MA30867B1 - Composes heteroaromatiques bicycliques - Google Patents
Composes heteroaromatiques bicycliquesInfo
- Publication number
- MA30867B1 MA30867B1 MA31844A MA31844A MA30867B1 MA 30867 B1 MA30867 B1 MA 30867B1 MA 31844 A MA31844 A MA 31844A MA 31844 A MA31844 A MA 31844A MA 30867 B1 MA30867 B1 MA 30867B1
- Authority
- MA
- Morocco
- Prior art keywords
- alkyl
- alcoxy
- halo
- aryl
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'INVENTION CONCERNE UN COMPOSÉ REPRÉSENTÉ PAR LA FORMULE (I) DANS LAQUELLE: R1 REPRÉSENTE UN GROUPE ARYLE, SUBSTITUÉ OU NON SUBSTITUÉ PAR 1, 2, 3 OU 4 SUBSTITUANTS QUI PEUVENT ÊTRE IDENTIQUES OU DIFFÉRENTS, SÉLECTIONNÉS DANS LE GROUPE COMPRENANT: ALKYLE C1-C6, ALCOXY C1-C6, ALKYLTHIO C1-C6, ARYL ALCOXY C1-C6, HYDROXY, HALO, CN, COR6, COOR6, NR6COR7, CONR8R9, SO2NR8R9, NR6SO2R7, NR8R9, HALO C1-C4 ALKYLE ET HALO C1-C4 ALCOXY; W REPRÉSENTE CH ET X REPRÉSENTE N, OU W REPRÉSENTE N ET X REPRÉSENTE CH, OU W ET X REPRÉSENTENT CH; Y REPRÉSENTE C2-C4ALKYLE, R2 REPRÉSENTE HYDROGÈNE, ALKYLE C1-C6, ALCOXY C1-C6, ALKYLTHIO C1-C6, ARYL C1-C6 ALCOXY, HYDROXY, HALO, CN, COR6, CARBOXY, COOR6, NR6COR7, CONR8R9, SO2NR8R9, NR6SO2R7, NR8R9, MONO À PERFLUORO-ALKYLE C1-C6, OU MONO À PERFLUORO-ALCOXY C1-C6; N VAUT ENTRE 0 ET 5; R3 REPRÉSENTE ALKYLE C1-C4; R4 REPRÉSENTE ALKYLE C1-C4; R5 REPRÉSENTE HYDROGÈNE, ALKYLE C1-C10, ALCÉNYLE C2-C10, ALCYNYLE C2-C10, HALO ALKYLE C1-C4, CYCLOALKYLE C3-C8, CYCLOALKYLE C3-C8 ALKYLE C1-C4, CYCLOALCÉNYLE C5-C8, CYCLOALCÉNYL C5-C8 ALKYLE C1-C4, HÉTÉROCYCLOALKYLE À 3 À 8 CHAÎNONS ALKYLE C3-C8 , HÉTÉROCYCLOALKYLE À 3 À 8 CHAÎNONS ALKYLE C1-C4, ARYLE C6-C14, ARYLE C6-C14 ALKYLE C1-C10, HÉTÉROARYLE, OU HÉTÉROARYLE ALKYLE C1_C10; CHAQUE GROUPE ÉTANT ÉVENTUELLEMENT UNE OU PLUSIEURS FOIS SUBSTITUÉ PAR LE MÊME GROUPE ET/OU UN GROUPE DIFFÉRENT QUI EST ALCOXY C1-C6, ALKYLTHIO C1-C6, ARYL C1-C6 ALCOXY, HYDROXY, HALO, CN, NR8R9, OU HALO C1-C4 ALCOXY, R6 ET R7 REPRÉSENTANT INDÉPENDAMMENT HYDROGÈNE OU ALKYLE C1_C10; R8 ET R9 ÉTANT IDENTIQUES OU DIFFÉRENTS ET REPRÉSENTANT HYDROGÈNE OU ALKYLE C1_C10, OU R9 ET R10 ASSOCIÉS À L'AZOTE AUQUEL ILS SONT LIÉS FORMENT UN NOYAU COMPORTANT DE 5 À 7 CHAÎNONS CONTENANT ÉVENTUELLEMENT UN OU PLUSIEURS AUTRES HÉTÉROATOMES SÉLECTIONNÉS PARMI HYDROGÈNE, AZOTE ET SOUFRE, ET ÉVENTUELLEMENT SUBSTITUÉS PAR UN OU DEUX SUBSTITUANTS SÉLECTIONNÉS DANS LE GROUPE COMPRENANT HYDROXY, HALO, OXO, ALKYLE C1-C4, ALKYLCARBOXY C1-C4, ARYLE ET ARYL ALKYLE C1-C4; OU UN SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CEUX-CI. LESDITS COMPOSÉS SONT UTILES POUR LE TRAITEMENT DE L'ATHÉROSCLÉROSE OU D'AUTRES MALADIES INFLAMMATOIRES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82932806P | 2006-10-13 | 2006-10-13 | |
US11/626,882 US7705005B2 (en) | 2006-10-13 | 2007-01-25 | Bicyclic heteroaromatic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30867B1 true MA30867B1 (fr) | 2009-11-02 |
