NO20081975L - Diarylamin-inneholdende forbindelser og sammensetninger, og deres anvendelse som modulatorer av C-kit-reseptorer - Google Patents

Diarylamin-inneholdende forbindelser og sammensetninger, og deres anvendelse som modulatorer av C-kit-reseptorer

Info

Publication number
NO20081975L
NO20081975L NO20081975A NO20081975A NO20081975L NO 20081975 L NO20081975 L NO 20081975L NO 20081975 A NO20081975 A NO 20081975A NO 20081975 A NO20081975 A NO 20081975A NO 20081975 L NO20081975 L NO 20081975L
Authority
NO
Norway
Prior art keywords
compounds
diarylamine
compositions
modulators
kit receptors
Prior art date
Application number
NO20081975A
Other languages
English (en)
Norwegian (no)
Inventor
Pascal Furet
Vito Guagnano
Shifeng Pan
Yi Liu
Valentina Molteni
Xiaolin Li
Donatella Chianelli
Jon Loren
Donald S Karanewsky
Shuli You
Juliet Nabakka
Xiaodong Liu
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of NO20081975L publication Critical patent/NO20081975L/no

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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2612227C (en) * 2005-06-14 2014-04-22 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
WO2007038669A2 (en) * 2005-09-27 2007-04-05 Irm Llc Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors
ES2589736T3 (es) * 2006-03-31 2016-11-16 Novartis Ag Derivados de piridina como inhibidores de DGAT
CN101687853A (zh) 2007-05-04 2010-03-31 Irm责任有限公司 作为c-kit和pdgfr激酶抑制剂的嘧啶衍生物和组合物
JP5603770B2 (ja) 2007-05-31 2014-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２受容体拮抗薬およびその使用
BRPI0815572A2 (pt) * 2007-08-22 2015-02-18 Irm Llc Compostos e composições como inibidores de quinases
KR101218926B1 (ko) * 2007-08-22 2013-01-04 아이알엠 엘엘씨 키나제 억제제로서의 5-(4-(할로알콕시)페닐)피리미딘-2-아민 화합물 및 조성물
US20090170842A1 (en) 2007-11-14 2009-07-02 University Of Kansas Brca1-based breast or ovarian cancer prevention agents and methods of use
ATE551342T1 (de) 2008-02-22 2012-04-15 Irm Llc Heterocyclische verbindungen und zusammensetzungen als c-kit- und pdgfr- kinasehemmer
KR101579999B1 (ko) 2008-04-21 2015-12-23 타이젠 바이오테크놀러지 컴퍼니 리미티드 헤테로사이클릭 화합물
JP2012512834A (ja) 2008-12-19 2012-06-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 炎症、喘息及びｃｏｐｄの処置のためのｃｃｒ２受容体アンタゴニストとしての環状ピリミジン−４−カルボキサミド
CN102933579B (zh) 2009-12-17 2015-07-15 贝林格尔.英格海姆国际有限公司 新的ccr2受体拮抗剂及其用途
WO2011141474A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
WO2011141477A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2571870B1 (en) 2010-05-17 2015-01-21 Boehringer Ingelheim International GmbH Ccr2 antagonists and uses thereof
JP5636094B2 (ja) 2010-05-25 2014-12-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２受容体アンタゴニスト
WO2011151251A1 (en) 2010-06-01 2011-12-08 Boehringer Ingelheim International Gmbh New ccr2 antagonists
GB201009603D0 (en) 2010-06-08 2010-07-21 Cambridge Entpr Ltd Anti-inflammatory agent
RU2436786C1 (ru) * 2010-07-23 2011-12-20 Александр Васильевич Иващенко Замещенные индолы, противовирусный активный компонент, способ получения и применения
JP6094578B2 (ja) * 2011-06-09 2017-03-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝性障害の治療のためのｇｐｒ１１９モジュレーターとしての置換ピペリジン
