NO20075298L - Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists - Google Patents
Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonistsInfo
- Publication number
- NO20075298L NO20075298L NO20075298A NO20075298A NO20075298L NO 20075298 L NO20075298 L NO 20075298L NO 20075298 A NO20075298 A NO 20075298A NO 20075298 A NO20075298 A NO 20075298A NO 20075298 L NO20075298 L NO 20075298L
- Authority
- NO
- Norway
- Prior art keywords
- sphingosine
- phosphate
- thiophene derivatives
- receptor agonists
- novel thiophene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2005003070 | 2005-03-23 | ||
| PCT/IB2006/050850 WO2006100633A1 (en) | 2005-03-23 | 2006-03-20 | NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-l-PHOSPHATE-1 RECEPTOR AGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20075298L true NO20075298L (no) | 2007-12-20 |
Family
ID=36699202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20075298A NO20075298L (no) | 2005-03-23 | 2007-10-17 | Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7605269B2 (es) |
| EP (1) | EP1863474B1 (es) |
| JP (1) | JP5072825B2 (es) |
| KR (1) | KR20070116645A (es) |
| CN (1) | CN101146529B (es) |
| AR (1) | AR055751A1 (es) |
| AT (1) | ATE413874T1 (es) |
| AU (1) | AU2006226020A1 (es) |
| BR (1) | BRPI0609668A2 (es) |
| CA (1) | CA2602475C (es) |
| CY (1) | CY1108750T1 (es) |
| DE (1) | DE602006003642D1 (es) |
| DK (1) | DK1863474T3 (es) |
| ES (1) | ES2316062T3 (es) |
| IL (1) | IL186150A0 (es) |
| MX (1) | MX2007011672A (es) |
| NO (1) | NO20075298L (es) |
| NZ (1) | NZ562561A (es) |
| PL (1) | PL1863474T3 (es) |
| PT (1) | PT1863474E (es) |
| RU (1) | RU2404178C2 (es) |
| SI (1) | SI1863474T1 (es) |
| TW (1) | TW200700406A (es) |
| WO (1) | WO2006100633A1 (es) |
| ZA (1) | ZA200709087B (es) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4678139B2 (ja) * | 2004-05-10 | 2011-04-27 | トヨタ自動車株式会社 | 自動車の暖房制御システム |
| WO2006010379A1 (en) * | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
| WO2006100633A1 (en) | 2005-03-23 | 2006-09-28 | Actelion Pharmaceuticals Ltd | NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-l-PHOSPHATE-1 RECEPTOR AGONISTS |
| EP1863787B1 (en) | 2005-03-23 | 2011-05-25 | Actelion Pharmaceuticals Ltd. | Hydogrenated benzo[c]thiophene derivatives as immunomodulators |
| AU2006226022A1 (en) | 2005-03-23 | 2006-09-28 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists |
| BRPI0611631A2 (pt) * | 2005-06-24 | 2010-09-21 | Actelion Pharmaceuticals Ltd | composto, composição farmacêutica, e, uso de um composto |
| AR057894A1 (es) * | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
| TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
| PL1979345T3 (pl) | 2006-01-24 | 2010-04-30 | Actelion Pharmaceuticals Ltd | Nowe pochodne pirydyny |
| WO2007116866A1 (ja) * | 2006-04-03 | 2007-10-18 | Astellas Pharma Inc. | ヘテロ化合物 |
| MX2009002233A (es) | 2006-09-07 | 2009-03-16 | Actelion Pharmaceuticals Ltd | Derivados de piridin-4-il como agentes inmunomoduladores. |
| AR061841A1 (es) * | 2006-09-07 | 2008-09-24 | Actelion Pharmaceuticals Ltd | Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores. |
