US3773946A
(en)
|
1969-09-02 |
1973-11-20 |
Parke Davis & Co |
Triglyceride-lowering compositions and methods
|
US3930024A
(en)
|
1969-09-02 |
1975-12-30 |
Parke Davis & Co |
Pharmaceutical compositions and methods
|
JPS5522636A
(en)
|
1978-08-04 |
1980-02-18 |
Takeda Chem Ind Ltd |
Thiazoliding derivative
|
WO1980000727A1
(en)
|
1978-09-29 |
1980-04-17 |
Secretary Energy Brit |
Improvements in and relating to electrical power transmission in fluid wells
|
US4469863A
(en)
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
AU548727B2
(en)
|
1981-03-12 |
1986-01-02 |
Gruppo Lepetit S.P.A. |
Beta-lactam acetic acid derivatives
|
JP2547714B2
(ja)
|
1981-10-23 |
1996-10-23 |
モルキユラ− バイオシステムズ インコ−ポレテツド |
オリゴヌクレオチド治療剤及びその製法
|
US5023243A
(en)
|
1981-10-23 |
1991-06-11 |
Molecular Biosystems, Inc. |
Oligonucleotide therapeutic agent and method of making same
|
IL64542A0
(en)
|
1981-12-15 |
1982-03-31 |
Yissum Res Dev Co |
Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them
|
JPS60136512A
(ja)
|
1983-12-26 |
1985-07-20 |
Eisai Co Ltd |
脂質代謝改善剤
|
DE3423166A1
(de)
|
1984-06-22 |
1986-01-02 |
Epis S.A., Zug |
Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
|
US4722840A
(en)
|
1984-09-12 |
1988-02-02 |
Chiron Corporation |
Hybrid particle immunogens
|
US4709017A
(en)
|
1985-06-07 |
1987-11-24 |
President And Fellows Of Harvard College |
Modified toxic vaccines
|
US5374426A
(en)
|
1986-09-03 |
1994-12-20 |
University Of Saskatchewan |
Rotavirus nucleocapsid protein VP6 in vaccine compositions
|
US4950740A
(en)
|
1987-03-17 |
1990-08-21 |
Cetus Corporation |
Recombinant diphtheria vaccines
|
GB8815795D0
(en)
|
1988-07-02 |
1988-08-10 |
Bkl Extrusions Ltd |
Glazing bead
|
NZ230747A
(en)
|
1988-09-30 |
1992-05-26 |
Bror Morein |
Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
|
DE3841091A1
(de)
|
1988-12-07 |
1990-06-13 |
Behringwerke Ag |
Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
|
EP0378881B1
(en)
|
1989-01-17 |
1993-06-09 |
ENIRICERCHE S.p.A. |
Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines
|
WO1990014837A1
(en)
|
1989-05-25 |
1990-12-13 |
Chiron Corporation |
Adjuvant formulation comprising a submicron oil droplet emulsion
|
EP0482068A1
(en)
|
1989-07-14 |
1992-04-29 |
American Cyanamid Company |
Cytokine and hormone carriers for conjugate vaccines
|
NZ235315A
(en)
|
1989-09-19 |
1991-09-25 |
Wellcome Found |
Chimaeric hepadnavirus core antigen proteins and their construction
|
IT1237764B
(it)
|
1989-11-10 |
1993-06-17 |
Eniricerche Spa |
Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
|
SE466259B
(sv)
|
1990-05-31 |
1992-01-20 |
Arne Forsgren |
Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
|
JP2999579B2
(ja)
|
1990-07-18 |
2000-01-17 |
武田薬品工業株式会社 |
Dnaおよびその用途
|
DE69113564T2
(de)
|
1990-08-13 |
1996-05-30 |
American Cyanamid Co |
Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff.
|
WO1992011291A1
(en)
|
1990-12-20 |
1992-07-09 |
Smithkline Beecham Biologicals (S.A.) |
Vaccines based on hepatitis b surface antigen
|
DE4202394A1
(de)
|
1991-04-04 |
1992-10-08 |
Teves Gmbh Alfred |
Schwimmsattel-teilbelagscheibenbremse mit einem bremsengehaeuse aus leichtmetall
|
IT1262896B
(it)
|
1992-03-06 |
1996-07-22 |
|
Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
|
AU4230493A
(en)
|
1992-05-06 |
1993-11-29 |
President And Fellows Of Harvard College |
Diphtheria toxin receptor-binding region
|
KR100278157B1
(ko)
|
1992-06-25 |
2001-01-15 |
장 스테판느 |
보조약을 함유하는 백신 조성물
|
IL102687A
(en)
|
1992-07-30 |
1997-06-10 |
Yeda Res & Dev |
Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
|
DK0812593T4
(da)
|
1993-03-23 |
2008-05-13 |
Smithkline Beecham Biolog |
Vaccinepræparater indeholdende 3-O-deacyleret monophosphoryllipid-A
|
GB9326253D0
(en)
|
1993-12-23 |
1994-02-23 |
Smithkline Beecham Biolog |
Vaccines
|
US5917017A
(en)
|
1994-06-08 |
1999-06-29 |
President And Fellows Of Harvard College |
Diphtheria toxin vaccines bearing a mutated R domain
|
US6455673B1
(en)
|
1994-06-08 |
2002-09-24 |
President And Fellows Of Harvard College |
Multi-mutant diphtheria toxin vaccines
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
EP0772619B2
(en)
|
1994-07-15 |
2010-12-08 |
The University of Iowa Research Foundation |
Immunomodulatory oligonucleotides
|
AUPM873294A0
(en)
|
1994-10-12 |
1994-11-03 |
Csl Limited |
Saponin preparations and use thereof in iscoms
|
US5648387A
(en)
|
1995-03-24 |
1997-07-15 |
Warner-Lambert Company |
Carboxyalkylethers, formulations, and treatment of vascular diseases
|
WO1996030523A2
(en)
|
1995-03-31 |
1996-10-03 |
Hans Wolf |
Antigen presentation system based on retrovirus-like particles
|
GB9513261D0
(en)
|
1995-06-29 |
1995-09-06 |
Smithkline Beecham Biolog |
Vaccines
|
GB9621091D0
(en)
|
1996-10-09 |
1996-11-27 |
Fondation Pour Le Perfectionem |
Attenuated microorganisms strains and their uses
|
ATE292980T1
(de)
|
1996-10-11 |
2005-04-15 |
Univ California |
Immunostimulierende oligonucleotidekonjugate
|
IL119971A
(en)
|
1997-01-07 |
2003-02-12 |
Yissum Res Dev Co |
Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
|
AUPO517897A0
(en)
|
1997-02-19 |
1997-04-11 |
Csl Limited |
Chelating immunostimulating complexes
|
JP2001513776A
(ja)
|
1997-02-28 |
2001-09-04 |
ユニバーシティ オブ アイオワ リサーチ ファウンデーション |
LPS関連障害の処置における非メチル化CpGジヌクレオチドを含む核酸の使用
|
WO1998040100A1
(en)
|
1997-03-10 |
1998-09-17 |
Ottawa Civic Loeb Research Institute |
USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE AS AN ADJUVANT
|
AU7690898A
(en)
|
1997-05-20 |
1998-12-11 |
Ottawa Civic Hospital Loeb Research Institute |
Vectors and methods for immunization or therapeutic protocols
|
CA2291483C
(en)
|
1997-06-06 |
2012-09-18 |
Dynavax Technologies Corporation |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
|
GB9712347D0
(en)
|
1997-06-14 |
1997-08-13 |
Smithkline Beecham Biolog |
Vaccine
|
GB9713156D0
(en)
|
1997-06-20 |
1997-08-27 |
Microbiological Res Authority |
Vaccines
|
IL121165A0
(en)
|
1997-06-26 |
1997-11-20 |
Yissum Res Dev Co |
Pharmaceutical compositions containing carboxylic acids and derivatives thereof
|
WO1999011241A1
(en)
|
1997-09-05 |
1999-03-11 |
Smithkline Beecham Biologicals S.A. |
Oil in water emulsions containing saponins
|
DE69911175T2
(de)
|
1998-02-12 |
2004-07-29 |
Apovia, Inc., San Diego |
Strategisch modifizierte hepatitis b kernproteine und ihre derivate
|
US6303114B1
(en)
|
1998-03-05 |
2001-10-16 |
The Medical College Of Ohio |
IL-12 enhancement of immune responses to T-independent antigens
|
JP2002510644A
(ja)
|
1998-04-03 |
2002-04-09 |
ユニバーシティ オブ アイオワ リサーチ ファウンデーション |
免疫治療用オリゴヌクレオチドおよびサイトカインを用いる免疫系刺激のための方法および産物
|
WO1999052549A1
(en)
|
1998-04-09 |
1999-10-21 |
Smithkline Beecham Biologicals S.A. |
Adjuvant compositions
|
TWI227241B
(en)
*
|
1998-06-20 |
2005-02-01 |
United Biomedical Inc |
IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate
|
GB9817052D0
(en)
|
1998-08-05 |
1998-09-30 |
Smithkline Beecham Biolog |
Vaccine
|
ES2188003T3
(es)
|
1998-09-18 |
2003-06-16 |
Pentapharm Ag |
Inhibidores de la uroquinasa.