Family
ID=39303784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31844A MA30867B1 (fr) | 2006-10-13 | 2009-05-06 | Composes heteroaromatiques bicycliques |
Country Status (15)
Country | Link |
---|---|
US (1) | US7705005B2 (fr) |
EP (1) | EP2081915A4 (fr) |
JP (1) | JP2010506851A (fr) |
KR (1) | KR20090079227A (fr) |
AU (1) | AU2007312995A1 (fr) |
BR (1) | BRPI0719861A2 (fr) |
CA (1) | CA2672926A1 (fr) |
CO (1) | CO6180449A2 (fr) |
CR (1) | CR10729A (fr) |
EA (1) | EA200970379A1 (fr) |
IL (1) | IL197960A0 (fr) |
MA (1) | MA30867B1 (fr) |
MX (1) | MX2009003882A (fr) |
NO (1) | NO20091451L (fr) |
WO (1) | WO2008048866A2 (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080090851A1 (en) * | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
US20080090852A1 (en) * | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
EP2582709B1 (fr) | 2010-06-18 | 2018-01-24 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
AU2011340690C1 (en) | 2010-12-06 | 2016-03-10 | Glaxo Group Limited | Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by Lp - PLA2 |
EP2651403B1 (fr) | 2010-12-17 | 2020-12-02 | Glaxo Group Limited | Procédés de traitement et de prévention de maladies oculaires |
WO2013014185A1 (fr) | 2011-07-27 | 2013-01-31 | Glaxo Group Limited | Composés pyrimidones bicycliques |
US8975400B2 (en) | 2011-07-27 | 2015-03-10 | Glaxo Group Limited | 2,3-dihydroimidazo[1, 2-c] pyrimidin-5(1 H)-one compounds use as LP-PLA2 inhibitors |
WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
EP2567959B1 (fr) | 2011-09-12 | 2014-04-16 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
EP2760862B1 (fr) | 2011-09-27 | 2015-10-21 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
EP2948452B1 (fr) | 2013-01-25 | 2017-08-09 | GlaxoSmithKline Intellectual Property Development Limited | Inhibiteurs de la phospholipase associée aux lipoprotéines a2 (lp-pla2) à base de 2,3-dihydro-imidazol[1,2-c]pyrimidin-5(1 h)-one |
CN105008365B (zh) | 2013-01-25 | 2017-03-15 | 葛兰素史密斯克莱知识产权发展有限公司 | 化合物 |
KR20150108896A (ko) | 2013-01-25 | 2015-09-30 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Lp-pla2의 억제제로서의 비시클릭 피리미돈 화합물 |
WO2016012916A1 (fr) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | Dérivés 1,2,3,5-tétrahydro-imidazo [1,2-c]pyrimidine utiles pour le traitement de maladies et de troubles médiés par la lp-pla2 |
WO2016012917A1 (fr) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | Dérivés 1,2,3,5-tétrahydro-imidazo [1,2-c]pyrimidine utiles pour le traitement de maladies et de troubles médiés par la lp-pla2 |
WO2021089032A1 (fr) | 2019-11-09 | 2021-05-14 | 上海赛默罗生物科技有限公司 | Dérivé de dihydroimidazopyrimidone tricyclique, son procédé de préparation, composition pharmaceutique et son utilisation |
CN115304620A (zh) | 2021-05-07 | 2022-11-08 | 上海赛默罗生物科技有限公司 | 嘧啶酮衍生物、其制备方法、药物组合物和用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE333446T1 (de) | 2000-02-16 | 2006-08-15 | Smithkline Beecham Plc | Pyrimidin-4-onderivat als ldl-pla2 inhibitor |
GB0024808D0 (en) * | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
GB0024807D0 (en) | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
GB0119795D0 (en) | 2001-08-14 | 2001-10-03 | Smithkline Beecham Plc | Novel process |
GB0127141D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham Plc | Novel compounds |
GB0127139D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
DE60226270T2 (de) * | 2001-12-07 | 2009-07-16 | Société de Technologie Michelin | Verfahren zur herstellung von butadien/isopren-copolymeren und dabei erhaltene copolymere |
GB0208279D0 (en) | 2002-04-10 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
GB0208280D0 (en) | 2002-04-10 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
US20080090852A1 (en) | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
US20080090851A1 (en) | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
-
2007
- 2007-01-25 US US11/626,882 patent/US7705005B2/en not_active Expired - Fee Related
- 2007-10-12 BR BRPI0719861-2A patent/BRPI0719861A2/pt not_active IP Right Cessation
- 2007-10-12 CA CA002672926A patent/CA2672926A1/fr not_active Abandoned
- 2007-10-12 MX MX2009003882A patent/MX2009003882A/es unknown
- 2007-10-12 WO PCT/US2007/081165 patent/WO2008048866A2/fr active Application Filing
- 2007-10-12 JP JP2009532588A patent/JP2010506851A/ja active Pending
- 2007-10-12 EP EP07844195A patent/EP2081915A4/fr not_active Withdrawn
- 2007-10-12 AU AU2007312995A patent/AU2007312995A1/en not_active Abandoned
- 2007-10-12 EA EA200970379A patent/EA200970379A1/ru unknown
- 2007-10-12 KR KR1020097009494A patent/KR20090079227A/ko not_active Application Discontinuation
-
2009
- 2009-04-05 IL IL197960A patent/IL197960A0/en unknown
- 2009-04-07 CO CO09035905A patent/CO6180449A2/es not_active Application Discontinuation
- 2009-04-14 NO NO20091451A patent/NO20091451L/no not_active Application Discontinuation
- 2009-04-17 CR CR10729A patent/CR10729A/es not_active Application Discontinuation
- 2009-05-06 MA MA31844A patent/MA30867B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
EA200970379A1 (ru) | 2009-08-28 |
US20080090853A1 (en) | 2008-04-17 |
EP2081915A4 (fr) | 2011-11-16 |
KR20090079227A (ko) | 2009-07-21 |
CR10729A (es) | 2009-05-25 |
WO2008048866A2 (fr) | 2008-04-24 |
BRPI0719861A2 (pt) | 2014-06-03 |
WO2008048866A3 (fr) | 2008-12-24 |
AU2007312995A1 (en) | 2008-04-24 |
MX2009003882A (es) | 2009-04-22 |
JP2010506851A (ja) | 2010-03-04 |
NO20091451L (no) | 2009-07-02 |
IL197960A0 (en) | 2009-12-24 |
CO6180449A2 (es) | 2010-07-19 |
CA2672926A1 (fr) | 2008-04-24 |
EP2081915A2 (fr) | 2009-07-29 |
US7705005B2 (en) | 2010-04-27 |
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