JP5786258B2 (ja) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規かつ選択的なｃｃｒ２拮抗薬
DK2968316T3 (da) 2013-03-13 2019-10-07 Forma Therapeutics Inc 2-hydroxy-1-{4-[(4-phenylphenyl)carbonyl]piperazin-1-yl}ethan-1-on-derivater og relaterede forbindelser som fedtsyresyntase (fasn)-inhibitorer til behandlingen af cancer
PT3071559T (pt) 2013-11-18 2018-02-05 Elanco Tiergesundheit Ag Novos compostos
WO2016100940A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands
ES2811098T3 (es) 2015-07-02 2021-03-10 Centrexion Therapeutics Corp Citrato de (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidin-1-il)(5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2hpirano-2-il) metilamino)pirimidin-4il) metanona
JP2020501503A (ja) 2016-12-15 2020-01-23 ソシエテ・デ・プロデュイ・ネスレ・エス・アー コンパニオンアニマルにおけるリン又は酵素を調節する組成物及び方法
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
US10793554B2 (en) 2018-10-29 2020-10-06 Forma Therapeutics, Inc. Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN114763342A (zh) * 2021-01-09 2022-07-19 江苏天士力帝益药业有限公司 一种高纯度4-甲基哌嗪-1-甲酸酯的合成方法
TW202237082A (zh) * 2021-01-22 2022-10-01 南韓商日東製藥股份有限公司 安諾特明６（Ａｎｏｃｔａｍｉｎ ６）之抑制劑及其用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670537A1 (de) * 1966-11-09 1970-10-29 Degussa Verfahren zur Herstellung neuer substituierter Aminopyrimidine
DE1918073A1 (de) * 1969-04-09 1970-10-15 Boehringer Sohn Ingelheim Verfahren zur Herstellung neuer 5-Aryl-1H-1,5-benzodiazepin-2,4-dione
GB1534593A (en) * 1976-09-03 1978-12-06 Soc D Etudes Prod Chimique N-2,6-dichlorophenyl-2-aminopyrimidine and therapeutic compositions containing it
EP0164204A1 (en) 1984-05-12 1985-12-11 FISONS plc Novel pharmaceutically useful pyrimidines
DK0619805T3 (da) * 1991-11-25 2000-06-05 Pfizer 5-(Hetero-eller carbocyclylamino)-indolderivater, deres fremstilling og anvendelse som 5-HT1-agonister
ATE253915T1 (de) * 1999-06-30 2003-11-15 Merck & Co Inc Src-kinase hemmende verbindungen
GB0022438D0 (en) * 2000-09-13 2000-11-01 Novartis Ag Organic Compounds
JP2004530722A (ja) * 2001-06-29 2004-10-07 アブ サイエンス 骨喪失を治療するためのチロシンキナーゼ阻害剤の使用法
US7109204B2 (en) * 2001-08-01 2006-09-19 Merck & Co., Inc. Tyrosine kinase inhibitors
EP1578722A4 (en) * 2001-10-12 2006-09-06 Irm Llc KINASEINHIBITOR SCAFFOLD AND METHOD FOR THE PRODUCTION THEREOF
WO2005113548A1 (en) * 2004-05-20 2005-12-01 Sugen, Inc. Thiophene heteroaryl amines
KR20070113288A (ko) * 2005-03-16 2007-11-28 탈자진 인코포레이티드 피리미딘 화합물 및 사용 방법
JP2008543775A (ja) * 2005-06-08 2008-12-04 ターゲジェン インコーポレーティッド 眼の障害を治療するための方法および組成物
WO2007038669A2 (en) * 2005-09-27 2007-04-05 Irm Llc Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors

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US7592349B2 (en) 2009-09-22
CN101272685A (zh) 2008-09-24
US7514447B2 (en) 2009-04-07
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AU2006297089B2 (en) 2012-05-03
US20090012094A1 (en) 2009-01-08
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RU2436776C2 (ru) 2011-12-20
KR101415426B1 (ko) 2014-07-04
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US20080139597A1 (en) 2008-06-12
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