|
JP2002527314A
(ja)
|
1998-09-28 |
2002-08-27 |
ハンス・バレ・エイピイエス |
車椅子上の座席用とすることが好ましいリフト
|
US6203837B1
(en)
|
1998-10-06 |
2001-03-20 |
Xcafe' Llc |
Coffee system
|
ATE357252T1
(de)
|
1998-10-16 |
2007-04-15 |
Glaxosmithkline Biolog Sa |
Adjuvanzsysteme und impfstoffe
|
AU770802B2
(en)
|
1998-10-21 |
2004-03-04 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Virus-like particles for the induction of autoantibodies
|
DK1119630T3
(da)
|
1998-11-05 |
2006-05-15 |
Powderject Vaccines Inc |
Nukleinsyrekonstruktioner til genetisk immunisering
|
RU2245163C2
(ru)
|
1998-11-30 |
2005-01-27 |
Сайтос Байотекнолэджи АГ |
Композиция (варианты), способ получения не природной упорядоченной и содержащей повторы антигенной матрицы, способ терапевтического лечения и способ иммунизации
|
DK1140157T3
(da)
|
1998-12-21 |
2009-06-08 |
Medimmune Inc |
Streptococcus pneumoniae-proteiner og immunogene fragmenter til vacciner
|
WO2000039299A2
(en)
|
1998-12-23 |
2000-07-06 |
Shire Biochem Inc. |
Streptococcus antigens
|
AUPP807399A0
(en)
|
1999-01-08 |
1999-02-04 |
Csl Limited |
Improved immunogenic lhrh composition and methods relating thereto
|
ES2572834T3
(es)
|
1999-02-17 |
2016-06-02 |
Csl Limited |
Complejos inmunogénicos y métodos relacionados con los mismos
|
PL203917B1
(pl)
|
1999-03-19 |
2009-11-30 |
Glaxosmithkline Biolog Sa |
Kompozycja immunogenna, sposób jej wytwarzania oraz zastosowanie
|
BR0009520A
(pt)
|
1999-04-01 |
2002-06-11 |
Esperion Therapeutics Inc |
Composto, método para sintetizar o mesmo, composição, metódos para o tratramento ou prevenção, em um paciente, de doença cardiovascular, dislipidemia, dislipoproteinemia, distúrbio de metabolismo de glucose, doença de alzheimer, sìndrome x ou sìndrome metabólica, septicemia, distúrbio trombótico, distúrbio associado com receptor ativado por proliferador de peroxissoma, obesidade, pancreatite, hipertensão, doença renal, câncer, inflamação, impotência, para reduzir o teor de gordura de carne de gado bovino, e, para reduzir o teor de colesterol de ovos de aves
|
AU781027B2
(en)
|
1999-04-09 |
2005-04-28 |
Department Of Health & Human Services |
Recombinant toxin a protein carrier for polysaccharide conjugate vaccines
|
GB9908533D0
(en)
|
1999-04-14 |
1999-06-09 |
Novartis Ag |
Organic compounds
|
CZ303515B6
(cs)
|
1999-04-19 |
2012-11-07 |
Smithkline Beecham Biologicals S. A. |
Adjuvantní prostredek
|
NO309798B1
(no)
*
|
1999-04-30 |
2001-04-02 |
Targovax As |
Peptidblanding, samt farmasoytisk sammensetning og kreftvaksine som innbefatter peptidblandingen
|
TR200200777T2
(tr)
|
1999-09-24 |
2002-09-23 |
Smithkline Beecham Biologicals S.A. |
Polioksietilen alkil eteri veya esteriyle en az bir iyonik olmayan yüzey aktif maddeli adjuvant.