| EP2069335B1 (en) | 2006-09-08 | 2012-12-26 | Actelion Pharmaceuticals Ltd. | Pyridin-3-yl derivatives as immunomodulating agents |
| JO2701B1 (en) | 2006-12-21 | 2013-03-03 | جلاكسو جروب ليميتد | Vehicles |
| ES2450750T3 (es) * | 2007-03-16 | 2014-03-25 | Actelion Pharmaceuticals Ltd. | Derivados de amino-piridina como agonistas del receptor S1P1/EDG1 |
| JO2686B1 (en) * | 2007-04-19 | 2013-03-03 | جلاكسو جروب ليمتد | Vehicles |
| TW200930363A (en) * | 2007-12-10 | 2009-07-16 | Actelion Pharmaceuticals Ltd | Novel thiophene derivatives |
| GB0725101D0 (en) | 2007-12-21 | 2008-01-30 | Glaxo Group Ltd | Compounds |
| PE20091339A1 (es) | 2007-12-21 | 2009-09-26 | Glaxo Group Ltd | Derivados de oxadiazol con actividad sobre receptores s1p1 |
| EP2262799B1 (en) * | 2008-03-06 | 2012-07-04 | Actelion Pharmaceuticals Ltd. | Pyridine compounds |
| US8575200B2 (en) * | 2008-03-07 | 2013-11-05 | Actelion Pharmaceuticals Ltd | Pyridin-2-yl derivatives as immunomodulating agents |
| SI2278960T2 (sl) | 2008-03-17 | 2020-02-28 | Actelion Pharmaceuticals Ltd. | Režim odmerjanja za selektivni agonist receptorja sip1 |
| GB0807910D0 (en) * | 2008-04-30 | 2008-06-04 | Glaxo Group Ltd | Compounds |
| WO2009153307A1 (en) * | 2008-06-20 | 2009-12-23 | Glaxo Group Limited | Compounds |
| CN104311472B9 (zh) | 2008-07-23 | 2020-03-17 | 艾尼纳制药公司 | 经取代的1,2,3,4-四氢环戊并[b]吲哚-3-基乙酸衍生物 |
| MX2011002199A (es) | 2008-08-27 | 2011-05-10 | Arena Pharm Inc | Derivados de acidos triciclicos substituidos como agonistas del receptor s1p1 utiles en el tratamiento de trastornos autoinmunes e inflamatorios. |
| US8389509B2 (en) | 2009-01-23 | 2013-03-05 | Bristol-Myers Squibb Company | Substituted pyrazole compounds |
| WO2010085582A1 (en) | 2009-01-23 | 2010-07-29 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
| US8354398B2 (en) | 2009-01-23 | 2013-01-15 | Bristol-Myers Squibb Company | Substituted isoxazole compounds |
| US20100249071A1 (en) * | 2009-03-30 | 2010-09-30 | Exelixis, Inc. | Modulators of S1P and Methods of Making And Using |
| DE102009002514A1 (de) | 2009-04-21 | 2010-10-28 | Evonik Degussa Gmbh | Verfahren zur Herstellung von substituierten 1,4-Chinonmethiden |
| GB0910674D0 (en) | 2009-06-19 | 2009-08-05 | Glaxo Group Ltd | Novel compounds |
| AR077413A1 (es) | 2009-07-16 | 2011-08-24 | Actelion Pharmaceuticals Ltd | Derivados piridin-4-ilo |
| US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
| US9216972B2 (en) | 2009-10-29 | 2015-12-22 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds |
| CN103221391B (zh) | 2010-01-27 | 2018-07-06 | 艾尼纳制药公司 | (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法 |
| CA2789480A1 (en) | 2010-03-03 | 2011-09-09 | Arena Pharmaceuticals, Inc. | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
| US8835470B2 (en) | 2010-04-23 | 2014-09-16 | Bristol-Myers Squibb Company | Mandelamide heterocyclic compounds |
| US8822510B2 (en) | 2010-07-20 | 2014-09-02 | Bristol-Myers Squibb Company | Substituted 3-phenyl-1,2,4-Oxadiazole compounds |
