 2019-07-09 | 成都金昆生物科技有限公司 | 一新型蛋白结合片段 |
| EP3178848A1 (fr) * | 2015-12-09 | 2017-06-14 | F. Hoffmann-La Roche AG | Anticorps de type ii contre cd20 pour la reduction de la formation des anticorps contre des médicaments |
| CA2997406C (fr) | 2015-12-09 | 2024-05-28 | F. Hoffmann-La Roche Ag | Anticorps anti-cd20 de type ii pour reduire la formation d'anticorps anti-medicament ou la liberation de cytokine |
| RU2652955C1 (ru) * | 2015-12-24 | 2018-05-03 | Федеральное государственное бюджетное учреждение "Российский научный центр рентгенорадиологии" Министерства здравоохранения российской федерации (ФГБУ "РНЦРР" Минздрава России) | Мономолекулярный химерный т-клеточный рецептор к раково-эмбриональному антигену |
| AU2017205089B2 (en) | 2016-01-08 | 2023-10-05 | F. Hoffmann-La Roche Ag | Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies |
| US10934359B2 (en) | 2016-04-21 | 2021-03-02 | Abbvie Stemcentrx Llc | Anti-BMPR1B antibodies and methods of use |
| UA126388C2 (uk) | 2016-11-18 | 2022-09-28 | Астеллас Фарма Інк. | Fab-фрагмент антитіла до muc1 людини |
| CN110505883A (zh) | 2017-04-13 | 2019-11-26 | 豪夫迈·罗氏有限公司 | 供治疗癌症的方法中使用的白介素-2免疫缀合物,cd40激动剂,和任选地pd-1轴结合拮抗剂 |
| TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段 |
| CN108219004A (zh) * | 2018-02-08 | 2018-06-29 | 吉林省拓华生物科技有限公司 | 双特异嵌合抗原受体修饰的t细胞、其制备方法及用途 |
| CA3115461A1 (fr) | 2018-03-09 | 2019-09-12 | AskGene Pharma, Inc. | Nouveaux promedicaments a base de cytokine |
| US11555071B2 (en) | 2018-06-03 | 2023-01-17 | Lamkap Bio Beta Ltd. | Bispecific antibodies against CEACAM5 and CD47 |
| CN112839683B (zh) | 2018-10-10 | 2023-11-14 | 安斯泰来制药株式会社 | 含有标记部-抗人抗体Fab片段复合物的药物组合物 |
| KR20210141794A (ko) * | 2019-03-15 | 2021-11-23 | 고에키자이단호진 간겐큐카이 | 항포도플라닌 항체 |
| CN114341189A (zh) | 2019-06-12 | 2022-04-12 | 奥美药业有限公司 | 全新il-15前药及其应用 |
| MX2021015221A (es) | 2019-06-13 | 2022-03-17 | Bolt Biotherapeutics Inc | Compuestos de aminobenzazepina, inmunoconjugados y usos de estos. |
| EP3992211A4 (fr) * | 2019-06-26 | 2023-01-04 | Jiangsu Hengrui Medicine Co., Ltd. | Anticorps anti-cea et son utilisation |
| AR119382A1 (es) | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | Anticuerpos de pre-direccionamiento y métodos de uso |
| WO2021046112A1 (fr) | 2019-09-03 | 2021-03-11 | Bolt Biotherapeutics, Inc. | Composés aminoquinoline, immunoconjugués et leurs utilisations |
| ES2975528T3 (es) | 2019-09-18 | 2024-07-08 | Lamkap Bio Alpha AG | Anticuerpos biespecíficos contra ceacam5 y cd3 |
| WO2021062406A1 (fr) | 2019-09-28 | 2021-04-01 | AskGene Pharma, Inc. | Promédicaments à base de cytokine et promédicaments doubles |
| JP2022549510A (ja) | 2019-09-30 | 2022-11-25 | ボルト バイオセラピューティクス、インコーポレーテッド | アミド結合したアミノベンズアゼピン免疫複合体、及びその使用 |
| WO2021081407A1 (fr) | 2019-10-25 | 2021-04-29 | Bolt Biotherapeutics, Inc. | Immunoconjugués de thiénoazépine et leurs utilisations |
| EP3831849A1 (fr) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Anticorps bispécifiques contre ceacam5 et cd47 |
| CA3176626A1 (fr) | 2020-05-08 | 2021-11-11 | David Dornan | Substrat pour elastase, immunoconjugues de liaison peptidique et leurs utilisations |
| CA3187277A1 (fr) | 2020-07-10 | 2022-01-13 | F. Hoffmann-La Roche Ag | Anticorps se liant a des cellules cancereuses et ciblant ces cellules avec des radionucleides |
| EP4196168A1 (fr) | 2020-08-13 | 2023-06-21 | Bolt Biotherapeutics, Inc. | Immunoconjugués de pyrazoloazépine et leurs utilisations |
| IL300500A (en) | 2020-08-20 | 2023-04-01 | A2 Biotherapeutics Inc | Preparations and methods for the treatment of mesothelin positive cancer |
| MX2023002017A (es) | 2020-08-20 | 2023-04-28 | A2 Biotherapeutics Inc | Composiciones y métodos para tratar cánceres positivos para ceacam. |
| US20220195066A1 (en) | 2020-12-11 | 2022-06-23 | Bolt Biotherapeutics, Inc. | Anti-cea immunoconjugates, and uses thereof |
| JP2024501453A (ja) | 2020-12-11 | 2024-01-12 | ボルト バイオセラピューティクス、インコーポレーテッド | 抗ｃｅａイムノコンジュゲート、及びそれらの使用 |
| WO2022133042A1 (fr) * | 2020-12-18 | 2022-06-23 | Bioardis, Llc | Molécules de liaison à ace5 et leurs utilisations |
| JP2024501809A (ja) | 2020-12-18 | 2024-01-16 | ランカプ バイオ ベータ リミテッド | Ｃｅａｃａｍ５およびｃｄ４７に対する二重特異性抗体 |
| WO2022152656A1 (fr) | 2021-01-12 | 2022-07-21 | F. Hoffmann-La Roche Ag | Anticorps fragmentés se liant à des cellules cancéreuses et ciblant ces cellules avec des radionucléides |
| KR20230131205A (ko) | 2021-01-13 | 2023-09-12 | 에프. 호프만-라 로슈 아게 | 병용 요법 |
| CN112557662B (zh) * | 2021-02-22 | 2021-07-06 | 和卓生物科技（上海）有限公司 | 一种结直肠癌检测试剂盒 |
| CA3212907A1 (fr) | 2021-03-26 | 2022-09-29 | Gary Brandt | Immunoconjugues de 2-amino-4-carboxamide-benzazepine et utilisations associees |
| EP4313162A1 (fr) | 2021-03-26 | 2024-02-07 | Bolt Biotherapeutics, Inc. | Immunoconjugués de 2-amino-4-carboxamide-benzazépine et leurs utilisations |
| CN115819596A (zh) * | 2021-09-17 | 2023-03-21 | 优迈生物科技(连云港)有限公司 | 一种靶向人ceacam5/6的抗体、制备方法和应用 |
| WO2023170474A1 (fr) | 2022-03-07 | 2023-09-14 | Novimmune Sa | Anticorps bispécifiques cd28 pour l'activation ciblée de lymphocytes t |
| WO2023180489A1 (fr) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Anticorps-conjugués pour le ciblage de tumeurs exprimant un antigène carcinoembryonnaire |
| WO2024110905A1 (fr) | 2022-11-24 | 2024-05-30 | Beigene, Ltd. | Conjugués anticorps anti-cea-médicament et procédés d'utilisation |
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