NO20082935L - Fremgangsmate for rensing av makrolidantibiotika - Google Patents
Fremgangsmate for rensing av makrolidantibiotikaInfo
- Publication number
- NO20082935L NO20082935L NO20082935A NO20082935A NO20082935L NO 20082935 L NO20082935 L NO 20082935L NO 20082935 A NO20082935 A NO 20082935A NO 20082935 A NO20082935 A NO 20082935A NO 20082935 L NO20082935 L NO 20082935L
- Authority
- NO
- Norway
- Prior art keywords
- macrolide antibiotics
- purifying
- procedure
- purification
- present
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000000843 powder Substances 0.000 abstract 3
- 238000000746 purification Methods 0.000 abstract 2
- 108010059993 Vancomycin Proteins 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
- 229960001572 vancomycin hydrochloride Drugs 0.000 abstract 1
- LCTORFDMHNKUSG-XTTLPDOESA-N vancomycin monohydrochloride Chemical compound Cl.O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 LCTORFDMHNKUSG-XTTLPDOESA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
Den foreliggende oppfinnelse angår en fremgangsmåte for rensingen av makrolidantibiotika. Nærmere bestemt angår oppfinnelsen en fremgangsmåte for rensingen av makrolidantibiotika som resulterer i et hvitt pulver. Pulveret forblir hvitt også etter noe tids lagring. Fremgangsmåten ved den foreliggende oppfinnelse utføres ved å løse makrolidantibiotika, feks. kommersielt vancomycin hydroklorid, i vann og utsette løsningen for ultrafiltrering med en membran som har en normal retensjon som er lavere enn 3000 Da, fortrinnsvis 10000 Da. Den rensede løsningen konsentreres fortrinnsvis ved hjelp av reversert osmose og lyofiliseres deretter ved de optimaliserte betingelser for trykk og temperatur for å oppnå et hvitt pulver.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05112283A EP1798237A1 (en) | 2005-12-16 | 2005-12-16 | Process for the purification of macrolide antibiotics |
| PCT/EP2006/069414 WO2007068644A1 (en) | 2005-12-16 | 2006-12-07 | Process for the purification of macrolide antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20082935L true NO20082935L (no) | 2008-06-30 |
Family
ID=36177625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20082935A NO20082935L (no) | 2005-12-16 | 2008-06-30 | Fremgangsmate for rensing av makrolidantibiotika |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8268963B2 (no) |
| EP (2) | EP1798237A1 (no) |
| JP (1) | JP5124475B2 (no) |
| CN (1) | CN101341167B (no) |
| AT (1) | ATE457994T1 (no) |
| AU (1) | AU2006326070B2 (no) |
| CA (1) | CA2628798C (no) |
| DE (1) | DE602006012360D1 (no) |
| DK (1) | DK1960418T3 (no) |
| ES (1) | ES2340804T3 (no) |
| NO (1) | NO20082935L (no) |
| PL (1) | PL1960418T3 (no) |
| PT (1) | PT1960418E (no) |
| RU (1) | RU2400489C2 (no) |
| WO (1) | WO2007068644A1 (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101101663B1 (ko) * | 2009-01-13 | 2011-12-30 | (주) 제노텍 | 반코마이신 습체의 정제방법 |
| ITLO20110001A1 (it) | 2011-05-03 | 2012-11-04 | Fisiopharma Srl | Flaconi di vancomicina cloroidrata con stabilità migliorata |
| EP2592090A1 (en) * | 2011-11-11 | 2013-05-15 | LEK Pharmaceuticals d.d. | Process of purification of teicoplanin |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2288473A1 (fr) * | 1974-10-22 | 1976-05-21 | Manche Union Coop Agr Laiti | Procede de traitement du lactoserum de fromagerie, notamment en vue de l'extraction de glycoproteides et d'acide sialique |
| US4667024A (en) | 1983-07-13 | 1987-05-19 | Smithkline Beckman Corporation | Process for the preparation of purified vancomycin class antibiotics |
| JPH0689038B2 (ja) * | 1983-12-12 | 1994-11-09 | イーライ・リリー・アンド・カンパニー | バンコマイシン改良精製法およびその生産物 |
| JPH0260598A (ja) * | 1988-08-22 | 1990-03-01 | Glaxo Group Ltd | 抗生物質の製造 |
| JP2577133B2 (ja) * | 1989-11-27 | 1997-01-29 | スティフティング フォール ド テフニスヘ ウェッテンスハッペン | 船舶のプロペラ |
| US5258495A (en) * | 1990-07-10 | 1993-11-02 | Abbott Laboratories | Process for making vancomycin HC1 |
| SI9500040B (sl) * | 1995-02-07 | 2002-02-28 | Lek, | Kromatografsko čiščenje Vankomicin hidroklorida z uporabo preparativne HPLC |
| SI9500039B (sl) | 1995-02-07 | 2002-02-28 | Lek, | Nov kombiniran postopek čiščenja Vankomicin hidroklorida |
| JPH10225299A (ja) * | 1996-12-11 | 1998-08-25 | Nippon Kayaku Co Ltd | バンコマイシンの製造方法 |
| US6391851B1 (en) * | 1997-03-10 | 2002-05-21 | Fujisawa Pharmaceutical Co., Ltd. | Hydrochlorides of vancomycin antibiotics and process for producing the same |
| JP4142149B2 (ja) | 1997-07-10 | 2008-08-27 | 明治製菓株式会社 | バンコマイシンの凍結乾燥製剤 |
| CN1056377C (zh) * | 1998-01-22 | 2000-09-13 | 清华大学 | 用环烷酸萃取体系提取和纯化抗生素 |
| US6696412B1 (en) * | 2000-01-20 | 2004-02-24 | Cubist Pharmaceuticals, Inc. | High purity lipopeptides, Lipopeptide micelles and processes for preparing same |
| KR100870660B1 (ko) * | 2001-12-31 | 2008-11-26 | 엘지디스플레이 주식회사 | 패널의 합착력이 향상된 액정표시소자 및 제조방법 |
| KR100476818B1 (ko) * | 2002-07-19 | 2005-03-17 | 종근당바이오 주식회사 | 테이코플라닌 에이 투 정제 방법 |
| CN1301331C (zh) * | 2003-12-26 | 2007-02-21 | 三达膜科技（厦门）有限公司 | 应用膜提取发酵类大环内酯型抗生素的方法 |
| KR100474653B1 (ko) * | 2004-04-16 | 2005-03-14 | 동국제약 주식회사 | 타이코플라닌의 고순도 생산방법 |
| SI21924A (sl) | 2004-12-07 | 2006-06-30 | Lek Farmacevtska Druzba D.D. | Cist vankomicin hidroklorid |
-
2005
- 2005-12-16 EP EP05112283A patent/EP1798237A1/en not_active Withdrawn
-
2006
- 2006-12-07 WO PCT/EP2006/069414 patent/WO2007068644A1/en not_active Ceased
- 2006-12-07 RU RU2008128465/04A patent/RU2400489C2/ru not_active IP Right Cessation
- 2006-12-07 DE DE602006012360T patent/DE602006012360D1/de active Active
- 2006-12-07 EP EP06841295A patent/EP1960418B1/en active Active
- 2006-12-07 JP JP2008544968A patent/JP5124475B2/ja active Active
- 2006-12-07 PT PT06841295T patent/PT1960418E/pt unknown
- 2006-12-07 ES ES06841295T patent/ES2340804T3/es active Active
- 2006-12-07 AT AT06841295T patent/ATE457994T1/de active
- 2006-12-07 CA CA2628798A patent/CA2628798C/en not_active Expired - Fee Related
- 2006-12-07 CN CN200680045911XA patent/CN101341167B/zh not_active Expired - Fee Related
- 2006-12-07 DK DK06841295.6T patent/DK1960418T3/da active
- 2006-12-07 PL PL06841295T patent/PL1960418T3/pl unknown
- 2006-12-07 US US12/095,642 patent/US8268963B2/en active Active
- 2006-12-07 AU AU2006326070A patent/AU2006326070B2/en not_active Ceased
-
2008
- 2008-06-30 NO NO20082935A patent/NO20082935L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK1960418T3 (da) | 2010-05-31 |
| CN101341167A (zh) | 2009-01-07 |
| DE602006012360D1 (de) | 2010-04-01 |
| CA2628798A1 (en) | 2007-06-21 |
| EP1798237A1 (en) | 2007-06-20 |
| ES2340804T3 (es) | 2010-06-09 |
| WO2007068644A1 (en) | 2007-06-21 |
| JP2009519294A (ja) | 2009-05-14 |
| PT1960418E (pt) | 2010-05-05 |
| RU2008128465A (ru) | 2010-01-27 |
| AU2006326070A1 (en) | 2007-06-21 |
| JP5124475B2 (ja) | 2013-01-23 |
| CN101341167B (zh) | 2012-08-15 |
| PL1960418T3 (pl) | 2010-07-30 |
| EP1960418B1 (en) | 2010-02-17 |
| AU2006326070B2 (en) | 2011-08-25 |
| EP1960418A1 (en) | 2008-08-27 |
| ATE457994T1 (de) | 2010-03-15 |
| RU2400489C2 (ru) | 2010-09-27 |
| US8268963B2 (en) | 2012-09-18 |
| US20100228005A1 (en) | 2010-09-09 |
| CA2628798C (en) | 2014-08-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |