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Expired
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GB13193/52A
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Individual
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Individual
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Publication of GB717008ApublicationCriticalpatent/GB717008A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
The invention comprises 14-hydroxy-dihydromorphinone and its salts, and preparation thereof by demethylating 14-hydroxy-dihydrocodeinone. In the example concentrated hydrobromic acid is used, the cooled diluted product being made alkaline and extracted with a water-immiscible liquid (e.g. chloroform) to remove unwanted material; the aqueous phase is acidified, ammonia is added and the desired product extracted with ether and crystallized from ethanol. Other demethylating agents are specified. The product forms salts with acids, e.g. a hydrochloride, hydrobromide, hydriodide, sulphate, orthophosphate, metaphosphate, nitrite, nitrate, bitartrate, salicylate, terephthalate, acetate, propionate, phthalate, benzoate, camphorsulphonate and citrate. It may be remethylated to 14-hydroxy-dihydrocodeinone.
PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH ANTI-INFLAMMATORY ACTION, AND PROCEDURE FOR THE PREPARATION OF MEDICINAL AROYL-SUBSTITUTED PHENYLAIC ACID DERIVATIVES.
PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS, THE FORMED PRODUCTS THEREFORE OBTAINED, AND PROCESS FOR PREPARING HYPOTENSIVELY ACTIVE HETEROCYCLIC GUANIDINOALKYL DERIVATIVES.
PROCESS FOR THE PREPARATION OF BICYCLICAL N-SUBSTITUATED TETRAHYDROPYRIDIN DERIVATIVES, PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS, AND THE FORMED PHARMACEUTICAL PREPARATIONS OBTAINED THEREFORE.
PROCESS FOR THE PREPARATION OF MEDICINAL DIBENZOCYCLOALKYL DERIVATIVES, PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT FROM THEIR AND FORMED MEDICINAL PRODUCT.
Process for the manufacture of cold-swelling starch preparations, the solutions of which, after drying, give water-resistant layers, and of solutions of these starch preparations, and products resulting therefrom
PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION, FORMED PREPARATION AND PROCEDURE FOR PREPARING A 2ALFA-CYANO 4ALFA, 5ALFA-EPOXY 3-OXOSTEROIDE COMPOUND.
PROCESS FOR THE PREPARATION OF PYRAZOL DERIVATIVES, PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION, AND FORMED PHARMACEUTICAL PREPARATION OBTAINED BY THIS PROCESS.
PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS CONTAINING ACTIVE SUBSTITUTED 3-AMINOPYRROLS OR SALTS THEREOF, THE PREPARATIONS FORMED AND PROCEDURE FOR PREPARING THE ACTIVE COMPOUNDS.
A process forthe carbonyl compounds, cyclopropane and ketenenes or manufacture of derivatives thereof by treating unsaturated organic compounds with nitrous oxide
A process forthe carbonyl compounds, cyclopropane and ketenenes or manufacture of derivatives thereof by treating unsaturated organic compounds with nitrous oxide