|
EP1221971A2
(en)
|
1999-09-24 |
2002-07-17 |
SmithKline Beecham Biologics SA |
Use of the combination of polyoxyethylene sorbitan ester and octoxynol as adjuvant and its use in vaccines
|
EP1220684B2
(en)
|
1999-09-27 |
2010-07-14 |
Coley Pharmaceutical Group, Inc. |
Methods related to immunostimulatory nucleic acid-induced interferon
|
GB0007432D0
(en)
|
2000-03-27 |
2000-05-17 |
Microbiological Res Authority |
Proteins for use as carriers in conjugate vaccines
|
EA200201077A1
(ru)
|
2000-04-07 |
2003-04-24 |
Юниверсити Оф Лидз Инновэйшнз Лимитед |
Коровые антигенные химерные белки гепатита в
|
EP1278542A2
(en)
|
2000-05-05 |
2003-01-29 |
Cytos Biotechnology AG |
Molecular antigen arrays and vaccines
|
KR100927767B1
(ko)
|
2000-06-20 |
2009-11-20 |
아이디 바이오메디칼 코포레이션 |
스트렙토코커스 항원
|
DK1294893T3
(da)
|
2000-06-22 |
2006-07-03 |
Ucb Pharma Ltd |
Modifikation af hepatitis B-kerneantigen
|
WO2002005690A1
(en)
|
2000-07-15 |
2002-01-24 |
Lighthouse Display International Limited |
Shelf edge display fittings
|
GB0121171D0
(en)
*
|
2001-08-31 |
2001-10-24 |
Glaxosmithkline Biolog Sa |
Vaccine
|
AUPQ912000A0
(en)
|
2000-07-31 |
2000-08-24 |
Crown In The Right Of The Queensland Department Of Health, The |
Improved virus like particles
|
US20030138769A1
(en)
|
2000-08-16 |
2003-07-24 |
Birkett Ashley J. |
Immunogenic HBc chimer particles having enhanced stability
|
US7264810B2
(en)
*
|
2001-01-19 |
2007-09-04 |
Cytos Biotechnology Ag |
Molecular antigen array
|
AU2002309706A1
(en)
|
2001-05-11 |
2002-11-25 |
Aventis Pasteur, Inc. |
Novel meningitis conjugate vaccine
|
US20030091593A1
(en)
|
2001-09-14 |
2003-05-15 |
Cytos Biotechnology Ag |
In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
|
AU2002339224B2
(en)
*
|
2001-09-14 |
2008-10-09 |
Kuros Us Llc |
Packaging of immunostimulatory substances into virus-like particles: method of preparation and use
|
ES2321491T3
(es)
|
2001-10-05 |
2009-06-08 |
Cytos Biotechnology Ag |
Conjugados que llevan peptido angiotensina y uso de los mismos.