| EP2619190B1 (en) | 2010-09-24 | 2015-08-12 | Bristol-Myers Squibb Company | Substituted oxadiazole compounds and their use as s1p1 agonists |
| CN103298807A (zh) | 2010-11-03 | 2013-09-11 | 百时美施贵宝公司 | 作为用于治疗自身免疫性疾病和血管疾病的s1p1激动剂的杂环化合物 |
| DK2665720T3 (en) | 2011-01-19 | 2015-07-13 | Actelion Pharmaceuticals Ltd | 2-methoxy-pyridin-4-yl-yl derivatives |
| CA2895172C (en) | 2012-08-17 | 2020-08-18 | Actelion Pharmaceuticals Ltd | Process for the preparation of|(2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-|(o-tolyl)thiazolidin-4-one and intermediate used in said process |
| UY35338A (es) | 2013-02-21 | 2014-08-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Compuestos bicíclicos moduladores de la actividad de s1p1 y composiciones farmacéuticas que los contienen |
| AR101591A1 (es) | 2014-08-20 | 2016-12-28 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos |
| AU2016205361C1 (en) | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| WO2016042172A1 (en) | 2015-02-03 | 2016-03-24 | Active Biotech Ab | Imidazo[2,1-b]thiazole and 5,6-dihydroimidazo[2,1-b]thiazole derivatives useful as s100-inhibitors |
| HUE047646T2 (hu) | 2015-05-20 | 2020-05-28 | Idorsia Pharmaceuticals Ltd | Az (S)-3-{4-[5-(2-ciklopentil-6-metoxi-piridin-4-il)-[1,2,4]oxadiazol-3-il]-2-etil-6-metil-fenoxi} -propán-1,2-diol vegyület kristályformája |
| US10111841B2 (en) | 2015-06-19 | 2018-10-30 | University Of South Florida | Stabilization of alcohol intoxication-induced cardiovascular instability |
| KR102603199B1 (ko) | 2015-06-22 | 2023-11-16 | 아레나 파마슈티칼스, 인크. | Ｓ1ｐ1 수용체-관련 장애에서의 사용을 위한 (ｒ)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[ｂ]인돌-3-일)아세트산 (화합물 1)의 결정성 ｌ-아르기닌 염 |
| WO2017004608A1 (en) * | 2015-07-02 | 2017-01-05 | Exelixis, Inc. | Oxadiazole modulators of s1p methods of making and using |
| EP3507278B1 (en) | 2016-09-02 | 2021-01-27 | Bristol-Myers Squibb Company | Substituted tricyclic heterocyclic compounds |
| MX2019009841A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la colangitis biliar primaria. |
| KR20190113955A (ko) | 2017-02-16 | 2019-10-08 | 아레나 파마슈티칼스, 인크. | 장-외 증상을 갖는 염증성 장질환의 치료를 위한 화합물 및 방법 |
| US11046646B2 (en) | 2017-08-09 | 2021-06-29 | Bristol-Myers Squibb Company | Alkylphenyl compounds |
| US11059784B2 (en) | 2017-08-09 | 2021-07-13 | Bristol-Myers Squibb Company | Oxime ether compounds |
| US11555015B2 (en) | 2018-09-06 | 2023-01-17 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
| US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
| US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
| US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
| US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991015583A1 (en) | 1990-04-05 | 1991-10-17 | The American National Red Cross | A protein family related to immediate-early protein expressed by human endothelial cells during differentiation |
| WO1999046277A1 (en) | 1998-03-09 | 1999-09-16 | Smithkline Beecham Corporation | HUMAN EDG-1c POLYNUCLEOTIDES AND POLYPEPTIDES AND METHODS OF USE |
| GB9808665D0 (en) * | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic compounds |
| ATE448193T1 (de) | 2002-01-18 | 2009-11-15 | Merck & Co Inc | ßN-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATE, PHOSPHONATE UND TETRAZOLE ALS EDG REZEPTORAGONISTENß |
| CA2488117A1 (en) * | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
| WO2004035538A1 (en) | 2002-10-15 | 2004-04-29 | Merck & Co., Inc. | Process for making azetidine-3-carboxylic acid |
| JP2006528980A (ja) * | 2003-05-15 | 2006-12-28 | メルク エンド カムパニー インコーポレーテッド | Ｓ１ｐ受容体作働薬としての３−（２−アミノ−１−アザシクロ）−５−アリール−１，２，４−オキサジアゾール類 |
| WO2006010379A1 (en) * | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
| WO2006037000A1 (en) | 2004-09-27 | 2006-04-06 | Avon Protection Systems, Inc. | Respirator exhalation unit |
| WO2006100633A1 (en) | 2005-03-23 | 2006-09-28 | Actelion Pharmaceuticals Ltd | NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-l-PHOSPHATE-1 RECEPTOR AGONISTS |
| AU2006226022A1 (en) | 2005-03-23 | 2006-09-28 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists |
| EP1863787B1 (en) | 2005-03-23 | 2011-05-25 | Actelion Pharmaceuticals Ltd. | Hydogrenated benzo[c]thiophene derivatives as immunomodulators |
| AR057894A1 (es) | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
| PL1979345T3 (pl) | 2006-01-24 | 2010-04-30 | Actelion Pharmaceuticals Ltd | Nowe pochodne pirydyny |
-
2006
- 2006-03-20 WO PCT/IB2006/050850 patent/WO2006100633A1/en active Application Filing
- 2006-03-20 KR KR1020077024345A patent/KR20070116645A/ko not_active Application Discontinuation
- 2006-03-20 AT AT06727683T patent/ATE413874T1/de active
- 2006-03-20 US US11/909,436 patent/US7605269B2/en not_active Expired - Fee Related
- 2006-03-20 EP EP06727683A patent/EP1863474B1/en active Active
- 2006-03-20 JP JP2008502540A patent/JP5072825B2/ja not_active Expired - Fee Related
- 2006-03-20 CN CN2006800092312A patent/CN101146529B/zh not_active Expired - Fee Related
- 2006-03-20 AU AU2006226020A patent/AU2006226020A1/en not_active Abandoned
- 2006-03-20 NZ NZ562561A patent/NZ562561A/en not_active IP Right Cessation
- 2006-03-20 RU RU2007138869/04A patent/RU2404178C2/ru not_active IP Right Cessation
- 2006-03-20 BR BRPI0609668-9A patent/BRPI0609668A2/pt not_active IP Right Cessation
- 2006-03-20 DK DK06727683T patent/DK1863474T3/da active
- 2006-03-20 PT PT06727683T patent/PT1863474E/pt unknown
- 2006-03-20 MX MX2007011672A patent/MX2007011672A/es active IP Right Grant
- 2006-03-20 PL PL06727683T patent/PL1863474T3/pl unknown
- 2006-03-20 DE DE602006003642T patent/DE602006003642D1/de active Active
- 2006-03-20 ES ES06727683T patent/ES2316062T3/es active Active
- 2006-03-20 SI SI200630178T patent/SI1863474T1/sl unknown
- 2006-03-20 CA CA2602475A patent/CA2602475C/en not_active Expired - Fee Related
- 2006-03-22 TW TW095109955A patent/TW200700406A/zh unknown
- 2006-03-22 AR ARP060101135A patent/AR055751A1/es not_active Application Discontinuation
-
2007
- 2007-09-20 IL IL186150A patent/IL186150A0/en unknown
- 2007-10-17 NO NO20075298A patent/NO20075298L/no not_active Application Discontinuation
- 2007-10-22 ZA ZA200709087A patent/ZA200709087B/xx unknown
-
2009
- 2009-02-05 CY CY20091100133T patent/CY1108750T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE413874T1 (de) | 2008-11-15 |
| AU2006226020A1 (en) | 2006-09-28 |
| CA2602475A1 (en) | 2006-09-28 |
| PT1863474E (pt) | 2009-01-20 |
| RU2404178C2 (ru) | 2010-11-20 |
| RU2007138869A (ru) | 2009-04-27 |
| TW200700406A (en) | 2007-01-01 |
| PL1863474T3 (pl) | 2009-04-30 |
| CN101146529B (zh) | 2012-08-29 |
| DK1863474T3 (da) | 2009-02-09 |
| AR055751A1 (es) | 2007-09-05 |
| CY1108750T1 (el) | 2014-04-09 |
| IL186150A0 (en) | 2008-01-20 |
| JP2008534491A (ja) | 2008-08-28 |
| ES2316062T3 (es) | 2009-04-01 |
| WO2006100633A1 (en) | 2006-09-28 |
| MX2007011672A (es) | 2007-11-15 |
| JP5072825B2 (ja) | 2012-11-14 |
| ZA200709087B (en) | 2008-09-25 |
| EP1863474B1 (en) | 2008-11-12 |
| CA2602475C (en) | 2014-11-04 |
| SI1863474T1 (sl) | 2009-04-30 |
| KR20070116645A (ko) | 2007-12-10 |
| US7605269B2 (en) | 2009-10-20 |
| US20080318955A1 (en) | 2008-12-25 |
| CN101146529A (zh) | 2008-03-19 |
| NZ562561A (en) | 2010-11-26 |
| DE602006003642D1 (en) | 2008-12-24 |
| BRPI0609668A2 (pt) | 2011-10-18 |
| EP1863474A1 (en) | 2007-12-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20075298L (no) | Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists | |
| NO20082793L (no) | Nye tiofenderivater | |
| NO20083462L (no) | Nye tiofenderivater som S1P1/EDG1-reseptoragonister | |
| NO20091395L (no) | Nye tiofenderivater | |
| NO20076648L (no) | Novel thiophene derivatives | |
| NO20071095L (no) | Hittil ukjente tiofenderivater | |
| NO20083630L (no) | Nye pyridinderivater | |
| NO20093146L (no) | Amino-pyridinderivater som S1P1/EDG1-reseptoragonister | |
| NO20075299L (no) | Hydrogenated benzo (c) thiophene derivatives as immunomodulators | |
| MX2010005889A (es) | Derivados de tiofeno como agonistas de s1p1/edg1. | |
| TW200716552A (en) | Novel thiophene derivatives | |
| DK1846394T3 (da) | Pyrazolylaminopyridinderivater, der er egnede som kinaseinhibitorer | |
| MX2010004576A (es) | Derivados de pirimidina novedosos. | |
| NO20090295L (no) | Substituerte heteroarylderivater | |
| WO2007133802A3 (en) | Pharmaceutical formulations of pimavanserin | |
| NO20085099L (no) | Puritonderivativer som HM74A agonister | |
| NO20085257L (no) | Purinonderivater som HM74a-agonister | |
| NO20083669L (no) | 4-aryl-2amino-pyrimidiner eller 4-aryl-2-aminoalkylpyrimidiner som jak-2-modulatorer og fremgangsmater for anvendelse derav | |
| TW200942524A (en) | Novel aminomethyl benzene derivatives | |
| DK1711177T3 (da) | 1H-thieno-2,3-c-pyrazolderivater, der er egnede som kinase-I-inhibitorer | |
| EA201170703A1 (ru) | Производные адамантилбензамида | |
| NO20081160L (no) | Benzimidazoltiofen forbindelser | |
| NO20084301L (no) | Tetrahydronaftalenderivater, fremgangsmate for deres fremstilling og anvendelse derav som anti-inflammatoriske midler | |
| DK2041069T3 (da) | Benzylaminer, fremgangsmåde til fremstilling deraf og deres anvendelse som anti-inflammatoriske midler | |
| DK1879580T3 (da) | 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinolinderivater som lægemidler til behandling af infertilitet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |