NO20092503L - Forbedret fremgangsmate for fremstilling av smertestillende midler - Google Patents
Forbedret fremgangsmate for fremstilling av smertestillende midlerInfo
- Publication number
- NO20092503L NO20092503L NO20092503A NO20092503A NO20092503L NO 20092503 L NO20092503 L NO 20092503L NO 20092503 A NO20092503 A NO 20092503A NO 20092503 A NO20092503 A NO 20092503A NO 20092503 L NO20092503 L NO 20092503L
- Authority
- NO
- Norway
- Prior art keywords
- oxymorphone hydrochloride
- painkillers
- preparation
- improved method
- oxymorphone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0624880.1A GB0624880D0 (en) | 2006-12-14 | 2006-12-14 | Improved method for making analgesics |
PCT/GB2007/050758 WO2008072018A1 (en) | 2006-12-14 | 2007-12-14 | Improved method for making analgesics |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20092503L true NO20092503L (no) | 2009-08-27 |
Family
ID=37712066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20092503A NO20092503L (no) | 2006-12-14 | 2009-07-02 | Forbedret fremgangsmate for fremstilling av smertestillende midler |
Country Status (13)
Country | Link |
---|---|
US (1) | US7851482B2 (es) |
EP (1) | EP2102213A1 (es) |
JP (2) | JP4786748B2 (es) |
CN (2) | CN102391271B (es) |
AU (1) | AU2007331223B2 (es) |
BR (1) | BRPI0720232A2 (es) |
CA (1) | CA2672644A1 (es) |
GB (1) | GB0624880D0 (es) |
MX (1) | MX337864B (es) |
NO (1) | NO20092503L (es) |
RU (1) | RU2422445C2 (es) |
WO (1) | WO2008072018A1 (es) |
ZA (1) | ZA200904317B (es) |
Families Citing this family (59)
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US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
WO2007103105A2 (en) * | 2006-03-02 | 2007-09-13 | Mallinckrodt Inc. | Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds |
US20080125592A1 (en) * | 2006-10-17 | 2008-05-29 | Penick Corporation | Process for preparing oxymorphone, naltrexone, and buprenorphine |
CA2674915C (en) * | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
ES2392594T3 (es) * | 2006-10-17 | 2012-12-12 | Penick Corporation | Procedimiento para preparar oximorfona |
DE102007011485A1 (de) * | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
JP2010522189A (ja) * | 2007-03-23 | 2010-07-01 | マリンクロッド・インコーポレイテッド | オリパビンからのオキシモルホンの改善された調製 |
CA2684458A1 (en) * | 2007-04-16 | 2008-10-30 | Mallinckrodt Inc. | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
FR2923484B1 (fr) * | 2007-11-09 | 2012-11-09 | Sanofi Aventis | Procede de preparation de composes morphiniques |
CA2713128C (en) | 2008-01-25 | 2016-04-05 | Gruenenthal Gmbh | Pharmaceutical dosage form |
WO2009135680A1 (en) | 2008-05-09 | 2009-11-12 | Grünenthal GmbH | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
ES2534908T3 (es) * | 2009-07-22 | 2015-04-30 | Grünenthal GmbH | Forma de dosificación de liberación controlada extruida por fusión en caliente |
CN102639118B (zh) | 2009-07-22 | 2015-07-29 | 格吕伦塔尔有限公司 | 氧化稳定的抗干扰剂型 |
WO2011154826A1 (en) | 2010-06-11 | 2011-12-15 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
ES2666404T3 (es) | 2010-06-11 | 2018-05-04 | Rhodes Technologies | Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos |
US8563571B2 (en) | 2010-07-22 | 2013-10-22 | Noramco, Inc. | Crystalline forms of oxymorphone hydrochloride |
EP2420503A1 (en) * | 2010-07-27 | 2012-02-22 | Universität Innsbruck | Process for the synthesis of 14-oxygenated morphinan-6-ones |
MX2013002293A (es) | 2010-09-02 | 2013-05-09 | Gruenenthal Gmbh | Forma de dosificacion resistente a alteracion que comprende un polimero anionico. |
PL2611426T3 (pl) | 2010-09-02 | 2014-09-30 | Gruenenthal Gmbh | Postać dawkowania zawierająca nieorganiczne sole, odporna na zgniatanie |
ES2613403T3 (es) | 2011-05-06 | 2017-05-24 | Brock University | Proceso de preparación de análogos de la morfina mediante N-desmetilación/funcionalización catalizada por metal y transferencia de grupo intramolecular |
WO2012163796A1 (en) | 2011-05-27 | 2012-12-06 | Grünenthal GmbH | Crystalline, anhydrous forms of oxymorphone hydrochloride |
RS56527B1 (sr) | 2011-07-29 | 2018-02-28 | Gruenenthal Gmbh | Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu |
DK2736495T3 (da) | 2011-07-29 | 2017-11-13 | Gruenenthal Gmbh | Misbrugsbestandig tablet som tilvejebringer øjeblikkelig frigivelse af lægemiddel |
EP2819656A1 (en) | 2012-02-28 | 2015-01-07 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
MX362357B (es) | 2012-04-18 | 2019-01-14 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis. |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
WO2013188418A1 (en) | 2012-06-11 | 2013-12-19 | Jianguang Sun | Improved method of preparing oxymorphone |
EP2872121B1 (en) | 2012-07-12 | 2018-09-05 | SpecGx LLC | Extended release, abuse deterrent pharmaceutical compositions |
TWI643859B (zh) | 2012-07-16 | 2018-12-11 | 羅德科技公司 | 改良之類鴉片合成方法 |
AU2013291723B2 (en) | 2012-07-16 | 2016-07-28 | Rhodes Technologies | Process for improved opioid synthesis |
CN103113378B (zh) * | 2013-02-20 | 2016-04-06 | 北京华素制药股份有限公司 | 一种盐酸羟吗啡酮的合成方法 |
US10154966B2 (en) | 2013-05-29 | 2018-12-18 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
AU2014273226B2 (en) | 2013-05-29 | 2019-06-27 | Grunenthal Gmbh | Tamper resistant dosage form with bimodal release profile |
JP6449871B2 (ja) | 2013-07-12 | 2019-01-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | エチレン−酢酸ビニルポリマーを含有する改変防止剤形 |
GB201313211D0 (en) | 2013-07-24 | 2013-09-04 | Cambrex Karlskoga Ab | New process |
GB201313915D0 (en) * | 2013-08-02 | 2013-09-18 | Johnson Matthey Plc | Process |
AU2014298257B2 (en) * | 2013-08-02 | 2016-11-10 | Macfarlan Smith Limited | Process for the preparation of oxymorphone |
BR112016010482B1 (pt) | 2013-11-26 | 2022-11-16 | Grünenthal GmbH | Preparação de uma composição farmacêutica em pó por meio de criomoagem |
US9932348B2 (en) | 2014-01-15 | 2018-04-03 | Rhodes Technologies | Process for improved oxycodone synthesis |
EP3094633B1 (en) | 2014-01-15 | 2018-03-14 | Rhodes Technologies | Process for improved oxymorphone synthesis |
US9062063B1 (en) | 2014-03-21 | 2015-06-23 | Johnson Matthey Public Limited Company | Forms of oxymorphone hydrochloride |
MX2016014738A (es) | 2014-05-12 | 2017-03-06 | Gruenenthal Gmbh | Formulacion en capsula de liberacion inmediata resistente a alteraciones que comprende tapentadol. |
CN106456550A (zh) | 2014-05-26 | 2017-02-22 | 格吕伦塔尔有限公司 | 避免乙醇剂量倾泻的多颗粒 |
MA40332A (fr) * | 2014-07-09 | 2021-04-28 | Rhodes Tech | Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane |
US20160052932A1 (en) * | 2014-08-25 | 2016-02-25 | Johnson Matthey Public Limited Company | Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone |
US9918979B2 (en) | 2015-01-29 | 2018-03-20 | Johnson Matthey Public Limited Company | Process of preparing low ABUK oxymorphone hydrochloride |
CA2983642A1 (en) | 2015-04-24 | 2016-10-27 | Grunenthal Gmbh | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