|
WO2003054007A2
(en)
|
2001-12-20 |
2003-07-03 |
Shire Biochem Inc. |
Streptococcus antigens
|
EP1517702A4
(en)
|
2002-02-21 |
2006-05-03 |
Apovia Inc |
IMMUNOGENIC HBC CHIMERIC PARTICLES STABILIZED WITH AN N-TERMINAL END CYSTEINE
|
GB0209878D0
(en)
|
2002-04-30 |
2002-06-05 |
Glaxosmithkline Biolog Sa |
Vaccine
|
RU2324704C2
(ru)
|
2002-07-17 |
2008-05-20 |
Цитос Байотекнолоджи Аг |
Молекулярные массивы антигенов
|
GB0219524D0
(en)
*
|
2002-08-21 |
2002-10-02 |
Queen Mary & Westfield College |
Therapeutic uses of monoclonal antibodies to the angiotensin-II type-1 receptor
|
ATE546156T1
(de)
|
2002-12-10 |
2012-03-15 |
Sanofi Pasteur Biologics Co |
Stabilisierte immunogene chimäre hbc-partikel
|
DE602004010376T2
(de)
|
2003-03-13 |
2008-10-23 |
Glaxosmithkline Biologicals S.A. |
Verfahren zur reinigung von bakteriellem cytolysin
|
EP1471152A1
(en)
|
2003-04-25 |
2004-10-27 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Mutations in the human PCSK9 gene associated to hypercholesterolemia
|
KR100958505B1
(ko)
|
2004-07-18 |
2010-05-17 |
씨에스엘 리미티드 |
면역자극 복합체 및 향상된 인터페론-감마 반응을 유도하기위한 올리고뉴클레오티드 제제
|
WO2006134423A2
(en)
|
2004-07-18 |
2006-12-21 |
Coley Pharmaceutical Group, Ltd. |
Methods and compositions for inducing innate immune responses
|
GB0421083D0
(en)
|
2004-09-22 |
2004-10-27 |
Glaxosmithkline Biolog Sa |
Purification process
|
EP1736538A1
(en)
|
2005-06-21 |
2006-12-27 |
Cytos Biotechnology AG |
Process for the preparative purification of virus-like-particles (VLPs)
|
DK2405002T3
(en)
|
2006-02-15 |
2015-01-05 |
Adiutide Pharmaceuticals Gmbh |
Compositions and methods for oligonukleotidformuleringer
|
CA2652247C
(en)
*
|
2006-05-08 |
2015-11-17 |
Adaerata, Limited Partnership |
Chimeric pcsk9 proteins, cells comprising same, and assays using same
|
US7572618B2
(en)
*
|
2006-06-30 |
2009-08-11 |
Bristol-Myers Squibb Company |
Polynucleotides encoding novel PCSK9 variants
|
US20080166785A1
(en)
|
2006-08-16 |
2008-07-10 |
Monica Sala-Schaeffer |
Polynucleotides allowing the expression and secretion of recombinant HBsAg virus-like particles containing a foreign peptide, their production and use
|
CA2680832A1
(en)
*
|
2007-03-27 |
2008-10-02 |
Merck & Co., Inc. |
Method for detecting autoprocessed, secreted pcsk9
|
CN101679527A
(zh)
*
|
2007-04-13 |
2010-03-24 |
诺瓦提斯公司 |
用于调节前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)的分子和方法
|
EA200901578A1
(ru)
|
2007-06-26 |
2010-08-30 |
Глаксосмитклайн Байолоджикалс С.А. |
Вакцина, содержащая конъюгаты капсульных полисахаридов streptococcus pneumoniae
|
JOP20080381B1
(ar)
*
|
2007-08-23 |
2023-03-28 |
Amgen Inc |
بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
|
SG2013014352A
(en)
*
|
2007-10-26 |
2014-09-26 |
Merck Sharp & Dohme |
Anti-pcsk9 and methods for treating lipid and cholesterol disorders
|
CA2710141A1
(en)
*
|
2007-12-20 |
2009-07-02 |
Cytos Biotechnology Ag |
Ngf conjugates and uses thereof
|
AR070316A1
(es)
|
2008-02-07 |
2010-03-31 |
Merck & Co Inc |
Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9)
|
AR070315A1
(es)
*
|
2008-02-07 |
2010-03-31 |
Merck & Co Inc |
Anticuerpos 1b20 antagonistas de pcsk9
|
TWI516501B
(zh)
*
|
2008-09-12 |
2016-01-11 |
禮納特神經系統科學公司 |
Pcsk9拮抗劑類
|
AT507604A1
(de)
|
2008-11-19 |
2010-06-15 |
Affiris Forschungs & Entwicklungs Gmbh |
Behandlung von atherosklerose
|
US9501570B2
(en)
|
2014-07-14 |
2016-11-22 |
Verizon Patent And Licensing Inc. |
Dynamic routing system
|
US9719791B2
(en)
|
2014-12-10 |
2017-08-01 |
Mapquest, Inc. |
Computerized systems and methods for providing travel information and/or content to users
|
US11780237B2
(en)
|
2015-06-23 |
2023-10-10 |
Ripples Ltd |
Method and apparatus for printing on a drink
|
US10114918B2
(en)
|
2016-01-27 |
2018-10-30 |
Arm Limited |
Physical placement control for an integrated circuit based on state bounds file
|