BR112013021460A2 - molécula de ligação ao antígeno variante, anticorpos isolado e que se liga ao antígeno carcinoembrionário humano, polinucleotídeo isolado, vetor, célula hospedeira, composição, métodos para induzir a lise celular de uma célula tumoral, de tratamento de um sujeito possuindo um câncer e para aumentar o tempo de sobrevida e uso - Google Patents

molécula de ligação ao antígeno variante, anticorpos isolado e que se liga ao antígeno carcinoembrionário humano, polinucleotídeo isolado, vetor, célula hospedeira, composição, métodos para induzir a lise celular de uma célula tumoral, de tratamento de um sujeito possuindo um câncer e para aumentar o tempo de sobrevida e uso

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Publication number
BR112013021460A2
BR112013021460A2 BR112013021460A BR112013021460A BR112013021460A2 BR 112013021460 A2 BR112013021460 A2 BR 112013021460A2 BR 112013021460 A BR112013021460 A BR 112013021460A BR 112013021460 A BR112013021460 A BR 112013021460A BR 112013021460 A2 BR112013021460 A2 BR 112013021460A2
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BR
Brazil
Prior art keywords
binding
methods
antigen
cell
cancer
Prior art date
Application number
BR112013021460A
Other languages
English (en)
Other versions
BR112013021460B1 (pt
Inventor
Ekkehard Moessner
Pablo Umana
Ralf Hosse
Thomas U Hofer
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of BR112013021460A2 publication Critical patent/BR112013021460A2/pt
Publication of BR112013021460B1 publication Critical patent/BR112013021460B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

molécula de ligação ao antígeno variante, anticorpos isolado e que se liga ao antígeno carcinoembrionário humano, polinucleotídeo isolado, vetor, célula hospedeira, composlção, métodos para induzlr a lise celular de uma célula tumoral, de tratamento de um sujeito possuindo um câncer e para aumentar o tempo de sobrevida e uso - a presete invenção provê moléculas de ligação ao antígeno (abm) que se ligam ao cea ligado à membrana, incluindo abms com propriedades terapêuticas melhoradas, e mélodos de utilização das mesmas.
BR112013021460-0A 2011-03-02 2012-02-29 Anticorpos, composição e uso do anticorpo BR112013021460B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11156665 2011-03-02
EP11156665.9 2011-03-02
PCT/EP2012/053390 WO2012117002A1 (en) 2011-03-02 2012-02-29 Cea antibodies

Publications (2)

Publication Number Publication Date
BR112013021460A2 true BR112013021460A2 (pt) 2016-10-25
BR112013021460B1 BR112013021460B1 (pt) 2022-12-20

Family

ID=45811481

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013021460-0A BR112013021460B1 (pt) 2011-03-02 2012-02-29 Anticorpos, composição e uso do anticorpo

Country Status (35)

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US (7) US8642742B2 (pt)
EP (2) EP3333193A1 (pt)
JP (1) JP6046642B2 (pt)
KR (1) KR101981342B1 (pt)
CN (1) CN103403029B (pt)
AR (1) AR085591A1 (pt)
AU (1) AU2012222463B9 (pt)
BR (1) BR112013021460B1 (pt)
CA (1) CA2827722C (pt)
CL (1) CL2013002203A1 (pt)
CO (1) CO6781491A2 (pt)
CR (1) CR20130359A (pt)
DK (1) DK2681244T3 (pt)
EA (1) EA029300B1 (pt)
EC (1) ECSP13012859A (pt)
ES (1) ES2657856T3 (pt)
HK (1) HK1187056A1 (pt)
HR (1) HRP20180147T1 (pt)
HU (1) HUE036229T2 (pt)
IL (1) IL227482B (pt)
LT (1) LT2681244T (pt)
MA (1) MA34927B1 (pt)
MX (1) MX347590B (pt)
MY (1) MY164647A (pt)
NO (1) NO2681244T3 (pt)
PE (1) PE20141017A1 (pt)
PL (1) PL2681244T3 (pt)
PT (1) PT2681244T (pt)
RS (1) RS56793B1 (pt)
SG (1) SG192972A1 (pt)
SI (1) SI2681244T1 (pt)
TW (1) TWI553016B (pt)
UA (1) UA115030C2 (pt)
WO (1) WO2012117002A1 (pt)
ZA (1) ZA201305323B (pt)

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