US20160340362A1 (en) * | 2015-05-20 | 2016-11-24 | Noramco, Inc. | Process For The Preparation Of Oxymorphone Freebase |
GB201513203D0 (en) | 2015-07-27 | 2015-09-09 | Cambrex Charles City Inc | New process |
CA2998259A1 (en) | 2015-09-10 | 2017-03-16 | Grunenthal Gmbh | Protecting oral overdose with abuse deterrent immediate release formulations |
EP3252055B1 (en) | 2016-05-31 | 2018-09-19 | Alcaliber Investigacion Desarrollo e Innovacion SLU | Process for obtaining 3,14-diacetyloxymorphone from oripavine |
US10941154B2 (en) * | 2017-06-20 | 2021-03-09 | Johnson Matthey Public Limited Company | Hydrogenation process for preparing oxycodone hydrochloride from 14-hydroxycodeinone |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
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GB717008A (en) * | 1951-05-29 | 1954-10-20 | Mozes Juda Lewenstein | Morphine derivative |
US3474101A (en) | 1960-09-05 | 1969-10-21 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
US3332950A (en) | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
GB1317210A (en) | 1970-12-11 | 1973-05-16 | Macarlan Smith Ltd | Reduction of thebaine |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
GB1478759A (en) | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
US4063064A (en) | 1976-02-23 | 1977-12-13 | Coherent Radiation | Apparatus for tracking moving workpiece by a laser beam |
US4200098A (en) | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
US4285987A (en) | 1978-10-23 | 1981-08-25 | Alza Corporation | Process for manufacturing device with dispersion zone |
US4861598A (en) | 1986-07-18 | 1989-08-29 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
DE3812567A1 (de) | 1988-04-15 | 1989-10-26 | Basf Ag | Verfahren zur herstellung pharmazeutischer mischungen |
FR2636330B1 (fr) | 1988-09-13 | 1990-11-30 | Sanofi Sa | Procede de preparation de derives de morphinane |
US5215758A (en) | 1991-09-11 | 1993-06-01 | Euroceltique, S.A. | Controlled release matrix suppository for pharmaceuticals |
US5472712A (en) | 1991-12-24 | 1995-12-05 | Euroceltique, S.A. | Controlled-release formulations coated with aqueous dispersions of ethylcellulose |
US5286493A (en) | 1992-01-27 | 1994-02-15 | Euroceltique, S.A. | Stabilized controlled release formulations having acrylic polymer coating |
US5273760A (en) | 1991-12-24 | 1993-12-28 | Euroceltigue, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5324351A (en) | 1992-08-13 | 1994-06-28 | Euroceltique | Aqueous dispersions of zein and preparation thereof |
IL107400A0 (en) * | 1992-11-10 | 1994-01-25 | Cortech Inc | Bradykinin antagonists |
AU3075197A (en) | 1996-05-21 | 1997-12-09 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Novel methods of o-demethylation and n-deprotection |
US6067749A (en) | 1996-07-11 | 2000-05-30 | Tasmanian Alkaloids Pty. Ltd. | Papaver somniferum strain with high concentration of thebaine and oripavine |
US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
GB9713703D0 (en) | 1997-06-30 | 1997-09-03 | Johnson Matthey Plc | Preparation of opiates |
GB9717629D0 (en) | 1997-08-21 | 1997-10-22 | Johnson Matthey Plc | Removal of residual organic solvents |
US6177567B1 (en) | 1999-10-15 | 2001-01-23 | Boehringer Ingelheim Chemicals, Inc. | Method for preparing oxycodone |
PL208484B1 (pl) | 2001-07-06 | 2011-05-31 | Penwest Pharmaceuticals Company | Sposoby wytwarzania preparatów oksymorfonu o przedłużonym uwalnianiu |
EP1406630A1 (en) * | 2001-07-06 | 2004-04-14 | Endo Pharmaceuticals Inc. | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
US7973064B2 (en) * | 2001-11-27 | 2011-07-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for potentiating an opiate analgesic |
US6864370B1 (en) | 2003-06-05 | 2005-03-08 | Zhaiwei Lin | Process for manufacturing oxycodone |
WO2005028483A1 (en) | 2003-09-22 | 2005-03-31 | Glaxosmithkline Australia Pty Ltd | Process for the synthesis of morphinane compounds and intermediates thereof |
US7875718B2 (en) | 2003-09-22 | 2011-01-25 | Johnson Matthey Public Limited Company | Process for the synthesis of morphinane compounds and intermediates thereof |
TWI365880B (en) * | 2004-03-30 | 2012-06-11 | Euro Celtique Sa | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp |
US6949645B1 (en) | 2004-05-20 | 2005-09-27 | Acura Pharmaceuticals, Inc. | Process for the production of opiates |
WO2006005112A1 (en) | 2004-07-09 | 2006-01-19 | Tasmanian Alkaloids Pty Ltd | Process for the synthesis of hydromorphone |
GB0421149D0 (en) | 2004-09-23 | 2004-10-27 | Johnson Matthey Plc | Preparation of oxycodone |
WO2006084389A1 (de) * | 2005-02-11 | 2006-08-17 | Cilag Ltd. | Verfahren zur reinigung von noroxymorphon-verbindungen |
WO2007103105A2 (en) * | 2006-03-02 | 2007-09-13 | Mallinckrodt Inc. | Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds |
US20080125592A1 (en) | 2006-10-17 | 2008-05-29 | Penick Corporation | Process for preparing oxymorphone, naltrexone, and buprenorphine |
-
2006
- 2006-12-14 GB GBGB0624880.1A patent/GB0624880D0/en not_active Ceased
-
2007
- 2007-10-03 US US11/866,840 patent/US7851482B2/en not_active Expired - Fee Related
- 2007-12-14 CN CN201110334801.8A patent/CN102391271B/zh not_active Expired - Fee Related
- 2007-12-14 BR BRPI0720232-6A2A patent/BRPI0720232A2/pt not_active Application Discontinuation
- 2007-12-14 RU RU2009126774/04A patent/RU2422445C2/ru not_active IP Right Cessation
- 2007-12-14 JP JP2009540878A patent/JP4786748B2/ja not_active Expired - Fee Related
- 2007-12-14 MX MX2009006283A patent/MX337864B/es active IP Right Grant
- 2007-12-14 ZA ZA200904317A patent/ZA200904317B/xx unknown
- 2007-12-14 CN CN200780051132A patent/CN101652371A/zh active Pending
- 2007-12-14 CA CA002672644A patent/CA2672644A1/en not_active Abandoned
- 2007-12-14 AU AU2007331223A patent/AU2007331223B2/en not_active Ceased
- 2007-12-14 WO PCT/GB2007/050758 patent/WO2008072018A1/en active Application Filing
- 2007-12-14 EP EP07848718A patent/EP2102213A1/en not_active Withdrawn
-
2009
- 2009-07-02 NO NO20092503A patent/NO20092503L/no not_active Application Discontinuation
-
2011
- 2011-05-27 JP JP2011118861A patent/JP2011201906A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RU2009126774A (ru) | 2011-01-20 |
JP4786748B2 (ja) | 2011-10-05 |
EP2102213A1 (en) | 2009-09-23 |
MX2009006283A (es) | 2009-10-12 |
US20080146601A1 (en) | 2008-06-19 |
CA2672644A1 (en) | 2008-06-19 |
MX337864B (es) | 2016-03-23 |
CN101652371A (zh) | 2010-02-17 |
WO2008072018A1 (en) | 2008-06-19 |
JP2011201906A (ja) | 2011-10-13 |
AU2007331223B2 (en) | 2010-08-26 |
RU2422445C2 (ru) | 2011-06-27 |
JP2010513260A (ja) | 2010-04-30 |
US7851482B2 (en) | 2010-12-14 |
CN102391271B (zh) | 2015-12-09 |
ZA200904317B (en) | 2010-08-25 |
CN102391271A (zh) | 2012-03-28 |
AU2007331223A1 (en) | 2008-06-19 |
BRPI0720232A2 (pt) | 2013-12-24 |
GB0624880D0 (en) | 2007-01-24 |
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Legal Events
Date | Code | Title | Description |
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |