NO20091451L - Bicykliske heteroaromatiske forbindelser - Google Patents
Bicykliske heteroaromatiske forbindelserInfo
- Publication number
- NO20091451L NO20091451L NO20091451A NO20091451A NO20091451L NO 20091451 L NO20091451 L NO 20091451L NO 20091451 A NO20091451 A NO 20091451A NO 20091451 A NO20091451 A NO 20091451A NO 20091451 L NO20091451 L NO 20091451L
- Authority
- NO
- Norway
- Prior art keywords
- calkyl
- halogen
- alkyl
- aryl
- nrr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Det er beskrevet en forbindelse av formel (I). hvori:. Rer an arylgruppe, usubstituert eller substituert med 1,2, 3 eller 4 substituenter som kan være like eller forskjellige, valgt fra gruppen bestående av Ci-C6 alkyl, d-C6 alkoksy, Ci-C6 alkyltio, aryl d-C6 alkoksy, hydroksy, halogen, CN, COR, COOR, NRCOR, CONRR, S02NRR, NRS0R, NRR, halogen C-Calkyl, og halogen C-Calkoksy;. W er CH og X er N, eller W er N og X er CH, eller W og X er CH;. Y er C-Calkyl,. Rer hydrogen, C-Calkyl, Ci-C6 alkoksy, C-Calkyltio, aryl C-Calkoksy, hydroksy, halogen, CN, COR, karboksy, COOR, NRCOR, CONRR, S0NRR, NS0R, NRR, mono til perfluor- CrCalkyl, eller mono til perfluor- C-Calkoksy; n er 0-5;. Rer Ci-C4 alkyl; Rer C-Calkyl;. Rer hydrogen, Ci-Qo alkyl, C-Calkenyl, C-Calkynyl, halogen C-Calkyl, C-Csykloalkyl, C-Csykloalkyl, C-Csykloalkyl C-Calkyl, C-Csykloalkenyl, C-Csykloalkenyl Cl-Calkyl, 3-8-leddet heterosykloalkyl, 3-8-leddet heterosykloalkyl C-Calkyl, C-Caryl, C-Caryl C-Calkyl, heteroaryl, eller heteroaryl C-Calkyl; hvori hver gruppe eventuelt er substituert én eller flere ganger med like og/eller forskjellige grupper som er C-Calkoksy, C-Calkyltio, aryl C-Calkoksy, hydroksy, halogen, CN, NRR, eller halogen C-Calkoksy. Rog Rer uavhengig hydrogen eller C-Calkyl;. Rog Rer like eller forskjellige og er hydrogen eller C-Qo alkyl, ellerog Rdanner sammen med nitrogenet som de er bundet til, en 5- til 7-leddet ring som eventuelt inneholder ett eller flere ytterligere heteroatomer valgt fra oksygen, nitrogen og svovel, og eventuelt substituert med én eller to substituenter valgt fra gruppen bestående av hydroksy, okso, C-Calkyl, C-Calkylkarboksy, aryl og aryl C-Calkyl; eller et farmasøytisk akseptabelt salt derav.Disse forbindelsene er nyttige for behandling av aterosklerose eller andre inflammatoriske sykdommer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82932806P | 2006-10-13 | 2006-10-13 | |
US11/626,882 US7705005B2 (en) | 2006-10-13 | 2007-01-25 | Bicyclic heteroaromatic compounds |
PCT/US2007/081165 WO2008048866A2 (en) | 2006-10-13 | 2007-10-12 | Bicyclic heteroaromatic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20091451L true NO20091451L (no) | 2009-07-02 |
Family
ID=39303784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20091451A NO20091451L (no) | 2006-10-13 | 2009-04-14 | Bicykliske heteroaromatiske forbindelser |
Country Status (15)
Country | Link |
---|---|
US (1) | US7705005B2 (no) |
EP (1) | EP2081915A4 (no) |
JP (1) | JP2010506851A (no) |
KR (1) | KR20090079227A (no) |
AU (1) | AU2007312995A1 (no) |
BR (1) | BRPI0719861A2 (no) |
CA (1) | CA2672926A1 (no) |
CO (1) | CO6180449A2 (no) |
CR (1) | CR10729A (no) |
EA (1) | EA200970379A1 (no) |
IL (1) | IL197960A0 (no) |
MA (1) | MA30867B1 (no) |
MX (1) | MX2009003882A (no) |
NO (1) | NO20091451L (no) |
WO (1) | WO2008048866A2 (no) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080090851A1 (en) * | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
US20080090852A1 (en) * | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
AU2011340690C1 (en) | 2010-12-06 | 2016-03-10 | Glaxo Group Limited | Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by Lp - PLA2 |
EP2651403B1 (en) | 2010-12-17 | 2020-12-02 | Glaxo Group Limited | Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases |
WO2013014185A1 (en) | 2011-07-27 | 2013-01-31 | Glaxo Group Limited | Bicyclic pyrimidone compounds |
US8975400B2 (en) | 2011-07-27 | 2015-03-10 | Glaxo Group Limited | 2,3-dihydroimidazo[1, 2-c] pyrimidin-5(1 H)-one compounds use as LP-PLA2 inhibitors |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2948452B1 (en) | 2013-01-25 | 2017-08-09 | GlaxoSmithKline Intellectual Property Development Limited | 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors |
CN105008365B (zh) | 2013-01-25 | 2017-03-15 | 葛兰素史密斯克莱知识产权发展有限公司 | 化合物 |
KR20150108896A (ko) | 2013-01-25 | 2015-09-30 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Lp-pla2의 억제제로서의 비시클릭 피리미돈 화합물 |
WO2016012916A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
WO2016012917A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
WO2021089032A1 (zh) | 2019-11-09 | 2021-05-14 | 上海赛默罗生物科技有限公司 | 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途 |
CN115304620A (zh) | 2021-05-07 | 2022-11-08 | 上海赛默罗生物科技有限公司 | 嘧啶酮衍生物、其制备方法、药物组合物和用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE333446T1 (de) | 2000-02-16 | 2006-08-15 | Smithkline Beecham Plc | Pyrimidin-4-onderivat als ldl-pla2 inhibitor |
GB0024808D0 (en) * | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
GB0024807D0 (en) | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
GB0119795D0 (en) | 2001-08-14 | 2001-10-03 | Smithkline Beecham Plc | Novel process |
GB0127141D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham Plc | Novel compounds |
GB0127139D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
DE60226270T2 (de) * | 2001-12-07 | 2009-07-16 | Société de Technologie Michelin | Verfahren zur herstellung von butadien/isopren-copolymeren und dabei erhaltene copolymere |
GB0208279D0 (en) | 2002-04-10 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
GB0208280D0 (en) | 2002-04-10 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
US20080090852A1 (en) | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
US20080090851A1 (en) | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
-
2007
- 2007-01-25 US US11/626,882 patent/US7705005B2/en not_active Expired - Fee Related
- 2007-10-12 BR BRPI0719861-2A patent/BRPI0719861A2/pt not_active IP Right Cessation
- 2007-10-12 CA CA002672926A patent/CA2672926A1/en not_active Abandoned
- 2007-10-12 MX MX2009003882A patent/MX2009003882A/es unknown
- 2007-10-12 WO PCT/US2007/081165 patent/WO2008048866A2/en active Application Filing
- 2007-10-12 JP JP2009532588A patent/JP2010506851A/ja active Pending
- 2007-10-12 EP EP07844195A patent/EP2081915A4/en not_active Withdrawn
- 2007-10-12 AU AU2007312995A patent/AU2007312995A1/en not_active Abandoned
- 2007-10-12 EA EA200970379A patent/EA200970379A1/ru unknown
- 2007-10-12 KR KR1020097009494A patent/KR20090079227A/ko not_active Application Discontinuation
-
2009
- 2009-04-05 IL IL197960A patent/IL197960A0/en unknown
- 2009-04-07 CO CO09035905A patent/CO6180449A2/es not_active Application Discontinuation
- 2009-04-14 NO NO20091451A patent/NO20091451L/no not_active Application Discontinuation
- 2009-04-17 CR CR10729A patent/CR10729A/es not_active Application Discontinuation
- 2009-05-06 MA MA31844A patent/MA30867B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
EA200970379A1 (ru) | 2009-08-28 |
US20080090853A1 (en) | 2008-04-17 |
EP2081915A4 (en) | 2011-11-16 |
KR20090079227A (ko) | 2009-07-21 |
CR10729A (es) | 2009-05-25 |
WO2008048866A2 (en) | 2008-04-24 |
MA30867B1 (fr) | 2009-11-02 |
BRPI0719861A2 (pt) | 2014-06-03 |
WO2008048866A3 (en) | 2008-12-24 |
AU2007312995A1 (en) | 2008-04-24 |
MX2009003882A (es) | 2009-04-22 |
JP2010506851A (ja) | 2010-03-04 |
IL197960A0 (en) | 2009-12-24 |
CO6180449A2 (es) | 2010-07-19 |
CA2672926A1 (en) | 2008-04-24 |
EP2081915A2 (en) | 2009-07-29 |
US7705005B2 (en) | 2010-04-27 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |